Abstract:
:The RIG-I-like receptors (RLRs)--RIG-I, MDA5, and LGP2--detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. The protein architecture of the RLR family consists of multiple functional domains, including N-terminal Caspase Activation and Recruitment Domains (CARDs) for signaling initiation, a central RNA helicase core, and a C-terminal domain for RNA sensing. With these specialized sensing-and-responding modules, RLRs are able to selectively bind non-self RNA species and trigger downstream signaling events leading to interferon production. This article summarizes the recent progress toward defining the precise mechanisms of RNA recognition and subsequent signal induction by RLRs.
journal_name
RNA Bioljournal_title
RNA biologyauthors
Luo Ddoi
10.4161/rna.27717subject
Has Abstractpub_date
2014-01-01 00:00:00pages
25-32issue
1eissn
1547-6286issn
1555-8584pii
27717journal_volume
11pub_type
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