IGHV mutational status and outcome for patients with chronic lymphocytic leukemia upon treatment: a Danish nationwide population-based study.

abstract：BACKGROUND AND OBJECTIVES:Chromosome 5 and/or 7 abnormalities are cytogenetic findings indicative of a poor prognosis in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The only potential cure for such patients is allogeneic stem cell transplantation (SCT). As data on allogeneic SCT in thi...

journal_title：Haematologica

authors： van der Straaten HM,van Biezen A,Brand R,Schattenberg AV,Egeler RM,Barge RM,Cornelissen JJ,Schouten HC,Ossenkoppele GJ,Verdonck LF,Netherlands Stem Cell Transplant Registry \TYPHON\.

更新日期：2005-10-01 00:00:00

abstract：:Rituximab plus CHOP (R-CHOP) has been proven to increase overall survival in aggressive bcl-2-positive lymphoma patients. Using competing risk analysis, we studied the long-term impact of this treatment in patients from a GELA trial: R-CHOP prevented from progression or relapse in both bcl-2-positive and bcl-2-negativ...

journal_title：Haematologica

authors： Mounier N,Briere J,Gisselbrecht C,Reyes F,Gaulard P,Coiffier B,Groupe d'Etude des Lymphomes de l'Adulte.

更新日期：2006-05-01 00:00:00

abstract：:In ribosomopathies, the Diamond-Blackfan anemia (DBA) or 5q- syndrome, ribosomal protein (RP) genes are affected by mutation or deletion, resulting in bone marrow erythroid hypoplasia. Unbalanced production of ribosomal subunits leading to a limited ribosome cellular content, regulates translation at the expense of th...

journal_title：Haematologica

authors： Boussaid I,Le Goff S,Floquet C,Gautier EF,Raimbault A,Viailly PJ,Al Dulaimi D,Burroni B,Dusanter-Fourt I,Hatin I,Mayeux P,Cosson B,Fontenay M

更新日期：2020-04-23 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Polycythemia vera (PV) is a myeloproliferative disorder, characterized by the expansion of the red cell mass. Our purpose was to evaluate the efficacy of pipobroman (PB) in the long-term control of PV and to assess early and late events. DESIGN AND METHODS:From June 1975 to December 1997, 163...

journal_title：Haematologica

authors： Passamonti F,Brusamolino E,Lazzarino M,Baraté C,Klersy C,Orlandi E,Canevari A,Castelli G,Merante S,Bernasconi C

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Chimeric oncogenes encoding constitutively active protein tyrosine kinases are associated with chronic myeloid neoplasms. TEL-PDGFRbeta (TPbeta, also called ETV6-PDGFRB) is a hybrid protein produced by the t(5;12) translocation, FIP1L1-PDGFRalpha (FPalpha) results from a deletion on chromosome 4q12 and ZNF19...

journal_title：Haematologica

authors： Toffalini F,Kallin A,Vandenberghe P,Pierre P,Michaux L,Cools J,Demoulin JB

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor mobilized peripheral blood stem cells are increasingly used instead of bone marrow as a stem cell source for transplantation. Whereas this change is almost complete for autologous transplantation, there are some concerns when considering allogeneic transplants. DESIGN A...

journal_title：Haematologica

authors： Gallardo D,de la Cámara R,Nieto JB,Espigado I,Iriondo A,Jiménez-Velasco A,Vallejo C,Martín C,Caballero D,Brunet S,Serrano D,Solano C,Ribera JM,de la Rubia J,Carreras E

更新日期：2009-09-01 00:00:00

abstract：:The aim of the study was to define the minimal effective dose (MED) of granulocyte colony-stimulating factor (G-CSF) among five daily doses following chemotherapy for peripheral blood stem cell (PBSC) collection. Twenty-five patients were included in this double-blind dose-finding phase II study conducted according to...

journal_title：Haematologica

authors： Lefrère F,Zohar S,Bresson JL,Chevret S,Mogenet A,Audat F,Durand-Zaleski I,Ghez D,Dal Cortivo L,Piesvaux P,Cavazzana-Calvo M,Varet B

更新日期：2006-04-01 00:00:00

abstract：:Imatinib mesylate is a tyrosine kinase inhibitor used as first line treatment in chronic myeloid leukemia and gastrointestinal stromal tumor patients. Although several in vitro and animal studies demonstrated that imatinib affects immune response, few immune alterations are described in humans. We retrospectively stud...

journal_title：Haematologica

authors： Santachiara R,Maffei R,Martinelli S,Arcari A,Piacentini F,Trabacchi E,Alfieri P,Ferrari A,Leonardi G,Luppi G,Longo G,Vallisa D,Marasca R,Torelli G

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Idarubicin (IDA) is relatively immune to the multidrug resistance P-gp mechanism that is frequently expressed in recurrent and refractory hematologic malignancies. Owing to rapid metabolism in vivo, a continuous infusion (CI) of IDA might prolong exposure time to the parent drug rather than its...

journal_title：Haematologica

authors： Bassan R,Chiodini B,Zucchetti M,Lerede T,Cornelli PE,Cortelazzo S,Barbui T

更新日期：1998-01-01 00:00:00

abstract：:Juvenile myelomonocytic leukemia is a rare myeloproliferative neoplasm characterized by hyperactive RAS signaling. Neurofibromin1 (encoded by the NF1 gene) is a negative regulator of RAS activation. Patients with neurofibromatosis type 1 harbor loss-of-function mutations in NF1 and have a 200- to 500-fold increased ri...

journal_title：Haematologica

authors： Sachs Z,Been RA,DeCoursin KJ,Nguyen HT,Mohd Hassan NA,Noble-Orcutt KE,Eckfeldt CE,Pomeroy EJ,Diaz-Flores E,Geurts JL,Diers MD,Hasz DE,Morgan KJ,MacMillan ML,Shannon KM,Largaespada DA,Wiesner SM

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The genetic characterization of chronic lymphocytic leukemia cells correlates with the behavior, progression and response to treatment of the disease. DESIGN AND METHODS:Our aim was to investigate the role of ATM gene alterations, their biological consequences and their value in predicting disease progressi...

journal_title：Haematologica

authors： Guarini A,Marinelli M,Tavolaro S,Bellacchio E,Magliozzi M,Chiaretti S,De Propris MS,Peragine N,Santangelo S,Paoloni F,Nanni M,Del Giudice I,Mauro FR,Torrente I,Foà R

更新日期：2012-01-01 00:00:00

abstract：:By combining the polymerase chain reaction (PCR) of the gamma globin gene promoters with synthetic oligonucleotide analysis we have diagnosed the -196 C----T and the -117 G----A substitutions in heterozygous carriers of non deletional A gamma HPFH from two unrelated Italian families. The identification of the beta-tha...

journal_title：Haematologica

authors： Gottardi E,Alfarano A,Serra A,Sciarratta G,Bertero MT,Saglio G,Camaschella C

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Patients with chronic renal failure show signs of accelerated atherosclerosis and high cardiovascular morbidity and mortality. Recent investigations indicate that uremia is associated with endothelial dysfunction and a microinflammatory state. We assessed changes in the expression of adhesion ...

journal_title：Haematologica

authors： Serradell M,Díaz-Ricart M,Cases A,Zurbano MJ,López-Pedret J,Arranz O,Ordinas A,Escolar G

更新日期：2002-10-01 00:00:00

abstract：:Treatment of adults with acute myeloblastic leukemia has changed substantially over the past two decades. Currently available estimates of survival do not reflect results from present state-of-the-art treatment due to a lag between the availability of new treatments and data concerning their effect on survival on the ...

journal_title：Haematologica

authors： Pulte D,Gondos A,Brenner H

更新日期：2008-04-01 00:00:00

abstract：:Circulating plasma thrombomodulin (TM) is an endothelial cell marker which may reflect endothelial injury. To find out to what extent diagnostic cardiac catheterization irritates vascular endothelium we conducted a prospective study in 91 children. Soluble TM concentrations, along with thrombin generation, were measur...

journal_title：Haematologica

authors： Vielhaber H,Kehl HG,Kececioglu D,Nowak-Göttl U

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:The relative efficacy of high-dose chemotherapy (HDC) compared to standard treatment for high-risk primary (HRPBC) or metastatic breast cancer (MBC) constitutes an area of intense controversy among the medical oncology community. A number of randomized trials have been conducted to address this issue. In mos...

journal_title：Haematologica

authors： Nieto Y

更新日期：2003-02-01 00:00:00

abstract：:New drugs are needed for the treatment of relapsed acute lymphoblastic leukemia and preclinical evaluation of the MEK inhibitor, selumetinib, has shown that this drug has excellent activity in those leukemias with RAS pathway mutations. The proapoptotic protein, BIM is pivotal in the induction of cell death by both se...

journal_title：Haematologica

authors： Matheson EC,Thomas H,Case M,Blair H,Jackson RK,Masic D,Veal G,Halsey C,Newell DR,Vormoor J,Irving JAE

更新日期：2019-09-01 00:00:00

abstract：:Advanced myelodysplastic syndrome harbors a high risk of progression to acute myeloid leukemia and poor prognosis. In children, there is no established treatment to prevent or delay progression to leukemia prior to hematopoietic stem cell transplantation. Azacitidine is a hypomethylating agent, which was shown to slow...

journal_title：Haematologica

authors： Waespe N,Van Den Akker M,Klaassen RJ,Lieberman L,Irwin MS,Ali SS,Abdelhaleem M,Zlateska B,Liebman M,Cada M,Schechter T,Dror Y

更新日期：2016-12-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase degrades the amino acid tryptophan which is essential for T cells. Tryptophan depletion causes T-cell cycle arrest and solid tumors that express high levels of indoleamine 2,3-dioxygenase can create immune suppression. Recently, blasts of patients with acute myeloid leukemia were shown to e...

journal_title：Haematologica

authors： Chamuleau ME,van de Loosdrecht AA,Hess CJ,Janssen JJ,Zevenbergen A,Delwel R,Valk PJ,Löwenberg B,Ossenkoppele GJ

更新日期：2008-12-01 00:00:00

abstract：:Multiple myeloma management has undergone profound changes in the past thanks to advances in our understanding of the disease biology and improvements in treatment and supportive care approaches. This article presents recommendations of the European Myeloma Network for newly diagnosed patients based on the GRADE syste...

journal_title：Haematologica

authors： Engelhardt M,Terpos E,Kleber M,Gay F,Wäsch R,Morgan G,Cavo M,van de Donk N,Beilhack A,Bruno B,Johnsen HE,Hajek R,Driessen C,Ludwig H,Beksac M,Boccadoro M,Straka C,Brighen S,Gramatzki M,Larocca A,Lokhorst H,Magar

更新日期：2014-02-01 00:00:00

abstract：:Sixteen patients with stage III multiple myeloma (MM) and a median age of 51 years were treated with autografting followed by reduced intensity conditioning allotransplantation (RICT). Nine patients are alive in remission at a median of 30 months after their transplants, one patient is alive in relapse and 6 patients ...

journal_title：Haematologica

authors： Carella AM,Beltrami G,Corsetti MT,Scalzulli P,Carella AM Jr,Musto P

更新日期：2004-12-01 00:00:00

abstract：:Not available. ...

journal_title：Haematologica

authors： Tanaka Y,Yeoh AEJ,Moriyama T,Li CK,Kudo K,Arakawa Y,Buaboonnam J,Zhang H,Liu HC,Ariffin H,Chen Z,Kham SKY,Nishii R,Hasegawa D,Fujimura J,Keino D,Kondoh K,Sato A,Ueda T,Yamamoto M,Taneyama Y,Hino M,Takagi M,O

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hemoglobin Constant Spring (Hb CS), caused by a termination codon mutation (TAA-->CAA) in the a2 gene, is the most common non-deletional type of a thalassemia in Southeast Asia. This mutation can most easily be detected by loss of an MseI-restriction site (T/TAA) spanning the termination codon...

journal_title：Haematologica

authors： Viprakasit V,Tanphaichitr VS,Pung-Amritt P,Petrarat S,Suwantol L,Fisher C,Higgs DR

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We assessed direct health care costs associated with the most commonly prescribed treatments for indolent follicular non-Hodgkin's lymphoma (FL). DESIGN AND METHODS:New and previously diagnosed FL patients (>or=18 years) known during 1997-1998 to 15 Dutch hospitals were selected for inclusion...

journal_title：Haematologica

authors： van Agthoven M,Kramer MH,Sonneveld P,van der Hem KG,Huijgens PC,Wijermans PW,Kluin-Nelemans HC,Schaafsma MR,Biesma DH,Mattijssen V,Uyl-de Groot CA,Hagenbeek A

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hepatitis C virus (HCV) infection is an important cause of morbidity and mortality in patients affected by hereditary bleeding disorders and treated with non-virus inactivated clotting factor concentrates during the 1970s. INFORMATION SOURCES:In this review, we briefly report the present know...

journal_title：Haematologica

authors： Franchini M,Capra F,Tagliaferri A,Rossetti G,De Gironcoli M,Rocca P,Aprili G,Gandini G

更新日期：2002-05-01 00:00:00

abstract：:As of 1999, the German registry of immune tolerance treatment in hemophilia has received reports on 146 patients who have undergone this therapy from 25 hemophilia centers. In 16 of the reported patients treatment is ongoing. Therapy has been completed in 126 patients of all groups with hemophilia A; most of them are ...

journal_title：Haematologica

authors： Lenk H,ITT Study Group.

更新日期：2000-10-01 00:00:00

abstract：:Leukemia stem cells (LSC) are more resistant to standard chemotherapy and their persistence during remission can cause relapse, which is still one of the major clinical challenges in the treatment of acute myeloid leukemia (AML). A better understanding of the mutational patterns and the prognostic impact of molecular ...

journal_title：Haematologica

authors： Bill M,Nicolet D,Kohlschmidt J,Walker CJ,Mrózek K,Eisfeld AK,Papaioannou D,Rong-Mullins X,Brannan Z,Kolitz JE,Powell BL,Archer KJ,Dorrance AM,Carroll AJ,Stone RM,Byrd JC,Garzon R,Bloomfield CD

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The Hong Kong government is planning to introduce an electronic smart identity card for all seven million citizens in 2003. If the smart card contains the full red cell phenotype/genotype of the individual, it may be possible to transfuse phenotype-matched blood units without pre-transfusion a...

journal_title：Haematologica

authors： Lau FY,Wong R,Chan NP,Chui CH,Ng E,Ng MH,Cheng G

更新日期：2001-07-01 00:00:00

abstract：:Renewing interest in cancer immunotherapy reflects the excellent results that have been obtained in animal models and the promising results in early clinical trails with dendritic cell (DC) based approaches. The central role that DCs play in the initiation of an immune response raises the possibility of using them to ...

journal_title：Haematologica

authors： Di Nicola M,Lemoli RM

更新日期：2000-02-01 00:00:00

abstract：:Multiple myeloma causes major morbidity resulting from osteolytic lesions that can be detected by metastatic bone surveys. Magnetic resonance imaging and positron emission tomography can detect bone marrow focal lesions long before development of osteolytic lesions. Using data from patients enrolled in Total Therapy 3...

journal_title：Haematologica

authors： Waheed S,Mitchell A,Usmani S,Epstein J,Yaccoby S,Nair B,van Hemert R,Angtuaco E,Brown T,Bartel T,McDonald J,Anaissie E,van Rhee F,Crowley J,Barlogie B

更新日期：2013-01-01 00:00:00