Abstract:
:De novo addition of telomeric sequences can occur at broken chromosomes and must be well controlled, which is essential during programmed DNA reorganization processes. In ciliated protozoa an extreme form of DNA-reorganization is observed during macronuclear differentiation after sexual reproduction leading to the elimination of specific parts of the germline genome. Regulating these processes involves small noncoding RNAs, but in addition DNA-reordering, excision and amplification require RNA templates deriving from the parental macronucleus. We show that these putative RNA templates can carry telomeric repeats. Microinjection of RNA templates carrying modified telomeres into the developing macronucleus leads to modified telomeres in vegetative cells, providing strong evidence, that de novo addition of telomeres depends on a telomere-containing transcript from the parental macronucleus.
journal_name
RNA Bioljournal_title
RNA biologyauthors
Fuhrmann G,Jönsson F,Weil PP,Postberg J,Lipps HJdoi
10.1080/15476286.2015.1134414subject
Has Abstractpub_date
2016-08-02 00:00:00pages
733-9issue
8eissn
1547-6286issn
1555-8584journal_volume
13pub_type
杂志文章相关文献
RNA Biology文献大全abstract::The GIR1 branching ribozyme constitutes a separate class of naturally occurring ribozymes. Most studies have been performed with the single GIR1 known from the myxomycete Didymium iridis whereas the large number of GIR1s found in the amoeboflagellate Naegleria has remained largely uncharacterized. Here, we investigate...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.6.16027
更新日期:2011-11-01 00:00:00
abstract::tRNA-dependent addition of amino acids to lipids on the outer surface of the bacterial membrane results in decreased effectiveness of antimicrobials such as cationic antimicrobial peptides (CAMPs) that target the membrane, and increased virulence of several pathogenic species. After a brief introduction to CAMPs and t...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.1080/15476286.2017.1356980
更新日期:2018-01-01 00:00:00
abstract::Circular RNAs (circRNAs) constitute a large class of RNA species formed by the back-splicing of co-linear exons, often within protein-coding transcripts. Despite much progress in the field, it remains elusive whether the majority of circRNAs are merely aberrant splicing by-products with unknown functions, or their pro...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2016.1207036
更新日期:2016-09-01 00:00:00
abstract::RNA interference (RNAi) is a powerful tool for gene functional analysis of plant-parasitic nematodes (PPNs). RNAi involving soaking in a dsRNA solution and in planta methods is commonly applied in the study of gene function in PPNs. However, certain problems restrict the application of these methods. Therefore, more c...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1852779
更新日期:2020-12-14 00:00:00
abstract::Many splicing regulators bind to their own pre-mRNAs to induce alternative splicing that leads to formation of unstable mRNA isoforms. This provides an autoregulatory feedback mechanism that regulates the cellular homeostasis of these factors. We have described such an autoregulatory mechanism for two core protein com...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2015.1096489
更新日期:2015-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are key regulators of gene expression and play critical roles in modulating metabolism, development and physiology in animals and plants. miRNA levels are transcriptionally and post-transcriptionally controlled for their proper function. Recent studies have shown that RNA-binding proteins play impor...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.22740
更新日期:2012-12-01 00:00:00
abstract::Processing bodies (P-bodies) are cytoplasmatic mRNP granules containing non-translating mRNAs and proteins from the mRNA decay and silencing machineries. The mechanism of P-body assembly has been typically addressed by depleting P-body components. Here we apply a complementary approach and establish an automated cell-...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.26851
更新日期:2013-11-01 00:00:00
abstract::The endoribonuclease toxins of the E. coli toxin-antitoxin systems arrest bacterial growth and protein synthesis by targeting cellular mRNAs. As an exception, E. coli MazF was reported to cleave also 16S rRNA at a single site and separate an anti-Shine-Dalgarno sequence-containing RNA fragment from the ribosome. We no...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2016.1259784
更新日期:2017-01-02 00:00:00
abstract::Amplification or overexpression of neuronal MYC (MYCN) is associated with poor prognosis of human neuroblastoma. Three isoforms of the MYCN protein have been described as well as a protein encoded by an antisense transcript (MYCNOS) that originates from the opposite strand at the MYCN locus. Recent findings suggest th...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2015.1063773
更新日期:2015-01-01 00:00:00
abstract::Population bottlenecks often cause strong reductions in genetic diversity and alter population structure. In the context of host-parasite interactions, bottlenecks could in theory benefit either the host or the pathogen. We predicted that bottlenecking of bacterial populations that evolve CRISPR immunity against bacte...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1578608
更新日期:2019-04-01 00:00:00
abstract::In plants, Potato spindle tuber viroid (PSTVd) replication triggers post-transcriptional gene silencing (PTGS) and RNA-directed DNA methylation (RdDM) of homologous RNA and DNA sequences, respectively. PTGS predominantly occurs in the cytoplasm, but nuclear PTGS has been also reported. In this study, we investigated w...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2015.1017216
更新日期:2015-01-01 00:00:00
abstract::RNA methylation, catalysed by a set of RNA methyltransferases (RNMTs), modulates RNA structures, properties, and biological functions. RNMTs are increasingly documented to be dysregulated in various human diseases, particularly developmental disorders and cancer. However, the genomic and transcriptomic alterations of ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1708549
更新日期:2020-04-01 00:00:00
abstract::Post-transcriptional control of gene expression is mediated via RNA-binding proteins (RBPs) that interact with mRNAs in a combinatorial fashion. While recent global RNA interactome capture experiments expanded the repertoire of cellular RBPs quiet dramatically, little is known about the assembly of RBPs on particular ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1662268
更新日期:2020-01-01 00:00:00
abstract::Myocyte enhancer factor 2c (MEF2C) is the MADS-box type transcription factor involved in the differentiation of cardiac and skeletal muscle and synaptic formation. Alternatively spliced transcripts of the MEF2C gene were proven to encode isoforms which exert distinct functions in transcriptional regulation. During the...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2015.1017213
更新日期:2015-01-01 00:00:00
abstract::We investigated the gene-expression variation among humans by analysing previously published mRNA-seq and ribosome footprint profiling of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1857508
更新日期:2020-12-11 00:00:00
abstract::Editing by ADAR enzymes is essential for mammalian life. Still, knowledge of the spatio-temporal editing patterns in mammals is limited. By use of 454 amplicon sequencing we examined the editing status of 12 regionally extracted mRNAs from porcine developing brain encompassing a total of 64 putative ADAR editing sites...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.21082
更新日期:2012-08-01 00:00:00
abstract::The subcellular localization of the nonsense mediated decay (NMD) of mRNA transcripts bearing premature termination codons has been controversial. Recently, it has been demonstrated that RNA tethering of key mediators of NMD, including human UPF3B, accurately recreates NMD. Here, we have used tethered UPF3B, combined ...
journal_title:RNA biology
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract::The non-coding roX1 and roX2 RNAs are components of the MSL dosage compensation complex in Drosophila. We found that multiple species of roX2 RNA are produced by alternative splicing, with one major and at least 20 different minor forms associated with MSL proteins. The alternative forms are generated by variable usag...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.2.4.2473
更新日期:2005-10-01 00:00:00
abstract::Significant structural and mechanistic similarities between the spliceosomal snRNAs and catalytically critical domains of self-splicing group II introns have led to the hypothesis that the spliceosomes and group II introns may be evolutionarily related. We have previously shown that in vitro-transcribed, protein-free ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.3.15386
更新日期:2011-05-01 00:00:00
abstract::A-to-I RNA editing by adenosine deaminases acting on RNA is a post-transcriptional modification that is crucial for normal life and development in vertebrates. RNA editing has been shown to be very abundant in the human transcriptome, specifically at the primate-specific Alu elements. The functional role of this wide-...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/15476286.2014.992286
更新日期:2014-01-01 00:00:00
abstract::Viroids are non-coding single-stranded circular RNA molecules that replicate autonomously in infected host plants causing mild to lethal symptoms. Their genomes contain about 250-400 nucleotides, depending on viroid species. Members of the family Pospiviroidae, like the Potato spindle tuber viroid (PSTVd), replicate v...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2016.1272745
更新日期:2017-03-04 00:00:00
abstract::RNA editing in flowering plant mitochondria targets several hundred C nucleotides mostly in mRNAs to be altered to U. Several nuclear encoded genes have been recently identified predominantly in Arabidopsis thaliana which code for proteins involved in specific RNA editing events in plastids or mitochondria. These nucl...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.1.14298
更新日期:2011-01-01 00:00:00
abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common dementia among the elderly. The pathophysiology of AD is characterized by two hallmarks: amyloid plaques, produced by amyloid β (Aβ) aggregation, and neurofibrillary tangle (NFT), produced by accumulation of phosphorylated tau. Th...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1788848
更新日期:2020-07-14 00:00:00
abstract::Studies on the regulation of gene expression in eukaryotes in the past 20 years have consistently revealed increasing levels of complexity. Thirty years ago it seemed that we had understood the basic principles of gene regulation in eukaryotes. It was thought that regulation of transcription was the first and most imp...
journal_title:RNA biology
pub_type:
doi:10.4161/rna.28037
更新日期:2014-01-01 00:00:00
abstract::tmRNA employs both tRNA-like and mRNA-like properties as it rescues stalled bacterial ribosomes, while targeting the defective mRNA and incomplete nascent protein for degradation. We describe variation of the tmRNA gene (ssrA) and how it informs tmRNA structure and function. Endosymbiont tmRNAs tend to lose secondary ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.6.4.9172
更新日期:2009-09-01 00:00:00
abstract::Selenoproteins are a unique class of proteins that contain the 21st amino acid, selenocysteine (Sec). Addition of Sec into a protein is achieved by recoding of the UGA stop codon. All 25 mammalian selenoprotein mRNAs possess a 3' UTR stem-loop structure, the Selenocysteine Insertion Sequence (SECIS), which is required...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1653681
更新日期:2019-12-01 00:00:00
abstract::The ribosome binding site of Escherichia coli rpoS mRNA, encoding the stationary sigma-factor RpoS, is sequestered by an inhibitory stem-loop structure (iss). Translational activation of rpoS mRNA at low temperature and during exponential growth includes Hfq-facilitated duplex formation between rpoS and the small regu...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.7.6.13768
更新日期:2010-11-01 00:00:00
abstract::Altered expression levels of protein-coding genes and microRNAs have been implicated in the pathogenesis of Huntington's disease (HD). The involvement of other ncRNAs, especially long ncRNAs (lncRNA), is being realized recently and the related knowledge is still rudimentary. Using small RNA sequencing and PCR arrays w...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2018.1534524
更新日期:2018-01-01 00:00:00
abstract::The development of rigorous molecular taxonomy pioneered by Carl Woese has freed evolution science to explore numerous cellular activities that lead to genome change in evolution. These activities include symbiogenesis, inter- and intracellular horizontal DNA transfer, incorporation of DNA from infectious agents, and ...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.27506
更新日期:2014-01-01 00:00:00
abstract::The acquisition of antibiotic resistance by human pathogens poses a significant threat to public health. The mechanisms that control the proliferation and expression of antibiotic resistance genes are not yet completely understood. The aminoglycosides are a historically important class of antibiotics that were introdu...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.25757
更新日期:2013-08-01 00:00:00