Regulatory roles of vertebrate Nocturnin: insights and remaining mysteries.

Abstract:

:Post-transcriptional control of messenger RNA (mRNA) is an important layer of gene regulation that modulates mRNA decay, translation, and localization. Eukaryotic mRNA decay begins with the catalytic removal of the 3' poly-adenosine tail by deadenylase enzymes. Multiple deadenylases have been identified in vertebrates and are known to have distinct biological roles; among these proteins is Nocturnin, which has been linked to circadian biology, adipogenesis, osteogenesis, and obesity. Multiple studies have investigated Nocturnin's involvement in these processes; however, a full understanding of its molecular function remains elusive. Recent studies have provided new insights by identifying putative Nocturnin-regulated mRNAs in mice and by determining the structure and regulatory activities of human Nocturnin. This review seeks to integrate these new discoveries into our understanding of Nocturnin's regulatory functions and highlight the important remaining unanswered questions surrounding its regulation, biochemical activities, protein partners, and target mRNAs.

journal_name

RNA Biol

journal_title

RNA biology

authors

Hughes KL,Abshire ET,Goldstrohm AC

doi

10.1080/15476286.2018.1526541

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

1255-1267

issue

10

eissn

1547-6286

issn

1555-8584

journal_volume

15

pub_type

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