In vivo priming with granulocyte colony-stimulating factor possibly enhances the effect of gemtuzumab-ozogamicin in acute myeloid leukemia: results of a pilot study.

abstract：BACKGROUND AND OBJECTIVES:A phase II study was conducted to investigate the effects of a therapeutic program based on the combination of fludarabine and cytarabine (ARA-C) administered as a sequential continuous infusion in untreated elderly patients with acute myeloid leukemia (AML). DESIGN AND METHODS:Sixty-three pa...

journal_title：Haematologica

authors： Ferrara F,D'Arco AM,De Simone M,Mele G,Califano C,Pocali B,Danise P,Palmieri S

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Familial aggregation has been recognized in patients with several lymphoid neoplasms, but the genetic basis for this familial clustering is not known. Germ-line mutations in the ataxia-telangiectasia mutated (ATM) and CHK2 genes have been detected in patients with mantle cell lymphoma (MCL), s...

journal_title：Haematologica

authors： Tort F,Camacho E,Bosch F,Harris NL,Montserrat E,Campo E

更新日期：2004-03-01 00:00:00

abstract：:The European Myeloma Network has organized two workshops on fluorescence in situ hybridization in multiple myeloma. The first aimed to identify specific indications and consensus technical approaches of current practice. A second workshop followed a quality control exercise in which 21 laboratories analyzed diagnostic...

journal_title：Haematologica

authors： Ross FM,Avet-Loiseau H,Ameye G,Gutiérrez NC,Liebisch P,O'Connor S,Dalva K,Fabris S,Testi AM,Jarosova M,Hodkinson C,Collin A,Kerndrup G,Kuglik P,Ladon D,Bernasconi P,Maes B,Zemanova Z,Michalova K,Michau L,Neben K,

更新日期：2012-08-01 00:00:00

abstract：:The long-term repopulating capacity of mobilized peripheral blood (MPB) CD34+ cells can be abrogated during ex vivo expansion due to cell-cycle related changes. In this study, we traced cell cycle kinetic and quiescent status of CD34+ cells during ex vivo expansion with exogenous cytokines. The addition of interleukin...

journal_title：Haematologica

authors： Sanchez-Garcia J,Torres A,Herrera C,Alvarez MA

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Fms-like tyrosine kinase-3 (FLT3) gene mutations are frequent in acute promyelocytic leukemia but their prognostic value is not well established. DESIGN AND METHODS:We evaluated FLT3-internal tandem duplication and FLT3-D835 mutations in patients treated with all-trans retinoic acid and anthracycline-based ...

journal_title：Haematologica

authors： Barragán E,Montesinos P,Camos M,González M,Calasanz MJ,Román-Gómez J,Gómez-Casares MT,Ayala R,López J,Fuster Ó,Colomer D,Chillón C,Larrayoz MJ,Sánchez-Godoy P,González-Campos J,Manso F,Amador ML,Vellenga E,Lowenberg B

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dendritic cells (DC) pulsed with multiple myeloma (MM) patient-specific idiotype (Id) protein can induce MM-specific T-cell responses. DESIGN AND METHODS:We established serum-free culture conditions to generate monocyte-derived DC for clinical use to circumvent anti-xenogenic immune responses...

journal_title：Haematologica

authors： Reichardt VL,Milazzo C,Brugger W,Einsele H,Kanz L,Brossart P

更新日期：2003-10-01 00:00:00

abstract：:All hematopoietic cells that develop in the bone marrow must cross the endothelial barrier to enter the blood circulation. Blood platelets, however, are released by bigger protrusions of huge progenitor cells, named megakaryocytes, and enter the blood stream as so-called proplatelets before fragmenting into mature pla...

journal_title：Haematologica

authors： Gorelashvili MG,Angay O,Hemmen K,Klaus V,Stegner D,Heinze KG

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Idarubicin (IDA) is relatively immune to the multidrug resistance P-gp mechanism that is frequently expressed in recurrent and refractory hematologic malignancies. Owing to rapid metabolism in vivo, a continuous infusion (CI) of IDA might prolong exposure time to the parent drug rather than its...

journal_title：Haematologica

authors： Bassan R,Chiodini B,Zucchetti M,Lerede T,Cornelli PE,Cortelazzo S,Barbui T

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia is the second most common leukemia among United States adults with a median age of 69 years. We investigated recent clinical practices related to treatments and disease outcomes in older patients with acute myeloid leukemia in the United States. DESIGN AND METHODS:In this retrospectiv...

journal_title：Haematologica

authors： Oran B,Weisdorf DJ

更新日期：2012-12-01 00:00:00

abstract：:Here we critically evaluate the role of elevated hematocrit as the principal determinant of thrombotic risk in polycythemia and erythrocytosis, defined by an expansion of red cell mass. Since red cell volume determination is no longer readily available, in clinical practice, polycythemia and erythrocytosis are defined...

journal_title：Haematologica

authors： Gordeuk VR,Key NS,Prchal JT

更新日期：2019-04-01 00:00:00

abstract：:Renewing interest in cancer immunotherapy reflects the excellent results that have been obtained in animal models and the promising results in early clinical trails with dendritic cell (DC) based approaches. The central role that DCs play in the initiation of an immune response raises the possibility of using them to ...

journal_title：Haematologica

authors： Di Nicola M,Lemoli RM

更新日期：2000-02-01 00:00:00

abstract：:We reviewed cardiac T2* assessments from 77 thalassemia major patients between the ages of 2.5 and 18 years to study optimal timing of cardiac iron screening by magnetic resonance imaging. No patient under 9.5 years of age showed detectable cardiac iron in contrast to 36% of patients between the ages of 15-18 years ol...

journal_title：Haematologica

authors： Wood JC,Origa R,Agus A,Matta G,Coates TD,Galanello R

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Mesenchymal stem cells (MSC) are progenitor cells that are capable of differentiating into mesenchymal tissues. Fetal and adult MSC have similar morphology but differ in proliferative, differentiating and immunosuppressive properties. Further exploring their differences could help in choosing ...

journal_title：Haematologica

authors： Götherström C,West A,Liden J,Uzunel M,Lahesmaa R,Le Blanc K

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We analyzed the factors that affected the number and quality of peripheral blood stem cells (PBSC) collected for transplant in order to establish a minimum threshold for rapid hematopoietic recovery. DESIGN AND METHODS:From January 1995 to November 1996, a consecutive series of 67 patients, wi...

journal_title：Haematologica

authors： Sampol Mayol A,Besalduch Vital J,Galmés Llodrá A,Bargay Lleonart J,Matamoros Flori N,Morey Sureda M,Novo García A,Mascaró Riera M,Gonzaléz Bach E,Martínez García P

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Transcription factors play essential roles in both normal and malignant hematopoiesis. This is the case for the growth factor independent 1b (GFI1B) transcription factor, which is required for erythroid and megakaryocytic differentiation and over-expressed in leukemic patients and cell lines. DESIGN AND MET...

journal_title：Haematologica

authors： Anguita E,Villegas A,Iborra F,Hernández A

更新日期：2010-01-01 00:00:00

abstract：:Since its first description in Hodgkin's disease, alcohol-induced pain has subsequently been described both in other neoplasms and in various non-malignant conditions. There seems little doubt that ethyl alcohol itself is responsible, although the mechanism for producing pain remains elusive. We report a case of alcoh...

journal_title：Haematologica

authors： Custodi P,Cerutti A,Bagnato R,Cassani P

更新日期：1993-11-01 00:00:00

abstract：:Patients with advanced myeloma experience a high symptom burden particularly near the end of life, making timely hospice use crucial. Little is known about the quality and determinants of end-of-life care for this population, including whether potential increases in hospice use are also accompanied by "late" enrollmen...

journal_title：Haematologica

authors： Odejide OO,Li L,Cronin AM,Murillo A,Richardson PG,Anderson KC,Abel GA

更新日期：2018-08-01 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome is a rare genetic disorder characterized by defective FAS-mediated apoptosis, autoimmune disease, accumulation of mature T-cell receptor alpha/beta positive, CD4 and CD8 double-negative T cells and increased risk of lymphoma. Despite frequent hematologic abnormalities, literatur...

journal_title：Haematologica

authors： Xie Y,Pittaluga S,Price S,Raffeld M,Hahn J,Jaffe ES,Rao VK,Maric I

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The limited value of qualitative reverse transcription polymerase chain-reaction (RT-PCR) for monitoring chronic myeloid leukemia (CML) patients has prompted the development of quantitative assays. We have developed a quantitative real-time PCR (QC-PCR) method in the LightCycler, based on the ...

journal_title：Haematologica

authors： Bolufer P,Sanz GF,Barragán E,Sanz MA,Cervera J,Lerma E,Senent L,Moreno I,Planelles MD

更新日期：2000-12-01 00:00:00

abstract：:In S. Camillo Hospital, Rome, the Apheresis Center (CNTS-CRI) and the Haematological Division, Authors treated 17 patients affected by haematologic malignances and solid tumours with leukoapheresis procedures for PBSC collection. Nine patients were treated with continuous-flow cell separator Dideco Vivacell, performin...

journal_title：Haematologica

authors： Del Monte C,Basso P,Consoli P,Cossutta M,Morara R,Pescarollo A,Lanti T

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Improvements in the management of childhood acute lymphoblastic leukemia (ALL) did not prevent 20% to 30% of patients suffering from relapse. Moreover, the probability of relapse can rise up to 50% for some children presenting with very high risk (VHR) factors. Intensive chemotherapy and espec...

journal_title：Haematologica

authors： Uderzo C,Balduzzi A

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:How to reach the correct diagnosis of a lymph node enlargement is still a problem which strongly challenges the knowledge and experience of the clinician. Organized and specifically oriented literature on the right sequential steps and the logical criteria that should guide this diagnostic appr...

journal_title：Haematologica

authors： Ghirardelli ML,Jemos V,Gobbi PG

更新日期：1999-03-01 00:00:00

abstract：:The success story of hemophilia care first began in the 1970s, when the availability of plasma-derived concentrates of coagulation factor VIII (FVIII) and factor IX (FIX) provided efficacious treatment of bleeding in patients with hemophilia A and B. This positive scenario was consolidated in terms of greater safety a...

journal_title：Haematologica

authors： Mannucci PM

更新日期：2020-03-01 00:00:00

abstract：:The present study reports a method for the easy, rapid and cost effective detection of heterozygous large deletions. As a model gene all exons of the antithrombin gene were amplified in a one tube multiplex polymerase chain reaction (PCR) and the products separated according to their size by reverse-phase ion-pair hig...

journal_title：Haematologica

authors： Pavlova A,El-Maarri O,Luxembourg B,Lindhoff-Last E,Kochhan L,Bruhn HD,Delev D,Watzka M,Seifried E,Oldenburg J

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The degree of globin chain imbalance and tissue hypoxia are important determinants of clinical severity in thalassemia syndromes. Thus phenotypic expression may be modified by interaction of alpha- and beta-thalassemia defects, level and type of hemoglobin synthesized and oxygen release to the...

journal_title：Haematologica

authors： Traeger-Synodinos J,Papassotiriou I,Vrettou C,Skarmoutsou C,Stamoulakatou A,Kanavakis E

更新日期：2001-04-01 00:00:00

abstract：:We report on a patient affected by multicentric Castleman's disease who developed an acute immunohemolytic anemia due to warm antibody. The clinical course was characterized by refractoriness to the steroidal treatment and by a dramatic improvement of the hematological and objective picture following combination chemo...

journal_title：Haematologica

authors： Liberato NL,Bollati P,Chiofalo F,Filipponi M,Poli M

更新日期：1996-01-01 00:00:00

abstract：:Antiphospholipid antibody syndrome is an autoimmune disease characterized by the presence of so-called antiphospholipid antibodies and clinical manifestations such as recurrent thromboembolic or pregnancy complications. Although the main antigenic determinant for antiphospholipid antibodies has been identified as the ...

journal_title：Haematologica

authors： de Moerloose P,Fickentscher C,Boehlen F,Tiercy JM,Kruithof EKO,Brandt KJ

更新日期：2017-08-01 00:00:00

abstract：:Homeobox containing transcription factors are frequently deregulated in human hematologic malignant diseases either indirectly through an abnormality of an upstream factor, or directly through rearrangement of the gene itself. Study of T-cell acute lymphoblastic leukemia identified the related non-clustered homeobox t...

journal_title：Haematologica

authors： Su X,Della-Valle V,Delabesse E,Azgui Z,Berger R,Merle-Béral H,Bernard OA,Nguyen-Khac F

更新日期：2008-07-01 00:00:00

abstract：:B-cell chronic lymphocytic leukemia-related genomic changes were analyzed by karyotyping, fluorescence in situ hybridization, and V(H) gene sequencing in a prospective clinical evaluation. The V(H) mutational status correlated with high-risk cytogenetic aberrations while no such relation could be demonstrated for spec...

journal_title：Haematologica

authors： Méhes G,Kovács G,Kajtár B,Lacza A,Várnai A,Losonczy H,Pajor L

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Transplantation from an HLA-matched sibling is the treatment of choice for young patients with acquired severe aplastic anemia. For older patients, the acceptable upper age limit for transplantation as first-line treatment varies. The current analysis, therefore, sought to identify age or ages at transplanta...

journal_title：Haematologica

authors： Gupta V,Eapen M,Brazauskas R,Carreras J,Aljurf M,Gale RP,Hale GA,Ilhan O,Passweg JR,Ringdén O,Sabloff M,Schrezenmeier H,Socié G,Marsh JC

更新日期：2010-12-01 00:00:00