Abstract:
:Circular RNAs (circRNAs) are closely associated with the development of non-small cell lung cancer (NSCLC); however, it is still unclear whether circular RNA circ-LDLRAD3 participated in the regulation of NSCLC progression. In this study, we found that circ-LDLRAD3 was high-expressed and miR-137 was low-expressed in NSCLC tissues and cells compared to their normal counterparts, which showed negative correlations in NSCLC tissues. Further experiments validated that miR-137 could be sponged and inhibited by circ-LDLRAD3 in NSCLC cells. In addition, knock-down of circ-LDLRAD3 and miR-137 overexpression promoted NSCLC cell apoptosis, and inhibited cell proliferation and invasion. Similarly, upregulation of circ-LDLRAD3 or miR-137 ablation had opposite effects on the above cell functions. Besides, the glutamine transporter SLC1A5 was validated to be the downstream target of circ-LDLRAD3 and miR-137, and upregulated circ-LDLRAD3 increased SLC1A5 expression levels by downregulating miR-137. Furthermore, the effects of downregulated circ-LDLRAD3 on cell proliferation, apoptosis and mobility were all reversed by knocking down miR-137 and overexpressing SLC1A5. Taken together, this in vitro study found that knock-down of circ-LDLRAD3 inhibited the development of NSCLC by regulating miR-137/SLC1A5 axis.
journal_name
RNA Bioljournal_title
RNA biologyauthors
Xue M,Hong W,Jiang J,Zhao F,Gao Xdoi
10.1080/15476286.2020.1789819subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1811-1822issue
12eissn
1547-6286issn
1555-8584journal_volume
17pub_type
杂志文章相关文献
RNA Biology文献大全abstract::MicroRNAs are small RNAs that post-transcriptionally regulate eukaryotic gene expression. In addition to their involvement in a wide range of physiological and pathological processes, including viral infections, microRNAs are increasingly implicated in the eukaryotic response to bacterial pathogens. Recent studies hav...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.20018
更新日期:2012-06-01 00:00:00
abstract::The ribosome binding site of Escherichia coli rpoS mRNA, encoding the stationary sigma-factor RpoS, is sequestered by an inhibitory stem-loop structure (iss). Translational activation of rpoS mRNA at low temperature and during exponential growth includes Hfq-facilitated duplex formation between rpoS and the small regu...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.7.6.13768
更新日期:2010-11-01 00:00:00
abstract::Deinococcus radiodurans is a highly stress resistant bacterium that encodes universal as well as lineage-specific factors involved in DNA transcription and repair. However, the effects of DNA lesions on RNA synthesis by D. radiodurans RNA polymerase (RNAP) have never been studied. We investigated the ability of this R...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1656027
更新日期:2019-12-01 00:00:00
abstract::Post-transcriptional control of messenger RNA (mRNA) is an important layer of gene regulation that modulates mRNA decay, translation, and localization. Eukaryotic mRNA decay begins with the catalytic removal of the 3' poly-adenosine tail by deadenylase enzymes. Multiple deadenylases have been identified in vertebrates...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2018.1526541
更新日期:2018-01-01 00:00:00
abstract::Interactions between glioma cells and their local environment are critical determinants of brain tumor growth, infiltration and neovascularisation. Communication with host cells and stroma via microvesicles represents one pathway by which tumors can modify their surroundings to achieve a tumor-permissive environment. ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.25281
更新日期:2013-08-01 00:00:00
abstract::A-to-I RNA editing by adenosine deaminases acting on RNA is a post-transcriptional modification that is crucial for normal life and development in vertebrates. RNA editing has been shown to be very abundant in the human transcriptome, specifically at the primate-specific Alu elements. The functional role of this wide-...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/15476286.2014.992286
更新日期:2014-01-01 00:00:00
abstract::As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst. The chaperoning function is found intrinsic to ribozymes involved in protein synthesis and tRNA maturation, enriching the primordial RNA world with ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1801199
更新日期:2021-01-01 00:00:00
abstract::Viroids are non-coding single-stranded circular RNA molecules that replicate autonomously in infected host plants causing mild to lethal symptoms. Their genomes contain about 250-400 nucleotides, depending on viroid species. Members of the family Pospiviroidae, like the Potato spindle tuber viroid (PSTVd), replicate v...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2016.1272745
更新日期:2017-03-04 00:00:00
abstract::We report here an in-depth characterization of the aptamer domain of the transcriptional adenine-sensing riboswitch (pbuE) by NMR and fluorescence spectroscopy. By NMR studies, the structure of two aptamer sequences with different lengths of the helix P1, the central element involved in riboswitch conformational switc...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.29439
更新日期:2014-01-01 00:00:00
abstract::RNA editing in flowering plant mitochondria targets several hundred C nucleotides mostly in mRNAs to be altered to U. Several nuclear encoded genes have been recently identified predominantly in Arabidopsis thaliana which code for proteins involved in specific RNA editing events in plastids or mitochondria. These nucl...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.1.14298
更新日期:2011-01-01 00:00:00
abstract::RNA methylation, catalysed by a set of RNA methyltransferases (RNMTs), modulates RNA structures, properties, and biological functions. RNMTs are increasingly documented to be dysregulated in various human diseases, particularly developmental disorders and cancer. However, the genomic and transcriptomic alterations of ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1708549
更新日期:2020-04-01 00:00:00
abstract::The endoribonuclease toxins of the E. coli toxin-antitoxin systems arrest bacterial growth and protein synthesis by targeting cellular mRNAs. As an exception, E. coli MazF was reported to cleave also 16S rRNA at a single site and separate an anti-Shine-Dalgarno sequence-containing RNA fragment from the ribosome. We no...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2016.1259784
更新日期:2017-01-02 00:00:00
abstract::5-fluorouracil (5-FU) was isolated as an inhibitor of thymidylate synthase, which is important for DNA synthesis. The drug was later found to also affect the conserved 3'-5' exoribonuclease EXOSC10/Rrp6, a catalytic subunit of the RNA exosome that degrades and processes protein-coding and non-coding transcripts. Work ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1581596
更新日期:2019-06-01 00:00:00
abstract::The NOVA (neuro-oncological ventral antigen) protein family, composed of two paralogs, NOVA1 and NOVA2, consists of RNA-binding proteins involving in processes such as alternative splicing and transport of some target mRNAs. The function of NOVA has been well studied, and increasing evidence has shown that NOVA protei...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1734372
更新日期:2020-06-01 00:00:00
abstract::The HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone, which remodels nucleic acid structures so that the most thermodynamically stable conformations are formed. This activity is essential for virus replication and has a critical role in mediating highly specific and efficient reverse transcription. NC's fun...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.6.14115
更新日期:2010-11-01 00:00:00
abstract::Myocyte enhancer factor 2c (MEF2C) is the MADS-box type transcription factor involved in the differentiation of cardiac and skeletal muscle and synaptic formation. Alternatively spliced transcripts of the MEF2C gene were proven to encode isoforms which exert distinct functions in transcriptional regulation. During the...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2015.1017213
更新日期:2015-01-01 00:00:00
abstract::The universal genetic code is a translation table by which nucleic acid sequences can be interpreted as polypeptides with a wide range of biological functions. That information is used by aminoacyl-tRNA synthetases to translate the code. Moreover, amino acid properties dictate protein folding. We recently reported tha...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2015.1112488
更新日期:2016-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are key regulators of gene expression and play critical roles in modulating metabolism, development and physiology in animals and plants. miRNA levels are transcriptionally and post-transcriptionally controlled for their proper function. Recent studies have shown that RNA-binding proteins play impor...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.22740
更新日期:2012-12-01 00:00:00
abstract::RNA-binding proteins (RBPs) are key regulators of posttranscriptional processes such as RNA maturation, localization, turnover and translation. Despite their dysregulation in various diseases including cancer, the landscape of RBP expression in human cancer has not been well elucidated. Here, we built a comprehensive ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1673657
更新日期:2020-02-01 00:00:00
abstract::Selenoproteins are a unique class of proteins that contain the 21st amino acid, selenocysteine (Sec). Addition of Sec into a protein is achieved by recoding of the UGA stop codon. All 25 mammalian selenoprotein mRNAs possess a 3' UTR stem-loop structure, the Selenocysteine Insertion Sequence (SECIS), which is required...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1653681
更新日期:2019-12-01 00:00:00
abstract::I am honored to have been asked to contribute to this memorial issue, although I cannot claim to have known Carl Woese well. Carl's insights and the discoveries that his research group made over the years certainly stimulated my own research program, and at several points early on, interactions with him were pivotal i...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.27799
更新日期:2014-01-01 00:00:00
abstract::Two different isolates of the myxomycete Didymium iridis harbour homing endonuclease genes that are expressed from group I introns inserted into identical sites within the small subunit ribosomal DNA. The homing endonuclease proteins are related in sequence, and their gene structures share similar features such as the...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.3.4.3958
更新日期:2006-10-01 00:00:00
abstract::Significant structural and mechanistic similarities between the spliceosomal snRNAs and catalytically critical domains of self-splicing group II introns have led to the hypothesis that the spliceosomes and group II introns may be evolutionarily related. We have previously shown that in vitro-transcribed, protein-free ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.3.15386
更新日期:2011-05-01 00:00:00
abstract::The non-coding roX1 and roX2 RNAs are components of the MSL dosage compensation complex in Drosophila. We found that multiple species of roX2 RNA are produced by alternative splicing, with one major and at least 20 different minor forms associated with MSL proteins. The alternative forms are generated by variable usag...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.2.4.2473
更新日期:2005-10-01 00:00:00
abstract::Transcription termination delineates the 3' ends of transcripts, prevents otherwise runaway RNA polymerase (RNAP) from intruding into downstream genes and regulatory elements, and enables release of the RNAP for recycling. While other eukaryotic RNAPs require complex cis-signals and/or accessory factors to achieve the...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2015.1116677
更新日期:2016-01-01 00:00:00
abstract::Conserved RNA secondary structures were predicted in the nucleoprotein (NP) segment of the influenza A virus genome using comparative sequence and structure analysis. A number of structural elements exhibiting nucleotide covariations were identified over the whole segment length, including protein-coding regions. Calc...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.29730
更新日期:2014-01-01 00:00:00
abstract::Alternative splicing (AS) in response to changing external conditions often requires alterations in the ability of sequence-specific RNA-binding proteins to bind to cis-acting sequences in their target pre-mRNA. While daily oscillations in AS events have been described in several organisms, cis-acting sequences that c...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2018.1502587
更新日期:2018-01-01 00:00:00
abstract::The development of rigorous molecular taxonomy pioneered by Carl Woese has freed evolution science to explore numerous cellular activities that lead to genome change in evolution. These activities include symbiogenesis, inter- and intracellular horizontal DNA transfer, incorporation of DNA from infectious agents, and ...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.27506
更新日期:2014-01-01 00:00:00
abstract::While disruption of alternative splicing underlies many diseases, modulation of splicing using antisense oligonucleotides (AONs) can have therapeutic implications. The most notable example is Duchenne muscular dystrophy (DMD), where antisense-mediated exon skipping can restore the open reading frame and allow the synt...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.4.12264
更新日期:2010-07-01 00:00:00
abstract::Circular RNAs (circRNAs) have been identified in diverse eukaryotic species and are characterized by RNA backsplicing events. Current available methods for circRNA identification are able to determine the start and end locations of circRNAs in the genome but not their full-length sequences. In this study, we developed...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2016.1245268
更新日期:2017-08-03 00:00:00