Abstract:
:tRNA-dependent addition of amino acids to lipids on the outer surface of the bacterial membrane results in decreased effectiveness of antimicrobials such as cationic antimicrobial peptides (CAMPs) that target the membrane, and increased virulence of several pathogenic species. After a brief introduction to CAMPs and the various bacterial resistance mechanisms used to counteract these compounds, this review focuses on recent advances in tRNA-dependent pathways for lipid modification in bacteria. Phenotypes associated with amino acid lipid modifications and regulation of their expression will also be discussed.
journal_name
RNA Bioljournal_title
RNA biologyauthors
Fields RN,Roy Hdoi
10.1080/15476286.2017.1356980subject
Has Abstractpub_date
2018-01-01 00:00:00pages
480-491issue
4-5eissn
1547-6286issn
1555-8584journal_volume
15pub_type
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