Monitoring BCR-ABL transcript levels by real-time quantitative polymerase chain reaction: a linear regression equation to convert from BCR-ABL/B2M ratio to estimated BCR-ABL/ABL ratio.

abstract：:Whole blood donors, especially frequently donating donors, have a risk of iron deficiency and low hemoglobin levels, which may affect their health and eligibility to donate. Lifestyle behaviors, such as dietary iron intake and physical activity, may influence iron stores and thereby hemoglobin levels. We aimed to inve...

journal_title：Haematologica

authors： Timmer TC,de Groot R,Rijnhart JJM,Lakerveld J,Brug J,Perenboom CWM,Baart MA,Prinsze FJ,Zalpuri S,van der Schoot EC,de Kort WLAM,van den Hurk K

更新日期：2020-10-01 00:00:00

abstract：:Peripheral cytopenia has been reported in a number of patients with the acquired immunodeficiency syndrome (AIDS), but the mechanism of bone marrow (BM) failure is unclear. We have examined the BM morphology and cytokinetics of 16 untreated HIV-positive patients whose clinical condition ranged from asymptomatic (stage...

journal_title：Haematologica

authors： Danova M,Riccardi A,Brugnatelli S,Maserati R,Comolli G,Mazzini G,Castello A,Ascari E,Rondanelli EG

更新日期：1989-07-01 00:00:00

abstract：:It has been postulated that monitoring measurable residual disease (MRD) could be used as a surrogate marker of progression-free survival (PFS) in chronic lymphocytic leukemia (CLL) patients after treatment with immunochemotherapy regimens. In this study, we analyzed the outcome of 84 patients at 3 years of follow-up ...

journal_title：Haematologica

authors： García-Marco JA,Jiménez JL,Recasens V,Zarzoso MF,González-Barca E,De Marcos NS,Ramírez MJ,Parraga FJP,Yañez L,De La Serna Torroba J,Malo MDG,Ariznavarreta GD,Persona EP,Guinaldo MAR,De Paz Arias R,Llanos EB,Jarque I,Val

更新日期：2019-11-01 00:00:00

abstract：:It is currently unknown whether immunosuppressive therapy or hematopoietic stem cell transplantation is the most appropriate treatment strategy for children with refractory cytopenia and normal karyotype or trisomy 8. We report on 31 children with hypoplastic refractory cytopenia treated with immunosuppressive therapy...

journal_title：Haematologica

authors： Yoshimi A,Baumann I,Führer M,Bergsträsser E,Göbel U,Sykora KW,Klingebiel T,Gross-Wieltsch U,van den Heuvel-Eibrink MM,Fischer A,Nöllke P,Niemeyer C

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:A progressively growing number of peripheral blood stem cell transplants (PBSCTs) are being performed in patients with newly diagnosed multiple myeloma (MM) since they are ever more frequently being offered as up-front therapy. Furthermore, there are considerable concerns regarding the appropr...

journal_title：Haematologica

authors： Morabito F,Martino M,Stelitano C,Oliva E,Kropp M,Irrera G,Console G,Fujo M,Messina G,Molica S,Callea V,Iacopino P

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Chronic graft-versus-host disease is a common late complication of allogeneic hematopoietic stem cell transplantation. Corticosteroids are the standard initial treatment. Second-line treatment has not been well defined. We evaluated the effectiveness and safety of low doses of alemtuzumab plus low doses of r...

journal_title：Haematologica

authors： Gutiérrez-Aguirre CH,Cantú-Rodríguez OG,Borjas-Almaguer OD,González-Llano O,Jaime-Pérez JC,Solano-Genesta M,Gómez-Guijosa M,Mancias-Guerra C,Tarin L,Gómez-Almaguer D

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Myeloid leukemia of Down's syndrome (ML-DS) has characteristic biological features (e.g. expression of the truncated GATA1s), which are different from those of non-DS childhood acute myeloid leukemias (AML). The objective of this study was to investigate factors predisposing to the development...

journal_title：Haematologica

authors： Langebrake C,Klusmann JH,Wortmann K,Kolar M,Puhlmann U,Reinhardt D

更新日期：2006-11-01 00:00:00

abstract：:A case of thrombotic thrombocytopenic purpura (TTP) in a 40-year-old bisexual man unaware of being HIV positive is reported. The hematologic syndrome represented the first clinical manifestation of this viral infection. The clinical picture, characterized by severe hemolytic microangiopathic anemia, thrombocytopenia, ...

journal_title：Haematologica

authors： Cruccu V,Parisio E,Pedretti D,Villa A,Confalonieri F

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Mantle cell lymphoma (MCL) is a separate histological and clinical entity recently recognized in the new revised European-American Lymphoma Classification. Little information exists regarding its therapy. We report the results of a retrospective study of 27 patients affected by MCL evaluating t...

journal_title：Haematologica

authors： Bertini M,Rus C,Freilone R,Botto B,Calvi R,Novero D,Orsucci L,Vitolo U,Palestro G,Resegotti L

更新日期：1998-04-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) can be administered after a peripheral blood stem cell transplantation with the aim of accelerating neutrophil recovery. In a randomized, single-blind study we studied a new administration schedule of G-CSF in this context. ...

journal_title：Haematologica

authors： Piccirillo N,De Matteis S,Sorà F,d'Onofrio G,Leone G,Sica S

更新日期：2004-09-01 00:00:00

abstract：:The availability of reliable and standardizable procedures with low contamination risk and less prominent loss in MNC, would solve the existing perplexities about the systematic use of this passage. We tried to experiment Areman's et al protocol that utilizes the CS 3000 blood cell processor without gradient, making s...

journal_title：Haematologica

authors： Franchini E,Porlezza M

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate the tolerability and effectiveness of a non-myeloablative conditioning regimen followed by autologous hematopoietic stem cell infusion for the treatment of severe autoimmune diseases. DESIGN AND METHODS:From 1996 patients with severe autoimmune disease no...

journal_title：Haematologica

authors： Rabusin M,Andolina M,Maximova N,Lepore L,Parco S,Tuveri G,Jankovic G

更新日期：2000-11-01 00:00:00

abstract：:There is increasing evidence that monoclonal proteins are implicated in the development of peripheral neuropathy. Approximately ten percent of patients with peripheral neuropathy of unknown cause have a monoclonal protein and this rate is significantly higher than prevalence rates of monoclonal protein in comparable s...

journal_title：Haematologica

authors： Nemni R,Gerosa E,Piccolo G,Merlini G

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:An effective second-line treatment for intermediate and high grade non-Hodgkin's lymphoma is greatly needed since 30% of patients do not achieved complete remission (CR) and another 20% to 30% of the CRs will eventually relapse. METHODS:A four-drug combination with Mitoxantrone, Etoposide, Cisplatin and Dex...

journal_title：Haematologica

authors： Vitolo U,Orsucci L,Bertini M,Cavallero G,Gallamini A,Ghio R,Levis A,Rota-Scalabrini D,Resegotti L

更新日期：1991-01-01 00:00:00

abstract：:Arecent source data meta-analysis of randomized trials in adults assessing the immunoconjugate gemtuzumab ozogamicin combined with standard chemotherapy in acute myeloid leukemia showed a significant survival benefit in patients without an adverse karyotype. It is not clear whether the optimal dose should be 3 mg/m(2)...

journal_title：Haematologica

authors： Burnett A,Cavenagh J,Russell N,Hills R,Kell J,Jones G,Nielsen OJ,Khwaja A,Thomas I,Clark R,UK NCRI AML Study Group.

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Assays to evaluate platelet function are often interchangeably used to assess "resistance" to aspirin. We compared different platelet function assays in patients treated or untreated with aspirin. DESIGN AND METHODS:Platelet function was evaluated in 162 subjects, 85 of whom were not being treated with any ...

journal_title：Haematologica

authors： Renda G,Zurro M,Malatesta G,Ruggieri B,De Caterina R

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:In recent years many therapeutic regimens have been designed in order to improve response rate and response duration in non-Hodgkin's lymphoma (NHL). In 1991 the Italian Lymphoma Study Group (GISL) started a prospective randomized trial on treatment of aggressive and advanced NHL, focused on the efficacy of ...

journal_title：Haematologica

authors： Brugiatelli M,Federico M,Gobbi PG,Avanzini P,Callea V,Cavanna L,De Pasquale A,Di Prisco AU,Di Rienzo N,Silingardi V

更新日期：1993-09-01 00:00:00

abstract：:The aim of this study was to investigate the microRNA (miRNA) expression pattern in neutrophils from rheumatoid arthritis (RA) patients and its contribution to their pathogenic profile and to analyze the effect of specific autoantibodies or inflammatory components in the regulation of miRNA in RA neutrophils and its m...

journal_title：Haematologica

authors： De la Rosa IA,Perez-Sanchez C,Ruiz-Limon P,Patiño-Trives A,Torres-Granados C,Jimenez-Gomez Y,Del Carmen Abalos-Aguilera M,Cecchi I,Ortega R,Caracuel MA,Calvo-Gutierrez J,Escudero-Contreras A,Collantes-Estevez E,Lopez-Pedrera C

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Pathogen-derived molecules are danger signals and are able to activate innate immunity that in turn controls and regulates generation of adaptive immune responses. Mycobacterium tuberculosis heat shock protein 70 (myc HSP70) has been shown to exert a potent adjuvant effect in vaccination again...

journal_title：Haematologica

authors： Liso A,Benedetti R,Fagioli M,Mariano A,Falini B

更新日期：2005-01-01 00:00:00

abstract：:Patients with refractory or relapsed and refractory multiple myeloma who no longer receive benefit from novel agents have limited treatment options and short expected survival. del(17p) and t(4;14) are correlated with shortened survival. The phase 3 MM-003 trial demonstrated significant progression-free and overall su...

journal_title：Haematologica

authors： Dimopoulos MA,Weisel KC,Song KW,Delforge M,Karlin L,Goldschmidt H,Moreau P,Banos A,Oriol A,Garderet L,Cavo M,Ivanova V,Alegre A,Martinez-Lopez J,Chen C,Spencer A,Knop S,Bahlis NJ,Renner C,Yu X,Hong K,Sternas L,

更新日期：2015-10-01 00:00:00

abstract：:Inherited factor VIl (FVII) deficiency is a rare autosomal recessive coagulation disorder characterized by a wide genet-ic heterogeneity and a poor relationship between FVII activity (FVII:C) levels and severity of the hemorrhagic diathesis. Given both the rarity and the heterogeneity of this disorder,genotype-phenoty...

journal_title：Haematologica

authors： Giansily-Blaizot M,Aguilar-Martinez P,Schved JF

更新日期：2002-03-01 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematopoietic neoplasm whose immunophenotype remains incompletely characterized, particularly in terms of distinction from reactive plasmacytoid dendritic cells (PDCs). This limitation complicates detection of low-level involvement by BPDCN as well as mini...

journal_title：Haematologica

authors： Wang W,Khoury JD,Miranda RN,Jorgensen JL,Xu J,Loghavi S,Li S,Pemmaraju N,Nguyen T,Medeiros LJ,Wang SA

更新日期：2020-04-02 00:00:00

abstract：BACKGROUND:LMO2 is highly expressed at the most immature stages of lymphopoiesis. In T-lymphocytes, aberrant LMO2 expression beyond those stages leads to T-cell acute lymphoblastic leukemia, while in B cells LMO2 is also expressed in germinal center lymphocytes and diffuse large B-cell lymphomas, where it predicts bett...

journal_title：Haematologica

authors： Malumbres R,Fresquet V,Roman-Gomez J,Bobadilla M,Robles EF,Altobelli GG,Calasanz MJ,Smeland EB,Aznar MA,Agirre X,Martin-Palanco V,Prosper F,Lossos IS,Martinez-Climent JA

更新日期：2011-07-01 00:00:00

abstract：:Juvenile hemochromatosis is a severe form of hereditary iron overload. It can be caused by mutations in either hepcidin or hemojuvelin genes. In this study we identified the molecular basis of juvenile hemochromatosis in three Australian families and assessed the role of potential modifying genes in individuals carryi...

journal_title：Haematologica

authors： Wallace DF,Dixon JL,Ramm GA,Anderson GJ,Powell LW,Subramaniam N

更新日期：2005-02-01 00:00:00

abstract：:The coexistence of chronic myeloid leukemia (CML) and B-cell chronic lymphocytic leukemia (CLL) in the same patient is rare. A 71-year-old woman developed a B-lineage lymphoid blast crisis at 18 months after diagnosis of Ph-positive CML. At this time, a lymphoid cell population with morphologic and immunophenotypic fe...

journal_title：Haematologica

authors： Esteve J,Cervantes F,Rives S,Rozman M,Zarco MA,Montserrat E

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Gastrointestinal bleeding is a frequent complication of liver cirrhosis (LC) and represents an important warning sign of imminent death. Platelet dysfunction is an abnormality occurring prevalently in severe liver failure, and could well predispose to bleeding. METHODS:One hundred and two patients with live...

journal_title：Haematologica

authors： Violi F,Leo R,Basili S,Ferro D,Cordova C,Balsano F,CALC Group.

更新日期：1994-01-01 00:00:00

abstract：:The immunomodulatory drugs, lenalidomide and pomalidomide yield high response rates in multiple myeloma patients, but are associated with a high rate of thrombocytopenia and increased risk of secondary hematologic malignancies. Here, we demonstrate that the immunomodulatory drugs induce self-renewal of hematopoietic p...

journal_title：Haematologica

authors： Liu A,Li S,Donnenberg V,Fu J,Gollin SM,Ma H,Lu C,Stolz DB,Mapara MY,Monaghan SA,Lentzsch S

更新日期：2018-10-01 00:00:00

abstract：:Evaluation of Anagrelide (Xagrid®) Efficacy and Long-term Safety, a phase IV, prospective, non-interventional study performed in 13 European countries enrolled high-risk essential thrombocythemia patients treated with cytoreductive therapy. The primary objectives were safety and pregnancy outcomes. Of 3721 registered ...

journal_title：Haematologica

authors： Birgegård G,Besses C,Griesshammer M,Gugliotta L,Harrison CN,Hamdani M,Wu J,Achenbach H,Kiladjian JJ

更新日期：2018-01-01 00:00:00

abstract：:HLA molecules play an important role for immunoreactivity in allogeneic hematopoietic stem cell transplantation. To elucidate the effect of specific HLA alleles on acute graft-versus-host disease, we conducted a retrospective analysis using 6967 Japanese patients transplanted with T-cell-replete marrow from an unrelat...

journal_title：Haematologica

authors： Morishima S,Kashiwase K,Matsuo K,Azuma F,Yabe T,Sato-Otsubo A,Ogawa S,Shiina T,Satake M,Saji H,Kato S,Kodera Y,Sasazuki T,Morishima Y,Japan Marrow Donor Program.

更新日期：2016-04-01 00:00:00

abstract：:Inherited bone marrow failure syndromes are experiments of nature characterized by impaired hematopoiesis with cancer and leukemia predisposition. The mutations associated with inherited bone marrow failure syndromes affect fundamental cellular pathways, such as DNA repair, telomere maintenance, or proteostasis. How t...

journal_title：Haematologica

authors： Oyarbide U,Topczewski J,Corey SJ

更新日期：2019-01-01 00:00:00