Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors.

Abstract:

:The RIG-I-like receptors (RLRs)--RIG-I, MDA5, and LGP2--detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. The protein architecture of the RLR family consists of multiple functional domains, including N-terminal Caspase Activation and Recruitment Domains (CARDs) for signaling initiation, a central RNA helicase core, and a C-terminal domain for RNA sensing. With these specialized sensing-and-responding modules, RLRs are able to selectively bind non-self RNA species and trigger downstream signaling events leading to interferon production. This article summarizes the recent progress toward defining the precise mechanisms of RNA recognition and subsequent signal induction by RLRs.

journal_name

RNA Biol

journal_title

RNA biology

authors

Luo D

doi

10.4161/rna.27717

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

25-32

issue

1

eissn

1547-6286

issn

1555-8584

pii

27717

journal_volume

11

pub_type

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