The Rf and Rf-like PPR in higher plants, a fast-evolving subclass of PPR genes.

abstract：:Prokaryotes immunize themselves against transmissible genetic elements by the integration (acquisition) in clustered regularly interspaced short palindromic repeats (CRISPR) loci of spacers homologous to invader nucleic acids, defined as protospacers. Following acquisition, mono-spacer CRISPR RNAs (termed crRNAs) guid...

journal_title：RNA biology

authors： Díez-Villaseñor C,Guzmán NM,Almendros C,García-Martínez J,Mojica FJ

更新日期：2013-05-01 00:00:00

abstract：:microRNAs (miRNAs) are critical regulators of gene expression. For elucidating functional roles of miRNAs, it is critical to identify their direct targets. There are debates about whether pulldown of biotinylated miRNA mimics can be used to identify miRNA targets or not. Here we show that biotin-labelled miR-34a can b...

journal_title：RNA biology

authors： Awan HM,Shah A,Rashid F,Wei S,Chen L,Shan G

更新日期：2018-01-02 00:00:00

abstract：:MicroRNAs are essential for spermatogenesis. However, the stage-specific requirements for particular miRNAs in the male mammalian germ line remain largely uncharacterized. The miR-34 family is, to date, the only miRNA proven to be necessary for the production of sperm in mammals, though its germline roles are poorly u...

journal_title：RNA biology

authors： Hilz S,Fogarty EA,Modzelewski AJ,Cohen PE,Grimson A

更新日期：2017-02-01 00:00:00

abstract：:Riboswitches are cis-encoded, cis-acting RNA elements that directly sense a physiological signal. Signal response results in a change in RNA structure that impacts gene expression. Elements of this type play an important role in bacteria, where they regulate a variety of fundamental cellular pathways. Riboswitch-media...

journal_title：RNA biology

authors： Smith AM,Fuchs RT,Grundy FJ,Henkin TM

更新日期：2010-01-01 00:00:00

abstract：:Many splicing regulators bind to their own pre-mRNAs to induce alternative splicing that leads to formation of unstable mRNA isoforms. This provides an autoregulatory feedback mechanism that regulates the cellular homeostasis of these factors. We have described such an autoregulatory mechanism for two core protein com...

journal_title：RNA biology

authors： Niemelä EH,Verbeeren J,Singha P,Nurmi V,Frilander MJ

更新日期：2015-01-01 00:00:00

abstract：:Termination of RNA polymerase II (RNAPII) transcription is a fundamental step of gene expression that involves the release of the nascent transcript and dissociation of RNAPII from the DNA template. As transcription termination is intimately linked to RNA 3' end processing, termination pathways have a key decisive inf...

journal_title：RNA biology

authors： Lemay JF,Bachand F

更新日期：2015-01-01 00:00:00

abstract：:The PDCD1 gene encodes PD-1, an important immune checkpoint protein and key immunotherapy target to treat cancer. PDCD1 is alternatively spliced to generate an exon 3-skipped isoform PD-1Δ3 that has been suggested to play an antagonistic role to PD-1, but the mechanism underlying alternative splicing of PDCD1 has neve...

journal_title：RNA biology

authors： Sun J,Bai J,Jiang T,Gao Y,Hua Y

更新日期：2019-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV) was the first human cancer-causing virus to be discovered over fifty years ago. Given its relatively large genome size for a virus and hence the capacity to store more than mere protein-coding information, EBV also harbours genetic material for producing an array of distinct noncoding (nc)RNAs...

journal_title：RNA biology

authors： Lee N

更新日期：2021-01-30 00:00:00

abstract：:Epithelial-mesenchymal interactions are required to coordinate cell proliferation, patterning, and functional differentiation of multiple cell types in a developing organ. This exquisite coordination is dependent on various secreted molecules that provide developmental signals to mediate these tissue interactions. Rec...

journal_title：RNA biology

authors： Hayashi T,Hoffman MP

更新日期：2017-12-02 00:00:00

abstract：:Bacterial small RNAs (sRNAs) are a class of structural RNAs that often regulate mRNA targets via post-transcriptional base pair interactions. We determined features that discriminate functional from non-functional interactions and assessed the influence of these features on genome-wide target predictions. For this pur...

journal_title：RNA biology

authors： Richter AS,Backofen R

更新日期：2012-07-01 00:00:00

abstract：:Population differences observed for complex traits may be attributed to the combined effect of socioeconomic, environmental, genetic and epigenetic factors. To better understand population differences in complex traits, genome-wide genetic and gene expression differences among ethnic populations have been studied. Her...

journal_title：RNA biology

authors： Huang RS,Gamazon ER,Ziliak D,Wen Y,Im HK,Zhang W,Wing C,Duan S,Bleibel WK,Cox NJ,Dolan ME

更新日期：2011-07-01 00:00:00

abstract：:RNA exosomes are large multi-subunit protein complexes involved in controlled and processive 3' to 5' RNA degradation. Exosomes form large molecular chambers and harbor multiple nuclease sites as well as RNA binding regions. This makes a quantitative kinetic analysis of RNA degradation with reliable parameter and erro...

journal_title：RNA biology

authors： Niederberger T,Hartung S,Hopfner KP,Tresch A

更新日期：2011-01-01 00:00:00

abstract：:Proper base-pairing of a miRNA with its target mRNA is a key step in miRNA-mediated mRNA repression. RNA remodelling by RNA-binding proteins (RBPs) can improve access of miRNAs to their target mRNAs. The largest isoform p45 of the RBP AUF1 has previously been shown to remodel viral or AU-rich RNA elements. Here, we sh...

journal_title：RNA biology

authors： Sänger L,Bender J,Rostowski K,Golbik R,Lilie H,Schmidt C,Behrens SE,Friedrich S

更新日期：2020-09-29 00:00:00

abstract：:Translation begins at AUG, GUG, or UUG codons in bacteria. Start codon recognition occurs in the P site, which may help explain this first-position degeneracy. However, the molecular basis of start codon specificity remains unclear. In this study, we measured the codon dependence of 30S•mRNA•tRNAfMet and 30S•mRNA•tRNA...

journal_title：RNA biology

authors： Roy B,Liu Q,Shoji S,Fredrick K

更新日期：2018-01-01 00:00:00

abstract：:De novo addition of telomeric sequences can occur at broken chromosomes and must be well controlled, which is essential during programmed DNA reorganization processes. In ciliated protozoa an extreme form of DNA-reorganization is observed during macronuclear differentiation after sexual reproduction leading to the eli...

journal_title：RNA biology

authors： Fuhrmann G,Jönsson F,Weil PP,Postberg J,Lipps HJ

更新日期：2016-08-02 00:00:00

abstract：:In a series of conceptual articles published around the millennium, Carl Woese emphasized that evolution of cells is the central problem of evolutionary biology, that the three-domain ribosomal tree of life is an essential framework for reconstructing cellular evolution, and that the evolutionary dynamics of functiona...

journal_title：RNA biology

authors： Koonin EV

更新日期：2014-01-01 00:00:00

abstract：:The synthesis of RNA is highly regulated at all stages by transcription factors. As an essential transcription elongation factor, NusA has been studied biochemically for more than 30 years. However, until now no structural information has been available on NusA-RNAP complexes and the NusA interaction site on RNAP was ...

journal_title：RNA biology

authors： Yang X,Lewis PJ

更新日期：2010-05-01 00:00:00

abstract：:Post-transcriptional control of messenger RNA (mRNA) is an important layer of gene regulation that modulates mRNA decay, translation, and localization. Eukaryotic mRNA decay begins with the catalytic removal of the 3' poly-adenosine tail by deadenylase enzymes. Multiple deadenylases have been identified in vertebrates...

journal_title：RNA biology

authors： Hughes KL,Abshire ET,Goldstrohm AC

更新日期：2018-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small noncoding RNAs about 22-nucleotide (nt) in length that collectively regulate more than 60% of coding genes. Aberrant miRNA expression is associated with numerous diseases, including cancer. miRNA biogenesis is licenced by the ribonuclease (RNase) III enzyme Drosha, the regulatio...

journal_title：RNA biology

authors： Dai L,Hallmark L,Bofill De Ros X,Crouch H,Chen S,Shi T,Yang A,Lian C,Zhao Y,Tran B,Gu S

更新日期：2020-11-01 00:00:00

abstract：:MicroRNA (miRs) are short non-coding RNAs that fine-tune the regulation of gene expression to coordinate a wide range of biological processes. MicroRNAs are transcribed from miR genes and primary miR transcripts are processed to approximately 22 nucleotide single strand mature forms that function as repressors of tran...

journal_title：RNA biology

authors： Desvignes T,Contreras A,Postlethwait JH

更新日期：2014-01-01 00:00:00

abstract：:Transcription termination delineates the 3' ends of transcripts, prevents otherwise runaway RNA polymerase (RNAP) from intruding into downstream genes and regulatory elements, and enables release of the RNAP for recycling. While other eukaryotic RNAPs require complex cis-signals and/or accessory factors to achieve the...

journal_title：RNA biology

authors： Arimbasseri AG,Maraia RJ

更新日期：2016-01-01 00:00:00

abstract：:Genuine La and La-related proteins group 7 (LARP7) bind to the non-coding RNAs transcribed by RNA polymerase III (RNAPIII), which end in UUU-3'OH. The La motif and RRM1 of these proteins (the La module) cooperate to bind the UUU-3'OH, protecting the RNA from degradation, while other domains may be important for RNA fo...

journal_title：RNA biology

authors： Singh M,Choi CP,Feigon J

更新日期：2013-03-01 00:00:00

abstract：:High concentrations (> 100 µM) of the ribonucleoside analog 4-thiouridine (4sU) is widely used in methods for RNA analysis like photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) and nascent messenger (m)RNA labeling (4sU-tagging). Here, we show that 4sU-tagging at low concentrati...

journal_title：RNA biology

authors： Burger K,Mühl B,Kellner M,Rohrmoser M,Gruber-Eber A,Windhager L,Friedel CC,Dölken L,Eick D

更新日期：2013-10-01 00:00:00

abstract：:A-to-I RNA editing by adenosine deaminases acting on RNA is a post-transcriptional modification that is crucial for normal life and development in vertebrates. RNA editing has been shown to be very abundant in the human transcriptome, specifically at the primate-specific Alu elements. The functional role of this wide-...

journal_title：RNA biology

authors： Liscovitch N,Bazak L,Levanon EY,Chechik G

更新日期：2014-01-01 00:00:00

abstract：:We previously showed that miR-122 was frequently downregulated in hepatocellular carcinoma (HCC) and C/EBPα transactivated miR-122 expression. In this study, we found that Sp1 bound to the miR-122 promoter at two different sites. Interestingly, either inhibition or overexpression of Sp1 could decrease the miR-122 prom...

journal_title：RNA biology

authors： Zeng C,Sang Y,Wang FY,Zhuang SM

更新日期：2020-02-01 00:00:00

abstract：:The quaking viable (qk(v)) mice have attracted attention because of their characteristic tremor caused by their dysmyelination. In the central nervous system, qk(v) mice fail to develop mature myelinating oligodendrocytes and display uncompacted myelin. The genetic defect in the qk(v) mice prevents the proper expressi...

journal_title：RNA biology

authors： Larocque D,Richard S

更新日期：2005-04-01 00:00:00

abstract：:tmRNA employs both tRNA-like and mRNA-like properties as it rescues stalled bacterial ribosomes, while targeting the defective mRNA and incomplete nascent protein for degradation. We describe variation of the tmRNA gene (ssrA) and how it informs tmRNA structure and function. Endosymbiont tmRNAs tend to lose secondary ...

journal_title：RNA biology

authors： Mao C,Bhardwaj K,Sharkady SM,Fish RI,Driscoll T,Wower J,Zwieb C,Sobral BW,Williams KP

更新日期：2009-09-01 00:00:00

abstract：:In mammals, the genic disequilibrium between males (XY) and females (XX) is resolved through the inactivation of one of the X-chromosomes in females. X-chromosome inactivation (XCI) takes place in all mammalian species, but has mainly been studied in the mouse model where it was shown to be controlled by the interplay...

journal_title：RNA biology

authors： Vallot C,Rougeulle C

更新日期：2013-08-01 00:00:00

abstract：:Telomeres, protective nucleoprotein structures located at the ends of eukaryotic chromosomes and until recently regarded as transcriptionally silent, are now known to be transcribed into non-coding RNA molecules called TERRA. The function(s) of TERRA in telomere metabolism is now the subject of intense study given the...

journal_title：RNA biology

authors： Caslini C

更新日期：2010-01-01 00:00:00

abstract：:As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst. The chaperoning function is found intrinsic to ribozymes involved in protein synthesis and tRNA maturation, enriching the primordial RNA world with ...

journal_title：RNA biology

authors： Son A,Horowitz S,Seong BL

更新日期：2021-01-01 00:00:00