Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis.

abstract：BACKGROUND AND OBJECTIVE:Hepatocyte growth factor (HGF) is known to augment the effects of stem cell factor, interleukin-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), erythropoetin, and granulocyte colony-stimulating factor, all of which are involved in hematopoiesis. HGF is also known to have a role in...

journal_title：Haematologica

authors： Ovali E,Ratip S,Kibaroglu A,Tekelioglu Y,Cetiner M,Karti S,Aydin F,Bayik M,Akoglu T

更新日期：2000-05-01 00:00:00

abstract：:Although myelodysplastic syndromes are heterogeneous disorders comprising a benign subset of bone marrow failure similar to aplastic anemia, no laboratory test has been established to distinguish it from bone marrow failures that can evolve into acute myeloid leukemia. Plasma thrombopoietin levels were measured in 120...

journal_title：Haematologica

authors： Seiki Y,Sasaki Y,Hosokawa K,Saito C,Sugimori N,Yamazaki H,Takami A,Nakao S

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Resistance to imatinib is an important clinical issue in the treatment of Philadelphia chromosome-positive leukemias which is being tackled by the development of new, more potent drugs, such as the dual Src/Abl tyrosine kinase inhibitors dasatinib and bosutinib and the imatinib analog nilotinib. In the curre...

journal_title：Haematologica

authors： Puttini M,Redaelli S,Moretti L,Brussolo S,Gunby RH,Mologni L,Marchesi E,Cleris L,Donella-Deana A,Drueckes P,Sala E,Lucchini V,Kubbutat M,Formelli F,Zambon A,Scapozza L,Gambacorti-Passerini C

更新日期：2008-05-01 00:00:00

abstract：:Ruxolitinib, a potent Janus kinase 1/2 inhibitor, resulted in rapid and durable improvements in splenomegaly and disease-related symptoms in the 2 phase III COMFORT studies. In addition, ruxolitinib was associated with prolonged survival compared with placebo (COMFORT-I) and best available therapy (COMFORT-II). We pre...

journal_title：Haematologica

authors： Vannucchi AM,Kantarjian HM,Kiladjian JJ,Gotlib J,Cervantes F,Mesa RA,Sarlis NJ,Peng W,Sandor V,Gopalakrishna P,Hmissi A,Stalbovskaya V,Gupta V,Harrison C,Verstovsek S,COMFORT Investigators.

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Chimeric oncogenes encoding constitutively active protein tyrosine kinases are associated with chronic myeloid neoplasms. TEL-PDGFRbeta (TPbeta, also called ETV6-PDGFRB) is a hybrid protein produced by the t(5;12) translocation, FIP1L1-PDGFRalpha (FPalpha) results from a deletion on chromosome 4q12 and ZNF19...

journal_title：Haematologica

authors： Toffalini F,Kallin A,Vandenberghe P,Pierre P,Michaux L,Cools J,Demoulin JB

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Preclinical studies have highlighted the activity of lenalidomide in mantle cell lymphoma and its anti-proliferative synergy with dexamethasone. DESIGN AND METHODS:In this prospective, multicenter, phase II study, patients with relapsed/refractory mantle cell lymphoma who were not eligible for, or had relap...

journal_title：Haematologica

authors： Zaja F,De Luca S,Vitolo U,Orsucci L,Levis A,Salvi F,Rusconi C,Ravelli E,Tucci A,Bottelli C,Balzarotti M,Brusamolino E,Bonfichi M,Pileri SA,Sabattini E,Volpetti S,Monagheddu C,Vacca A,Ria R,Fanin R

更新日期：2012-03-01 00:00:00

abstract：:A case of cholesterol embolism of bone marrow, concerning the pelvis and lumbar region and clinically masquerading as systemic disease or metastatic tumor, is reported in an 82-year-old man hospitalized for acute onset of reddish purple nodules on the legs and toes, intense myalgia and dorsal vertebral bone pain. The ...

journal_title：Haematologica

authors： Muretto P,Carnevali A,Ansini AL

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Loss of heterozygosity (LOH) on the long arm of chromosome 7 (7q) has been frequently reported in several types of human cancer including hematologic malignancies. Moreover, monosomy of chromosome 7 and 7q deletions have been associated in acute myeloid leukemia (AML) with aggressive disease a...

journal_title：Haematologica

authors： Basiricò R,Pirrotta R,Fabbiano F,Mirto S,Cascio L,Pagano M,Cammarata G,Magrin S,Santoro A

更新日期：2003-04-01 00:00:00

abstract：:In the eighties there has been an enormous increase in our knowledge about erythropoietin, previously defined as "an elusive hormone". In this review we summarize the structural and molecular features, the mechanisms of production and of metabolism, the more important methods of assay, the mechanism of action and the ...

journal_title：Haematologica

authors： Liberato NL,Costa A,Barosi G

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Idarubicin (IDA) is relatively immune to the multidrug resistance P-gp mechanism that is frequently expressed in recurrent and refractory hematologic malignancies. Owing to rapid metabolism in vivo, a continuous infusion (CI) of IDA might prolong exposure time to the parent drug rather than its...

journal_title：Haematologica

authors： Bassan R,Chiodini B,Zucchetti M,Lerede T,Cornelli PE,Cortelazzo S,Barbui T

更新日期：1998-01-01 00:00:00

abstract：:Systemic anaplastic large cell lymphoma is a category of T-cell non-Hodgkin's lymphoma which can be further subdivided into two distinct entities (ALK(+) and ALK(-)) based on the presence or absence of ALK gene rearrangements. Among several pathways triggered by ALK signaling, constitutive activation of STAT3 is stric...

journal_title：Haematologica

authors： Spaccarotella E,Pellegrino E,Ferracin M,Ferreri C,Cuccuru G,Liu C,Iqbal J,Cantarella D,Taulli R,Provero P,Di Cunto F,Medico E,Negrini M,Chan WC,Inghirami G,Piva R

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Antithymocyte globulin or human Jurkat T-cell-line-derived antilymphocyte globulin is used in allogeneic stem cell transplantation to induce in vivo T-cell depletion to facilitate engraftment and lower graft-versus-host disease. In vitro studies suggest that antithymocyte globulin, besides causing T-cell dep...

journal_title：Haematologica

authors： Ayuk F,Perez-Simon JA,Shimoni A,Sureda A,Zabelina T,Schwerdtfeger R,Martino R,Sayer HG,Alegre A,Lahuerta JJ,Atanackovic D,Wolschke C,Nagler A,Zander AR,San Miguel JF,Kröger N

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/progenitor cells overexpressing miR-125b is able to induce l...

journal_title：Haematologica

authors： Bousquet M,Nguyen D,Chen C,Shields L,Lodish HF

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:An effective second-line treatment for intermediate and high grade non-Hodgkin's lymphoma is greatly needed since 30% of patients do not achieved complete remission (CR) and another 20% to 30% of the CRs will eventually relapse. METHODS:A four-drug combination with Mitoxantrone, Etoposide, Cisplatin and Dex...

journal_title：Haematologica

authors： Vitolo U,Orsucci L,Bertini M,Cavallero G,Gallamini A,Ghio R,Levis A,Rota-Scalabrini D,Resegotti L

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Patients with hematologic malignancies can be successfully treated with donor lymphocyte infusion after HLA-matched allogeneic hematopoietic stem cell transplantation. The effect of donor lymphocyte infusion is mediated by donor T cells recognizing minor histocompatibility antigens. T cells recognizing hemat...

journal_title：Haematologica

authors： Griffioen M,Honders MW,van der Meijden ED,van Luxemburg-Heijs SA,Lurvink EG,Kester MG,van Bergen CA,Falkenburg JH

更新日期：2012-08-01 00:00:00

abstract：:In 2004, we reported the short-term results of a multicentric, phase 2 study of imatinib 400 mg daily and pegylated interferon-alpha in the treatment of 76 early chronic phase Philadelphia-positive chronic myeloid leukemia patients. In this report, we update the results with an observation time of five years. After tw...

journal_title：Haematologica

authors： Palandri F,Iacobucci I,Castagnetti F,Testoni N,Poerio A,Amabile M,Breccia M,Intermesoli T,Iuliano F,Rege-Cambrin G,Tiribelli M,Miglino M,Pane F,Saglio G,Martinelli G,Rosti G,Baccarani M,GIMEMA Working Party on CML.

更新日期：2008-05-01 00:00:00

abstract：:Epidemiological evidence suggests that infection is involved in the etiology of common acute lymphoblastic leukemia, either by stimulating an inappropriate immune response or in the form of a classical transforming agent. In an attempt to elucidate the role that infection is playing in this disease, we used representa...

journal_title：Haematologica

authors： MacKenzie J,Greaves MF,Eden TO,Clayton RA,Perry J,Wilson KS,Jarrett RF

更新日期：2006-02-01 00:00:00

abstract：:Blackfan-Diamond anemia (BDA) is a rare hypoproliferative anemia occurring in infancy or in early childhood. Patients who fail on usual doses of steroids did not achieve remission with other pharmacological agents. Claims that other molecules such as cyclosporin A (CSA) or antithymocyte globulin (ATG) are effective re...

journal_title：Haematologica

authors： Bejaoui M,Fitouri Z,Sfar MT,Lakhoua R

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Epigenetic changes are involved in the extinction of the B-cell gene expression program of classical Hodgkin's lymphoma. However, little is known regarding epigenetic similarities between cells of classical Hodgkin's lymphoma and plasma cell myeloma, both of which share extinction of the gene expression prog...

journal_title：Haematologica

authors： Seitz V,Thomas PE,Zimmermann K,Paul U,Ehlers A,Joosten M,Dimitrova L,Lenze D,Sommerfeld A,Oker E,Leser U,Stein H,Hummel M

更新日期：2011-06-01 00:00:00

abstract：:Hodgkin's lymphoma (HL) simulating acute cholestatic hepatitis is a very unusual clinical picture. Massive liver infiltration with conspicuous acute cholestatic symptoms, in fact, suggests more aggressive systemic diseases such as non Hodgkin's lymphomas or acute leukemias. Nevertheless, we observed two cases of mixed...

journal_title：Haematologica

authors： Marinone G,Lazzari R,Pellizzari F,Marinone MG

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Thrombosis is the major risk factor for death in patients with paroxysmal nocturnal hemoglobinuria. Previous case reports indicate that venous thrombosis in patients with paroxysmal nocturnal hemoglobinuria is amenable to thrombolysis. DESIGN AND METHODS:We reviewed the outcome of thrombolytic therapy for p...

journal_title：Haematologica

authors： Araten DJ,Notaro R,Thaler HT,Kernan N,Boulad F,Castro-Malaspina H,Small T,Scaradavou A,Magnan H,Prockop S,Chaffee S,Gonsky J,Thertulien R,Tarquini R,Luzzatto L

更新日期：2012-03-01 00:00:00

abstract：:Plasma transfusion is indicated for replenishment of coagulative proteins to stop or prevent bleeding. In 2014, the Netherlands switched from using ~300mL fresh frozen plasma (FFP) units to using 200mL Omniplasma, a solvent/detergent treated pooled plasma (SD plasma), units. We evaluated the effect of the introduction...

journal_title：Haematologica

authors： Saadah NH,Schipperus MR,Wiersum-Osselton JC,van Kraaij MG,Caram-Deelder C,Beckers EAM,Leyte A,Rondeel JMM,de Vooght KMK,Weerkamp F,Zwaginga JJ,van der Bom JG

更新日期：2020-04-01 00:00:00

abstract：:Over the last decades, incrementally improved xenograft mouse models, supporting the engraftment and development of a human hemato-lymphoid system, have been developed and now represent an important research tool in the field. The most significant contributions made by means of humanized mice are the identification of...

journal_title：Haematologica

authors： Theocharides AP,Rongvaux A,Fritsch K,Flavell RA,Manz MG

更新日期：2016-01-01 00:00:00

abstract：:Second-line therapy for corticosteroid-refractory or -dependent acute graft-versus-host disease remains ill-defined, due to limited efficacy of drugs and evolving clinical trial endpoints. Six-month freedom from treatment failure has been proposed as a novel clinical trial endpoint and is defined by the absence of dea...

journal_title：Haematologica

authors： Das-Gupta E,Greinix H,Jacobs R,Zhou L,Savani BN,Engelhardt BG,Kassim A,Worel N,Knobler R,Russell N,Jagasia M

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Imatinib can induce severe hepatotoxicity, in 1-5% of CML patients, many of whom need permanent imatinib discontinuation. DESIGN AND RESULTS:We report 5 CML patients who developed grade 3-4 hepatotoxicity after 2-8 months in imatinib. Different aetiologies of liver damage were ruled out and toxicity recurre...

journal_title：Haematologica

authors： Ferrero D,Pogliani EM,Rege-Cambrin G,Fava C,Mattioli G,Dellacasa C,Campa E,Perfetti P,Fumagalli M,Boccadoro M

更新日期：2006-06-01 00:00:00

abstract：:Multiple myeloma is an incurable hematologic cancer characterized by the clonal proliferation of malignant plasma cells within the bone marrow. Numerous studies suggest that the myeloma plasma cells occupy and alter the stromal tissue of the bone marrow as a means of enhancing their survival and growth. However, the n...

journal_title：Haematologica

authors： Noll JE,Williams SA,Tong CM,Wang H,Quach JM,Purton LE,Pilkington K,To LB,Evdokiou A,Gronthos S,Zannettino AC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:In trials designed to evaluate new therapies for hematologic malignancies, end points such as leukemia-free survival are often used as surrogates for overall survival in acute leukemia. We aimed to assess whether leukemia-free survival is an acceptable statistical surrogate for overall survival when applied ...

journal_title：Haematologica

authors： Buyse M,Michiels S,Squifflet P,Lucchesi KJ,Hellstrand K,Brune ML,Castaigne S,Rowe JM

更新日期：2011-08-01 00:00:00

abstract：:Sixteen autologous stem cell transplant recipients received three vaccinations with conjugated haemophilus influenzae type b vaccine. Quantitative and qualitative aspects of the antibody response were studied. The vaccination schedule resulted in high antibody response rates and functional maturation of antibodies, as...

journal_title：Haematologica

authors： van der Velden AM,Claessen AM,van Velzen-Blad H,Biesma DH,Rijker GT

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Many different techniques have been designed for the quantification of JAK2V617F allelic burden, sometimes producing discrepant results. DESIGN AND METHODS:JAK2V617F quantification techniques were compared among 16 centers using 11 assays based on quantitative polymerase chain reaction (with mutation-specif...

journal_title：Haematologica

authors： Lippert E,Girodon F,Hammond E,Jelinek J,Reading NS,Fehse B,Hanlon K,Hermans M,Richard C,Swierczek S,Ugo V,Carillo S,Harrivel V,Marzac C,Pietra D,Sobas M,Mounier M,Migeon M,Ellard S,Kröger N,Herrmann R,Prchal JT

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Effective gene transfer into human hematopoietic stem/progenitor cells is a compromise between achieving high transduction efficiency and maintaining the desired biological characteristics of the target cell. The aim of our work was to exploit the stromal microenvironment to increase gene tran...

journal_title：Haematologica

authors： Dando JS,Ficara F,Deola S,Roncarolo MG,Bordignon C,Aiuti A

更新日期：2004-04-01 00:00:00