Arsenic trioxide in the treatment of advanced acute promyelocytic leukemia.

abstract：:Alemtuzumab serum levels and clinical response after subcutaneous administration (10 mg 3 times/week for six weeks) have been explored in 29 chronic lymphocytic leukemia patients receiving the monoclonal antibody as consolidation. Serum concentrations after each administration gradually increased during the first week...

journal_title：Haematologica

authors： Montagna M,Montillo M,Avanzini MA,Tinelli C,Tedeschi A,Visai L,Ricci F,Vismara E,Morra E,Regazzi M

更新日期：2011-06-01 00:00:00

abstract：:Our preliminary results suggest the existence of quantitative and qualitative differences in immune cells and type1 and type2 cytokines between granulocyte colony-stimulating factor (G-CSF) primed bone marrow (G-BM) and G-CSF-mobilized peripheral blood grafts (G-PB). Our findings suggest that lower T-cell hyporesponsi...

journal_title：Haematologica

authors： Jun HX,Jun CY,Yu ZX

更新日期：2005-05-01 00:00:00

abstract：:Hepcidin levels are high and iron absorption is limited in acute malaria. The mechanism(s) that regulate hepcidin secretion remain undefined. We have measured hepcidin concentration and cytokines in 100 Kenyan children with acute falciparum malaria and different degrees of anemia. Hepcidin was increased on admission a...

journal_title：Haematologica

authors： Casals-Pascual C,Huang H,Lakhal-Littleton S,Thezenas ML,Kai O,Newton CR,Roberts DJ

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Fms-like tyrosine kinase-3 (FLT3) gene mutations are frequent in acute promyelocytic leukemia but their prognostic value is not well established. DESIGN AND METHODS:We evaluated FLT3-internal tandem duplication and FLT3-D835 mutations in patients treated with all-trans retinoic acid and anthracycline-based ...

journal_title：Haematologica

authors： Barragán E,Montesinos P,Camos M,González M,Calasanz MJ,Román-Gómez J,Gómez-Casares MT,Ayala R,López J,Fuster Ó,Colomer D,Chillón C,Larrayoz MJ,Sánchez-Godoy P,González-Campos J,Manso F,Amador ML,Vellenga E,Lowenberg B

更新日期：2011-10-01 00:00:00

abstract：:Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-autonomous process, which is the focus of another review in the same issue of Haematologica However, studies on the microenvironment that maintains and regulates HSC (HSC niche) over the past 20 years have suggested that microenvironme...

journal_title：Haematologica

authors： Ho YH,Méndez-Ferrer S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The degree of globin chain imbalance and tissue hypoxia are important determinants of clinical severity in thalassemia syndromes. Thus phenotypic expression may be modified by interaction of alpha- and beta-thalassemia defects, level and type of hemoglobin synthesized and oxygen release to the...

journal_title：Haematologica

authors： Traeger-Synodinos J,Papassotiriou I,Vrettou C,Skarmoutsou C,Stamoulakatou A,Kanavakis E

更新日期：2001-04-01 00:00:00

abstract：:In patients with low and intermediate risk myelodysplastic syndrome and deletion 5q (del(5q)) treated with lenalidomide, monitoring of cytogenetic response is mandatory, since patients without cytogenetic response have a significantly increased risk of progression. Therefore, we have reviewed cytogenetic data of 302 p...

journal_title：Haematologica

authors： Göhring G,Giagounidis A,Büsche G,Hofmann W,Kreipe HH,Fenaux P,Hellström-Lindberg E,Schlegelberger B

更新日期：2011-02-01 00:00:00

abstract：:We studied the impact of comorbidities on survival and evaluated the prognostic utility of comorbidity scores in MDS patients, who received best supportive care and were assessable according to the Charlson Comorbidity Index (CCI) and the Hematopoietic Stem Cell Transplantation Comorbidity Index (HCTCI): 171 patients ...

journal_title：Haematologica

authors： Zipperer E,Pelz D,Nachtkamp K,Kuendgen A,Strupp C,Gattermann N,Haas R,Germing U

更新日期：2009-05-01 00:00:00

abstract：:Patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma often present with B-symptoms or hemophagocytosis and generate an anti-tumor immune response. Specific serum cytokine levels or profiles may reflect the tumor burden, non-specific immune stimulation by the tumor or differences in the stre...

journal_title：Haematologica

authors： Knörr F,Damm-Welk C,Ruf S,Singh VK,Zimmermann M,Reiter A,Woessmann W

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Patients with acute myeloblastic leukemia (AML) with features of myelodysplastic syndrome and abnormalities of megakaryocytopoiesis often have cytogenetic aberrations of 3q21 and 3q26 bands involving the paracentric inversion [inv(3) (q21q26)] or a reciprocal translocation [t(3;3) (q21;q26)]. ...

journal_title：Haematologica

authors： Martinelli G,Ottaviani E,Buonamici S,Isidori A,Borsaru G,Visani G,Piccaluga PP,Malagola M,Testoni N,Rondoni M,Nucifora G,Tura S,Baccarani M

更新日期：2003-11-01 00:00:00

abstract：:This study reports a case of granulocytic sarcoma that developed in the epidural zone 25 days before clinical evidence of an acute promyelocytic leukemia. The case presented the diagnostic difficulties that are common to all aleukemic granulocytic sarcomas. Moreover, it highlights the very rare association between gra...

journal_title：Haematologica

authors： Tosi A,De Paoli A,Fava S,Luoni M,Sironi M,Tocci A,Assi A,Cassi E

更新日期：1995-01-01 00:00:00

abstract：:The sialic-acid-binding immunoglobulin-like lectin SIGLEC-G is a negative regulator of B-cell receptor-mediated calcium signaling. Its deficiency leads to reduced turnover and increased proliferation and survival of murine B-1a cells. Siglecg(-/-) mice show a premature expansion of polyclonal CD5(+) B cells in the spl...

journal_title：Haematologica

authors： Simonetti G,Bertilaccio MT,Rodriguez TV,Apollonio B,Dagklis A,Rocchi M,Innocenzi A,Casola S,Winkler TH,Nitschke L,Ponzoni M,Caligaris-Cappio F,Ghia P

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Patients with beta-thalassemia, like those with genetic hemochromatosis, develop iron overload due to increased iron absorption, and their iron burden is further exacerbated by transfusion therapy. Hepcidin, a hepatic hormone, regulates systemic iron homeostasis by inhibiting the absorption of...

journal_title：Haematologica

authors： Origa R,Galanello R,Ganz T,Giagu N,Maccioni L,Faa G,Nemeth E

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Anaplastic lymphoma kinase (ALK) oncogenic fusion proteins, expressed in about 60% of anaplastic large cell lymphomas (ALCL), are tumor-specific molecular targets for such a malignancy. One of the promising ALK-targeted therapeutic options is cancer vaccination. In this study, we investigate w...

journal_title：Haematologica

authors： Passoni L,Gallo B,Biganzoli E,Stefanoni R,Massimino M,Di Nicola M,Gianni AM,Gambacorti-Passerini C

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Mantle cell lymphoma (MCL) is a separate histological and clinical entity recently recognized in the new revised European-American Lymphoma Classification. Little information exists regarding its therapy. We report the results of a retrospective study of 27 patients affected by MCL evaluating t...

journal_title：Haematologica

authors： Bertini M,Rus C,Freilone R,Botto B,Calvi R,Novero D,Orsucci L,Vitolo U,Palestro G,Resegotti L

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Rituximab reacts specifically with the CD20 antigen and induces B-cell depletion. This could interfere with the production of autoantibodies in some immune diseases. The objective of this study was to assess the effects of rituximab in autoimmune hemolytic anemia and thrombocytopenia. DESIGN ...

journal_title：Haematologica

authors： Zaja F,Iacona I,Masolini P,Russo D,Sperotto A,Prosdocimo S,Patriarca F,de Vita S,Regazzi M,Baccarani M,Fanin R

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Preclinical studies have highlighted the activity of lenalidomide in mantle cell lymphoma and its anti-proliferative synergy with dexamethasone. DESIGN AND METHODS:In this prospective, multicenter, phase II study, patients with relapsed/refractory mantle cell lymphoma who were not eligible for, or had relap...

journal_title：Haematologica

authors： Zaja F,De Luca S,Vitolo U,Orsucci L,Levis A,Salvi F,Rusconi C,Ravelli E,Tucci A,Bottelli C,Balzarotti M,Brusamolino E,Bonfichi M,Pileri SA,Sabattini E,Volpetti S,Monagheddu C,Vacca A,Ria R,Fanin R

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Pathogen-derived molecules are danger signals and are able to activate innate immunity that in turn controls and regulates generation of adaptive immune responses. Mycobacterium tuberculosis heat shock protein 70 (myc HSP70) has been shown to exert a potent adjuvant effect in vaccination again...

journal_title：Haematologica

authors： Liso A,Benedetti R,Fagioli M,Mariano A,Falini B

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Immunoglobulin gene somatic hypermutation is a biologically relevant and clinically useful prognostic factor in different types of low-grade B-cell lymphomas, including chronic lymphocytic leukemia, mantle cell lymphoma and splenic marginal zone lymphoma. DESIGN AND METHODS:With the aim of identifying surro...

journal_title：Haematologica

authors： Tracey L,Aggarwal M,García-Cosio M,Villuendas R,Algara P,Sánchez-Beato M,Sánchez-Aguilera A,García JF,Rodríguez A,Camacho FI,Martínez N,Ruiz-Ballesteros E,Mollejo M,Piris MA

更新日期：2008-08-01 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematopoietic neoplasm whose immunophenotype remains incompletely characterized, particularly in terms of distinction from reactive plasmacytoid dendritic cells (PDCs). This limitation complicates detection of low-level involvement by BPDCN as well as mini...

journal_title：Haematologica

authors： Wang W,Khoury JD,Miranda RN,Jorgensen JL,Xu J,Loghavi S,Li S,Pemmaraju N,Nguyen T,Medeiros LJ,Wang SA

更新日期：2020-04-02 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia is a clonal hematopoietic malignant disease; about 45-50% of cases do not have detectable chromosomal abnormalities. Here, we identified hidden genomic alterations and novel disease-related regions in normal karyotype acute myeloid leukemia/myelodysplastic syndrome samples. DESIGN AND...

journal_title：Haematologica

authors： Akagi T,Ogawa S,Dugas M,Kawamata N,Yamamoto G,Nannya Y,Sanada M,Miller CW,Yung A,Schnittger S,Haferlach T,Haferlach C,Koeffler HP

更新日期：2009-02-01 00:00:00

abstract：:Effects of concurrent inhibition of mTORC1/2 and Bcl-2/Bcl-xL in human acute myeloid leukemia cells were examined. Tetracycline-inducible Bcl-2/Bcl-xL dual knockdown markedly sensitized acute myeloid leukemia cells to the dual TORC1/2 inhibitor INK128 in vitro as well as in vivo. Moreover, INK128 co-administered with ...

journal_title：Haematologica

authors： Rahmani M,Aust MM,Hawkins E,Parker RE,Ross M,Kmieciak M,Reshko LB,Rizzo KA,Dumur CI,Ferreira-Gonzalez A,Grant S

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We analyzed the factors that affected the number and quality of peripheral blood stem cells (PBSC) collected for transplant in order to establish a minimum threshold for rapid hematopoietic recovery. DESIGN AND METHODS:From January 1995 to November 1996, a consecutive series of 67 patients, wi...

journal_title：Haematologica

authors： Sampol Mayol A,Besalduch Vital J,Galmés Llodrá A,Bargay Lleonart J,Matamoros Flori N,Morey Sureda M,Novo García A,Mascaró Riera M,Gonzaléz Bach E,Martínez García P

更新日期：1998-06-01 00:00:00

abstract：:We previously reported initial results in 102 multiple myeloma (MM) patients treated with sequential high-dose melphalan and autologous hematopoietic cell transplantation followed by 200 cGy total body irradiation with or without fludarabine 90 mg/m2 and allogeneic hematopoietic cell transplantation. Here we present l...

journal_title：Haematologica

authors： Maffini E,Storer BE,Sandmaier BM,Bruno B,Sahebi F,Shizuru JA,Chauncey TR,Hari P,Lange T,Pulsipher MA,McSweeney PA,Holmberg L,Becker PS,Green DJ,Mielcarek M,Maloney DG,Storb R

更新日期：2019-02-01 00:00:00

abstract：:To identify factors associated with relapse-free survival (RFS), 80 patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia, enrolled in a phase II study of imatinib-combined chemotherapy, were analyzed. The median follow-up of surviving patients was 26.7 months (maximum, 52.5 month...

journal_title：Haematologica

authors： Yanada M,Takeuchi J,Sugiura I,Akiyama H,Usui N,Yagasaki F,Nishii K,Ueda Y,Takeuchi M,Miyawaki S,Maruta A,Narimatsu H,Miyazaki Y,Ohtake S,Jinnai I,Matsuo K,Naoe T,Ohno R,Japan Adult Leukemia Study Group.

更新日期：2008-02-01 00:00:00

abstract：:Cough mixture abuse has been reported to cause severe folate deficiency and neurological defects. We carried out a prospective case-controlled survey to confirm this association and define the incidence and severity of the problem. A total of 57 cough mixture abusers and 47 other substance abusers (controls) were stud...

journal_title：Haematologica

authors： Au WY,Tsang SK,Cheung BK,Siu TS,Ma ES,Tam S

更新日期：2007-04-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis is a life-threatening systemic hyperinflammatory disorder with primary and secondary forms. Primary hemophagocytic lymphohistiocytosis is associated with inherited defects in various genes that affect the immunological cytolytic pathway. Secondary hemophagocytic lymphohistiocytosis i...

journal_title：Haematologica

authors： Tsuboi I,Harada T,Hirabayashi Y,Aizawa S

更新日期：2019-10-01 00:00:00

abstract：:Since its first description in Hodgkin's disease, alcohol-induced pain has subsequently been described both in other neoplasms and in various non-malignant conditions. There seems little doubt that ethyl alcohol itself is responsible, although the mechanism for producing pain remains elusive. We report a case of alcoh...

journal_title：Haematologica

authors： Custodi P,Cerutti A,Bagnato R,Cassani P

更新日期：1993-11-01 00:00:00

abstract：:Evaluation of Anagrelide (Xagrid®) Efficacy and Long-term Safety, a phase IV, prospective, non-interventional study performed in 13 European countries enrolled high-risk essential thrombocythemia patients treated with cytoreductive therapy. The primary objectives were safety and pregnancy outcomes. Of 3721 registered ...

journal_title：Haematologica

authors： Birgegård G,Besses C,Griesshammer M,Gugliotta L,Harrison CN,Hamdani M,Wu J,Achenbach H,Kiladjian JJ

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Interleukin-17A is the signature cytokine of the Th17 subset and drives inflammatory pathology, but its relevance to autoantibody-mediated diseases is unclear. Th1 cells secreting interferon-γ have been implicated in autoimmune hemolytic anemia, so the aim was to determine which cytokine is more closely asso...

journal_title：Haematologica

authors： Hall AM,Zamzami OM,Whibley N,Hampsey DP,Haggart AM,Vickers MA,Barker RN

更新日期：2012-10-01 00:00:00