Abstract:
BACKGROUND:Imatinib can induce severe hepatotoxicity, in 1-5% of CML patients, many of whom need permanent imatinib discontinuation. DESIGN AND RESULTS:We report 5 CML patients who developed grade 3-4 hepatotoxicity after 2-8 months in imatinib. Different aetiologies of liver damage were ruled out and toxicity recurred in 2 patients with further attempts at low dose imatinib. In all patients prednisone or methylprednisolone at 25- 40 mg/day resolved hepatotoxicity in 3-8 weeks and allowed imatinib to be resumed at full doses. Corticosteroid were tapered off in 3-5 months without hepatotoxicity recurrence. CONCLUSIONS:Corticosteroid may avoid discontinuation for hepatotoxicity of the most effective anti-CML therapy.
journal_name
Haematologicajournal_title
Haematologicaauthors
Ferrero D,Pogliani EM,Rege-Cambrin G,Fava C,Mattioli G,Dellacasa C,Campa E,Perfetti P,Fumagalli M,Boccadoro Msubject
Has Abstractpub_date
2006-06-01 00:00:00pages
ECR27issue
6 Suppleissn
0390-6078issn
1592-8721journal_volume
91pub_type
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