Abstract:
:MicroRNAs are small RNAs that post-transcriptionally regulate eukaryotic gene expression. In addition to their involvement in a wide range of physiological and pathological processes, including viral infections, microRNAs are increasingly implicated in the eukaryotic response to bacterial pathogens. Recent studies have characterized changes in host microRNA expression following infection with exclusively extracellular (Helicobacter pylori) or intracellular (Salmonella enterica) Gram-negative bacteria, as well as in the response to Gram-positive (Listeria monocytogenes) and other pathogens (Mycobacterium and Francisella species). In this review, we discuss the emerging roles of microRNAs in mammalian host signaling and defense against bacterial pathogens.
journal_name
RNA Bioljournal_title
RNA biologyauthors
Eulalio A,Schulte L,Vogel Jdoi
10.4161/rna.20018subject
Has Abstractpub_date
2012-06-01 00:00:00pages
742-50issue
6eissn
1547-6286issn
1555-8584pii
20018journal_volume
9pub_type
杂志文章,评审相关文献
RNA Biology文献大全abstract::Genuine La and La-related proteins group 7 (LARP7) bind to the non-coding RNAs transcribed by RNA polymerase III (RNAPIII), which end in UUU-3'OH. The La motif and RRM1 of these proteins (the La module) cooperate to bind the UUU-3'OH, protecting the RNA from degradation, while other domains may be important for RNA fo...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.23608
更新日期:2013-03-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of small noncoding RNAs about 22-nucleotide (nt) in length that collectively regulate more than 60% of coding genes. Aberrant miRNA expression is associated with numerous diseases, including cancer. miRNA biogenesis is licenced by the ribonuclease (RNase) III enzyme Drosha, the regulatio...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1813439
更新日期:2020-11-01 00:00:00
abstract::The human genome encodes several thousand long non-protein coding transcripts>200 nucleotides in length, a subset of which were shown to play important roles in regulation of gene expression. We recently identified TINCR, a lncRNA required for induction of key differentiation genes in epidermal tissue, including genes...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.26249
更新日期:2013-10-01 00:00:00
abstract::RNA helicases contribute to diverse aspects of RNA metabolism through their functions in re-arranging RNA structures. Identification of the remodelling targets of RNA helicases is a critical step in elucidating their cellular functions. Here, we show that, in contrast to many other ribosome biogenesis factors, the DEx...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1829366
更新日期:2020-10-13 00:00:00
abstract::In plants, endogenes are less prone to RNA silencing than transgenes. While both can be efficiently targeted by small RNAs for post-transcriptional gene silencing (PTGS), generally only transgene PTGS is accompanied by transitivity, RNA-directed DNA methylation (RdDM) and systemic silencing. In order to investigate wh...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.29623
更新日期:2014-01-01 00:00:00
abstract::Heterogeneous nuclear ribonucleoprotein L (hnRNP L) is a multifunctional RNA-binding protein that is involved in many different processes, such as regulation of transcription, translation, and RNA stability. We have previously characterized hnRNP L as a global regulator of alternative splicing, binding to CA-repeat, a...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.27991
更新日期:2014-01-01 00:00:00
abstract::Termination of RNA polymerase II (RNAPII) transcription is a fundamental step of gene expression that involves the release of the nascent transcript and dissociation of RNAPII from the DNA template. As transcription termination is intimately linked to RNA 3' end processing, termination pathways have a key decisive inf...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.1080/15476286.2015.1073433
更新日期:2015-01-01 00:00:00
abstract::Altered expression levels of protein-coding genes and microRNAs have been implicated in the pathogenesis of Huntington's disease (HD). The involvement of other ncRNAs, especially long ncRNAs (lncRNA), is being realized recently and the related knowledge is still rudimentary. Using small RNA sequencing and PCR arrays w...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2018.1534524
更新日期:2018-01-01 00:00:00
abstract::Eukaryotic gene expression must be coordinated for the proper functioning of biological processes. This coordination can be achieved both at the transcriptional and post-transcriptional levels. In both cases, regulatory sequences placed at either promoter regions or on UTRs function as markers recognized by regulators...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.7116
更新日期:2008-10-01 00:00:00
abstract::By differential high-throughput RNA sequencing (dRNA-seq) we have identified "product RNAs" (pRNAs) as short as 8-12 nucleotides that are synthesized by Bacillus subtilis RNA polymerase (RNAP) in vivo using the regulatory 6S-1 RNA as template. The dRNA-seq data were confirmed by in vitro transcription experiments and ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.5.16151
更新日期:2011-09-01 00:00:00
abstract::In an earlier report two P-transposon insertion alleles of the noncoding hsromega gene, hsromega(05241) and P292 were shown to enhance neurodegeneration caused by expression of ataxin-1 protein with expanded poly-Q in a Drosophila model. In present study, we examined the possible relation between hsromega gene express...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.3.1.2559
更新日期:2006-01-01 00:00:00
abstract::YchF is one of two universally conserved GTPases with unknown cellular function. As a first step toward elucidating YchF's cellular role, we performed a detailed biochemical characterization of the protein from Escherichia coli. Our data from fluorescence titrations not only confirmed the surprising finding that YchFE...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.22131
更新日期:2012-10-01 00:00:00
abstract::Earlier we have demonstrated the presence of internal ribosome entry site (IRES) within tumor suppressor p53 mRNA. Here we have mapped the putative secondary structure of p53- IRES RNA using information from chemical probing and nuclease mapping experiments. Additionally, the secondary structure of the IRES element of...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.1.14260
更新日期:2011-01-01 00:00:00
abstract::The PDCD1 gene encodes PD-1, an important immune checkpoint protein and key immunotherapy target to treat cancer. PDCD1 is alternatively spliced to generate an exon 3-skipped isoform PD-1Δ3 that has been suggested to play an antagonistic role to PD-1, but the mechanism underlying alternative splicing of PDCD1 has neve...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1659080
更新日期:2019-12-01 00:00:00
abstract::Transcription termination delineates the 3' ends of transcripts, prevents otherwise runaway RNA polymerase (RNAP) from intruding into downstream genes and regulatory elements, and enables release of the RNAP for recycling. While other eukaryotic RNAPs require complex cis-signals and/or accessory factors to achieve the...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2015.1116677
更新日期:2016-01-01 00:00:00
abstract::Long noncoding RNAs (lncRNAs) are pervasively transcribed and critical regulators of the epigenome[1, 2]. These long, polyadenylated RNAs do not code for proteins, but function directly as RNAs, recruiting chromatin modifiers to mediate transcriptional changes in processes ranging from X-inactivation (XIST) to imprint...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.7.5.13216
更新日期:2010-09-01 00:00:00
abstract::Human Enterovirus 71 (EV71) is an emerging pathogen of infectious disease and a serious threat to public health. Currently, there are no antivirals or vaccines to slow down or prevent EV71 infections, thus underscoring the urgency to better understand mechanisms of host-enterovirus interactions. EV71 uses a type I int...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.25107
更新日期:2013-07-01 00:00:00
abstract::The genome of most prokaryotes gives rise to surprisingly complex transcriptomes, comprising not only protein-coding mRNAs, often organized as operons, but also harbors dozens or even hundreds of highly structured small regulatory RNAs and unexpectedly large levels of anti-sense transcripts. Comprehensive surveys of p...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.28647
更新日期:2014-01-01 00:00:00
abstract::One of the many important consequences that temperature down-shift has on cells is stabilization of secondary structures of RNAs. This stabilization has wide-spread effects, such as inhibition of expression of several genes due to termination of their transcription and inefficient RNA degradation that adversely affect...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.6.13482
更新日期:2010-11-01 00:00:00
abstract::The chromatoid body is a large perinuclear ribonucleoprotein particle of germ cells. The chromatoid body is also present in stem cells from planarians. This particle shares markers specific to protein aggresomes and P-bodies, and concentrate several RNA pathways. The assembly mechanism of chromatoid bodies is unknown,...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.6.2.8049
更新日期:2009-04-01 00:00:00
abstract::Ribosome biogenesis is an essential process initiated in the nucleolus. In eukaryotes, multiple ribosome biogenesis factors (RBFs) can be found in the nucleolus, the nucleus and in the cytoplasm. They act in processing, folding and modification of the pre-ribosomal (r)RNAs, incorporation of ribosomal proteins (RPs), e...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2016.1154252
更新日期:2016-01-01 00:00:00
abstract::Population bottlenecks often cause strong reductions in genetic diversity and alter population structure. In the context of host-parasite interactions, bottlenecks could in theory benefit either the host or the pathogen. We predicted that bottlenecking of bacterial populations that evolve CRISPR immunity against bacte...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1578608
更新日期:2019-04-01 00:00:00
abstract::The protein domain arrangement known as the La-module, comprised of a La motif (LaM) followed by a linker and RNA recognition motif (RRM), is found in seven La-related proteins: LARP1, LARP1B, LARP3 (La protein), LARP4, LARP4B, LARP6, and LARP7 in humans. Several LARPs have been characterized for their distinct activi...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1860376
更新日期:2020-12-23 00:00:00
abstract::Polycystic ovary syndrome (PCOS) causes anovulatory infertility in women of reproductive age, but etiopathogenesis of PCOS remains undetermined. Taurine up-regulated 1 (TUG1), an evolutionarily conserved long non-coding RNA, performs various biological functions; however, the role of TUG1 in PCOS remains unclear. Here...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1783850
更新日期:2020-12-01 00:00:00
abstract::The RNA component of the RNase P complex is found throughout most branches of the tree of life and is principally responsible for removing the 5' leader sequence from pre-tRNA transcripts during tRNA maturation. RNase P RNA has a number of universal core features, however variations in sequence and structure found in ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.21502
更新日期:2012-09-01 00:00:00
abstract::As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst. The chaperoning function is found intrinsic to ribozymes involved in protein synthesis and tRNA maturation, enriching the primordial RNA world with ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1801199
更新日期:2021-01-01 00:00:00
abstract::Physical entanglement, and particularly knots arise spontaneously in equilibrated polymers that are sufficiently long and densely packed. Biopolymers are no exceptions: knots have long been known to occur in proteins as well as in encapsidated viral DNA. The rapidly growing number of RNA structures has recently made i...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2015.1132069
更新日期:2016-01-01 00:00:00
abstract::Oncogenic viruses are associated with approximately 15% of human cancers. In viral infections, microRNAs play an important role in host-pathogen interactions. miR-21 is a highly conserved non-coding RNA that not only regulates the development of oncogenic viral diseases, but also responds to the regulation of intracel...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2021.1880756
更新日期:2021-01-27 00:00:00
abstract::The HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone, which remodels nucleic acid structures so that the most thermodynamically stable conformations are formed. This activity is essential for virus replication and has a critical role in mediating highly specific and efficient reverse transcription. NC's fun...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.6.14115
更新日期:2010-11-01 00:00:00
abstract::We investigated the gene-expression variation among humans by analysing previously published mRNA-seq and ribosome footprint profiling of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1857508
更新日期:2020-12-11 00:00:00