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Riboswitch RNAs: regulation of gene expression by direct monitoring of a physiological signal.

Abstract：

:Riboswitches are cis-encoded, cis-acting RNA elements that directly sense a physiological signal. Signal response results in a change in RNA structure that impacts gene expression. Elements of this type play an important role in bacteria, where they regulate a variety of fundamental cellular pathways. Riboswitch-mediated gene regulation most commonly occurs by effects on transcription attenuation, to control whether a full-length transcript is synthesized, or on translation initiation, in which case the transcript is constitutively synthesized but binding of the translation initiation complex is modulated. An overview of the role of riboswitch RNAs in bacterial gene expression will be provided, and a few examples are described in more detail to illustrate the types of mechanisms that have been uncovered.

journal_name

RNA Biol

journal_title

RNA biology

authors

Smith AM,Fuchs RT,Grundy FJ,Henkin TM

doi

10.4161/rna.7.1.10757

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

104-10

issue

1

eissn

1547-6286

issn

1555-8584

pii

10757

journal_volume

7

pub_type

杂志文章,评审

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