Abstract:
:Tyrosine kinase inhibitors (TKIs) are highly effective for the treatment of chronic myeloid leukemia (CML), but very few patients are cured. The major drawbacks regarding TKIs are their low efficacy in eradicating the leukemic stem cells responsible for disease maintenance and relapse upon drug cessation. Herein, we performed ribonucleic acid sequencing of flow-sorted primitive (CD34+CD38low) and progenitor (CD34+ CD38+) chronic phase CML cells, and identified transcriptional upregulation of 32 cell surface molecules relative to corresponding normal bone marrow cells. Focusing on novel markers with increased expression on primitive CML cells, we confirmed upregulation of the scavenger receptor CD36 and the leptin receptor by flow cytometry. We also delineate a subpopulation of primitive CML cells expressing CD36 that is less sensitive to imatinib treatment. Using CD36 targeting antibodies, we show that the CD36 positive cells can be targeted and killed by antibody-dependent cellular cytotoxicity. In summary, CD36 defines a subpopulation of primitive CML cells with decreased imatinib sensitivity that can be effectively targeted and killed using an anti-CD36 antibody.
journal_name
Haematologicajournal_title
Haematologicaauthors
Landberg N,von Palffy S,Askmyr M,Lilljebjörn H,Sandén C,Rissler M,Mustjoki S,Hjorth-Hansen H,Richter J,Ågerstam H,Järås M,Fioretos Tdoi
10.3324/haematol.2017.169946subject
Has Abstractpub_date
2018-03-01 00:00:00pages
447-455issue
3eissn
0390-6078issn
1592-8721pii
haematol.2017.169946journal_volume
103pub_type
杂志文章相关文献
HAEMATOLOGICA文献大全abstract:BACKGROUND:Oral deferiprone was suggested to be more effective than subcutaneous desferrioxamine for removing heart iron. Oral once-daily chelator deferasirox has recently been made commercially available but its long-term efficacy on cardiac iron and function has not yet been established. Our study aimed to compare th...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.019042
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:We have previously shown that bortezomib induces a depletion of alloreactive T cells and allows the expansion of T cells with suppressive properties. In the current study, we analyzed the potential synergistic effect of bortezomib in conjunction with sirolimus in order to reduce-graft-versus-host disease wit...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2011.058677
更新日期:2012-09-01 00:00:00
abstract::We performed a dose-escalation study of bendamustine in 31 patients with multiple myeloma that had progressed after high-dose chemotherapy. Bendamustine 100 mg/m2 on days 1 and 2 per cycle was found to be the maximal tolerated dose. The overall response rate was 55% with a median progression-free survival of 26 (0-61)...
journal_title:Haematologica
pub_type: 信件
doi:
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:It has been shown that fludarabine (FLU) is superior to conventional treatment in B-CLL for rate and quality of response, leading to CR even at the molecular level. In this paper we report our preliminary results with this drug in B-CLL patients. METHODS AND PATIENTS:Twenty-seven B-CLL patients (16 refracto...
journal_title:Haematologica
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::Mechanistic target of rapamycin (mTOR) complex 1 is a central integrator of nutrient and growth factor inputs that controls cell growth in eukaryotes. The second generation of mTOR kinase inhibitors (TORKi), directly targeting the mTOR catalytic site, are more effective than rapamycin and its analogs in cancer treatme...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2016.159160
更新日期:2017-04-01 00:00:00
abstract::The success story of hemophilia care first began in the 1970s, when the availability of plasma-derived concentrates of coagulation factor VIII (FVIII) and factor IX (FIX) provided efficacious treatment of bleeding in patients with hemophilia A and B. This positive scenario was consolidated in terms of greater safety a...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2019.232132
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Imatinib induces complete cytogenetic responses (CCR) in the majority of patients with chronic myeloid leukemia (CML) in chronic phase (CP). However, a subgroup of patients is refractory at the cytogenetic level. Clinically, it would be advantageous to identify such patients a priori, since th...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:2005-04-01 00:00:00
abstract::As the defective genes for more and more genetic disorders become unravelled, it is clear that patients with apparently identical genotypes can have many different clinical conditions even in simple monogenic disorders. Beta thalassemia occurs when there is a deficiency in the synthesis of beta globin chains. The clin...
journal_title:Haematologica
pub_type: 杂志文章,评审
doi:
更新日期:2005-05-01 00:00:00
abstract::Eight elderly patients with relapsed or refractory acute myeloid leukemia were treated sequentially with recombinant human granulocyte colony-stimulating factor with rhG-CSF and Mylotarg. Priming with rhG-CSF in vivo induced an increase in the proportion of CD33+ cycling blasts. Four patients (50% ) achieved a complet...
journal_title:Haematologica
pub_type: 信件
doi:
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:The functional activity of the organic cation transporter 1 (OCT-1) protein (OCT-1 activity) is an excellent predictor of molecular response and progression-free survival in patients with newly diagnosed chronic phase chronic myeloid leukemia treated with imatinib as front-line therapy. DESIGN AND METHODS:I...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3324/haematol.2011.056457
更新日期:2012-06-01 00:00:00
abstract::In patients with low and intermediate risk myelodysplastic syndrome and deletion 5q (del(5q)) treated with lenalidomide, monitoring of cytogenetic response is mandatory, since patients without cytogenetic response have a significantly increased risk of progression. Therefore, we have reviewed cytogenetic data of 302 p...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2010.026658
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Diffuse large B-cell lymphomas (DLBCL) have a variable outcome, and powerful methods of prognostication are needed in order to choose the best treatment for each patient. Immunophenotypic classification of the tumor as germinal center (GC) or non-germinal center-like (nGC) and early response e...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.10895
更新日期:2007-06-01 00:00:00
abstract::The National Institutes of Health global score for chronic graft-versus-host disease was devised by experts but was not based on empirical data. We hypothesized that analysis of prospectively collected data would enable derivation of a more accurate model for estimating mortality risk. We analyzed 574 adult patients w...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:10.3324/haematol.2014.109611
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Vgamma9Vdelta2 T lymphocytes are regarded as promising mediators of cancer immunotherapy due to their capacity to eliminate multiple experimental tumors, particularly within those of hematopoietic origin. However, Vgamma9Vdelta2 T-cell based lymphoma clinical trials have suffered from the lack of biomarkers ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.020602
更新日期:2010-08-01 00:00:00
abstract::Immunoparesis or suppression of polyclonal immunoglobulins is a very common condition in newly diagnosed myeloma patients. However, the recovery of polyclonal immunoglobulins in the setting of immune reconstitution after autologous stem cell transplantation and its effect on outcome has not yet been explored. We condu...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:10.3324/haematol.2016.158345
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:The risk for donors of allogeneic hematopoietic stem cells transplants is generally considered negligible. Scattered reports of severe complications and a recent controversy on hematopoietic malignancies after granulocyte colony-stimulating factor administration have challenged this opinion. DESIGN AND METH...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.13668
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The mechanisms accounting for the increased risk of thrombosis in patients with essential thrombocythemia (ET) are not well known. The aim of the present study was to ascertain the role of platelet and leukocyte activation in the thrombosis of ET. DESIGN AND METHODS:The activation status of p...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:2006-02-01 00:00:00
abstract::We report a positive association between HLA-DRB1*15 (p= 0.0002) in Turkish patients with pediatric severe aplastic anemia (SAA) and a paradoxically favorable influence of the susceptibility marker on the clinical response to immunosuppressive therapy. These findings point to an immune mechanism mediated by DRB1*15 in...
journal_title:Haematologica
pub_type: 信件
doi:
更新日期:2002-07-01 00:00:00
abstract::The immunomodulatory drugs, lenalidomide and pomalidomide yield high response rates in multiple myeloma patients, but are associated with a high rate of thrombocytopenia and increased risk of secondary hematologic malignancies. Here, we demonstrate that the immunomodulatory drugs induce self-renewal of hematopoietic p...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.188227
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In March 1987 AIEOP started the AIEOP-ALL-87 study, based on the previous AIEOP-ALL-82. The aim of this new study was to evaluate, for all risk groups: a) the efficacy of treatment intensification achieved by adding a fourth drug (daunomycin) in the induction phase and a 3-drug reinduction pha...
journal_title:Haematologica
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2001-05-01 00:00:00
abstract::Distinct expression patterns of pro- and anti-apoptotic proteins may contribute to different prognoses and therapy outcomes in adult versus childhood acute myeloid leukemia (AML). Therefore, we investigated whether expression levels of apoptosis-related proteins CD95, Bcl-2, Bax, Bcl-xL, procaspase-3, XIAP, cIAP-1, an...
journal_title:Haematologica
pub_type: 信件
doi:
更新日期:2004-03-01 00:00:00
abstract::Factor V Leiden (FVL) and prothrombin G20210A mutation (PTM) are the two most common genetic polymorphisms known to predispose to a first episode of venous thromboembolism (VTE). However, whether these thrombophilic abnormalities are also risk factors for recurrent VTE is unclear. We conducted a systematic review of p...
journal_title:Haematologica
pub_type: 杂志文章,评审
doi:10.3324/haematol.10234
更新日期:2007-08-01 00:00:00
abstract::A case-control study was conducted among Italian children treated with a stem cell transplant (SCT). Cases (n = 43) were allogeneic recipients with osteonecrosis, and the controls (n = 129) were matched to the corresponding cases on the basis of survival, SCT center and date of transplant. Univariate analysis showed t...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:
更新日期:2006-08-01 00:00:00
abstract::Umbilical cord blood stem cell transplants are commonly used in adults lacking HLA-identical donors. Delays in hematopoietic recovery contribute to mortality and morbidity. To hasten recovery, we used co-infusion of progenitor cells from a partially matched related donor and from an umbilical cord blood graft (haplo-c...
journal_title:Haematologica
pub_type: 临床试验,杂志文章
doi:10.3324/haematol.2015.138594
更新日期:2016-05-01 00:00:00
abstract::Although myelodysplastic syndromes are heterogeneous disorders comprising a benign subset of bone marrow failure similar to aplastic anemia, no laboratory test has been established to distinguish it from bone marrow failures that can evolve into acute myeloid leukemia. Plasma thrombopoietin levels were measured in 120...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2012.066217
更新日期:2013-06-01 00:00:00
abstract::Platelets are critical to arterial thrombosis, which underlies myocardial infarction and stroke. Activated platelets, regardless of the nature of their stimulus, initiate energy-intensive processes that sustain thrombus, while adapting to potential adversities of hypoxia and nutrient deprivation within the densely pac...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.205724
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Although several studies have reported on the use of children as donors for peripheral blood progenitor cells (PBPC), no specific characteristics have been identified as predictors of PBPC collection in this population. In this study we analyzed predictive factors for PBPC collection in pediat...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:2003-08-01 00:00:00
abstract::The aim of this study was to investigate the microRNA (miRNA) expression pattern in neutrophils from rheumatoid arthritis (RA) patients and its contribution to their pathogenic profile and to analyze the effect of specific autoantibodies or inflammatory components in the regulation of miRNA in RA neutrophils and its m...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.205047
更新日期:2020-09-01 00:00:00
abstract::The lupus anticoagulant (LAC) and anticardiolipin antibody (ACA) syndromes require particular therapeutic approaches: thrombotic accidents are an indication for oral anticoagulant therapy (OAT), whereas severe thrombocytopenia may require the special treatments used for immunologic thrombocytopenic purpura (ITP). We d...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract::We reviewed cardiac T2* assessments from 77 thalassemia major patients between the ages of 2.5 and 18 years to study optimal timing of cardiac iron screening by magnetic resonance imaging. No patient under 9.5 years of age showed detectable cardiac iron in contrast to 36% of patients between the ages of 15-18 years ol...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.12513
更新日期:2008-06-01 00:00:00