Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology.

abstract：:Telomeres, protective nucleoprotein structures located at the ends of eukaryotic chromosomes and until recently regarded as transcriptionally silent, are now known to be transcribed into non-coding RNA molecules called TERRA. The function(s) of TERRA in telomere metabolism is now the subject of intense study given the...

journal_title：RNA biology

authors： Caslini C

更新日期：2010-01-01 00:00:00

abstract：:One of the many important consequences that temperature down-shift has on cells is stabilization of secondary structures of RNAs. This stabilization has wide-spread effects, such as inhibition of expression of several genes due to termination of their transcription and inefficient RNA degradation that adversely affect...

journal_title：RNA biology

authors： Phadtare S,Severinov K

更新日期：2010-11-01 00:00:00

abstract：:"What does one do when the giants pass away?" remarked a very famous microbiologist to me, soon after the death of Carl Woese in late 2012. I teach microbiology and introductory cell and molecular biology at a small undergraduate institution; Woese's example and contributions have long been part of every class I teach...

journal_title：RNA biology

authors： Martin M

更新日期：2014-01-01 00:00:00

abstract：:Conserved RNA secondary structures were predicted in the nucleoprotein (NP) segment of the influenza A virus genome using comparative sequence and structure analysis. A number of structural elements exhibiting nucleotide covariations were identified over the whole segment length, including protein-coding regions. Calc...

journal_title：RNA biology

authors： Gultyaev AP,Tsyganov-Bodounov A,Spronken MI,van der Kooij S,Fouchier RA,Olsthoorn RC

更新日期：2014-01-01 00:00:00

abstract：:Single-stranded oligonucleotides (ssOligos) are efficiently taken up by living cells without the use of transfection reagents. This phenomenon called 'gymnosis' enables the sequence-specific silencing of target genes in various types of cells. Several antisense ssOligos are used for the treatment of human diseases. Ho...

journal_title：RNA biology

authors： Takahashi M,Contu VR,Kabuta C,Hase K,Fujiwara Y,Wada K,Kabuta T

更新日期：2017-11-02 00:00:00

abstract：:While disruption of alternative splicing underlies many diseases, modulation of splicing using antisense oligonucleotides (AONs) can have therapeutic implications. The most notable example is Duchenne muscular dystrophy (DMD), where antisense-mediated exon skipping can restore the open reading frame and allow the synt...

journal_title：RNA biology

authors： Aartsma-Rus A

更新日期：2010-07-01 00:00:00

abstract：:Physical entanglement, and particularly knots arise spontaneously in equilibrated polymers that are sufficiently long and densely packed. Biopolymers are no exceptions: knots have long been known to occur in proteins as well as in encapsidated viral DNA. The rapidly growing number of RNA structures has recently made i...

journal_title：RNA biology

authors： Burton AS,Di Stefano M,Lehman N,Orland H,Micheletti C

更新日期：2016-01-01 00:00:00

abstract：:The endoribonuclease toxins of the E. coli toxin-antitoxin systems arrest bacterial growth and protein synthesis by targeting cellular mRNAs. As an exception, E. coli MazF was reported to cleave also 16S rRNA at a single site and separate an anti-Shine-Dalgarno sequence-containing RNA fragment from the ribosome. We no...

journal_title：RNA biology

authors： Mets T,Lippus M,Schryer D,Liiv A,Kasari V,Paier A,Maiväli Ü,Remme J,Tenson T,Kaldalu N

更新日期：2017-01-02 00:00:00

abstract：:Interactions between glioma cells and their local environment are critical determinants of brain tumor growth, infiltration and neovascularisation. Communication with host cells and stroma via microvesicles represents one pathway by which tumors can modify their surroundings to achieve a tumor-permissive environment. ...

journal_title：RNA biology

authors： Li CC,Eaton SA,Young PE,Lee M,Shuttleworth R,Humphreys DT,Grau GE,Combes V,Bebawy M,Gong J,Brammah S,Buckland ME,Suter CM

更新日期：2013-08-01 00:00:00

abstract：:Skeletal muscle is the dominant executant in locomotion and regulator in energy metabolism. Embryonic myogenesis and postnatal muscle growth are controlled by a cascade of transcription factors and epigenetic regulatory mechanisms. MicroRNAs (miRNAs), a family of non-coding RNA of 22 nucleotides in length, post-transc...

journal_title：RNA biology

authors： Ma M,Wang X,Chen X,Cai R,Chen F,Dong W,Yang G,Pang W

更新日期：2017-03-04 00:00:00

abstract：:The genome of most prokaryotes gives rise to surprisingly complex transcriptomes, comprising not only protein-coding mRNAs, often organized as operons, but also harbors dozens or even hundreds of highly structured small regulatory RNAs and unexpectedly large levels of anti-sense transcripts. Comprehensive surveys of p...

journal_title：RNA biology

authors： Backofen R,Amman F,Costa F,Findeiß S,Richter AS,Stadler PF

更新日期：2014-01-01 00:00:00

abstract：:Long non-coding RNAs have emerged as an important regulatory layer in biological systems. Of the various types of lncRNAs, one class (designated as divergent RNAs/XH), which is in head-to-head overlap with the coding genes, has emerged as a critical biotype that regulates development and cellular differentiation. This...

journal_title：RNA biology

authors： Prajapati B,Fatma M,Maddhesiya P,Sodhi MK,Fatima M,Dargar T,Bhagat R,Seth P,Sinha S

更新日期：2019-01-01 00:00:00

abstract：:Heterogeneous nuclear ribonucleoprotein L (hnRNP L) is a multifunctional RNA-binding protein that is involved in many different processes, such as regulation of transcription, translation, and RNA stability. We have previously characterized hnRNP L as a global regulator of alternative splicing, binding to CA-repeat, a...

journal_title：RNA biology

authors： Rossbach O,Hung LH,Khrameeva E,Schreiner S,König J,Curk T,Zupan B,Ule J,Gelfand MS,Bindereif A

更新日期：2014-01-01 00:00:00

abstract：:The innate immune system is the frontline host protection against pathogens. Effective antiviral immunity is elicited upon recognition of viral RNAs by the host pattern recognition receptors. One of the major viral RNA sensors is retinoic acid inducible gene-1, which triggers the production of interferons (IFNs). In t...

journal_title：RNA biology

authors： Kuo YP,Ma CP,Chen HW,Chen YT,Lai YH,Liu H,Kuo RL,Chin-Ming Tan B

更新日期：2019-09-01 00:00:00

abstract：:RNA methylation, catalysed by a set of RNA methyltransferases (RNMTs), modulates RNA structures, properties, and biological functions. RNMTs are increasingly documented to be dysregulated in various human diseases, particularly developmental disorders and cancer. However, the genomic and transcriptomic alterations of ...

journal_title：RNA biology

authors： Manning M,Jiang Y,Wang R,Liu L,Rode S,Bonahoom M,Kim S,Yang ZQ

更新日期：2020-04-01 00:00:00

abstract：:Amplification or overexpression of neuronal MYC (MYCN) is associated with poor prognosis of human neuroblastoma. Three isoforms of the MYCN protein have been described as well as a protein encoded by an antisense transcript (MYCNOS) that originates from the opposite strand at the MYCN locus. Recent findings suggest th...

journal_title：RNA biology

authors： Vadie N,Saayman S,Lenox A,Ackley A,Clemson M,Burdach J,Hart J,Vogt PK,Morris KV

更新日期：2015-01-01 00:00:00

abstract：:Amphioxus is the closest living proxy for exploring the evolutionary origin of the immune system in vertebrates. To understand the immune responses of amphioxus to lipopolysaccharide (LPS), 5 ribosomal RNA (rRNA)-depleted libraries of amphioxus were constructed, including one control (0 h) library and 4 treatment libr...

journal_title：RNA biology

authors： Zhang QL,Zhu QH,Xie ZQ,Xu B,Wang XQ,Chen JY

更新日期：2017-12-02 00:00:00

abstract：:Altered expression levels of protein-coding genes and microRNAs have been implicated in the pathogenesis of Huntington's disease (HD). The involvement of other ncRNAs, especially long ncRNAs (lncRNA), is being realized recently and the related knowledge is still rudimentary. Using small RNA sequencing and PCR arrays w...

journal_title：RNA biology

authors： Chanda K,Das S,Chakraborty J,Bucha S,Maitra A,Chatterjee R,Mukhopadhyay D,Bhattacharyya NP

更新日期：2018-01-01 00:00:00

abstract：:Earlier we have demonstrated the presence of internal ribosome entry site (IRES) within tumor suppressor p53 mRNA. Here we have mapped the putative secondary structure of p53- IRES RNA using information from chemical probing and nuclease mapping experiments. Additionally, the secondary structure of the IRES element of...

journal_title：RNA biology

authors： Grover R,Sharathchandra A,Ponnuswamy A,Khan D,Das S

更新日期：2011-01-01 00:00:00

abstract：:Circular RNAs (circRNAs) have been identified in diverse eukaryotic species and are characterized by RNA backsplicing events. Current available methods for circRNA identification are able to determine the start and end locations of circRNAs in the genome but not their full-length sequences. In this study, we developed...

journal_title：RNA biology

authors： Ye CY,Zhang X,Chu Q,Liu C,Yu Y,Jiang W,Zhu QH,Fan L,Guo L

更新日期：2017-08-03 00:00:00

abstract：:Non-coding RNA (ncRNA) molecules have fundamental roles in cells and many are also stable in body fluids as extracellular RNAs. In this study, we used RNA sequencing (RNA-seq) to investigate the profile of small non-coding RNA (sncRNA) in human serum. We analyzed 10 billion Illumina reads from 477 serum samples, inclu...

journal_title：RNA biology

authors： Umu SU,Langseth H,Bucher-Johannessen C,Fromm B,Keller A,Meese E,Lauritzen M,Leithaug M,Lyle R,Rounge TB

更新日期：2018-02-01 00:00:00

abstract：:RBM10 is an RNA binding protein and alternative splicing regulator frequently mutated in lung adenocarcinomas. Recent results indicate that RBM10 inhibits proliferation of lung cancer cells by promoting skipping of exon 9 of the gene NUMB, a frequent alternative splicing change in lung cancer generating a negative reg...

journal_title：RNA biology

authors： Hernández J,Bechara E,Schlesinger D,Delgado J,Serrano L,Valcárcel J

更新日期：2016-01-01 00:00:00

abstract：:Contributions of dietary miRNAs to circulating small RNA profiles would have profound implications for interpretation of miRNA biomarker studies: presumptive disease-specific markers might instead indicate responses to disease-associated quantitative or qualitative dietary alteration. This examination weighs the evide...

journal_title：RNA biology

authors： Witwer KW

更新日期：2012-09-01 00:00:00

abstract：:Alternative splicing (AS) of pre-messenger RNAs is a major process contributing to both transcriptome and proteome diversity in various physiological and pathological situations. There is also accumulating evidence that various stresses impact on AS. In particular, recent analyses of the transcriptome reveal large num...

journal_title：RNA biology

authors： Dutertre M,Sanchez G,Barbier J,Corcos L,Auboeuf D

更新日期：2011-09-01 00:00:00

abstract：:How have the branchpoint motifs evolved in organisms of different complexity? Here we identified and examined the consensus motifs (R1C2T3R4A5Y6, R: A or G, Y: C or T) of 898 fungal genomes. In Ascomycota unicellular yeasts, the G4/A4 ratio is mostly (98%) below 0.125 but increases sharply in multicellular species by ...

journal_title：RNA biology

authors： Nguyen H,Das U,Xie J

更新日期：2020-03-01 00:00:00

abstract：:Selenoproteins are a unique class of proteins that contain the 21st amino acid, selenocysteine (Sec). Addition of Sec into a protein is achieved by recoding of the UGA stop codon. All 25 mammalian selenoprotein mRNAs possess a 3' UTR stem-loop structure, the Selenocysteine Insertion Sequence (SECIS), which is required...

journal_title：RNA biology

authors： Cockman EM,Narayan V,Willard B,Shetty SP,Copeland PR,Driscoll DM

更新日期：2019-12-01 00:00:00

abstract：:A very conserved pseudoknot structure has been shown to fold in influenza virus RNA. The pseudoknot encompasses the 3' splice site of segment 8 RNA in both influenza A and B viruses. By sequence comparison of influenza virus strains, we derive a consensus motif that defines a novel RNA pseudoknot family. The orientati...

journal_title：RNA biology

authors： Gultyaev AP,Olsthoorn RC

更新日期：2010-03-01 00:00:00

abstract：:Translation begins at AUG, GUG, or UUG codons in bacteria. Start codon recognition occurs in the P site, which may help explain this first-position degeneracy. However, the molecular basis of start codon specificity remains unclear. In this study, we measured the codon dependence of 30S•mRNA•tRNAfMet and 30S•mRNA•tRNA...

journal_title：RNA biology

authors： Roy B,Liu Q,Shoji S,Fredrick K

更新日期：2018-01-01 00:00:00

abstract：:As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst. The chaperoning function is found intrinsic to ribozymes involved in protein synthesis and tRNA maturation, enriching the primordial RNA world with ...

journal_title：RNA biology

authors： Son A,Horowitz S,Seong BL

更新日期：2021-01-01 00:00:00

abstract：:The RNase II family of enzymes is ubiquitous and has crucial roles in the processing, degradation and quality control of all types of RNA. These exoribonucleases processively degrade RNA from the 3'-end releasing 5'-nucleotide monophosphates. In prokaryotes, RNase II and RNase R have two N-terminal CSD and one C-termi...

journal_title：RNA biology

authors： Arraiano CM,Matos RG,Barbas A

更新日期：2010-05-01 00:00:00