Abstract:
:The genome of most prokaryotes gives rise to surprisingly complex transcriptomes, comprising not only protein-coding mRNAs, often organized as operons, but also harbors dozens or even hundreds of highly structured small regulatory RNAs and unexpectedly large levels of anti-sense transcripts. Comprehensive surveys of prokaryotic transcriptomes and the need to characterize also their non-coding components is heavily dependent on computational methods and workflows, many of which have been developed or at least adapted specifically for the use with bacterial and archaeal data. This review provides an overview on the state-of-the-art of RNA bioinformatics focusing on applications to prokaryotes.
journal_name
RNA Bioljournal_title
RNA biologyauthors
Backofen R,Amman F,Costa F,Findeiß S,Richter AS,Stadler PFdoi
10.4161/rna.28647subject
Has Abstractpub_date
2014-01-01 00:00:00pages
470-83issue
5eissn
1547-6286issn
1555-8584pii
28647journal_volume
11pub_type
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