Aerobic glycolysis fuels platelet activation: small-molecule modulators of platelet metabolism as anti-thrombotic agents.

abstract：:Rituximab use in severe auto-immune diseases has recently increased. Scattered reports of opportunistic infections were the only reported serious side effects related to rituximab in pediatric patients .Here, we report transient severe acute thrombocytopenia and neutropenia respectively a few days after rituximab infu...

journal_title：Haematologica

authors： Larrar S,Guitton C,Willems M,Bader-Meunier B

更新日期：2006-08-01 00:00:00

abstract：:The prognosis of patients with acute myeloid leukemia in whom primary treatment fails remains very poor. In order to improve such patients' outcome, we conducted a phase 2, prospective, multicenter trial to test the feasibility of a new sequential regimen, combining a short course of intensive chemotherapy and a reduc...

journal_title：Haematologica

authors： Mohty M,Malard F,Blaise D,Milpied N,Socié G,Huynh A,Reman O,Yakoub-Agha I,Furst S,Guillaume T,Tabrizi R,Vigouroux S,Peterlin P,El-Cheikh J,Moreau P,Labopin M,Chevallier P

更新日期：2017-01-01 00:00:00

abstract：:It is currently unknown whether immunosuppressive therapy or hematopoietic stem cell transplantation is the most appropriate treatment strategy for children with refractory cytopenia and normal karyotype or trisomy 8. We report on 31 children with hypoplastic refractory cytopenia treated with immunosuppressive therapy...

journal_title：Haematologica

authors： Yoshimi A,Baumann I,Führer M,Bergsträsser E,Göbel U,Sykora KW,Klingebiel T,Gross-Wieltsch U,van den Heuvel-Eibrink MM,Fischer A,Nöllke P,Niemeyer C

更新日期：2007-03-01 00:00:00

abstract：:Homeobox containing transcription factors are frequently deregulated in human hematologic malignant diseases either indirectly through an abnormality of an upstream factor, or directly through rearrangement of the gene itself. Study of T-cell acute lymphoblastic leukemia identified the related non-clustered homeobox t...

journal_title：Haematologica

authors： Su X,Della-Valle V,Delabesse E,Azgui Z,Berger R,Merle-Béral H,Bernard OA,Nguyen-Khac F

更新日期：2008-07-01 00:00:00

abstract：:Since its first description in Hodgkin's disease, alcohol-induced pain has subsequently been described both in other neoplasms and in various non-malignant conditions. There seems little doubt that ethyl alcohol itself is responsible, although the mechanism for producing pain remains elusive. We report a case of alcoh...

journal_title：Haematologica

authors： Custodi P,Cerutti A,Bagnato R,Cassani P

更新日期：1993-11-01 00:00:00

abstract：:Next generation sequencing technologies have provided insights into the molecular heterogeneity of various myeloid neoplasms, revealing previously unknown somatic genetic events. In our cohort of 1444 cases analyzed by next generation sequencing, somatic mutations in the gene BRCA1-BRCA2-containing complex 3 (BRCC3) w...

journal_title：Haematologica

authors： Huang D,Nagata Y,Grossmann V,Radivoyevitch T,Okuno Y,Nagae G,Hosono N,Schnittger S,Sanada M,Przychodzen B,Kon A,Polprasert C,Shen W,Clemente MJ,Phillips JG,Alpermann T,Yoshida K,Nadarajah N,Sekeres MA,Oakley K,Ngu

更新日期：2015-08-01 00:00:00

abstract：:Not available. ...

journal_title：Haematologica

authors： Tanaka Y,Yeoh AEJ,Moriyama T,Li CK,Kudo K,Arakawa Y,Buaboonnam J,Zhang H,Liu HC,Ariffin H,Chen Z,Kham SKY,Nishii R,Hasegawa D,Fujimura J,Keino D,Kondoh K,Sato A,Ueda T,Yamamoto M,Taneyama Y,Hino M,Takagi M,O

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Patients affected by Hodgkin's disease (HD) in pathologic stage IA-IIA have a strong possibility of remission and long-term survival when treated with radiotherapy to extended fields. However, 20-30% of cases relapse in the five years following treatment and consequently need further therapy. T...

journal_title：Haematologica

authors： Enrici RM,Anselmo AP,Donato V,Falchetto Osti M,Santoro M,Tombolini V,Mandelli F

更新日期：1999-10-01 00:00:00

abstract：:Patients with chronic lymphocytic leukemia and unmutated immunoglobulin heavy-chain variable region gene (IGHV) have inferior survival from time of treatment in clinical studies. We assessed real-world outcomes based on mutational status and treatment regimen in a nationwide population-based cohort, comprising all 4,1...

journal_title：Haematologica

authors： Rotbain EC,Frederiksen H,Hjalgrim H,Rostgaard K,Egholm GJ,Zahedi B,Poulsen CB,Enggard L,da Cunha-Bang C,Niemann CU

更新日期：2020-06-01 00:00:00

abstract：:The majority of responses produced in patients with low-grade lymphomas are unique among non-Hodgkin's lymphomas (NHL), and even with a more intensive chemotherapy regimen, they are only partial; the very few complete responses which are induced are usually of short duration and do not influence overall survival. Ther...

journal_title：Haematologica

authors： Zinzani PL

更新日期：1997-09-01 00:00:00

abstract：:The aim of this study was to investigate the microRNA (miRNA) expression pattern in neutrophils from rheumatoid arthritis (RA) patients and its contribution to their pathogenic profile and to analyze the effect of specific autoantibodies or inflammatory components in the regulation of miRNA in RA neutrophils and its m...

journal_title：Haematologica

authors： De la Rosa IA,Perez-Sanchez C,Ruiz-Limon P,Patiño-Trives A,Torres-Granados C,Jimenez-Gomez Y,Del Carmen Abalos-Aguilera M,Cecchi I,Ortega R,Caracuel MA,Calvo-Gutierrez J,Escudero-Contreras A,Collantes-Estevez E,Lopez-Pedrera C

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We evaluated bacterial infections (BIs) in patients with multiple myeloma (MM) treated with two different schedules of vincristine-adriamycin-dexamethasone (VAD). DESIGN AND METHODS:Ninety-seven patients were studied during 340 VAD cycles. VAD was given by either continuous intravenous infusi...

journal_title：Haematologica

authors： Cesana C,Nosari AM,Klersy C,Miqueleiz S,Rossi V,Ferrando P,Valentini M,Barbarano L,Morra E

更新日期：2003-09-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase degrades the amino acid tryptophan which is essential for T cells. Tryptophan depletion causes T-cell cycle arrest and solid tumors that express high levels of indoleamine 2,3-dioxygenase can create immune suppression. Recently, blasts of patients with acute myeloid leukemia were shown to e...

journal_title：Haematologica

authors： Chamuleau ME,van de Loosdrecht AA,Hess CJ,Janssen JJ,Zevenbergen A,Delwel R,Valk PJ,Löwenberg B,Ossenkoppele GJ

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:The hemangioblast is a bi-potential precursor cell with the capacity to differentiate into hematopoietic and vascular cells. In mouse E7.0-7.5 embryos, the hemangioblast can be identified by a clonal blast colony-forming cell (BL-CFC) assay or single cell OP9 co-culture. However, the ontogeny of the hemangio...

journal_title：Haematologica

authors： He WY,Lan Y,Yao HY,Li Z,Wang XY,Li XS,Zhang JY,Zhang Y,Liu B,Mao N

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The detection of PML-RARalpha by real-time polymerase chain reaction (RQ-PCR) is becoming an important tool for monitoring minimal residual disease (MRD) in patients with acute promyelocytic leukemia (APL). However, its clinical value remains to be determined. Our aim was to analyze any associ...

journal_title：Haematologica

authors： Santamaría C,Chillón MC,Fernández C,Martín-Jiménez P,Balanzategui A,García Sanz R,San Miguel JF,González MG

更新日期：2007-03-01 00:00:00

abstract：:C-Mpl and PRV-1 expression was measured in a cohort of 48 patients with essential thrombocythemia (ET). A retrospective analysis was conducted to asses whether the presence of one or both markers correlates with a higher risk of developing thromboembolic complications. In this cohort, PRV-1 overexpression was associat...

journal_title：Haematologica

authors： Goerttler PL,März E,Johansson PL,Andreasson B,Kutti J,Moliterno AR,Marchioli R,Spivak JL,Pahl HL,MPD Research Consortium.

更新日期：2005-06-01 00:00:00

abstract：:Prostacyclin (PGI2) controls platelet activation and thrombosis through a cyclic adenosine monophosphate (cAMP) signaling cascade. However, in patients with cardiovascular diseases this protective mechanism fails for reasons that are unclear. Using both pharmacological and genetic approaches we describe a mechanism by...

journal_title：Haematologica

authors： Berger M,Raslan Z,Aburima A,Magwenzi S,Wraith KS,Spurgeon BEJ,Hindle MS,Law R,Febbraio M,Naseem KM

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/progenitor cells overexpressing miR-125b is able to induce l...

journal_title：Haematologica

authors： Bousquet M,Nguyen D,Chen C,Shields L,Lodish HF

更新日期：2012-11-01 00:00:00

abstract：:The long-term repopulating capacity of mobilized peripheral blood (MPB) CD34+ cells can be abrogated during ex vivo expansion due to cell-cycle related changes. In this study, we traced cell cycle kinetic and quiescent status of CD34+ cells during ex vivo expansion with exogenous cytokines. The addition of interleukin...

journal_title：Haematologica

authors： Sanchez-Garcia J,Torres A,Herrera C,Alvarez MA

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Treatment of older patients with non-Hodgkin's lymphoma (NHL) is difficult and conflicting. Lower responsiveness to therapy has been reported; however, the high risk of treatment morbidity, drug-dose reduction, and the occurrence of unrelated deaths might account for the poor outcome of NHL in the elderly. ...

journal_title：Haematologica

authors： Orlandi E,Lazzarino M,Brusamolino E,Castelli G,Pagnucco G,Morra E,Bernasconi C

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Hemoglobin sickle cell disease is one of the most frequent hemoglobinopathies. Surprisingly, few studies have been dedicated to this disease, currently considered to be a mild variant of homozygous sickle cell disease. The aim of this study was to update our knowledge about hemoglobin sickle cell disease. D...

journal_title：Haematologica

authors： Lionnet F,Hammoudi N,Stojanovic KS,Avellino V,Grateau G,Girot R,Haymann JP

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:The suppression of Ph1-positive hemopoiesis is a major goal in the treatment of CML; in this context the CML patients in blast crisis obtaining a complete clinical remission represent a useful model to investigate the behavior of the Ph1-positive and negative clones during bone marrow repopulation after abla...

journal_title：Haematologica

authors： Guerrasio A,Martinelli G,Ambrosetti A,Falda M,Paolino F,Rege-Cambrin G,Rosso C,Pignatti PF,Gasparini P,Perona G

更新日期：1991-03-01 00:00:00

abstract：:We investigated the role of single nucleotide polymorphisms in genes encoding for drug-metabolizing enzymes in 209 newly diagnosed multiple myeloma patients included in a clinical trial comparing single with double intensive therapy. We observed no significant association between polymorphisms in CYP3A4, CYP3A5, MDR1,...

journal_title：Haematologica

authors： Schilthuizen C,Broyl A,van der Holt B,de Knegt Y,Lokhorst H,Sonneveld P

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Polymorphic differences between donor and recipient human leukocyte antigen class I molecules can result in graft-versus-host disease due to distinct peptide presentation. As part of the peptide-loading complex, tapasin plays an important role in selecting peptides from the pool of potential ligands. Class I...

journal_title：Haematologica

authors： Badrinath S,Saunders P,Huyton T,Aufderbeck S,Hiller O,Blasczyk R,Bade-Doeding C

更新日期：2012-01-01 00:00:00

abstract：:The success of hematopoietic stem cell transplantation is determined by multiple factors. Additional complexity is conferred by covariables showing time-dependent effects. We evaluated the effect of predictors on competing-risk outcomes after hematopoietic stem cell transplantation in a time-dependent manner. We analy...

journal_title：Haematologica

authors： Fuerst D,Frank S,Mueller C,Beelen DW,Schetelig J,Niederwieser D,Finke J,Bunjes D,Kröger N,Neuchel C,Tsamadou C,Schrezenmeier H,Beyersmann J,Mytilineos J

更新日期：2018-09-01 00:00:00

abstract：:Despite improvements in standard therapy with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone for patients with untreated, diffuse large B-cell lymphoma, up to 40% of these patients relapse. Lenalidomide alone or in combination with rituximab has been shown to be active in relapsed/refractory aggr...

journal_title：Haematologica

authors： Chiappella A,Tucci A,Castellino A,Pavone V,Baldi I,Carella AM,Orsucci L,Zanni M,Salvi F,Liberati AM,Gaidano G,Bottelli C,Rossini B,Perticone S,De Masi P,Ladetto M,Ciccone G,Palumbo A,Rossi G,Vitolo U,Fondazione It

更新日期：2013-11-01 00:00:00

abstract：:To evaluate the effects of high-dose dexamethasone (HD-DXM) on the balance of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well as IFN-gamma, IL-4 plasma levels and platelet counts were determined in 17 ITP patients receiving DXM 40 mg/day for ...

journal_title：Haematologica

authors： Shan NN,Zhu XJ,Wang Q,Wang CY,Qin P,Peng J,Hou M

更新日期：2009-11-01 00:00:00

abstract：:Evaluation of Anagrelide (Xagrid®) Efficacy and Long-term Safety, a phase IV, prospective, non-interventional study performed in 13 European countries enrolled high-risk essential thrombocythemia patients treated with cytoreductive therapy. The primary objectives were safety and pregnancy outcomes. Of 3721 registered ...

journal_title：Haematologica

authors： Birgegård G,Besses C,Griesshammer M,Gugliotta L,Harrison CN,Hamdani M,Wu J,Achenbach H,Kiladjian JJ

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:This study was designed to evaluate the efficacy and toxicity of monthly alternating ABVD/MOPP compared to ABVD/OPP regimens in patients with advanced stage Hodgkin's disease (HD), as well as in early stage patients with systemic symptoms and/or bulky disease. DESIGN AND METHODS:218 patients w...

journal_title：Haematologica

authors： Anselmo AP,Cavalieri E,Enrici RM,Donato V,Pescarmona E,Biagini C,Mandelli F

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Children with Down syndrome have an increased risk of developing acute lymphoblastic leukemia and a poor tolerance of methotrexate. This latter problem is assumed to be caused by a higher cellular sensitivity of tissues in children with Down syndrome. However, whether differences in pharmacokinetics play a r...

journal_title：Haematologica

authors： Buitenkamp TD,Mathôt RA,de Haas V,Pieters R,Zwaan CM

更新日期：2010-07-01 00:00:00