Hepatic and splenic mycosis in children with acute leukemia.

abstract：:Treatment of adults with acute myeloblastic leukemia has changed substantially over the past two decades. Currently available estimates of survival do not reflect results from present state-of-the-art treatment due to a lag between the availability of new treatments and data concerning their effect on survival on the ...

journal_title：Haematologica

authors： Pulte D,Gondos A,Brenner H

更新日期：2008-04-01 00:00:00

abstract：:In the European Intergroup EURO-LB02 trial, children and adolescents with lymphoblastic lymphoma underwent the non-Hodgkin lymphoma Berlin-Frankfurt-Münster protocol without prophylactic cranial radiotherapy. The primary aims of this trial were to test whether replacing prednisone with dexamethasone during induction i...

journal_title：Haematologica

authors： Landmann E,Burkhardt B,Zimmermann M,Meyer U,Woessmann W,Klapper W,Wrobel G,Rosolen A,Pillon M,Escherich G,Attarbaschi A,Beishuizen A,Mellgren K,Wynn R,Ratei R,Plesa A,Schrappe M,Reiter A,Bergeron C,Patte C,Bertran

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported to the plasma via the iron export protein ferroportin. In the plas...

journal_title：Haematologica

authors： Marro S,Chiabrando D,Messana E,Stolte J,Turco E,Tolosano E,Muckenthaler MU

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Although IFN-beta is 30-40% homologous with IFN-alpha, its intrinsic biological properties are not identical. Compared with IFN-alpha, IFN-beta exerts greater in vitro antiproliferative activity on many cell lines, stimulates peripheral blood stem cells of hairy-cell leukemia (HCL) patients to differentiate ...

journal_title：Haematologica

authors： Liberati AM,Schippa M,Portuesi MG,Grazia Proietti M,De Angelis V,Ferrajoli A,Cinieri S,Di Clemente F,Palmisano L,Berruto P

更新日期：1991-09-01 00:00:00

abstract：:In the eighties there has been an enormous increase in our knowledge about erythropoietin, previously defined as "an elusive hormone". In this review we summarize the structural and molecular features, the mechanisms of production and of metabolism, the more important methods of assay, the mechanism of action and the ...

journal_title：Haematologica

authors： Liberato NL,Costa A,Barosi G

更新日期：1990-07-01 00:00:00

abstract：:Left ventricular (LV) failure is the main cause of death in thalassemia. Iron overload in patients with thalassemia leads to the formation of oxygen free radicals. Of the various apolipoprotein E (apoE) alleles, apoE4 is the least efficient in conditions of oxidative stress in comparison with apoE2 and apoE3. Our resu...

journal_title：Haematologica

authors： Bazrgar M,Karimi M,Peiravian F,Fathzadeh M

更新日期：2007-02-01 00:00:00

abstract：:JAK2 V617F, identified in the majority of patients with myeloproliferative neoplasms, tyrosine phosphorylates SOCS3 and escapes its inhibition. Here, we demonstrate that the JAK2 exon 12 mutants described in a subset of V617F-negative MPN cases, also stabilize tyrosine phosphorylated SOCS3. SOCS3 tyrosine phosphorylat...

journal_title：Haematologica

authors： Elliott J,Suessmuth Y,Scott LM,Nahlik K,McMullin MF,Constantinescu SN,Green AR,Johnston JA

更新日期：2009-04-01 00:00:00

abstract：:Twice-weekly carfilzomib is approved at 27 and 56 mg/m2 to treat relapsed multiple myeloma patients. In the phase III study ARROW, once-weekly 70 mg/m 2 carfilzomib prolonged the median progression-free survival of relapsed multiple myeloma patients in comparison with twice-weekly 27 mg/m2 carfilzomib, without adding ...

journal_title：Haematologica

authors： Bringhen S,Mina R,Petrucci MT,Gaidano G,Ballanti S,Musto P,Offidani M,Spada S,Benevolo G,Ponticelli E,Galieni P,Cavo M,Di Toritto TC,Di Raimondo F,Montefusco V,Palumbo A,Boccadoro M,Larocca A

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Dyskeratosis congenita is a cancer-prone bone marrow failure syndrome caused by aberrations in telomere biology. DESIGN AND METHODS:We studied 65 patients with dyskeratosis congenita and 127 unaffected relatives. Telomere length was measured by automated multicolor flow fluorescence in situ hybridization in...

journal_title：Haematologica

authors： Alter BP,Rosenberg PS,Giri N,Baerlocher GM,Lansdorp PM,Savage SA

更新日期：2012-03-01 00:00:00

abstract：:Hypertension is a major, independent risk factor for atherosclerotic cardiovascular disease. However, this pathology can arise through multiple pathways, which could influence vascular disease through distinct mechanisms. An overactive sympathetic nervous system is a dominant pathway that can precipitate in elevated b...

journal_title：Haematologica

authors： Al-Sharea A,Lee MKS,Whillas A,Michell DL,Shihata WA,Nicholls AJ,Cooney OD,Kraakman MJ,Veiga CB,Jefferis AM,Jackson K,Nagareddy PR,Lambert G,Wong CHY,Andrews KL,Head GA,Chin-Dusting J,Murphy AJ

更新日期：2019-03-01 00:00:00

abstract：:The effect of treatment with 1,25-dihydroxyvitamin D3 administered at the dose of 1.50-3.00 ug/day for at least 12 months was evaluated in three patients with idiopathic myelofibrosis and in five patients with idiopathic thrombocythemia. This treatment did not cause any significant change in the hematological values o...

journal_title：Haematologica

authors： Foa P,Maiolo AT,Cortellaro M,Ortolani S,Pogliani E,Deliliers GL,Iurlo A,Zocchi L,Gualdoni A,Polli E

更新日期：1990-05-01 00:00:00

abstract：:One hundred patients with newly diagnosed multiple myeloma (MM) were treated with high-dose chemotherapy followed by single or double autologous stem cell transplantation (ASCT). Up-front treatment with a double ASCT tended to prolong progression-free and overall survival. ...

journal_title：Haematologica

authors： Putkonen M,Rauhala A,Itälä M,Kauppila M,Pelliniemi TT,Remes K

更新日期：2005-04-01 00:00:00

abstract：:Vitamin B12 deficiency causes decreased Methionine Synthase and L-Methylmalonyl-CoA Mutase activity and results in accumulation of Homocysteine, Methylmalonic acid and Propionylcarnitine. Propionylcarnitine is included in tandem mass spectrometry-based newborn screening programs for detection of certain inborn errors ...

journal_title：Haematologica

authors： Campbell CD,Ganesh J,Ficicioglu C

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Novel therapies capable of targeting drug resistant clonogenic MM cells are required for more effective treatment of multiple myeloma. This study investigates the cytotoxicity of natural killer cell lines against bulk and clonogenic multiple myeloma and evaluates the tumor burden after NK cell therapy in a b...

journal_title：Haematologica

authors： Swift BE,Williams BA,Kosaka Y,Wang XH,Medin JA,Viswanathan S,Martinez-Lopez J,Keating A

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:It is often difficult to obtain good karyotypes of cells from children with acute lymphoblastic leukemia (ALL) because of poor morphology and spreading. Detailed karyotyping can be further hampered by the presence of multiple rearrangements. Our objective was to search for cryptic rearrangemen...

journal_title：Haematologica

authors： Poppe B,Cauwelier B,Van Limbergen H,Yigit N,Philippé J,Verhasselt B,De Paepe A,Benoit Y,Speleman F

更新日期：2005-09-01 00:00:00

abstract：:Mucosa-associated lymphoid tissue (MALT) lymphoma originates from a background of diverse chronic inflammatory disorders at various anatomic sites. The genetics underlying its development, particularly in those associated with autoimmune disorders, is poorly characterized. By whole exome sequencing of 21 cases of MALT...

journal_title：Haematologica

authors： Moody S,Thompson JS,Chuang SS,Liu H,Raderer M,Vassiliou G,Wlodarska I,Wu F,Cogliatti S,Robson A,Ashton-Key M,Bi Y,Goodlad J,Du MQ

更新日期：2018-08-01 00:00:00

abstract：:Acquired aplastic anemia, the prototypical bone marrow failure disease, is characterized by pancytopenia and marrow hypoplasia. Most aplastic anemia patients respond to immunosuppressive therapy, usually with anti-thymocyte globulin and cyclosporine, but some relapse on cyclosporine withdrawal or require long-term adm...

journal_title：Haematologica

authors： Feng X,Lin Z,Sun W,Hollinger MK,Desierto MJ,Keyvanfar K,Malide D,Muranski P,Chen J,Young NS

更新日期：2017-10-01 00:00:00

abstract：:Hereditary spherocytosis (HS) originates from defective anchoring of the cytoskeletal network to the transmembrane protein complexes of the red blood cell (RBC). Red cells in HS are characterized by membrane instability and reduced deformability and there is marked heterogeneity in disease severity among patients. To ...

journal_title：Haematologica

authors： Huisjes R,Makhro A,Llaudet-Planas E,Hertz L,Petkova-Kirova P,Verhagen LP,Pignatelli S,Rab MAE,Schiffelers RM,Seiler E,van Solinge WW,Corrons JV,Kaestner L,Mañú-Pereira M,Bogdanova A,van Wijk R

更新日期：2020-01-31 00:00:00

abstract：:Homeobox containing transcription factors are frequently deregulated in human hematologic malignant diseases either indirectly through an abnormality of an upstream factor, or directly through rearrangement of the gene itself. Study of T-cell acute lymphoblastic leukemia identified the related non-clustered homeobox t...

journal_title：Haematologica

authors： Su X,Della-Valle V,Delabesse E,Azgui Z,Berger R,Merle-Béral H,Bernard OA,Nguyen-Khac F

更新日期：2008-07-01 00:00:00

abstract：:Tyrosine kinase inhibitors (TKIs) are highly effective for the treatment of chronic myeloid leukemia (CML), but very few patients are cured. The major drawbacks regarding TKIs are their low efficacy in eradicating the leukemic stem cells responsible for disease maintenance and relapse upon drug cessation. Herein, we p...

journal_title：Haematologica

authors： Landberg N,von Palffy S,Askmyr M,Lilljebjörn H,Sandén C,Rissler M,Mustjoki S,Hjorth-Hansen H,Richter J,Ågerstam H,Järås M,Fioretos T

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Classical Hodgkin's lymphoma is characterized by a minority of neoplastic cells surrounded by a heterogeneous background population of non-neoplastic cells including lymphoma-associated macrophages. High levels of expression of both the monocyte/macrophage lineage-associated antigens CD68 and CD163 have been...

journal_title：Haematologica

authors： Kamper P,Bendix K,Hamilton-Dutoit S,Honoré B,Nyengaard JR,d'Amore F

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The benefits of high-dose cytarabine, anthracyclines and hematopoietic stem cell transplantation in the treatment of acute myeloid leukemia (AML) are greater in younger rather than in older patients. We assessed the proportion of patients over 60 years with de novo AML who qualified for intens...

journal_title：Haematologica

authors： Oriol A,Ribera JM,Esteve J,Guàrdia R,Brunet S,Bueno J,Pedro C,Llorente A,Tormo M,Besalduch J,Sánchez JM,Batlle M,Vivancos P,Carreras E,Vilà JM,Julià A,Sierra J,Montserrat E,Feliu E,CETLAM AML-99.

更新日期：2004-07-01 00:00:00

abstract：:In this open label pilot safety study 80 children over 3 months old with deep venous thrombosis were treated with enoxaparin with a target 4 h anti-factor Xa activity between 0.5-0.8 IU/mL. The children were stratified to receive once daily or twice daily doses. The study end-points were post-thrombotic syndrome, re-t...

journal_title：Haematologica

authors： Schobess R,Düring C,Bidlingmaier C,Heinecke A,Merkel N,Nowak-Göttl U

更新日期：2006-12-01 00:00:00

abstract：:Platelet-type von Willebrand disease (PT-VWD) is a rare autosomal dominant bleeding disorder which is due to a mutation in the gene encoding for platelet glycoprotein Ibalpha (GPIbalpha) resulting in enhanced affinity for von Willebrand factor (VWF). PT-VWD is often mistakenly diagnosed as type 2B VWD for the similari...

journal_title：Haematologica

authors： Giannini S,Cecchetti L,Mezzasoma AM,Gresele P

更新日期：2010-06-01 00:00:00

abstract：:HLA molecules play an important role for immunoreactivity in allogeneic hematopoietic stem cell transplantation. To elucidate the effect of specific HLA alleles on acute graft-versus-host disease, we conducted a retrospective analysis using 6967 Japanese patients transplanted with T-cell-replete marrow from an unrelat...

journal_title：Haematologica

authors： Morishima S,Kashiwase K,Matsuo K,Azuma F,Yabe T,Sato-Otsubo A,Ogawa S,Shiina T,Satake M,Saji H,Kato S,Kodera Y,Sasazuki T,Morishima Y,Japan Marrow Donor Program.

更新日期：2016-04-01 00:00:00

abstract：:Normal and clonal hematopoietic progenitor cells have been demonstrated to coexist in chronic-phase chronic myelogenous leukemia (CML), but few data are available on the presence of non neoplastic hematopoiesis during the blastic transformation phase. We used reverse transcription-polymerase chain reaction (RT-PCR) to...

journal_title：Haematologica

authors： Martinelli G,Lemoli RM,Farabegoli P,Zaccaria A,Testoni N,Buzzi M,Fogli M,Visani G,Tosi P,Motta MR

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Somatic hypermutation of the BCL6 gene and its expression in lymphoma represent specific markers for B-cell transit through the germinal center. Thus, analysis of BCL6 may aid in clarifying the relationship between primary mediastinal B-cell lymphoma (PMBL) and other non-thymic diffuse large c...

journal_title：Haematologica

authors： Malpeli G,Barbi S,Moore PS,Scardoni M,Chilosi M,Scarpa A,Menestrina F

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:MicroRNAs can play an important role in tumorigenesis through post-transcriptional regulation of gene expression, and are not well characterized in follicular lymphoma. DESIGN AND METHODS:MicroRNA profiles of enriched follicular lymphoma tumor cells from 16 patients were generated by assaying 851 human micr...

journal_title：Haematologica

authors： Wang W,Corrigan-Cummins M,Hudson J,Maric I,Simakova O,Neelapu SS,Kwak LW,Janik JE,Gause B,Jaffe ES,Calvo KR

更新日期：2012-04-01 00:00:00

abstract：:Ten consecutive patients (pts), suffering from hematological malignancies (5 NHL, 3 ANLL and 2 HD), received high doses of radio-chemotherapy and autologous peripheral blood stem cell (PBSC) transplantation. Seven of them were in 1st CR, two in 3rd CR and one in refractory status. The recruitment of PBSC was performed...

journal_title：Haematologica

authors： Fioritoni G,Iacone A,D'Antonio D,Dragani A,Quaglietta AM,Accorsi P,Angelini A,Spadano A,Natale D,Berardi A

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Effective gene transfer into human hematopoietic stem/progenitor cells is a compromise between achieving high transduction efficiency and maintaining the desired biological characteristics of the target cell. The aim of our work was to exploit the stromal microenvironment to increase gene tran...

journal_title：Haematologica

authors： Dando JS,Ficara F,Deola S,Roncarolo MG,Bordignon C,Aiuti A

更新日期：2004-04-01 00:00:00