Abstract:
:Differential mRNA stability is an important mechanism for regulation of virulence factors in Streptococcus pyogenes (group A streptococcus, GAS), a serious and prevalent human pathogen. We have described 2 Classes of mRNA in GAS that are distinguishable by 1) stability in the stationary phase of growth, 2) kinetics of decay in exponential phase, and 3) effect of depletion of RNases J1 and J2 and polynucleotide phosphorylase (PNPase) on decay in exponential phase. We discuss features of the structure of an mRNA that appear to be important for determining the Class to which it belongs and present a model to explain differential mRNA decay.
journal_name
RNA Bioljournal_title
RNA biologyauthors
Bugrysheva JV,Scott JRdoi
10.4161/rna.7.5.13097subject
Has Abstractpub_date
2010-09-01 00:00:00pages
569-72issue
5eissn
1547-6286issn
1555-8584pii
13097journal_volume
7pub_type
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