Regulatory roles of vertebrate Nocturnin: insights and remaining mysteries.


:Post-transcriptional control of messenger RNA (mRNA) is an important layer of gene regulation that modulates mRNA decay, translation, and localization. Eukaryotic mRNA decay begins with the catalytic removal of the 3' poly-adenosine tail by deadenylase enzymes. Multiple deadenylases have been identified in vertebrates and are known to have distinct biological roles; among these proteins is Nocturnin, which has been linked to circadian biology, adipogenesis, osteogenesis, and obesity. Multiple studies have investigated Nocturnin's involvement in these processes; however, a full understanding of its molecular function remains elusive. Recent studies have provided new insights by identifying putative Nocturnin-regulated mRNAs in mice and by determining the structure and regulatory activities of human Nocturnin. This review seeks to integrate these new discoveries into our understanding of Nocturnin's regulatory functions and highlight the important remaining unanswered questions surrounding its regulation, biochemical activities, protein partners, and target mRNAs.


RNA Biol


RNA biology


Hughes KL,Abshire ET,Goldstrohm AC




Has Abstract


2018-01-01 00:00:00












  • Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis.

    abstract::The immaculate annotation of all microRNAs (miRNAs) is a prerequisite to study their biological function on a genome-wide scale. However, the original criteria for proper miRNA annotation seem unsuited for the automated analysis of the immense number of small RNA reads available in next generation sequencing (NGS) dat...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Hansen TB,Kjems J,Bramsen JB

    更新日期:2011-05-01 00:00:00

  • Wobble uridine modifications-a reason to live, a reason to die?!

    abstract::Wobble uridines (U34) are generally modified in all species. U34 modifications can be essential in metazoans but are not required for viability in fungi. In this review, we provide an overview on the types of modifications and how they affect the physico-chemical properties of wobble uridines. We describe the molecula...

    journal_title:RNA biology

    pub_type: 杂志文章,评审


    authors: Schaffrath R,Leidel SA

    更新日期:2017-09-02 00:00:00

  • Carl Woese's vision of cellular evolution and the domains of life.

    abstract::In a series of conceptual articles published around the millennium, Carl Woese emphasized that evolution of cells is the central problem of evolutionary biology, that the three-domain ribosomal tree of life is an essential framework for reconstructing cellular evolution, and that the evolutionary dynamics of functiona...

    journal_title:RNA biology

    pub_type: 杂志文章,评审


    authors: Koonin EV

    更新日期:2014-01-01 00:00:00

  • Population differences in microRNA expression and biological implications.

    abstract::Population differences observed for complex traits may be attributed to the combined effect of socioeconomic, environmental, genetic and epigenetic factors. To better understand population differences in complex traits, genome-wide genetic and gene expression differences among ethnic populations have been studied. Her...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Huang RS,Gamazon ER,Ziliak D,Wen Y,Im HK,Zhang W,Wing C,Duan S,Bleibel WK,Cox NJ,Dolan ME

    更新日期:2011-07-01 00:00:00

  • Modeling SNP mediated differential targeting of homologous 3'UTR by microRNA.

    abstract::We had previously proposed that the post-transcriptional regulation through microRNA as a mechanism for incomplete penetrance and variable expressivity, leads to lack of correlation between genotype and phenotype. Here we report the validation of miRNA-target interactions we predicted earlier and demonstrate the regul...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Ahluwalia JK,Soni K,Sivasubbu S,Brahmachari V

    更新日期:2012-03-01 00:00:00

  • RNA repair--the latest addition to the toolbox for macromolecular maintenance.

    abstract::All organisms must keep their DNA intact and free of lesions to obtain faithful transmission of genetic information, and many cellular proteins are involved in genome maintenance. However, also other macromolecules may be subject to repair. Deleterious lesions in proteins can be reversed by several mechanisms, and thi...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Falnes PØ

    更新日期:2005-01-01 00:00:00

  • Prediction and diversity of tracrRNAs from type II CRISPR-Cas systems.

    abstract::Type II CRISPR-Cas9 systems require a small RNA called the trans-activating CRISPR RNA (tracrRNA) in order to function. The prediction of these non-coding RNAs in prokaryotic genomes is challenging because they have dissimilar structures, having short stems (3-6 bp) and non-canonical base-pairs e.g. G-A. Much of the t...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Chyou TY,Brown CM

    更新日期:2019-04-01 00:00:00

  • Nonsense mediated decay induced by tethered human UPF3B is restricted to the cytoplasm.

    abstract::The subcellular localization of the nonsense mediated decay (NMD) of mRNA transcripts bearing premature termination codons has been controversial. Recently, it has been demonstrated that RNA tethering of key mediators of NMD, including human UPF3B, accurately recreates NMD. Here, we have used tethered UPF3B, combined ...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Lu S,Cullen BR

    更新日期:2004-05-01 00:00:00

  • RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling.

    abstract::The Hedgehog (HH) signaling pathway has important roles in tumorigenesis and in embryonal patterning. The Glioma-associated oncogene 1 (GLI1) is a key molecule in HH signaling, acting as a transcriptional effector and, moreover, is considered to be a potential therapeutic target for several types of cancer. To extend ...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Shimokawa T,Rahman MF,Tostar U,Sonkoly E,Ståhle M,Pivarcsi A,Palaniswamy R,Zaphiropoulos PG

    更新日期:2013-02-01 00:00:00

  • Viroid-specific small RNA in plant disease.

    abstract::Viroids are the smallest autonomous infectious nucleic acids known today. They are non-coding, unencapsidated, circular RNAs with sizes ranging from 250 to 400 nucleotides and infect certain plants. These RNAs are transcribed by rolling-circle mechanisms in the plant host's nuclei (Pospiviroidae) or chloroplasts (Avsu...

    journal_title:RNA biology

    pub_type: 杂志文章,评审


    authors: Hammann C,Steger G

    更新日期:2012-06-01 00:00:00

  • Toxins MazF and MqsR cleave Escherichia coli rRNA precursors at multiple sites.

    abstract::The endoribonuclease toxins of the E. coli toxin-antitoxin systems arrest bacterial growth and protein synthesis by targeting cellular mRNAs. As an exception, E. coli MazF was reported to cleave also 16S rRNA at a single site and separate an anti-Shine-Dalgarno sequence-containing RNA fragment from the ribosome. We no...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Mets T,Lippus M,Schryer D,Liiv A,Kasari V,Paier A,Maiväli Ü,Remme J,Tenson T,Kaldalu N

    更新日期:2017-01-02 00:00:00

  • LINC01198 facilitates gliomagenesis through activating PI3K/AKT pathway.

    abstract::Glioma is the most malignant primary brain cancer which frequently occurred in adults. In recent years, long-non coding RNAs (lncRNAs) have been demonstrated to play pivotal roles in human cancers. However, the role of most lncRNAs in gliomagenesis has not been probed. Presently, through TCGA, a novel lncRNA LINC01198...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Xie Y,Cheng Y

    更新日期:2020-07-01 00:00:00

  • FMR1 RNA within the intranuclear inclusions of fragile X-associated tremor/ataxia syndrome (FXTAS).

    abstract::Fragile X-associated tremor/ataxia syndrome (FXTAS) is a recently identified neurodegenerative disorder affecting older adult males with premutation alleles of the fragile X mental retardation 1 (FMR1) gene. The principal clinical features of FXTAS include progressive intention tremor, gait ataxia, parkinsonism, and a...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Tassone F,Iwahashi C,Hagerman PJ

    更新日期:2004-07-01 00:00:00

  • The emerging role of pre-messenger RNA splicing in stress responses: sending alternative messages and silent messengers.

    abstract::Alternative splicing (AS) of pre-messenger RNAs is a major process contributing to both transcriptome and proteome diversity in various physiological and pathological situations. There is also accumulating evidence that various stresses impact on AS. In particular, recent analyses of the transcriptome reveal large num...

    journal_title:RNA biology

    pub_type: 杂志文章,评审


    authors: Dutertre M,Sanchez G,Barbier J,Corcos L,Auboeuf D

    更新日期:2011-09-01 00:00:00

  • Natural variation of the cardiac transcriptome in humans.

    abstract::We investigated the gene-expression variation among humans by analysing previously published mRNA-seq and ribosome footprint profiling of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features ...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Domitrovic T,Moreira MH,Carneiro RL,Ribeiro-Alves M,Palhano FL

    更新日期:2020-12-11 00:00:00

  • Identification of NOVA family proteins as novel β-catenin RNA-binding proteins that promote epithelial-mesenchymal transition.

    abstract::The NOVA (neuro-oncological ventral antigen) protein family, composed of two paralogs, NOVA1 and NOVA2, consists of RNA-binding proteins involving in processes such as alternative splicing and transport of some target mRNAs. The function of NOVA has been well studied, and increasing evidence has shown that NOVA protei...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Tang S,Zhao Y,He X,Zhu J,Chen S,Wen J,Deng Y

    更新日期:2020-06-01 00:00:00

  • The cryptic unstable transcripts are associated with developmentally regulated gene expression in blood-stage Plasmodium falciparum.

    abstract::The tight gene expression regulation controls the development and pathogenesis of human malaria parasite Plasmodium falciparum throughout the complex life cycle. Recent studies have revealed the pervasive nascent transcripts in the genome of P. falciparum, suggesting the existence of a hidden transcriptome involved in...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Yin S,Fan Y,He X,Wei G,Wen Y,Zhao Y,Shi M,Wei J,Chen H,Han J,Jiang L,Zhang Q

    更新日期:2020-06-01 00:00:00

  • Characterization of cis-acting elements that control oscillating alternative splicing.

    abstract::Alternative splicing (AS) in response to changing external conditions often requires alterations in the ability of sequence-specific RNA-binding proteins to bind to cis-acting sequences in their target pre-mRNA. While daily oscillations in AS events have been described in several organisms, cis-acting sequences that c...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Goldammer G,Neumann A,Strauch M,Müller-McNicoll M,Heyd F,Preußner M

    更新日期:2018-01-01 00:00:00

  • xRRM: a new class of RRM found in the telomerase La family protein p65.

    abstract::Genuine La and La-related proteins group 7 (LARP7) bind to the non-coding RNAs transcribed by RNA polymerase III (RNAPIII), which end in UUU-3'OH. The La motif and RRM1 of these proteins (the La module) cooperate to bind the UUU-3'OH, protecting the RNA from degradation, while other domains may be important for RNA fo...

    journal_title:RNA biology

    pub_type: 杂志文章,评审


    authors: Singh M,Choi CP,Feigon J

    更新日期:2013-03-01 00:00:00

  • Long non-coding RNAs and human X-chromosome regulation: a coat for the active X chromosome.

    abstract::In mammals, the genic disequilibrium between males (XY) and females (XX) is resolved through the inactivation of one of the X-chromosomes in females. X-chromosome inactivation (XCI) takes place in all mammalian species, but has mainly been studied in the mouse model where it was shown to be controlled by the interplay...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Vallot C,Rougeulle C

    更新日期:2013-08-01 00:00:00

  • Long noncoding RNA in genome regulation: prospects and mechanisms.

    abstract::Long noncoding RNAs (lncRNAs) are pervasively transcribed and critical regulators of the epigenome[1, 2]. These long, polyadenylated RNAs do not code for proteins, but function directly as RNAs, recruiting chromatin modifiers to mediate transcriptional changes in processes ranging from X-inactivation (XIST) to imprint...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Hung T,Chang HY

    更新日期:2010-09-01 00:00:00

  • Mechanistic insights into mRNA export through structures of Dbp5.

    abstract::Nuclear export of mRNA is a critical event in mRNA biogenesis. Passage of mature messenger ribonucleoproteins (mRNPs) through nuclear pore complexes (NPCs) is facilitated by the Mex67/Mtr2 heterodimer. At the NPC cytoplasmic face, the DEAD-box RNA helicase Dbp5 remodels mRNPs by removing Mex67/Mtr2. This remodeling pr...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Ling SH,Song H

    更新日期:2010-01-01 00:00:00

  • Fail-safe transcription termination: Because one is never enough.

    abstract::Termination of RNA polymerase II (RNAPII) transcription is a fundamental step of gene expression that involves the release of the nascent transcript and dissociation of RNAPII from the DNA template. As transcription termination is intimately linked to RNA 3' end processing, termination pathways have a key decisive inf...

    journal_title:RNA biology

    pub_type: 杂志文章,评审


    authors: Lemay JF,Bachand F

    更新日期:2015-01-01 00:00:00

  • miR-206 knockout shows it is critical for myogenesis and directly regulates newly identified target mRNAs.

    abstract::The muscle specific miRNA, miR-206, is important for the process of myogenesis; however, studying the function of miR-206 in muscle development and differentiation still proves challenging because the complement of mRNA targets it regulates remains undefined. In addition, miR-206 shares close sequence similarity to mi...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Salant GM,Tat KL,Goodrich JA,Kugel JF

    更新日期:2020-07-01 00:00:00

  • Role and mechanism of U1-independent pre-mRNA splicing in the regulation of alternative splicing.

    abstract::In metazoan organisms, alternative splicing is a central mechanism for the regulation of gene expression. However, many questions remain about the underlying molecular mechanisms. Our recent work suggests that U1 snRNP-independent premRNA splicing occurs in humans, which contributes to the regulation of alternative sp...

    journal_title:RNA biology

    pub_type: 杂志文章,评审


    authors: Fukumura K,Inoue K

    更新日期:2009-09-01 00:00:00

  • Small non-coding RNAs in plant-pathogenic Xanthomonas spp.

    abstract::The genus Xanthomonas comprises a large group of plant-pathogenic bacteria. The infection and bacterial multiplication in the plant tissue depends on the type III secretion system and other virulence determinants. Recent studies revealed that bacterial virulence is also controlled at the post-transcriptional level by ...

    journal_title:RNA biology

    pub_type: 杂志文章,评审


    authors: Abendroth U,Schmidtke C,Bonas U

    更新日期:2014-01-01 00:00:00

  • Organ-specific small non-coding RNA responses in domestic (Sudani) ducks experimentally infected with highly pathogenic avian influenza virus (H5N1).

    abstract::The duck represents an important reservoir of influenza viruses for transmission to other avian and mammalian hosts, including humans. The increased pathogenicity of the recently emerging clades of highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype in ducks features systemic viral spread and organ-to...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Samir M,Vidal RO,Abdallah F,Capece V,Seehusen F,Geffers R,Hussein A,Ali AAH,Bonn S,Pessler F

    更新日期:2020-01-01 00:00:00

  • XenomiRs and miRNA homeostasis in health and disease: evidence that diet and dietary miRNAs directly and indirectly influence circulating miRNA profiles.

    abstract::Contributions of dietary miRNAs to circulating small RNA profiles would have profound implications for interpretation of miRNA biomarker studies: presumptive disease-specific markers might instead indicate responses to disease-associated quantitative or qualitative dietary alteration. This examination weighs the evide...

    journal_title:RNA biology

    pub_type: 杂志文章,评审


    authors: Witwer KW

    更新日期:2012-09-01 00:00:00

  • RNA-template dependent de novo telomere addition.

    abstract::De novo addition of telomeric sequences can occur at broken chromosomes and must be well controlled, which is essential during programmed DNA reorganization processes. In ciliated protozoa an extreme form of DNA-reorganization is observed during macronuclear differentiation after sexual reproduction leading to the eli...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Fuhrmann G,Jönsson F,Weil PP,Postberg J,Lipps HJ

    更新日期:2016-08-02 00:00:00

  • Identification of the Selenoprotein S Positive UGA Recoding (SPUR) element and its position-dependent activity.

    abstract::Selenoproteins are a unique class of proteins that contain the 21st amino acid, selenocysteine (Sec). Addition of Sec into a protein is achieved by recoding of the UGA stop codon. All 25 mammalian selenoprotein mRNAs possess a 3' UTR stem-loop structure, the Selenocysteine Insertion Sequence (SECIS), which is required...

    journal_title:RNA biology

    pub_type: 杂志文章


    authors: Cockman EM,Narayan V,Willard B,Shetty SP,Copeland PR,Driscoll DM

    更新日期:2019-12-01 00:00:00