Abstract:
:In mammals, the genic disequilibrium between males (XY) and females (XX) is resolved through the inactivation of one of the X-chromosomes in females. X-chromosome inactivation (XCI) takes place in all mammalian species, but has mainly been studied in the mouse model where it was shown to be controlled by the interplay of several long non-coding RNA (lncRNA). However, recent data point toward the existence of species divergences among mammals in the strategies used to achieve XCI. The recent discovery of XACT, a novel lncRNA that coats the active X-chromosome specifically in human pluripotent cells, further highlights the existence of human-specific mechanisms of X-chromosome regulation. Here, we discuss the roles of lncRNAs in defining species-specific mechanisms controlling X-inactivation and explore the potential role of large lncRNAs in gene activation.
journal_name
RNA Bioljournal_title
RNA biologyauthors
Vallot C,Rougeulle Cdoi
10.4161/rna.25802subject
Has Abstractpub_date
2013-08-01 00:00:00pages
1262-5issue
8eissn
1547-6286issn
1555-8584pii
25802journal_volume
10pub_type
杂志文章相关文献
RNA Biology文献大全abstract::High concentrations (> 100 µM) of the ribonucleoside analog 4-thiouridine (4sU) is widely used in methods for RNA analysis like photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) and nascent messenger (m)RNA labeling (4sU-tagging). Here, we show that 4sU-tagging at low concentrati...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.26214
更新日期:2013-10-01 00:00:00
abstract::Viroids are non-coding single-stranded circular RNA molecules that replicate autonomously in infected host plants causing mild to lethal symptoms. Their genomes contain about 250-400 nucleotides, depending on viroid species. Members of the family Pospiviroidae, like the Potato spindle tuber viroid (PSTVd), replicate v...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2016.1272745
更新日期:2017-03-04 00:00:00
abstract::MicroRNAs (miRNAs) are key regulators of gene expression and play critical roles in modulating metabolism, development and physiology in animals and plants. miRNA levels are transcriptionally and post-transcriptionally controlled for their proper function. Recent studies have shown that RNA-binding proteins play impor...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.22740
更新日期:2012-12-01 00:00:00
abstract::We investigated the gene-expression variation among humans by analysing previously published mRNA-seq and ribosome footprint profiling of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1857508
更新日期:2020-12-11 00:00:00
abstract::Translation begins at AUG, GUG, or UUG codons in bacteria. Start codon recognition occurs in the P site, which may help explain this first-position degeneracy. However, the molecular basis of start codon specificity remains unclear. In this study, we measured the codon dependence of 30S•mRNA•tRNAfMet and 30S•mRNA•tRNA...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2017.1379636
更新日期:2018-01-01 00:00:00
abstract::The instructions to make proteins and structural RNAs are laid down in gene sequences. Yet, in certain instances, these primary instructions need to be modified considerably during gene expression, most often at the transcript level. Here we review a case of massive post-transcriptional revisions via trans-splicing an...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.1080/15476286.2016.1240143
更新日期:2016-12-01 00:00:00
abstract::Nonsense-mediated decay (NMD) is a RNA surveillance pathway that degrades subsets of normal and aberrant mRNAs. Mutations that perturb NMD cause neurological disorders in humans, suggesting that NMD has roles in the brain. Recently, it was shown that NMD is repressed during neural development to allow for the stabiliz...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.9.1.18010
更新日期:2012-01-01 00:00:00
abstract::How have the branchpoint motifs evolved in organisms of different complexity? Here we identified and examined the consensus motifs (R1C2T3R4A5Y6, R: A or G, Y: C or T) of 898 fungal genomes. In Ascomycota unicellular yeasts, the G4/A4 ratio is mostly (98%) below 0.125 but increases sharply in multicellular species by ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1697548
更新日期:2020-03-01 00:00:00
abstract::Proper base-pairing of a miRNA with its target mRNA is a key step in miRNA-mediated mRNA repression. RNA remodelling by RNA-binding proteins (RBPs) can improve access of miRNAs to their target mRNAs. The largest isoform p45 of the RBP AUF1 has previously been shown to remodel viral or AU-rich RNA elements. Here, we sh...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1822637
更新日期:2020-09-29 00:00:00
abstract::In plants, Potato spindle tuber viroid (PSTVd) replication triggers post-transcriptional gene silencing (PTGS) and RNA-directed DNA methylation (RdDM) of homologous RNA and DNA sequences, respectively. PTGS predominantly occurs in the cytoplasm, but nuclear PTGS has been also reported. In this study, we investigated w...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2015.1017216
更新日期:2015-01-01 00:00:00
abstract::The synthesis of RNA is highly regulated at all stages by transcription factors. As an essential transcription elongation factor, NusA has been studied biochemically for more than 30 years. However, until now no structural information has been available on NusA-RNAP complexes and the NusA interaction site on RNAP was ...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.3.12021
更新日期:2010-05-01 00:00:00
abstract::RNA exosomes are large multi-subunit protein complexes involved in controlled and processive 3' to 5' RNA degradation. Exosomes form large molecular chambers and harbor multiple nuclease sites as well as RNA binding regions. This makes a quantitative kinetic analysis of RNA degradation with reliable parameter and erro...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.1.14067
更新日期:2011-01-01 00:00:00
abstract::Genuine La and La-related proteins group 7 (LARP7) bind to the non-coding RNAs transcribed by RNA polymerase III (RNAPIII), which end in UUU-3'OH. The La motif and RRM1 of these proteins (the La module) cooperate to bind the UUU-3'OH, protecting the RNA from degradation, while other domains may be important for RNA fo...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.23608
更新日期:2013-03-01 00:00:00
abstract::One of the many important consequences that temperature down-shift has on cells is stabilization of secondary structures of RNAs. This stabilization has wide-spread effects, such as inhibition of expression of several genes due to termination of their transcription and inefficient RNA degradation that adversely affect...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.6.13482
更新日期:2010-11-01 00:00:00
abstract::RNA editing in flowering plant mitochondria targets several hundred C nucleotides mostly in mRNAs to be altered to U. Several nuclear encoded genes have been recently identified predominantly in Arabidopsis thaliana which code for proteins involved in specific RNA editing events in plastids or mitochondria. These nucl...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.1.14298
更新日期:2011-01-01 00:00:00
abstract::Telomeres, protective nucleoprotein structures located at the ends of eukaryotic chromosomes and until recently regarded as transcriptionally silent, are now known to be transcribed into non-coding RNA molecules called TERRA. The function(s) of TERRA in telomere metabolism is now the subject of intense study given the...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.1.10257
更新日期:2010-01-01 00:00:00
abstract::By differential high-throughput RNA sequencing (dRNA-seq) we have identified "product RNAs" (pRNAs) as short as 8-12 nucleotides that are synthesized by Bacillus subtilis RNA polymerase (RNAP) in vivo using the regulatory 6S-1 RNA as template. The dRNA-seq data were confirmed by in vitro transcription experiments and ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.5.16151
更新日期:2011-09-01 00:00:00
abstract::The two major steps of gene expression are transcription and translation. While hundreds of studies regarding the effect of sequence features on the translation elongation process have been published, very few connect sequence features to the transcription elongation rate. We suggest, for the first time, that short tr...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2017.1384118
更新日期:2018-01-02 00:00:00
abstract::Staphylococcus aureus is one of the major human pathogens, which causes numerous community-associated and hospital-acquired infections. The regulation of the expression of numerous virulence factors is coordinated by complex interplays between two component systems, transcriptional regulatory proteins, and regulatory ...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.20103
更新日期:2012-04-01 00:00:00
abstract::RNA helicases contribute to diverse aspects of RNA metabolism through their functions in re-arranging RNA structures. Identification of the remodelling targets of RNA helicases is a critical step in elucidating their cellular functions. Here, we show that, in contrast to many other ribosome biogenesis factors, the DEx...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1829366
更新日期:2020-10-13 00:00:00
abstract::Contributions of dietary miRNAs to circulating small RNA profiles would have profound implications for interpretation of miRNA biomarker studies: presumptive disease-specific markers might instead indicate responses to disease-associated quantitative or qualitative dietary alteration. This examination weighs the evide...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.21619
更新日期:2012-09-01 00:00:00
abstract::The immaculate annotation of all microRNAs (miRNAs) is a prerequisite to study their biological function on a genome-wide scale. However, the original criteria for proper miRNA annotation seem unsuited for the automated analysis of the immense number of small RNA reads available in next generation sequencing (NGS) dat...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.3.14333
更新日期:2011-05-01 00:00:00
abstract::RNase J is a prokaryotic 5'-3' exo/endoribonuclease that functions in mRNA decay and rRNA maturation. Here, we report a novel duplex unwinding activity of mpy-RNase J, an archaeal RNase J from Methanolobus psychrophilus, which enables it to degrade duplex RNAs with hairpins up to 40 bp when linking a 5' single-strande...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1777379
更新日期:2020-10-01 00:00:00
abstract::Processing bodies (P-bodies) are cytoplasmatic mRNP granules containing non-translating mRNAs and proteins from the mRNA decay and silencing machineries. The mechanism of P-body assembly has been typically addressed by depleting P-body components. Here we apply a complementary approach and establish an automated cell-...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.26851
更新日期:2013-11-01 00:00:00
abstract::A recent study revealed that poly(A)-binding protein (PABP) bound to poly(A) RNA exhibits a sharply bent configuration at the linker region between RNA-recognition motif 2 (RRM2) and RRM3, whereas free PABP exhibits a highly flexible linear configuration. However, the physiological role of the bent structure of mRNA-b...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2017.1280224
更新日期:2017-03-04 00:00:00
abstract::Type II CRISPR-Cas9 systems require a small RNA called the trans-activating CRISPR RNA (tracrRNA) in order to function. The prediction of these non-coding RNAs in prokaryotic genomes is challenging because they have dissimilar structures, having short stems (3-6 bp) and non-canonical base-pairs e.g. G-A. Much of the t...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2018.1498281
更新日期:2019-04-01 00:00:00
abstract::Alternative splicing (AS) plays a central role during cell-fate determination. However, how the core spliceosomal factors (CSFs) are involved in this process is poorly understood. Here, we report the down-regulation of the U2AF1 CSF during stem cell differentiation. To investigate its function in stemness and differen...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1733800
更新日期:2020-06-01 00:00:00
abstract::Circular RNAs (circRNAs) are closely associated with the development of non-small cell lung cancer (NSCLC); however, it is still unclear whether circular RNA circ-LDLRAD3 participated in the regulation of NSCLC progression. In this study, we found that circ-LDLRAD3 was high-expressed and miR-137 was low-expressed in N...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1789819
更新日期:2020-12-01 00:00:00
abstract::Transcriptional regulation of microRNA (miRNA) expression is one of the least understood aspects of miRNA biogenesis. In C. elegans the list of miRNAs whose transcriptional control has been described in some detail is currently limited to four: let-7, lin-4, lsy-6, and mir-61. Each of these genes has been shown experi...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.6.1.7574
更新日期:2009-01-01 00:00:00
abstract::Earlier we have demonstrated the presence of internal ribosome entry site (IRES) within tumor suppressor p53 mRNA. Here we have mapped the putative secondary structure of p53- IRES RNA using information from chemical probing and nuclease mapping experiments. Additionally, the secondary structure of the IRES element of...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.1.14260
更新日期:2011-01-01 00:00:00