Modeling the Thermoproteaceae RNase P RNA.

abstract：:The non-coding roX1 and roX2 RNAs are components of the MSL dosage compensation complex in Drosophila. We found that multiple species of roX2 RNA are produced by alternative splicing, with one major and at least 20 different minor forms associated with MSL proteins. The alternative forms are generated by variable usag...

journal_title：RNA biology

authors： Park Y,Oh H,Meller VH,Kuroda MI

更新日期：2005-10-01 00:00:00

abstract：:Traditionally the principles of protein folding in vivo have been obtained largely from molecular chaperone studies. Through extensive studies on molecular chaperones, it becomes clear that most proteins can fold without their assistance in vivo, suggesting the existence of other chaperone types and mechanisms. Since ...

journal_title：RNA biology

authors： Choi SI,Ryu K,Seong BL

更新日期：2009-01-01 00:00:00

abstract：:Earlier we have demonstrated the presence of internal ribosome entry site (IRES) within tumor suppressor p53 mRNA. Here we have mapped the putative secondary structure of p53- IRES RNA using information from chemical probing and nuclease mapping experiments. Additionally, the secondary structure of the IRES element of...

journal_title：RNA biology

authors： Grover R,Sharathchandra A,Ponnuswamy A,Khan D,Das S

更新日期：2011-01-01 00:00:00

abstract：:RNase J is a prokaryotic 5'-3' exo/endoribonuclease that functions in mRNA decay and rRNA maturation. Here, we report a novel duplex unwinding activity of mpy-RNase J, an archaeal RNase J from Methanolobus psychrophilus, which enables it to degrade duplex RNAs with hairpins up to 40 bp when linking a 5' single-strande...

journal_title：RNA biology

authors： Li J,Hou Y,Gu X,Yue L,Guo L,Li D,Dong X

更新日期：2020-10-01 00:00:00

abstract：:The GIR1 branching ribozyme constitutes a separate class of naturally occurring ribozymes. Most studies have been performed with the single GIR1 known from the myxomycete Didymium iridis whereas the large number of GIR1s found in the amoeboflagellate Naegleria has remained largely uncharacterized. Here, we investigate...

journal_title：RNA biology

authors： Tang Y,Nielsen H,Birgisdottir AB,Johansen S

更新日期：2011-11-01 00:00:00

abstract：:All organisms must keep their DNA intact and free of lesions to obtain faithful transmission of genetic information, and many cellular proteins are involved in genome maintenance. However, also other macromolecules may be subject to repair. Deleterious lesions in proteins can be reversed by several mechanisms, and thi...

journal_title：RNA biology

authors： Falnes PØ

更新日期：2005-01-01 00:00:00

abstract：:Nonsense-mediated decay (NMD) is a RNA surveillance pathway that degrades subsets of normal and aberrant mRNAs. Mutations that perturb NMD cause neurological disorders in humans, suggesting that NMD has roles in the brain. Recently, it was shown that NMD is repressed during neural development to allow for the stabiliz...

journal_title：RNA biology

authors： Karam R,Wilkinson M

更新日期：2012-01-01 00:00:00

abstract：:De novo addition of telomeric sequences can occur at broken chromosomes and must be well controlled, which is essential during programmed DNA reorganization processes. In ciliated protozoa an extreme form of DNA-reorganization is observed during macronuclear differentiation after sexual reproduction leading to the eli...

journal_title：RNA biology

authors： Fuhrmann G,Jönsson F,Weil PP,Postberg J,Lipps HJ

更新日期：2016-08-02 00:00:00

abstract：:Myocyte enhancer factor 2c (MEF2C) is the MADS-box type transcription factor involved in the differentiation of cardiac and skeletal muscle and synaptic formation. Alternatively spliced transcripts of the MEF2C gene were proven to encode isoforms which exert distinct functions in transcriptional regulation. During the...

journal_title：RNA biology

authors： Lin JC

更新日期：2015-01-01 00:00:00

abstract：:Prokaryotic immunity against foreign nucleic acids mediated by clustered, regularly interspaced, short palindromic repeats (CRISPR) depends on the expression of the CRISPR-associated (Cas) proteins and the formation of small CRISPR RNAs (crRNAs). The crRNA-loaded Cas ribonucleoprotein complexes convey the specific rec...

journal_title：RNA biology

authors： Arslan Z,Stratmann T,Wurm R,Wagner R,Schnetz K,Pul Ü

更新日期：2013-05-01 00:00:00

abstract：:The instructions to make proteins and structural RNAs are laid down in gene sequences. Yet, in certain instances, these primary instructions need to be modified considerably during gene expression, most often at the transcript level. Here we review a case of massive post-transcriptional revisions via trans-splicing an...

journal_title：RNA biology

authors： Valach M,Moreira S,Faktorová D,Lukeš J,Burger G

更新日期：2016-12-01 00:00:00

abstract：:RNA editing in flowering plant mitochondria targets several hundred C nucleotides mostly in mRNAs to be altered to U. Several nuclear encoded genes have been recently identified predominantly in Arabidopsis thaliana which code for proteins involved in specific RNA editing events in plastids or mitochondria. These nucl...

journal_title：RNA biology

authors： Zehrmann A,Verbitskiy D,Härtel B,Brennicke A,Takenaka M

更新日期：2011-01-01 00:00:00

abstract：:Chemical modification of nucleobases plays an important role for the control of gene expression on different levels. That includes the modulation of translation by modified tRNA-bases or silencing and reactivation of genes by methylation and demethylation of cytosine in promoter regions. Especially dynamic methylation...

journal_title：RNA biology

authors： Traube FR,Carell T

更新日期：2017-09-02 00:00:00

abstract：:MicroRNAs are essential for spermatogenesis. However, the stage-specific requirements for particular miRNAs in the male mammalian germ line remain largely uncharacterized. The miR-34 family is, to date, the only miRNA proven to be necessary for the production of sperm in mammals, though its germline roles are poorly u...

journal_title：RNA biology

authors： Hilz S,Fogarty EA,Modzelewski AJ,Cohen PE,Grimson A

更新日期：2017-02-01 00:00:00

abstract：:The NOVA (neuro-oncological ventral antigen) protein family, composed of two paralogs, NOVA1 and NOVA2, consists of RNA-binding proteins involving in processes such as alternative splicing and transport of some target mRNAs. The function of NOVA has been well studied, and increasing evidence has shown that NOVA protei...

journal_title：RNA biology

authors： Tang S,Zhao Y,He X,Zhu J,Chen S,Wen J,Deng Y

更新日期：2020-06-01 00:00:00

abstract：:YchF is one of two universally conserved GTPases with unknown cellular function. As a first step toward elucidating YchF's cellular role, we performed a detailed biochemical characterization of the protein from Escherichia coli. Our data from fluorescence titrations not only confirmed the surprising finding that YchFE...

journal_title：RNA biology

authors： Becker M,Gzyl KE,Altamirano AM,Vuong A,Urban K,Wieden HJ

更新日期：2012-10-01 00:00:00

abstract：:Changing the abundance of transcripts by regulated RNA degradation is a critical step in the control of various biological pathways. Recently, genome-wide inhibitor-free technologies for determining RNA stabilities in mammalian cells have been developed. In these methods, endogenous RNAs are pulse labeled by uridine a...

journal_title：RNA biology

authors： Tani H,Akimitsu N

更新日期：2012-10-01 00:00:00

abstract：:Seryl-tRNA synthetase (SerRS) catalyzes the ligation of serine to the 3'-end of serine tRNA (tRNA(Ser)), which is typical of the type-2 tRNAs characterized by a long extra arm. The SerRSs are divided into two types, the archaeal/eukaryal and bacterial types. In this study, we solved the crystal structures of the SerRS...

journal_title：RNA biology

authors： Itoh Y,Sekine S,Kuroishi C,Terada T,Shirouzu M,Kuramitsu S,Yokoyama S

更新日期：2008-07-01 00:00:00

abstract：:The quaking viable (qk(v)) mice have attracted attention because of their characteristic tremor caused by their dysmyelination. In the central nervous system, qk(v) mice fail to develop mature myelinating oligodendrocytes and display uncompacted myelin. The genetic defect in the qk(v) mice prevents the proper expressi...

journal_title：RNA biology

authors： Larocque D,Richard S

更新日期：2005-04-01 00:00:00

abstract：:The RNase II family of enzymes is ubiquitous and has crucial roles in the processing, degradation and quality control of all types of RNA. These exoribonucleases processively degrade RNA from the 3'-end releasing 5'-nucleotide monophosphates. In prokaryotes, RNase II and RNase R have two N-terminal CSD and one C-termi...

journal_title：RNA biology

authors： Arraiano CM,Matos RG,Barbas A

更新日期：2010-05-01 00:00:00

abstract：:Alternative splicing (AS) plays a central role during cell-fate determination. However, how the core spliceosomal factors (CSFs) are involved in this process is poorly understood. Here, we report the down-regulation of the U2AF1 CSF during stem cell differentiation. To investigate its function in stemness and differen...

journal_title：RNA biology

authors： Laaref AM,Manchon L,Bareche Y,Lapasset L,Tazi J

更新日期：2020-06-01 00:00:00

abstract：:The chromatoid body is a large perinuclear ribonucleoprotein particle of germ cells. The chromatoid body is also present in stem cells from planarians. This particle shares markers specific to protein aggresomes and P-bodies, and concentrate several RNA pathways. The assembly mechanism of chromatoid bodies is unknown,...

journal_title：RNA biology

authors： Roucou X

更新日期：2009-04-01 00:00:00

abstract：:Physical entanglement, and particularly knots arise spontaneously in equilibrated polymers that are sufficiently long and densely packed. Biopolymers are no exceptions: knots have long been known to occur in proteins as well as in encapsidated viral DNA. The rapidly growing number of RNA structures has recently made i...

journal_title：RNA biology

authors： Burton AS,Di Stefano M,Lehman N,Orland H,Micheletti C

更新日期：2016-01-01 00:00:00

abstract：:RNA helicases contribute to diverse aspects of RNA metabolism through their functions in re-arranging RNA structures. Identification of the remodelling targets of RNA helicases is a critical step in elucidating their cellular functions. Here, we show that, in contrast to many other ribosome biogenesis factors, the DEx...

journal_title：RNA biology

authors： Choudhury P,Kretschmer J,Hackert P,Bohnsack KE,Bohnsack MT

更新日期：2020-10-13 00:00:00

abstract：:The question of how cysteinyl-tRNA(Cys) is synthesized in organisms that lack a canonical cysteinyl-tRNA synthetase (CysRS) is an important open question in understanding protein synthesis. The prolyl-tRNA synthetase (ProRS) of wide ranging organisms has the ability to mis-activate cysteine without editing. This raise...

journal_title：RNA biology

authors： Zhang CM,Hou YM

更新日期：2004-05-01 00:00:00

abstract：:We previously showed that miR-122 was frequently downregulated in hepatocellular carcinoma (HCC) and C/EBPα transactivated miR-122 expression. In this study, we found that Sp1 bound to the miR-122 promoter at two different sites. Interestingly, either inhibition or overexpression of Sp1 could decrease the miR-122 prom...

journal_title：RNA biology

authors： Zeng C,Sang Y,Wang FY,Zhuang SM

更新日期：2020-02-01 00:00:00

abstract：:Differential mRNA stability is an important mechanism for regulation of virulence factors in Streptococcus pyogenes (group A streptococcus, GAS), a serious and prevalent human pathogen. We have described 2 Classes of mRNA in GAS that are distinguishable by 1) stability in the stationary phase of growth, 2) kinetics of...

journal_title：RNA biology

authors： Bugrysheva JV,Scott JR

更新日期：2010-09-01 00:00:00

abstract：:RNA exosomes are large multi-subunit protein complexes involved in controlled and processive 3' to 5' RNA degradation. Exosomes form large molecular chambers and harbor multiple nuclease sites as well as RNA binding regions. This makes a quantitative kinetic analysis of RNA degradation with reliable parameter and erro...

journal_title：RNA biology

authors： Niederberger T,Hartung S,Hopfner KP,Tresch A

更新日期：2011-01-01 00:00:00

abstract：:Alzheimer's disease (AD) has devastating consequences for patients during its slow, progressive course. It is important to understand the pathology of AD onset. Recently, circular RNAs (circRNAs) have been found to participate in many human diseases including cancers and neurodegenerative conditions. In this study, we...

journal_title：RNA biology

authors： Lo I,Hill J,Vilhjálmsson BJ,Kjems J

更新日期：2020-12-01 00:00:00

abstract：:The duck represents an important reservoir of influenza viruses for transmission to other avian and mammalian hosts, including humans. The increased pathogenicity of the recently emerging clades of highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype in ducks features systemic viral spread and organ-to...

journal_title：RNA biology

authors： Samir M,Vidal RO,Abdallah F,Capece V,Seehusen F,Geffers R,Hussein A,Ali AAH,Bonn S,Pessler F

更新日期：2020-01-01 00:00:00