Abstract:
:Wobble uridines (U34) are generally modified in all species. U34 modifications can be essential in metazoans but are not required for viability in fungi. In this review, we provide an overview on the types of modifications and how they affect the physico-chemical properties of wobble uridines. We describe the molecular machinery required to introduce these modifications into tRNA posttranscriptionally and discuss how posttranslational regulation may affect the activity of the modifying enzymes. We highlight the activity of anticodon specific RNases that target U34 containing tRNA. Finally, we discuss how defects in wobble uridine modifications lead to phenotypes in different species. Importantly, this review will mainly focus on the cytoplasmic tRNAs of eukaryotes. A recent review has extensively covered their bacterial and mitochondrial counterparts. 1.
journal_name
RNA Bioljournal_title
RNA biologyauthors
Schaffrath R,Leidel SAdoi
10.1080/15476286.2017.1295204subject
Has Abstractpub_date
2017-09-02 00:00:00pages
1209-1222issue
9eissn
1547-6286issn
1555-8584journal_volume
14pub_type
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