Abstract:
:The synthesis of RNA is highly regulated at all stages by transcription factors. As an essential transcription elongation factor, NusA has been studied biochemically for more than 30 years. However, until now no structural information has been available on NusA-RNAP complexes and the NusA interaction site on RNAP was a point of speculation. Determination of the structure of RNA polymerase in complex with NusA is helping us understand how NusA regulates transcription. The resulting model of RNA polymerase in complex with NusA has shed light on the transition from the initiation to elongation stages of transcription, and how NusA functions in promoting regulatory pausing and termination.
journal_name
RNA Bioljournal_title
RNA biologyauthors
Yang X,Lewis PJdoi
10.4161/rna.7.3.12021subject
Has Abstractpub_date
2010-05-01 00:00:00pages
272-5issue
3eissn
1547-6286issn
1555-8584pii
12021journal_volume
7pub_type
杂志文章,评审相关文献
RNA Biology文献大全abstract::A-to-I RNA editing by adenosine deaminases acting on RNA is a post-transcriptional modification that is crucial for normal life and development in vertebrates. RNA editing has been shown to be very abundant in the human transcriptome, specifically at the primate-specific Alu elements. The functional role of this wide-...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/15476286.2014.992286
更新日期:2014-01-01 00:00:00
abstract::The PDCD1 gene encodes PD-1, an important immune checkpoint protein and key immunotherapy target to treat cancer. PDCD1 is alternatively spliced to generate an exon 3-skipped isoform PD-1Δ3 that has been suggested to play an antagonistic role to PD-1, but the mechanism underlying alternative splicing of PDCD1 has neve...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1659080
更新日期:2019-12-01 00:00:00
abstract::In mammals, the genic disequilibrium between males (XY) and females (XX) is resolved through the inactivation of one of the X-chromosomes in females. X-chromosome inactivation (XCI) takes place in all mammalian species, but has mainly been studied in the mouse model where it was shown to be controlled by the interplay...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.25802
更新日期:2013-08-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) causes anovulatory infertility in women of reproductive age, but etiopathogenesis of PCOS remains undetermined. Taurine up-regulated 1 (TUG1), an evolutionarily conserved long non-coding RNA, performs various biological functions; however, the role of TUG1 in PCOS remains unclear. Here...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1783850
更新日期:2020-12-01 00:00:00
abstract::"What does one do when the giants pass away?" remarked a very famous microbiologist to me, soon after the death of Carl Woese in late 2012. I teach microbiology and introductory cell and molecular biology at a small undergraduate institution; Woese's example and contributions have long been part of every class I teach...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.28002
更新日期:2014-01-01 00:00:00
abstract::The HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone, which remodels nucleic acid structures so that the most thermodynamically stable conformations are formed. This activity is essential for virus replication and has a critical role in mediating highly specific and efficient reverse transcription. NC's fun...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.6.14115
更新日期:2010-11-01 00:00:00
abstract::RNA-binding proteins (RBPs) are key regulators of posttranscriptional processes such as RNA maturation, localization, turnover and translation. Despite their dysregulation in various diseases including cancer, the landscape of RBP expression in human cancer has not been well elucidated. Here, we built a comprehensive ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1673657
更新日期:2020-02-01 00:00:00
abstract::As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst. The chaperoning function is found intrinsic to ribozymes involved in protein synthesis and tRNA maturation, enriching the primordial RNA world with ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1801199
更新日期:2021-01-01 00:00:00
abstract::Riboswitches are cis-encoded, cis-acting RNA elements that directly sense a physiological signal. Signal response results in a change in RNA structure that impacts gene expression. Elements of this type play an important role in bacteria, where they regulate a variety of fundamental cellular pathways. Riboswitch-media...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.1.10757
更新日期:2010-01-01 00:00:00
abstract::The human genome encodes several thousand long non-protein coding transcripts>200 nucleotides in length, a subset of which were shown to play important roles in regulation of gene expression. We recently identified TINCR, a lncRNA required for induction of key differentiation genes in epidermal tissue, including genes...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.26249
更新日期:2013-10-01 00:00:00
abstract::AU-rich elements (AREs) are cis-acting instability and translation inhibition elements that are present in the 3'UTR of most inducible inflammatory mRNAs such as TNF and Cxcl2. mRNAs that contain AREs are, by default, repressed and only transiently expressed in response to stimuli. They are targeted by the inducible R...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1572437
更新日期:2019-03-01 00:00:00
abstract::The subcellular localization of the nonsense mediated decay (NMD) of mRNA transcripts bearing premature termination codons has been controversial. Recently, it has been demonstrated that RNA tethering of key mediators of NMD, including human UPF3B, accurately recreates NMD. Here, we have used tethered UPF3B, combined ...
journal_title:RNA biology
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract::Ribosome biogenesis is an essential process initiated in the nucleolus. In eukaryotes, multiple ribosome biogenesis factors (RBFs) can be found in the nucleolus, the nucleus and in the cytoplasm. They act in processing, folding and modification of the pre-ribosomal (r)RNAs, incorporation of ribosomal proteins (RPs), e...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2016.1154252
更新日期:2016-01-01 00:00:00
abstract::The universal genetic code is a translation table by which nucleic acid sequences can be interpreted as polypeptides with a wide range of biological functions. That information is used by aminoacyl-tRNA synthetases to translate the code. Moreover, amino acid properties dictate protein folding. We recently reported tha...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2015.1112488
更新日期:2016-01-01 00:00:00
abstract::We investigated the gene-expression variation among humans by analysing previously published mRNA-seq and ribosome footprint profiling of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1857508
更新日期:2020-12-11 00:00:00
abstract::The genus Xanthomonas comprises a large group of plant-pathogenic bacteria. The infection and bacterial multiplication in the plant tissue depends on the type III secretion system and other virulence determinants. Recent studies revealed that bacterial virulence is also controlled at the post-transcriptional level by ...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.28240
更新日期:2014-01-01 00:00:00
abstract::Circular RNAs (circRNAs) have been identified in diverse eukaryotic species and are characterized by RNA backsplicing events. Current available methods for circRNA identification are able to determine the start and end locations of circRNAs in the genome but not their full-length sequences. In this study, we developed...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2016.1245268
更新日期:2017-08-03 00:00:00
abstract::In an earlier report two P-transposon insertion alleles of the noncoding hsromega gene, hsromega(05241) and P292 were shown to enhance neurodegeneration caused by expression of ataxin-1 protein with expanded poly-Q in a Drosophila model. In present study, we examined the possible relation between hsromega gene express...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.3.1.2559
更新日期:2006-01-01 00:00:00
abstract::Wobble uridines (U34) are generally modified in all species. U34 modifications can be essential in metazoans but are not required for viability in fungi. In this review, we provide an overview on the types of modifications and how they affect the physico-chemical properties of wobble uridines. We describe the molecula...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.1080/15476286.2017.1295204
更新日期:2017-09-02 00:00:00
abstract::The Hedgehog (HH) signaling pathway has important roles in tumorigenesis and in embryonal patterning. The Glioma-associated oncogene 1 (GLI1) is a key molecule in HH signaling, acting as a transcriptional effector and, moreover, is considered to be a potential therapeutic target for several types of cancer. To extend ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.23343
更新日期:2013-02-01 00:00:00
abstract::The NOVA (neuro-oncological ventral antigen) protein family, composed of two paralogs, NOVA1 and NOVA2, consists of RNA-binding proteins involving in processes such as alternative splicing and transport of some target mRNAs. The function of NOVA has been well studied, and increasing evidence has shown that NOVA protei...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1734372
更新日期:2020-06-01 00:00:00
abstract::We previously showed that miR-122 was frequently downregulated in hepatocellular carcinoma (HCC) and C/EBPα transactivated miR-122 expression. In this study, we found that Sp1 bound to the miR-122 promoter at two different sites. Interestingly, either inhibition or overexpression of Sp1 could decrease the miR-122 prom...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1673656
更新日期:2020-02-01 00:00:00
abstract::We report here an in-depth characterization of the aptamer domain of the transcriptional adenine-sensing riboswitch (pbuE) by NMR and fluorescence spectroscopy. By NMR studies, the structure of two aptamer sequences with different lengths of the helix P1, the central element involved in riboswitch conformational switc...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.29439
更新日期:2014-01-01 00:00:00
abstract::The innate immune system is the frontline host protection against pathogens. Effective antiviral immunity is elicited upon recognition of viral RNAs by the host pattern recognition receptors. One of the major viral RNA sensors is retinoic acid inducible gene-1, which triggers the production of interferons (IFNs). In t...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1624471
更新日期:2019-09-01 00:00:00
abstract::The protein domain arrangement known as the La-module, comprised of a La motif (LaM) followed by a linker and RNA recognition motif (RRM), is found in seven La-related proteins: LARP1, LARP1B, LARP3 (La protein), LARP4, LARP4B, LARP6, and LARP7 in humans. Several LARPs have been characterized for their distinct activi...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1860376
更新日期:2020-12-23 00:00:00
abstract::Translation begins at AUG, GUG, or UUG codons in bacteria. Start codon recognition occurs in the P site, which may help explain this first-position degeneracy. However, the molecular basis of start codon specificity remains unclear. In this study, we measured the codon dependence of 30S•mRNA•tRNAfMet and 30S•mRNA•tRNA...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2017.1379636
更新日期:2018-01-01 00:00:00
abstract::At low temperatures the Escherichia coli rpoS mRNA, encoding the stationary phase sigma factor RpoS, forms an intramolecular secondary structure (iss) that impedes translation initiation. Under these conditions the small RNA DsrA, which is stabilzed by Hfq, forms a duplex with rpoS mRNA sequences opposite of the ribos...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.27100
更新日期:2013-12-01 00:00:00
abstract::Many splicing regulators bind to their own pre-mRNAs to induce alternative splicing that leads to formation of unstable mRNA isoforms. This provides an autoregulatory feedback mechanism that regulates the cellular homeostasis of these factors. We have described such an autoregulatory mechanism for two core protein com...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2015.1096489
更新日期:2015-01-01 00:00:00
abstract::The importance of telomere function for human health is exemplified by a collection of Mendelian disorders referred to as the telomere biology disorders (TBDs), telomeropathies, or syndromes of telomere shortening. Collectively, the TBDs cover a spectrum of conditions from multisystem disease presenting in infancy to ...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.1080/15476286.2015.1094596
更新日期:2016-08-02 00:00:00
abstract::Single-stranded oligonucleotides (ssOligos) are efficiently taken up by living cells without the use of transfection reagents. This phenomenon called 'gymnosis' enables the sequence-specific silencing of target genes in various types of cells. Several antisense ssOligos are used for the treatment of human diseases. Ho...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2017.1302641
更新日期:2017-11-02 00:00:00