RBM4-MEF2C network constitutes a feed-forward circuit that facilitates the differentiation of brown adipocytes.

abstract：:Physical entanglement, and particularly knots arise spontaneously in equilibrated polymers that are sufficiently long and densely packed. Biopolymers are no exceptions: knots have long been known to occur in proteins as well as in encapsidated viral DNA. The rapidly growing number of RNA structures has recently made i...

journal_title：RNA biology

authors： Burton AS,Di Stefano M,Lehman N,Orland H,Micheletti C

更新日期：2016-01-01 00:00:00

abstract：:The synthesis of RNA is highly regulated at all stages by transcription factors. As an essential transcription elongation factor, NusA has been studied biochemically for more than 30 years. However, until now no structural information has been available on NusA-RNAP complexes and the NusA interaction site on RNAP was ...

journal_title：RNA biology

authors： Yang X,Lewis PJ

更新日期：2010-05-01 00:00:00

abstract：:We investigated the gene-expression variation among humans by analysing previously published mRNA-seq and ribosome footprint profiling of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features ...

journal_title：RNA biology

authors： Domitrovic T,Moreira MH,Carneiro RL,Ribeiro-Alves M,Palhano FL

更新日期：2020-12-11 00:00:00

abstract：:We had previously proposed that the post-transcriptional regulation through microRNA as a mechanism for incomplete penetrance and variable expressivity, leads to lack of correlation between genotype and phenotype. Here we report the validation of miRNA-target interactions we predicted earlier and demonstrate the regul...

journal_title：RNA biology

authors： Ahluwalia JK,Soni K,Sivasubbu S,Brahmachari V

更新日期：2012-03-01 00:00:00

abstract：:The subcellular localization of the nonsense mediated decay (NMD) of mRNA transcripts bearing premature termination codons has been controversial. Recently, it has been demonstrated that RNA tethering of key mediators of NMD, including human UPF3B, accurately recreates NMD. Here, we have used tethered UPF3B, combined ...

journal_title：RNA biology

authors： Lu S,Cullen BR

更新日期：2004-05-01 00:00:00

abstract：:AU-rich elements (AREs) are cis-acting instability and translation inhibition elements that are present in the 3'UTR of most inducible inflammatory mRNAs such as TNF and Cxcl2. mRNAs that contain AREs are, by default, repressed and only transiently expressed in response to stimuli. They are targeted by the inducible R...

journal_title：RNA biology

authors： Mahmoud L,Moghrabi W,Khabar KSA,Hitti EG

更新日期：2019-03-01 00:00:00

abstract：:Ribosome biogenesis is an essential process initiated in the nucleolus. In eukaryotes, multiple ribosome biogenesis factors (RBFs) can be found in the nucleolus, the nucleus and in the cytoplasm. They act in processing, folding and modification of the pre-ribosomal (r)RNAs, incorporation of ribosomal proteins (RPs), e...

journal_title：RNA biology

authors： Palm D,Simm S,Darm K,Weis BL,Ruprecht M,Schleiff E,Scharf C

更新日期：2016-01-01 00:00:00

abstract：:Long non-coding RNAs have emerged as an important regulatory layer in biological systems. Of the various types of lncRNAs, one class (designated as divergent RNAs/XH), which is in head-to-head overlap with the coding genes, has emerged as a critical biotype that regulates development and cellular differentiation. This...

journal_title：RNA biology

authors： Prajapati B,Fatma M,Maddhesiya P,Sodhi MK,Fatima M,Dargar T,Bhagat R,Seth P,Sinha S

更新日期：2019-01-01 00:00:00

abstract：:Seryl-tRNA synthetase (SerRS) catalyzes the ligation of serine to the 3'-end of serine tRNA (tRNA(Ser)), which is typical of the type-2 tRNAs characterized by a long extra arm. The SerRSs are divided into two types, the archaeal/eukaryal and bacterial types. In this study, we solved the crystal structures of the SerRS...

journal_title：RNA biology

authors： Itoh Y,Sekine S,Kuroishi C,Terada T,Shirouzu M,Kuramitsu S,Yokoyama S

更新日期：2008-07-01 00:00:00

abstract：:Termination of RNA polymerase II (RNAPII) transcription is a fundamental step of gene expression that involves the release of the nascent transcript and dissociation of RNAPII from the DNA template. As transcription termination is intimately linked to RNA 3' end processing, termination pathways have a key decisive inf...

journal_title：RNA biology

authors： Lemay JF,Bachand F

更新日期：2015-01-01 00:00:00

abstract：:Deinococcus radiodurans is a highly stress resistant bacterium that encodes universal as well as lineage-specific factors involved in DNA transcription and repair. However, the effects of DNA lesions on RNA synthesis by D. radiodurans RNA polymerase (RNAP) have never been studied. We investigated the ability of this R...

journal_title：RNA biology

authors： Agapov A,Esyunina D,Kulbachinskiy A

更新日期：2019-12-01 00:00:00

abstract：:The genome of most prokaryotes gives rise to surprisingly complex transcriptomes, comprising not only protein-coding mRNAs, often organized as operons, but also harbors dozens or even hundreds of highly structured small regulatory RNAs and unexpectedly large levels of anti-sense transcripts. Comprehensive surveys of p...

journal_title：RNA biology

authors： Backofen R,Amman F,Costa F,Findeiß S,Richter AS,Stadler PF

更新日期：2014-01-01 00:00:00

abstract：:Staphylococcus aureus is one of the major human pathogens, which causes numerous community-associated and hospital-acquired infections. The regulation of the expression of numerous virulence factors is coordinated by complex interplays between two component systems, transcriptional regulatory proteins, and regulatory ...

journal_title：RNA biology

authors： Romilly C,Caldelari I,Parmentier D,Lioliou E,Romby P,Fechter P

更新日期：2012-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small noncoding RNAs about 22-nucleotide (nt) in length that collectively regulate more than 60% of coding genes. Aberrant miRNA expression is associated with numerous diseases, including cancer. miRNA biogenesis is licenced by the ribonuclease (RNase) III enzyme Drosha, the regulatio...

journal_title：RNA biology

authors： Dai L,Hallmark L,Bofill De Ros X,Crouch H,Chen S,Shi T,Yang A,Lian C,Zhao Y,Tran B,Gu S

更新日期：2020-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) was the first human cancer-causing virus to be discovered over fifty years ago. Given its relatively large genome size for a virus and hence the capacity to store more than mere protein-coding information, EBV also harbours genetic material for producing an array of distinct noncoding (nc)RNAs...

journal_title：RNA biology

authors： Lee N

更新日期：2021-01-30 00:00:00

abstract：:The quaking viable (qk(v)) mice have attracted attention because of their characteristic tremor caused by their dysmyelination. In the central nervous system, qk(v) mice fail to develop mature myelinating oligodendrocytes and display uncompacted myelin. The genetic defect in the qk(v) mice prevents the proper expressi...

journal_title：RNA biology

authors： Larocque D,Richard S

更新日期：2005-04-01 00:00:00

abstract：:tmRNA employs both tRNA-like and mRNA-like properties as it rescues stalled bacterial ribosomes, while targeting the defective mRNA and incomplete nascent protein for degradation. We describe variation of the tmRNA gene (ssrA) and how it informs tmRNA structure and function. Endosymbiont tmRNAs tend to lose secondary ...

journal_title：RNA biology

authors： Mao C,Bhardwaj K,Sharkady SM,Fish RI,Driscoll T,Wower J,Zwieb C,Sobral BW,Williams KP

更新日期：2009-09-01 00:00:00

abstract：:Type II CRISPR-Cas9 systems require a small RNA called the trans-activating CRISPR RNA (tracrRNA) in order to function. The prediction of these non-coding RNAs in prokaryotic genomes is challenging because they have dissimilar structures, having short stems (3-6 bp) and non-canonical base-pairs e.g. G-A. Much of the t...

journal_title：RNA biology

authors： Chyou TY,Brown CM

更新日期：2019-04-01 00:00:00

abstract：:microRNAs (miRNAs) are critical regulators of gene expression. For elucidating functional roles of miRNAs, it is critical to identify their direct targets. There are debates about whether pulldown of biotinylated miRNA mimics can be used to identify miRNA targets or not. Here we show that biotin-labelled miR-34a can b...

journal_title：RNA biology

authors： Awan HM,Shah A,Rashid F,Wei S,Chen L,Shan G

更新日期：2018-01-02 00:00:00

abstract：:Altered expression levels of protein-coding genes and microRNAs have been implicated in the pathogenesis of Huntington's disease (HD). The involvement of other ncRNAs, especially long ncRNAs (lncRNA), is being realized recently and the related knowledge is still rudimentary. Using small RNA sequencing and PCR arrays w...

journal_title：RNA biology

authors： Chanda K,Das S,Chakraborty J,Bucha S,Maitra A,Chatterjee R,Mukhopadhyay D,Bhattacharyya NP

更新日期：2018-01-01 00:00:00

abstract：:In eukaryotes and viruses that infect them, the 5' end of mRNA molecules, and also many other functionally important RNAs, are modified to form a so-called cap structure that is important for interactions of these RNAs with many nuclear and cytoplasmic proteins. The RNA cap has multiple roles in gene expression, inclu...

journal_title：RNA biology

authors： Byszewska M,Śmietański M,Purta E,Bujnicki JM

更新日期：2014-01-01 00:00:00

abstract：:Trans-activating CRISPR (tracr) RNA is a distinct RNA species that interacts with the CRISPR (cr) RNA to form the dual guide (g) RNA in type II and subtype V-B CRISPR-Cas systems. The tracrRNA-crRNA interaction is essential for pre-crRNA processing as well as target recognition and cleavage. The tracrRNA consists of a...

journal_title：RNA biology

authors： Faure G,Shmakov SA,Makarova KS,Wolf YI,Crawley AB,Barrangou R,Koonin EV

更新日期：2019-04-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) causes anovulatory infertility in women of reproductive age, but etiopathogenesis of PCOS remains undetermined. Taurine up-regulated 1 (TUG1), an evolutionarily conserved long non-coding RNA, performs various biological functions; however, the role of TUG1 in PCOS remains unclear. Here...

journal_title：RNA biology

authors： Li Y,Zhang J,Liu YD,Zhou XY,Chen X,Zhe J,Zhang QY,Zhang XF,Chen YX,Wang Z,Chen SL

更新日期：2020-12-01 00:00:00

abstract：:Non-coding RNA (ncRNA) molecules have fundamental roles in cells and many are also stable in body fluids as extracellular RNAs. In this study, we used RNA sequencing (RNA-seq) to investigate the profile of small non-coding RNA (sncRNA) in human serum. We analyzed 10 billion Illumina reads from 477 serum samples, inclu...

journal_title：RNA biology

authors： Umu SU,Langseth H,Bucher-Johannessen C,Fromm B,Keller A,Meese E,Lauritzen M,Leithaug M,Lyle R,Rounge TB

更新日期：2018-02-01 00:00:00

abstract：:Sin Nombre hantavirus (SNV) is a New World hantavirus and causes hantavirus cardiopulmonary syndrome. The viral nucleocapsid protein (N) is an RNA chaperone and has multiple functions important in virus replication. The three negative sense RNA segments of hantaviruses form panhandle structures through imperfect hydro...

journal_title：RNA biology

authors： Brown BA,Panganiban AT

更新日期：2010-11-01 00:00:00

abstract：:The protein domain arrangement known as the La-module, comprised of a La motif (LaM) followed by a linker and RNA recognition motif (RRM), is found in seven La-related proteins: LARP1, LARP1B, LARP3 (La protein), LARP4, LARP4B, LARP6, and LARP7 in humans. Several LARPs have been characterized for their distinct activi...

journal_title：RNA biology

authors： Mattijssen S,Kozlov G,Gaidamakov S,Ranjan A,Fonseca BD,Gehring K,Maraia RJ

更新日期：2020-12-23 00:00:00

abstract：:In a series of conceptual articles published around the millennium, Carl Woese emphasized that evolution of cells is the central problem of evolutionary biology, that the three-domain ribosomal tree of life is an essential framework for reconstructing cellular evolution, and that the evolutionary dynamics of functiona...

journal_title：RNA biology

authors： Koonin EV

更新日期：2014-01-01 00:00:00

abstract：:Earlier we have demonstrated the presence of internal ribosome entry site (IRES) within tumor suppressor p53 mRNA. Here we have mapped the putative secondary structure of p53- IRES RNA using information from chemical probing and nuclease mapping experiments. Additionally, the secondary structure of the IRES element of...

journal_title：RNA biology

authors： Grover R,Sharathchandra A,Ponnuswamy A,Khan D,Das S

更新日期：2011-01-01 00:00:00

abstract：:RNase J is a prokaryotic 5'-3' exo/endoribonuclease that functions in mRNA decay and rRNA maturation. Here, we report a novel duplex unwinding activity of mpy-RNase J, an archaeal RNase J from Methanolobus psychrophilus, which enables it to degrade duplex RNAs with hairpins up to 40 bp when linking a 5' single-strande...

journal_title：RNA biology

authors： Li J,Hou Y,Gu X,Yue L,Guo L,Li D,Dong X

更新日期：2020-10-01 00:00:00

abstract：:RNA exosomes are large multi-subunit protein complexes involved in controlled and processive 3' to 5' RNA degradation. Exosomes form large molecular chambers and harbor multiple nuclease sites as well as RNA binding regions. This makes a quantitative kinetic analysis of RNA degradation with reliable parameter and erro...

journal_title：RNA biology

authors： Niederberger T,Hartung S,Hopfner KP,Tresch A

更新日期：2011-01-01 00:00:00