Identification of a region of hantavirus nucleocapsid protein required for RNA chaperone activity.

abstract：:Chemical modification of nucleobases plays an important role for the control of gene expression on different levels. That includes the modulation of translation by modified tRNA-bases or silencing and reactivation of genes by methylation and demethylation of cytosine in promoter regions. Especially dynamic methylation...

journal_title：RNA biology

authors： Traube FR,Carell T

更新日期：2017-09-02 00:00:00

abstract：:The HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone, which remodels nucleic acid structures so that the most thermodynamically stable conformations are formed. This activity is essential for virus replication and has a critical role in mediating highly specific and efficient reverse transcription. NC's fun...

journal_title：RNA biology

authors： Levin JG,Mitra M,Mascarenhas A,Musier-Forsyth K

更新日期：2010-11-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are pervasively transcribed and critical regulators of the epigenome[1, 2]. These long, polyadenylated RNAs do not code for proteins, but function directly as RNAs, recruiting chromatin modifiers to mediate transcriptional changes in processes ranging from X-inactivation (XIST) to imprint...

journal_title：RNA biology

authors： Hung T,Chang HY

更新日期：2010-09-01 00:00:00

abstract：:Skeletal muscle is the dominant executant in locomotion and regulator in energy metabolism. Embryonic myogenesis and postnatal muscle growth are controlled by a cascade of transcription factors and epigenetic regulatory mechanisms. MicroRNAs (miRNAs), a family of non-coding RNA of 22 nucleotides in length, post-transc...

journal_title：RNA biology

authors： Ma M,Wang X,Chen X,Cai R,Chen F,Dong W,Yang G,Pang W

更新日期：2017-03-04 00:00:00

abstract：:This review emphasizes the function and regulation of the Csr regulatory system in the human enteropathogen Yersinia pseudotuberculosis and compares its features with the homologous Csr/Rsm systems of related pathogens. The Csr/Rsm systems of eubacteria form a complex regulatory network in which redundant non-translat...

journal_title：RNA biology

authors： Heroven AK,Böhme K,Dersch P

更新日期：2012-04-01 00:00:00

abstract：:Epstein-Barr virus (EBV) was the first human cancer-causing virus to be discovered over fifty years ago. Given its relatively large genome size for a virus and hence the capacity to store more than mere protein-coding information, EBV also harbours genetic material for producing an array of distinct noncoding (nc)RNAs...

journal_title：RNA biology

authors： Lee N

更新日期：2021-01-30 00:00:00

abstract：:I am honored to have been asked to contribute to this memorial issue, although I cannot claim to have known Carl Woese well. Carl's insights and the discoveries that his research group made over the years certainly stimulated my own research program, and at several points early on, interactions with him were pivotal i...

journal_title：RNA biology

authors： Gray MW

更新日期：2014-01-01 00:00:00

abstract：:Selenoproteins are a unique class of proteins that contain the 21st amino acid, selenocysteine (Sec). Addition of Sec into a protein is achieved by recoding of the UGA stop codon. All 25 mammalian selenoprotein mRNAs possess a 3' UTR stem-loop structure, the Selenocysteine Insertion Sequence (SECIS), which is required...

journal_title：RNA biology

authors： Cockman EM,Narayan V,Willard B,Shetty SP,Copeland PR,Driscoll DM

更新日期：2019-12-01 00:00:00

abstract：:In an earlier report two P-transposon insertion alleles of the noncoding hsromega gene, hsromega(05241) and P292 were shown to enhance neurodegeneration caused by expression of ataxin-1 protein with expanded poly-Q in a Drosophila model. In present study, we examined the possible relation between hsromega gene express...

journal_title：RNA biology

authors： Sengupta S,Lakhotia SC

更新日期：2006-01-01 00:00:00

abstract：:Previous mRNA transcriptome studies of Euglena gracilis have shown that this organism possesses a large and diverse complement of protein coding genes; however, the study of non-coding RNA classes has been limited. The natural extensive fragmentation of the E. gracilis large subunit ribosomal RNA presents additional b...

journal_title：RNA biology

authors： Moore AN,McWatters DC,Hudson AJ,Russell AG

更新日期：2018-01-01 00:00:00

abstract：:"What does one do when the giants pass away?" remarked a very famous microbiologist to me, soon after the death of Carl Woese in late 2012. I teach microbiology and introductory cell and molecular biology at a small undergraduate institution; Woese's example and contributions have long been part of every class I teach...

journal_title：RNA biology

authors： Martin M

更新日期：2014-01-01 00:00:00

abstract：:The universal genetic code is a translation table by which nucleic acid sequences can be interpreted as polypeptides with a wide range of biological functions. That information is used by aminoacyl-tRNA synthetases to translate the code. Moreover, amino acid properties dictate protein folding. We recently reported tha...

journal_title：RNA biology

authors： Carter CW Jr,Wolfenden R

更新日期：2016-01-01 00:00:00

abstract：:MicroRNAs are small RNAs that post-transcriptionally regulate eukaryotic gene expression. In addition to their involvement in a wide range of physiological and pathological processes, including viral infections, microRNAs are increasingly implicated in the eukaryotic response to bacterial pathogens. Recent studies hav...

journal_title：RNA biology

authors： Eulalio A,Schulte L,Vogel J

更新日期：2012-06-01 00:00:00

abstract：:In a series of conceptual articles published around the millennium, Carl Woese emphasized that evolution of cells is the central problem of evolutionary biology, that the three-domain ribosomal tree of life is an essential framework for reconstructing cellular evolution, and that the evolutionary dynamics of functiona...

journal_title：RNA biology

authors： Koonin EV

更新日期：2014-01-01 00:00:00

abstract：:Circular RNAs (circRNAs) are closely associated with the development of non-small cell lung cancer (NSCLC); however, it is still unclear whether circular RNA circ-LDLRAD3 participated in the regulation of NSCLC progression. In this study, we found that circ-LDLRAD3 was high-expressed and miR-137 was low-expressed in N...

journal_title：RNA biology

authors： Xue M,Hong W,Jiang J,Zhao F,Gao X

更新日期：2020-12-01 00:00:00

abstract：:A recent study revealed that poly(A)-binding protein (PABP) bound to poly(A) RNA exhibits a sharply bent configuration at the linker region between RNA-recognition motif 2 (RRM2) and RRM3, whereas free PABP exhibits a highly flexible linear configuration. However, the physiological role of the bent structure of mRNA-b...

journal_title：RNA biology

authors： Hong KY,Lee SH,Gu S,Kim E,An S,Kwon J,Lee JB,Jang SK

更新日期：2017-03-04 00:00:00

abstract：:Interactions between glioma cells and their local environment are critical determinants of brain tumor growth, infiltration and neovascularisation. Communication with host cells and stroma via microvesicles represents one pathway by which tumors can modify their surroundings to achieve a tumor-permissive environment. ...

journal_title：RNA biology

authors： Li CC,Eaton SA,Young PE,Lee M,Shuttleworth R,Humphreys DT,Grau GE,Combes V,Bebawy M,Gong J,Brammah S,Buckland ME,Suter CM

更新日期：2013-08-01 00:00:00

abstract：:The development of rigorous molecular taxonomy pioneered by Carl Woese has freed evolution science to explore numerous cellular activities that lead to genome change in evolution. These activities include symbiogenesis, inter- and intracellular horizontal DNA transfer, incorporation of DNA from infectious agents, and ...

journal_title：RNA biology

authors： Shapiro JA

更新日期：2014-01-01 00:00:00

abstract：:Oncogenic viruses are associated with approximately 15% of human cancers. In viral infections, microRNAs play an important role in host-pathogen interactions. miR-21 is a highly conserved non-coding RNA that not only regulates the development of oncogenic viral diseases, but also responds to the regulation of intracel...

journal_title：RNA biology

authors： He G,Ding J,Zhang Y,Cai M,Yang J,Cho WC,Zheng Y

更新日期：2021-01-27 00:00:00

abstract：:Ribonuclease P (RNase P) is a ribonucleoprotein comprised of a catalytic RNA subunit and one or several protein subunits. RNase P is best known for its role in 5'-processing of tRNA precursors. RNase P enzymes from almost all forms of life, including protein-synthesizing organelles, contain an RNase P with a conserved...

journal_title：RNA biology

authors： Ellis JC,Brown JW

更新日期：2009-09-01 00:00:00

abstract：:tRNA-dependent addition of amino acids to lipids on the outer surface of the bacterial membrane results in decreased effectiveness of antimicrobials such as cationic antimicrobial peptides (CAMPs) that target the membrane, and increased virulence of several pathogenic species. After a brief introduction to CAMPs and t...

journal_title：RNA biology

authors： Fields RN,Roy H

更新日期：2018-01-01 00:00:00

abstract：:The ribosome binding site of Escherichia coli rpoS mRNA, encoding the stationary sigma-factor RpoS, is sequestered by an inhibitory stem-loop structure (iss). Translational activation of rpoS mRNA at low temperature and during exponential growth includes Hfq-facilitated duplex formation between rpoS and the small regu...

journal_title：RNA biology

authors： Resch A,Većerek B,Palavra K,Bläsi U

更新日期：2010-11-01 00:00:00

abstract：:Differential mRNA stability is an important mechanism for regulation of virulence factors in Streptococcus pyogenes (group A streptococcus, GAS), a serious and prevalent human pathogen. We have described 2 Classes of mRNA in GAS that are distinguishable by 1) stability in the stationary phase of growth, 2) kinetics of...

journal_title：RNA biology

authors： Bugrysheva JV,Scott JR

更新日期：2010-09-01 00:00:00

abstract：:As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst. The chaperoning function is found intrinsic to ribozymes involved in protein synthesis and tRNA maturation, enriching the primordial RNA world with ...

journal_title：RNA biology

authors： Son A,Horowitz S,Seong BL

更新日期：2021-01-01 00:00:00

abstract：:Viroids are the smallest autonomous infectious nucleic acids known today. They are non-coding, unencapsidated, circular RNAs with sizes ranging from 250 to 400 nucleotides and infect certain plants. These RNAs are transcribed by rolling-circle mechanisms in the plant host's nuclei (Pospiviroidae) or chloroplasts (Avsu...

journal_title：RNA biology

authors： Hammann C,Steger G

更新日期：2012-06-01 00:00:00

abstract：:The protein domain arrangement known as the La-module, comprised of a La motif (LaM) followed by a linker and RNA recognition motif (RRM), is found in seven La-related proteins: LARP1, LARP1B, LARP3 (La protein), LARP4, LARP4B, LARP6, and LARP7 in humans. Several LARPs have been characterized for their distinct activi...

journal_title：RNA biology

authors： Mattijssen S,Kozlov G,Gaidamakov S,Ranjan A,Fonseca BD,Gehring K,Maraia RJ

更新日期：2020-12-23 00:00:00

abstract：:MicroRNA (miRs) are short non-coding RNAs that fine-tune the regulation of gene expression to coordinate a wide range of biological processes. MicroRNAs are transcribed from miR genes and primary miR transcripts are processed to approximately 22 nucleotide single strand mature forms that function as repressors of tran...

journal_title：RNA biology

authors： Desvignes T,Contreras A,Postlethwait JH

更新日期：2014-01-01 00:00:00

abstract：:Termination of RNA polymerase II (RNAPII) transcription is a fundamental step of gene expression that involves the release of the nascent transcript and dissociation of RNAPII from the DNA template. As transcription termination is intimately linked to RNA 3' end processing, termination pathways have a key decisive inf...

journal_title：RNA biology

authors： Lemay JF,Bachand F

更新日期：2015-01-01 00:00:00

abstract：:The muscle specific miRNA, miR-206, is important for the process of myogenesis; however, studying the function of miR-206 in muscle development and differentiation still proves challenging because the complement of mRNA targets it regulates remains undefined. In addition, miR-206 shares close sequence similarity to mi...

journal_title：RNA biology

authors： Salant GM,Tat KL,Goodrich JA,Kugel JF

更新日期：2020-07-01 00:00:00

abstract：:Circular RNAs (circRNAs) have been identified in diverse eukaryotic species and are characterized by RNA backsplicing events. Current available methods for circRNA identification are able to determine the start and end locations of circRNAs in the genome but not their full-length sequences. In this study, we developed...

journal_title：RNA biology

authors： Ye CY,Zhang X,Chu Q,Liu C,Yu Y,Jiang W,Zhu QH,Fan L,Guo L

更新日期：2017-08-03 00:00:00