Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway.

abstract：:The importance of telomere function for human health is exemplified by a collection of Mendelian disorders referred to as the telomere biology disorders (TBDs), telomeropathies, or syndromes of telomere shortening. Collectively, the TBDs cover a spectrum of conditions from multisystem disease presenting in infancy to ...

journal_title：RNA biology

authors： Bertuch AA

更新日期：2016-08-02 00:00:00

abstract：:The chromatoid body is a large perinuclear ribonucleoprotein particle of germ cells. The chromatoid body is also present in stem cells from planarians. This particle shares markers specific to protein aggresomes and P-bodies, and concentrate several RNA pathways. The assembly mechanism of chromatoid bodies is unknown,...

journal_title：RNA biology

authors： Roucou X

更新日期：2009-04-01 00:00:00

abstract：:The two major steps of gene expression are transcription and translation. While hundreds of studies regarding the effect of sequence features on the translation elongation process have been published, very few connect sequence features to the transcription elongation rate. We suggest, for the first time, that short tr...

journal_title：RNA biology

authors： Cohen E,Zafrir Z,Tuller T

更新日期：2018-01-02 00:00:00

abstract：:Previous mRNA transcriptome studies of Euglena gracilis have shown that this organism possesses a large and diverse complement of protein coding genes; however, the study of non-coding RNA classes has been limited. The natural extensive fragmentation of the E. gracilis large subunit ribosomal RNA presents additional b...

journal_title：RNA biology

authors： Moore AN,McWatters DC,Hudson AJ,Russell AG

更新日期：2018-01-01 00:00:00

abstract：:Interactions between glioma cells and their local environment are critical determinants of brain tumor growth, infiltration and neovascularisation. Communication with host cells and stroma via microvesicles represents one pathway by which tumors can modify their surroundings to achieve a tumor-permissive environment. ...

journal_title：RNA biology

authors： Li CC,Eaton SA,Young PE,Lee M,Shuttleworth R,Humphreys DT,Grau GE,Combes V,Bebawy M,Gong J,Brammah S,Buckland ME,Suter CM

更新日期：2013-08-01 00:00:00

abstract：:How have the branchpoint motifs evolved in organisms of different complexity? Here we identified and examined the consensus motifs (R1C2T3R4A5Y6, R: A or G, Y: C or T) of 898 fungal genomes. In Ascomycota unicellular yeasts, the G4/A4 ratio is mostly (98%) below 0.125 but increases sharply in multicellular species by ...

journal_title：RNA biology

authors： Nguyen H,Das U,Xie J

更新日期：2020-03-01 00:00:00

abstract：:RNA exosomes are large multi-subunit protein complexes involved in controlled and processive 3' to 5' RNA degradation. Exosomes form large molecular chambers and harbor multiple nuclease sites as well as RNA binding regions. This makes a quantitative kinetic analysis of RNA degradation with reliable parameter and erro...

journal_title：RNA biology

authors： Niederberger T,Hartung S,Hopfner KP,Tresch A

更新日期：2011-01-01 00:00:00

abstract：:The non-coding roX1 and roX2 RNAs are components of the MSL dosage compensation complex in Drosophila. We found that multiple species of roX2 RNA are produced by alternative splicing, with one major and at least 20 different minor forms associated with MSL proteins. The alternative forms are generated by variable usag...

journal_title：RNA biology

authors： Park Y,Oh H,Meller VH,Kuroda MI

更新日期：2005-10-01 00:00:00

abstract：:The duck represents an important reservoir of influenza viruses for transmission to other avian and mammalian hosts, including humans. The increased pathogenicity of the recently emerging clades of highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype in ducks features systemic viral spread and organ-to...

journal_title：RNA biology

authors： Samir M,Vidal RO,Abdallah F,Capece V,Seehusen F,Geffers R,Hussein A,Ali AAH,Bonn S,Pessler F

更新日期：2020-01-01 00:00:00

abstract：:The quaking viable (qk(v)) mice have attracted attention because of their characteristic tremor caused by their dysmyelination. In the central nervous system, qk(v) mice fail to develop mature myelinating oligodendrocytes and display uncompacted myelin. The genetic defect in the qk(v) mice prevents the proper expressi...

journal_title：RNA biology

authors： Larocque D,Richard S

更新日期：2005-04-01 00:00:00

abstract：:Alzheimer's disease (AD) has devastating consequences for patients during its slow, progressive course. It is important to understand the pathology of AD onset. Recently, circular RNAs (circRNAs) have been found to participate in many human diseases including cancers and neurodegenerative conditions. In this study, we...

journal_title：RNA biology

authors： Lo I,Hill J,Vilhjálmsson BJ,Kjems J

更新日期：2020-12-01 00:00:00

abstract：:tmRNA employs both tRNA-like and mRNA-like properties as it rescues stalled bacterial ribosomes, while targeting the defective mRNA and incomplete nascent protein for degradation. We describe variation of the tmRNA gene (ssrA) and how it informs tmRNA structure and function. Endosymbiont tmRNAs tend to lose secondary ...

journal_title：RNA biology

authors： Mao C,Bhardwaj K,Sharkady SM,Fish RI,Driscoll T,Wower J,Zwieb C,Sobral BW,Williams KP

更新日期：2009-09-01 00:00:00

abstract：:As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst. The chaperoning function is found intrinsic to ribozymes involved in protein synthesis and tRNA maturation, enriching the primordial RNA world with ...

journal_title：RNA biology

authors： Son A,Horowitz S,Seong BL

更新日期：2021-01-01 00:00:00

abstract：:In mammals, the genic disequilibrium between males (XY) and females (XX) is resolved through the inactivation of one of the X-chromosomes in females. X-chromosome inactivation (XCI) takes place in all mammalian species, but has mainly been studied in the mouse model where it was shown to be controlled by the interplay...

journal_title：RNA biology

authors： Vallot C,Rougeulle C

更新日期：2013-08-01 00:00:00

abstract：:Differential mRNA stability is an important mechanism for regulation of virulence factors in Streptococcus pyogenes (group A streptococcus, GAS), a serious and prevalent human pathogen. We have described 2 Classes of mRNA in GAS that are distinguishable by 1) stability in the stationary phase of growth, 2) kinetics of...

journal_title：RNA biology

authors： Bugrysheva JV,Scott JR

更新日期：2010-09-01 00:00:00

abstract：:We previously showed that miR-122 was frequently downregulated in hepatocellular carcinoma (HCC) and C/EBPα transactivated miR-122 expression. In this study, we found that Sp1 bound to the miR-122 promoter at two different sites. Interestingly, either inhibition or overexpression of Sp1 could decrease the miR-122 prom...

journal_title：RNA biology

authors： Zeng C,Sang Y,Wang FY,Zhuang SM

更新日期：2020-02-01 00:00:00

abstract：:Glioma is the most malignant primary brain cancer which frequently occurred in adults. In recent years, long-non coding RNAs (lncRNAs) have been demonstrated to play pivotal roles in human cancers. However, the role of most lncRNAs in gliomagenesis has not been probed. Presently, through TCGA, a novel lncRNA LINC01198...

journal_title：RNA biology

authors： Xie Y,Cheng Y

更新日期：2020-07-01 00:00:00

abstract：:The subcellular localization of the nonsense mediated decay (NMD) of mRNA transcripts bearing premature termination codons has been controversial. Recently, it has been demonstrated that RNA tethering of key mediators of NMD, including human UPF3B, accurately recreates NMD. Here, we have used tethered UPF3B, combined ...

journal_title：RNA biology

authors： Lu S,Cullen BR

更新日期：2004-05-01 00:00:00

abstract：:Chemical modification of nucleobases plays an important role for the control of gene expression on different levels. That includes the modulation of translation by modified tRNA-bases or silencing and reactivation of genes by methylation and demethylation of cytosine in promoter regions. Especially dynamic methylation...

journal_title：RNA biology

authors： Traube FR,Carell T

更新日期：2017-09-02 00:00:00

abstract：:Nuclear export of mRNA is a critical event in mRNA biogenesis. Passage of mature messenger ribonucleoproteins (mRNPs) through nuclear pore complexes (NPCs) is facilitated by the Mex67/Mtr2 heterodimer. At the NPC cytoplasmic face, the DEAD-box RNA helicase Dbp5 remodels mRNPs by removing Mex67/Mtr2. This remodeling pr...

journal_title：RNA biology

authors： Ling SH,Song H

更新日期：2010-01-01 00:00:00

abstract：:Myocyte enhancer factor 2c (MEF2C) is the MADS-box type transcription factor involved in the differentiation of cardiac and skeletal muscle and synaptic formation. Alternatively spliced transcripts of the MEF2C gene were proven to encode isoforms which exert distinct functions in transcriptional regulation. During the...

journal_title：RNA biology

authors： Lin JC

更新日期：2015-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of naturally occurring, small, non-coding RNAs that control gene expression during development,normal cell function and disease. Although there is emerging evidence that some miRNAs can function as oncogenes or tumor suppressors, there is limited understanding of the role of miRNAs in ca...

journal_title：RNA biology

authors： Guo X,Wu Y,Hartley RS

更新日期：2009-11-01 00:00:00

abstract：:Skeletal muscle is the dominant executant in locomotion and regulator in energy metabolism. Embryonic myogenesis and postnatal muscle growth are controlled by a cascade of transcription factors and epigenetic regulatory mechanisms. MicroRNAs (miRNAs), a family of non-coding RNA of 22 nucleotides in length, post-transc...

journal_title：RNA biology

authors： Ma M,Wang X,Chen X,Cai R,Chen F,Dong W,Yang G,Pang W

更新日期：2017-03-04 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) causes anovulatory infertility in women of reproductive age, but etiopathogenesis of PCOS remains undetermined. Taurine up-regulated 1 (TUG1), an evolutionarily conserved long non-coding RNA, performs various biological functions; however, the role of TUG1 in PCOS remains unclear. Here...

journal_title：RNA biology

authors： Li Y,Zhang J,Liu YD,Zhou XY,Chen X,Zhe J,Zhang QY,Zhang XF,Chen YX,Wang Z,Chen SL

更新日期：2020-12-01 00:00:00

abstract：:MicroRNAs are essential for spermatogenesis. However, the stage-specific requirements for particular miRNAs in the male mammalian germ line remain largely uncharacterized. The miR-34 family is, to date, the only miRNA proven to be necessary for the production of sperm in mammals, though its germline roles are poorly u...

journal_title：RNA biology

authors： Hilz S,Fogarty EA,Modzelewski AJ,Cohen PE,Grimson A

更新日期：2017-02-01 00:00:00

abstract：:The RIG-I-like receptors (RLRs)--RIG-I, MDA5, and LGP2--detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. The protein architecture of the RLR family consists of multiple functional domains, including N-terminal Caspase Activation and Recruitment Domains (CARDs) for sig...

journal_title：RNA biology

authors： Luo D

更新日期：2014-01-01 00:00:00

abstract：:MicroRNAs are small RNAs that post-transcriptionally regulate eukaryotic gene expression. In addition to their involvement in a wide range of physiological and pathological processes, including viral infections, microRNAs are increasingly implicated in the eukaryotic response to bacterial pathogens. Recent studies hav...

journal_title：RNA biology

authors： Eulalio A,Schulte L,Vogel J

更新日期：2012-06-01 00:00:00

abstract：:Earlier we have demonstrated the presence of internal ribosome entry site (IRES) within tumor suppressor p53 mRNA. Here we have mapped the putative secondary structure of p53- IRES RNA using information from chemical probing and nuclease mapping experiments. Additionally, the secondary structure of the IRES element of...

journal_title：RNA biology

authors： Grover R,Sharathchandra A,Ponnuswamy A,Khan D,Das S

更新日期：2011-01-01 00:00:00

abstract：:Wobble uridines (U34) are generally modified in all species. U34 modifications can be essential in metazoans but are not required for viability in fungi. In this review, we provide an overview on the types of modifications and how they affect the physico-chemical properties of wobble uridines. We describe the molecula...

journal_title：RNA biology

authors： Schaffrath R,Leidel SA

更新日期：2017-09-02 00:00:00

abstract：:The human genome contains some thousands of long non coding RNAs (lncRNAs). Many of these transcripts are presently considered crucial regulators of gene expression and functionally implicated in developmental processes in Eukaryotes. Notably, despite a huge number of lncRNAs are expressed in the Central Nervous Syste...

journal_title：RNA biology

authors： Bevilacqua V,Gioia U,Di Carlo V,Tortorelli AF,Colombo T,Bozzoni I,Laneve P,Caffarelli E

更新日期：2015-01-01 00:00:00