Abstract:
:Termination of RNA polymerase II (RNAPII) transcription is a fundamental step of gene expression that involves the release of the nascent transcript and dissociation of RNAPII from the DNA template. As transcription termination is intimately linked to RNA 3' end processing, termination pathways have a key decisive influence on the fate of the transcribed RNA. Quite remarkably, when reaching the 3' end of genes, a substantial fraction of RNAPII fail to terminate transcription, requiring the contribution of alternative or "fail-safe" mechanisms of termination to release the polymerase. This point of view covers redundant mechanisms of transcription termination and how they relate to conventional termination models. In particular, we expand on recent findings that propose a reverse torpedo model of termination, in which the 3'5' exonucleolytic activity of the RNA exosome targets transcription events associated with paused and backtracked RNAPII.
journal_name
RNA Bioljournal_title
RNA biologyauthors
Lemay JF,Bachand Fdoi
10.1080/15476286.2015.1073433subject
Has Abstractpub_date
2015-01-01 00:00:00pages
927-32issue
9eissn
1547-6286issn
1555-8584journal_volume
12pub_type
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