FMR1 RNA within the intranuclear inclusions of fragile X-associated tremor/ataxia syndrome (FXTAS).

abstract：:The NOVA (neuro-oncological ventral antigen) protein family, composed of two paralogs, NOVA1 and NOVA2, consists of RNA-binding proteins involving in processes such as alternative splicing and transport of some target mRNAs. The function of NOVA has been well studied, and increasing evidence has shown that NOVA protei...

journal_title：RNA biology

authors： Tang S,Zhao Y,He X,Zhu J,Chen S,Wen J,Deng Y

更新日期：2020-06-01 00:00:00

abstract：:De novo addition of telomeric sequences can occur at broken chromosomes and must be well controlled, which is essential during programmed DNA reorganization processes. In ciliated protozoa an extreme form of DNA-reorganization is observed during macronuclear differentiation after sexual reproduction leading to the eli...

journal_title：RNA biology

authors： Fuhrmann G,Jönsson F,Weil PP,Postberg J,Lipps HJ

更新日期：2016-08-02 00:00:00

abstract：:Alzheimer's disease (AD) has devastating consequences for patients during its slow, progressive course. It is important to understand the pathology of AD onset. Recently, circular RNAs (circRNAs) have been found to participate in many human diseases including cancers and neurodegenerative conditions. In this study, we...

journal_title：RNA biology

authors： Lo I,Hill J,Vilhjálmsson BJ,Kjems J

更新日期：2020-12-01 00:00:00

abstract：:In plants, endogenes are less prone to RNA silencing than transgenes. While both can be efficiently targeted by small RNAs for post-transcriptional gene silencing (PTGS), generally only transgene PTGS is accompanied by transitivity, RNA-directed DNA methylation (RdDM) and systemic silencing. In order to investigate wh...

journal_title：RNA biology

authors： Dadami E,Dalakouras A,Zwiebel M,Krczal G,Wassenegger M

更新日期：2014-01-01 00:00:00

abstract：:With a minimal (250-400 nt), non-protein-coding, circular RNA genome, viroids rely on sequence/structural motifs for replication and colonization of their host plants. These motifs are embedded in a compact secondary structure whose elucidation is crucial to understand how they function. Viroid RNA structure has been ...

journal_title：RNA biology

authors： López-Carrasco A,Flores R

更新日期：2017-08-03 00:00:00

abstract：:Eukaryotic gene expression must be coordinated for the proper functioning of biological processes. This coordination can be achieved both at the transcriptional and post-transcriptional levels. In both cases, regulatory sequences placed at either promoter regions or on UTRs function as markers recognized by regulators...

journal_title：RNA biology

authors： Yoon K,Ko D,Doderer M,Livi CB,Penalva LO

更新日期：2008-10-01 00:00:00

abstract：:RNA editing in flowering plant mitochondria targets several hundred C nucleotides mostly in mRNAs to be altered to U. Several nuclear encoded genes have been recently identified predominantly in Arabidopsis thaliana which code for proteins involved in specific RNA editing events in plastids or mitochondria. These nucl...

journal_title：RNA biology

authors： Zehrmann A,Verbitskiy D,Härtel B,Brennicke A,Takenaka M

更新日期：2011-01-01 00:00:00

abstract：:tmRNA employs both tRNA-like and mRNA-like properties as it rescues stalled bacterial ribosomes, while targeting the defective mRNA and incomplete nascent protein for degradation. We describe variation of the tmRNA gene (ssrA) and how it informs tmRNA structure and function. Endosymbiont tmRNAs tend to lose secondary ...

journal_title：RNA biology

authors： Mao C,Bhardwaj K,Sharkady SM,Fish RI,Driscoll T,Wower J,Zwieb C,Sobral BW,Williams KP

更新日期：2009-09-01 00:00:00

abstract：:MicroRNAs are essential for spermatogenesis. However, the stage-specific requirements for particular miRNAs in the male mammalian germ line remain largely uncharacterized. The miR-34 family is, to date, the only miRNA proven to be necessary for the production of sperm in mammals, though its germline roles are poorly u...

journal_title：RNA biology

authors： Hilz S,Fogarty EA,Modzelewski AJ,Cohen PE,Grimson A

更新日期：2017-02-01 00:00:00

abstract：:We report here an in-depth characterization of the aptamer domain of the transcriptional adenine-sensing riboswitch (pbuE) by NMR and fluorescence spectroscopy. By NMR studies, the structure of two aptamer sequences with different lengths of the helix P1, the central element involved in riboswitch conformational switc...

journal_title：RNA biology

authors： Nozinovic S,Reining A,Kim YB,Noeske J,Schlepckow K,Wöhnert J,Schwalbe H

更新日期：2014-01-01 00:00:00

abstract：:The duck represents an important reservoir of influenza viruses for transmission to other avian and mammalian hosts, including humans. The increased pathogenicity of the recently emerging clades of highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype in ducks features systemic viral spread and organ-to...

journal_title：RNA biology

authors： Samir M,Vidal RO,Abdallah F,Capece V,Seehusen F,Geffers R,Hussein A,Ali AAH,Bonn S,Pessler F

更新日期：2020-01-01 00:00:00

abstract：:tRNA molecules undergo extensive post-transcriptional processing to generate the mature functional tRNA species that are essential for translation in all organisms. These processing steps include the introduction of numerous specific chemical modifications to nucleotide bases and sugars; among these modifications, met...

journal_title：RNA biology

authors： Swinehart WE,Jackman JE

更新日期：2015-01-01 00:00:00

abstract：:Alternative splicing (AS) in response to changing external conditions often requires alterations in the ability of sequence-specific RNA-binding proteins to bind to cis-acting sequences in their target pre-mRNA. While daily oscillations in AS events have been described in several organisms, cis-acting sequences that c...

journal_title：RNA biology

authors： Goldammer G,Neumann A,Strauch M,Müller-McNicoll M,Heyd F,Preußner M

更新日期：2018-01-01 00:00:00

abstract：:In eukaryotes, the 3' ends of RNA polymerase II-transcribed RNAs are generated in the majority of cases by site-specific endonucleolytic cleavage, followed by the addition of a poly(A) tail. Through alternative polyadenylation, a gene can give rise to multiple mRNA isoforms that differ in the length of their 3' UTRs a...

journal_title：RNA biology

authors： Gruber AR,Martin G,Keller W,Zavolan M

更新日期：2012-12-01 00:00:00

abstract：:Mutations in genes that encode tRNAs, aminoacyl-tRNA syntheases, tRNA modifying enzymes and other tRNA interacting partners are associated with neuropathies, cancer, type-II diabetes and hearing loss, but how these mutations cause disease is unclear. We have hypothesized that levels of tRNA decoding error (mistranslat...

journal_title：RNA biology

authors： Reverendo M,Soares AR,Pereira PM,Carreto L,Ferreira V,Gatti E,Pierre P,Moura GR,Santos MA

更新日期：2014-01-01 00:00:00

abstract：:Post-transcriptional control of gene expression is mediated via RNA-binding proteins (RBPs) that interact with mRNAs in a combinatorial fashion. While recent global RNA interactome capture experiments expanded the repertoire of cellular RBPs quiet dramatically, little is known about the assembly of RBPs on particular ...

journal_title：RNA biology

authors： Iadevaia V,Wouters MD,Kanitz A,Matia-González AM,Laing EE,Gerber AP

更新日期：2020-01-01 00:00:00

abstract：:In plants, Potato spindle tuber viroid (PSTVd) replication triggers post-transcriptional gene silencing (PTGS) and RNA-directed DNA methylation (RdDM) of homologous RNA and DNA sequences, respectively. PTGS predominantly occurs in the cytoplasm, but nuclear PTGS has been also reported. In this study, we investigated w...

journal_title：RNA biology

authors： Dalakouras A,Dadami E,Bassler A,Zwiebel M,Krczal G,Wassenegger M

更新日期：2015-01-01 00:00:00

abstract：:The signal recognition particle (SRP) is a ribonucleoprotein complex which participates in the targeting of protein to cellular membranes. The RNA component of the SRP has been found in all domains of life, but the size of the molecule and the number of RNA secondary structure elements vary considerably between the di...

journal_title：RNA biology

authors： Rosenblad MA,Larsen N,Samuelsson T,Zwieb C

更新日期：2009-11-01 00:00:00

abstract：:RNA interference (RNAi) is a powerful tool for gene functional analysis of plant-parasitic nematodes (PPNs). RNAi involving soaking in a dsRNA solution and in planta methods is commonly applied in the study of gene function in PPNs. However, certain problems restrict the application of these methods. Therefore, more c...

journal_title：RNA biology

authors： Ding S,Wang D,Xu C,Yang S,Cheng X,Peng X,Chen C,Xie H

更新日期：2020-12-14 00:00:00

abstract：:We had previously proposed that the post-transcriptional regulation through microRNA as a mechanism for incomplete penetrance and variable expressivity, leads to lack of correlation between genotype and phenotype. Here we report the validation of miRNA-target interactions we predicted earlier and demonstrate the regul...

journal_title：RNA biology

authors： Ahluwalia JK,Soni K,Sivasubbu S,Brahmachari V

更新日期：2012-03-01 00:00:00

abstract：:Pentatricopeptide repeat (PPR) proteins control diverse aspects of RNA metabolism across the eukaryotic domain. Recent computational and structural studies have provided new insights into how they recognize RNA, and show that the recognition is sequence-specific and modular. The modular code for RNA-binding by PPR pro...

journal_title：RNA biology

authors： Filipovska A,Rackham O

更新日期：2013-01-01 00:00:00

abstract：:MicroRNAs are small, non-coding RNAs that are increasingly appreciated to play critical roles in the modulation of gene expression. In mammalian cells, our knowledge regarding the full impact of microRNAs on cellular behavior remains fragmentary. This has been due, in significant part, to the limited availability of e...

journal_title：RNA biology

authors： Valastyan S,Weinberg RA

更新日期：2009-11-01 00:00:00

abstract：:Editing by ADAR enzymes is essential for mammalian life. Still, knowledge of the spatio-temporal editing patterns in mammals is limited. By use of 454 amplicon sequencing we examined the editing status of 12 regionally extracted mRNAs from porcine developing brain encompassing a total of 64 putative ADAR editing sites...

journal_title：RNA biology

authors： Venø MT,Bramsen JB,Bendixen C,Panitz F,Holm IE,Öhman M,Kjems J

更新日期：2012-08-01 00:00:00

abstract：:We previously showed that miR-122 was frequently downregulated in hepatocellular carcinoma (HCC) and C/EBPα transactivated miR-122 expression. In this study, we found that Sp1 bound to the miR-122 promoter at two different sites. Interestingly, either inhibition or overexpression of Sp1 could decrease the miR-122 prom...

journal_title：RNA biology

authors： Zeng C,Sang Y,Wang FY,Zhuang SM

更新日期：2020-02-01 00:00:00

abstract：:Glioma is the most malignant primary brain cancer which frequently occurred in adults. In recent years, long-non coding RNAs (lncRNAs) have been demonstrated to play pivotal roles in human cancers. However, the role of most lncRNAs in gliomagenesis has not been probed. Presently, through TCGA, a novel lncRNA LINC01198...

journal_title：RNA biology

authors： Xie Y,Cheng Y

更新日期：2020-07-01 00:00:00

abstract：:Proper base-pairing of a miRNA with its target mRNA is a key step in miRNA-mediated mRNA repression. RNA remodelling by RNA-binding proteins (RBPs) can improve access of miRNAs to their target mRNAs. The largest isoform p45 of the RBP AUF1 has previously been shown to remodel viral or AU-rich RNA elements. Here, we sh...

journal_title：RNA biology

authors： Sänger L,Bender J,Rostowski K,Golbik R,Lilie H,Schmidt C,Behrens SE,Friedrich S

更新日期：2020-09-29 00:00:00

abstract：:The RNase II family of enzymes is ubiquitous and has crucial roles in the processing, degradation and quality control of all types of RNA. These exoribonucleases processively degrade RNA from the 3'-end releasing 5'-nucleotide monophosphates. In prokaryotes, RNase II and RNase R have two N-terminal CSD and one C-termi...

journal_title：RNA biology

authors： Arraiano CM,Matos RG,Barbas A

更新日期：2010-05-01 00:00:00

abstract：:How have the branchpoint motifs evolved in organisms of different complexity? Here we identified and examined the consensus motifs (R1C2T3R4A5Y6, R: A or G, Y: C or T) of 898 fungal genomes. In Ascomycota unicellular yeasts, the G4/A4 ratio is mostly (98%) below 0.125 but increases sharply in multicellular species by ...

journal_title：RNA biology

authors： Nguyen H,Das U,Xie J

更新日期：2020-03-01 00:00:00

abstract：:Genuine La and La-related proteins group 7 (LARP7) bind to the non-coding RNAs transcribed by RNA polymerase III (RNAPIII), which end in UUU-3'OH. The La motif and RRM1 of these proteins (the La module) cooperate to bind the UUU-3'OH, protecting the RNA from degradation, while other domains may be important for RNA fo...

journal_title：RNA biology

authors： Singh M,Choi CP,Feigon J

更新日期：2013-03-01 00:00:00

abstract：:Translation begins at AUG, GUG, or UUG codons in bacteria. Start codon recognition occurs in the P site, which may help explain this first-position degeneracy. However, the molecular basis of start codon specificity remains unclear. In this study, we measured the codon dependence of 30S•mRNA•tRNAfMet and 30S•mRNA•tRNA...

journal_title：RNA biology

authors： Roy B,Liu Q,Shoji S,Fredrick K

更新日期：2018-01-01 00:00:00