Variable splicing of non-coding roX2 RNAs influences targeting of MSL dosage compensation complexes in Drosophila.

abstract：:Eukaryotic gene expression must be coordinated for the proper functioning of biological processes. This coordination can be achieved both at the transcriptional and post-transcriptional levels. In both cases, regulatory sequences placed at either promoter regions or on UTRs function as markers recognized by regulators...

journal_title：RNA biology

authors： Yoon K,Ko D,Doderer M,Livi CB,Penalva LO

更新日期：2008-10-01 00:00:00

abstract：:The muscle specific miRNA, miR-206, is important for the process of myogenesis; however, studying the function of miR-206 in muscle development and differentiation still proves challenging because the complement of mRNA targets it regulates remains undefined. In addition, miR-206 shares close sequence similarity to mi...

journal_title：RNA biology

authors： Salant GM,Tat KL,Goodrich JA,Kugel JF

更新日期：2020-07-01 00:00:00

abstract：:Heterogeneous nuclear ribonucleoprotein L (hnRNP L) is a multifunctional RNA-binding protein that is involved in many different processes, such as regulation of transcription, translation, and RNA stability. We have previously characterized hnRNP L as a global regulator of alternative splicing, binding to CA-repeat, a...

journal_title：RNA biology

authors： Rossbach O,Hung LH,Khrameeva E,Schreiner S,König J,Curk T,Zupan B,Ule J,Gelfand MS,Bindereif A

更新日期：2014-01-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are pervasively transcribed and critical regulators of the epigenome[1, 2]. These long, polyadenylated RNAs do not code for proteins, but function directly as RNAs, recruiting chromatin modifiers to mediate transcriptional changes in processes ranging from X-inactivation (XIST) to imprint...

journal_title：RNA biology

authors： Hung T,Chang HY

更新日期：2010-09-01 00:00:00

abstract：:The human genome encodes several thousand long non-protein coding transcripts>200 nucleotides in length, a subset of which were shown to play important roles in regulation of gene expression. We recently identified TINCR, a lncRNA required for induction of key differentiation genes in epidermal tissue, including genes...

journal_title：RNA biology

authors： Kretz M

更新日期：2013-10-01 00:00:00

abstract：:In eukaryotes, the 3' ends of RNA polymerase II-transcribed RNAs are generated in the majority of cases by site-specific endonucleolytic cleavage, followed by the addition of a poly(A) tail. Through alternative polyadenylation, a gene can give rise to multiple mRNA isoforms that differ in the length of their 3' UTRs a...

journal_title：RNA biology

authors： Gruber AR,Martin G,Keller W,Zavolan M

更新日期：2012-12-01 00:00:00

abstract：:microRNAs (miRNAs) are critical regulators of gene expression. For elucidating functional roles of miRNAs, it is critical to identify their direct targets. There are debates about whether pulldown of biotinylated miRNA mimics can be used to identify miRNA targets or not. Here we show that biotin-labelled miR-34a can b...

journal_title：RNA biology

authors： Awan HM,Shah A,Rashid F,Wei S,Chen L,Shan G

更新日期：2018-01-02 00:00:00

abstract：:We report here an in-depth characterization of the aptamer domain of the transcriptional adenine-sensing riboswitch (pbuE) by NMR and fluorescence spectroscopy. By NMR studies, the structure of two aptamer sequences with different lengths of the helix P1, the central element involved in riboswitch conformational switc...

journal_title：RNA biology

authors： Nozinovic S,Reining A,Kim YB,Noeske J,Schlepckow K,Wöhnert J,Schwalbe H

更新日期：2014-01-01 00:00:00

abstract：:The Hedgehog (HH) signaling pathway has important roles in tumorigenesis and in embryonal patterning. The Glioma-associated oncogene 1 (GLI1) is a key molecule in HH signaling, acting as a transcriptional effector and, moreover, is considered to be a potential therapeutic target for several types of cancer. To extend ...

journal_title：RNA biology

authors： Shimokawa T,Rahman MF,Tostar U,Sonkoly E,Ståhle M,Pivarcsi A,Palaniswamy R,Zaphiropoulos PG

更新日期：2013-02-01 00:00:00

abstract：:YchF is one of two universally conserved GTPases with unknown cellular function. As a first step toward elucidating YchF's cellular role, we performed a detailed biochemical characterization of the protein from Escherichia coli. Our data from fluorescence titrations not only confirmed the surprising finding that YchFE...

journal_title：RNA biology

authors： Becker M,Gzyl KE,Altamirano AM,Vuong A,Urban K,Wieden HJ

更新日期：2012-10-01 00:00:00

abstract：:AU-rich elements (AREs) are cis-acting instability and translation inhibition elements that are present in the 3'UTR of most inducible inflammatory mRNAs such as TNF and Cxcl2. mRNAs that contain AREs are, by default, repressed and only transiently expressed in response to stimuli. They are targeted by the inducible R...

journal_title：RNA biology

authors： Mahmoud L,Moghrabi W,Khabar KSA,Hitti EG

更新日期：2019-03-01 00:00:00

abstract：:Alzheimer's disease (AD) has devastating consequences for patients during its slow, progressive course. It is important to understand the pathology of AD onset. Recently, circular RNAs (circRNAs) have been found to participate in many human diseases including cancers and neurodegenerative conditions. In this study, we...

journal_title：RNA biology

authors： Lo I,Hill J,Vilhjálmsson BJ,Kjems J

更新日期：2020-12-01 00:00:00

abstract：:Amplification or overexpression of neuronal MYC (MYCN) is associated with poor prognosis of human neuroblastoma. Three isoforms of the MYCN protein have been described as well as a protein encoded by an antisense transcript (MYCNOS) that originates from the opposite strand at the MYCN locus. Recent findings suggest th...

journal_title：RNA biology

authors： Vadie N,Saayman S,Lenox A,Ackley A,Clemson M,Burdach J,Hart J,Vogt PK,Morris KV

更新日期：2015-01-01 00:00:00

abstract：:The chromatoid body is a large perinuclear ribonucleoprotein particle of germ cells. The chromatoid body is also present in stem cells from planarians. This particle shares markers specific to protein aggresomes and P-bodies, and concentrate several RNA pathways. The assembly mechanism of chromatoid bodies is unknown,...

journal_title：RNA biology

authors： Roucou X

更新日期：2009-04-01 00:00:00

abstract：:Glioma is the most malignant primary brain cancer which frequently occurred in adults. In recent years, long-non coding RNAs (lncRNAs) have been demonstrated to play pivotal roles in human cancers. However, the role of most lncRNAs in gliomagenesis has not been probed. Presently, through TCGA, a novel lncRNA LINC01198...

journal_title：RNA biology

authors： Xie Y,Cheng Y

更新日期：2020-07-01 00:00:00

abstract：:Enzymes of the cytosine-5 RNA methyltransferase Trm4/NSun2 family methylate tRNAs at C48 and C49 in multiple tRNAs, as well as C34 and C40 in selected tRNAs. In contrast to most other organisms, fission yeast Schizosaccharomyces pombe carries two Trm4/NSun2 homologs, Trm4a (SPAC17D4.04) and Trm4b (SPAC23C4.17). Here, ...

journal_title：RNA biology

authors： Müller M,Samel-Pommerencke A,Legrand C,Tuorto F,Lyko F,Ehrenhofer-Murray AE

更新日期：2019-03-01 00:00:00

abstract：:Post-transcriptional control of gene expression is mediated via RNA-binding proteins (RBPs) that interact with mRNAs in a combinatorial fashion. While recent global RNA interactome capture experiments expanded the repertoire of cellular RBPs quiet dramatically, little is known about the assembly of RBPs on particular ...

journal_title：RNA biology

authors： Iadevaia V,Wouters MD,Kanitz A,Matia-González AM,Laing EE,Gerber AP

更新日期：2020-01-01 00:00:00

abstract：:Prokaryotes immunize themselves against transmissible genetic elements by the integration (acquisition) in clustered regularly interspaced short palindromic repeats (CRISPR) loci of spacers homologous to invader nucleic acids, defined as protospacers. Following acquisition, mono-spacer CRISPR RNAs (termed crRNAs) guid...

journal_title：RNA biology

authors： Díez-Villaseñor C,Guzmán NM,Almendros C,García-Martínez J,Mojica FJ

更新日期：2013-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are ubiquitous regulators of gene expression that contribute to almost any cellular process. Methods for managing of miRNA activity are attracting increasing attention in relation to diverse experimental and therapeutic applications. DNA-encoded miRNA inhibitors expressed from plasmid or virus-based...

journal_title：RNA biology

authors： Hollensen AK,Bak RO,Haslund D,Mikkelsen JG

更新日期：2013-03-01 00:00:00

abstract：:RNA helicases contribute to diverse aspects of RNA metabolism through their functions in re-arranging RNA structures. Identification of the remodelling targets of RNA helicases is a critical step in elucidating their cellular functions. Here, we show that, in contrast to many other ribosome biogenesis factors, the DEx...

journal_title：RNA biology

authors： Choudhury P,Kretschmer J,Hackert P,Bohnsack KE,Bohnsack MT

更新日期：2020-10-13 00:00:00

abstract：:Processing bodies (P-bodies) are cytoplasmatic mRNP granules containing non-translating mRNAs and proteins from the mRNA decay and silencing machineries. The mechanism of P-body assembly has been typically addressed by depleting P-body components. Here we apply a complementary approach and establish an automated cell-...

journal_title：RNA biology

authors： Martínez JP,Pérez-Vilaró G,Muthukumar Y,Scheller N,Hirsch T,Diestel R,Steinmetz H,Jansen R,Frank R,Sasse F,Meyerhans A,Díez J

更新日期：2013-11-01 00:00:00

abstract：:Termination of RNA polymerase II (RNAPII) transcription is a fundamental step of gene expression that involves the release of the nascent transcript and dissociation of RNAPII from the DNA template. As transcription termination is intimately linked to RNA 3' end processing, termination pathways have a key decisive inf...

journal_title：RNA biology

authors： Lemay JF,Bachand F

更新日期：2015-01-01 00:00:00

abstract：:By differential high-throughput RNA sequencing (dRNA-seq) we have identified "product RNAs" (pRNAs) as short as 8-12 nucleotides that are synthesized by Bacillus subtilis RNA polymerase (RNAP) in vivo using the regulatory 6S-1 RNA as template. The dRNA-seq data were confirmed by in vitro transcription experiments and ...

journal_title：RNA biology

authors： Beckmann BM,Burenina OY,Hoch PG,Kubareva EA,Sharma CM,Hartmann RK

更新日期：2011-09-01 00:00:00

abstract：:The PDCD1 gene encodes PD-1, an important immune checkpoint protein and key immunotherapy target to treat cancer. PDCD1 is alternatively spliced to generate an exon 3-skipped isoform PD-1Δ3 that has been suggested to play an antagonistic role to PD-1, but the mechanism underlying alternative splicing of PDCD1 has neve...

journal_title：RNA biology

authors： Sun J,Bai J,Jiang T,Gao Y,Hua Y

更新日期：2019-12-01 00:00:00

abstract：:The development of rigorous molecular taxonomy pioneered by Carl Woese has freed evolution science to explore numerous cellular activities that lead to genome change in evolution. These activities include symbiogenesis, inter- and intracellular horizontal DNA transfer, incorporation of DNA from infectious agents, and ...

journal_title：RNA biology

authors： Shapiro JA

更新日期：2014-01-01 00:00:00

abstract：:Single-stranded oligonucleotides (ssOligos) are efficiently taken up by living cells without the use of transfection reagents. This phenomenon called 'gymnosis' enables the sequence-specific silencing of target genes in various types of cells. Several antisense ssOligos are used for the treatment of human diseases. Ho...

journal_title：RNA biology

authors： Takahashi M,Contu VR,Kabuta C,Hase K,Fujiwara Y,Wada K,Kabuta T

更新日期：2017-11-02 00:00:00

abstract：:Bacteria, like mammals, have to constantly defend themselves from viral attack. Like mammals, they use both innate and adaptive defense mechanisms. In this point of view we highlight the commonalities between defense systems of bacteria and mammals. Our focus is on the recently discovered bacterial adaptive immune sys...

journal_title：RNA biology

authors： Goren M,Yosef I,Edgar R,Qimron U

更新日期：2012-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common dementia among the elderly. The pathophysiology of AD is characterized by two hallmarks: amyloid plaques, produced by amyloid β (Aβ) aggregation, and neurofibrillary tangle (NFT), produced by accumulation of phosphorylated tau. Th...

journal_title：RNA biology

authors： Li D,Zhang J,Li X,Chen Y,Yu F,Liu Q

更新日期：2020-07-14 00:00:00

abstract：:As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst. The chaperoning function is found intrinsic to ribozymes involved in protein synthesis and tRNA maturation, enriching the primordial RNA world with ...

journal_title：RNA biology

authors： Son A,Horowitz S,Seong BL

更新日期：2021-01-01 00:00:00

abstract：:Proper base-pairing of a miRNA with its target mRNA is a key step in miRNA-mediated mRNA repression. RNA remodelling by RNA-binding proteins (RBPs) can improve access of miRNAs to their target mRNAs. The largest isoform p45 of the RBP AUF1 has previously been shown to remodel viral or AU-rich RNA elements. Here, we sh...

journal_title：RNA biology

authors： Sänger L,Bender J,Rostowski K,Golbik R,Lilie H,Schmidt C,Behrens SE,Friedrich S

更新日期：2020-09-29 00:00:00