microRNA-21: a key modulator in oncogenic viral infections.

abstract：:MicroRNAs (miRNAs) are a class of small noncoding RNAs about 22-nucleotide (nt) in length that collectively regulate more than 60% of coding genes. Aberrant miRNA expression is associated with numerous diseases, including cancer. miRNA biogenesis is licenced by the ribonuclease (RNase) III enzyme Drosha, the regulatio...

journal_title：RNA biology

authors： Dai L,Hallmark L,Bofill De Ros X,Crouch H,Chen S,Shi T,Yang A,Lian C,Zhao Y,Tran B,Gu S

更新日期：2020-11-01 00:00:00

abstract：:Bacteria, like mammals, have to constantly defend themselves from viral attack. Like mammals, they use both innate and adaptive defense mechanisms. In this point of view we highlight the commonalities between defense systems of bacteria and mammals. Our focus is on the recently discovered bacterial adaptive immune sys...

journal_title：RNA biology

authors： Goren M,Yosef I,Edgar R,Qimron U

更新日期：2012-05-01 00:00:00

abstract：:Translation begins at AUG, GUG, or UUG codons in bacteria. Start codon recognition occurs in the P site, which may help explain this first-position degeneracy. However, the molecular basis of start codon specificity remains unclear. In this study, we measured the codon dependence of 30S•mRNA•tRNAfMet and 30S•mRNA•tRNA...

journal_title：RNA biology

authors： Roy B,Liu Q,Shoji S,Fredrick K

更新日期：2018-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are key regulators of gene expression and play critical roles in modulating metabolism, development and physiology in animals and plants. miRNA levels are transcriptionally and post-transcriptionally controlled for their proper function. Recent studies have shown that RNA-binding proteins play impor...

journal_title：RNA biology

authors： Ren G,Yu B

更新日期：2012-12-01 00:00:00

abstract：:tRNA-dependent addition of amino acids to lipids on the outer surface of the bacterial membrane results in decreased effectiveness of antimicrobials such as cationic antimicrobial peptides (CAMPs) that target the membrane, and increased virulence of several pathogenic species. After a brief introduction to CAMPs and t...

journal_title：RNA biology

authors： Fields RN,Roy H

更新日期：2018-01-01 00:00:00

abstract：:The acquisition of antibiotic resistance by human pathogens poses a significant threat to public health. The mechanisms that control the proliferation and expression of antibiotic resistance genes are not yet completely understood. The aminoglycosides are a historically important class of antibiotics that were introdu...

journal_title：RNA biology

authors： He W,Zhang X,Zhang J,Jia X,Zhang J,Sun W,Jiang H,Chen D,Murchie AI

更新日期：2013-08-01 00:00:00

abstract：:In eukaryotes and viruses that infect them, the 5' end of mRNA molecules, and also many other functionally important RNAs, are modified to form a so-called cap structure that is important for interactions of these RNAs with many nuclear and cytoplasmic proteins. The RNA cap has multiple roles in gene expression, inclu...

journal_title：RNA biology

authors： Byszewska M,Śmietański M,Purta E,Bujnicki JM

更新日期：2014-01-01 00:00:00

abstract：:The RIG-I-like receptors (RLRs)--RIG-I, MDA5, and LGP2--detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. The protein architecture of the RLR family consists of multiple functional domains, including N-terminal Caspase Activation and Recruitment Domains (CARDs) for sig...

journal_title：RNA biology

authors： Luo D

更新日期：2014-01-01 00:00:00

abstract：:High concentrations (> 100 µM) of the ribonucleoside analog 4-thiouridine (4sU) is widely used in methods for RNA analysis like photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) and nascent messenger (m)RNA labeling (4sU-tagging). Here, we show that 4sU-tagging at low concentrati...

journal_title：RNA biology

authors： Burger K,Mühl B,Kellner M,Rohrmoser M,Gruber-Eber A,Windhager L,Friedel CC,Dölken L,Eick D

更新日期：2013-10-01 00:00:00

abstract：:This review emphasizes the function and regulation of the Csr regulatory system in the human enteropathogen Yersinia pseudotuberculosis and compares its features with the homologous Csr/Rsm systems of related pathogens. The Csr/Rsm systems of eubacteria form a complex regulatory network in which redundant non-translat...

journal_title：RNA biology

authors： Heroven AK,Böhme K,Dersch P

更新日期：2012-04-01 00:00:00

abstract：:We previously showed that miR-122 was frequently downregulated in hepatocellular carcinoma (HCC) and C/EBPα transactivated miR-122 expression. In this study, we found that Sp1 bound to the miR-122 promoter at two different sites. Interestingly, either inhibition or overexpression of Sp1 could decrease the miR-122 prom...

journal_title：RNA biology

authors： Zeng C,Sang Y,Wang FY,Zhuang SM

更新日期：2020-02-01 00:00:00

abstract：:The immaculate annotation of all microRNAs (miRNAs) is a prerequisite to study their biological function on a genome-wide scale. However, the original criteria for proper miRNA annotation seem unsuited for the automated analysis of the immense number of small RNA reads available in next generation sequencing (NGS) dat...

journal_title：RNA biology

authors： Hansen TB,Kjems J,Bramsen JB

更新日期：2011-05-01 00:00:00

abstract：:Wobble uridines (U34) are generally modified in all species. U34 modifications can be essential in metazoans but are not required for viability in fungi. In this review, we provide an overview on the types of modifications and how they affect the physico-chemical properties of wobble uridines. We describe the molecula...

journal_title：RNA biology

authors： Schaffrath R,Leidel SA

更新日期：2017-09-02 00:00:00

abstract：:The question of how cysteinyl-tRNA(Cys) is synthesized in organisms that lack a canonical cysteinyl-tRNA synthetase (CysRS) is an important open question in understanding protein synthesis. The prolyl-tRNA synthetase (ProRS) of wide ranging organisms has the ability to mis-activate cysteine without editing. This raise...

journal_title：RNA biology

authors： Zhang CM,Hou YM

更新日期：2004-05-01 00:00:00

abstract：:As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst. The chaperoning function is found intrinsic to ribozymes involved in protein synthesis and tRNA maturation, enriching the primordial RNA world with ...

journal_title：RNA biology

authors： Son A,Horowitz S,Seong BL

更新日期：2021-01-01 00:00:00

abstract：:Circular RNAs (circRNAs) have been identified in diverse eukaryotic species and are characterized by RNA backsplicing events. Current available methods for circRNA identification are able to determine the start and end locations of circRNAs in the genome but not their full-length sequences. In this study, we developed...

journal_title：RNA biology

authors： Ye CY,Zhang X,Chu Q,Liu C,Yu Y,Jiang W,Zhu QH,Fan L,Guo L

更新日期：2017-08-03 00:00:00

abstract：:We report here an in-depth characterization of the aptamer domain of the transcriptional adenine-sensing riboswitch (pbuE) by NMR and fluorescence spectroscopy. By NMR studies, the structure of two aptamer sequences with different lengths of the helix P1, the central element involved in riboswitch conformational switc...

journal_title：RNA biology

authors： Nozinovic S,Reining A,Kim YB,Noeske J,Schlepckow K,Wöhnert J,Schwalbe H

更新日期：2014-01-01 00:00:00

abstract：:Alternative splicing (AS) in response to changing external conditions often requires alterations in the ability of sequence-specific RNA-binding proteins to bind to cis-acting sequences in their target pre-mRNA. While daily oscillations in AS events have been described in several organisms, cis-acting sequences that c...

journal_title：RNA biology

authors： Goldammer G,Neumann A,Strauch M,Müller-McNicoll M,Heyd F,Preußner M

更新日期：2018-01-01 00:00:00

abstract：:Non-coding RNA (ncRNA) molecules have fundamental roles in cells and many are also stable in body fluids as extracellular RNAs. In this study, we used RNA sequencing (RNA-seq) to investigate the profile of small non-coding RNA (sncRNA) in human serum. We analyzed 10 billion Illumina reads from 477 serum samples, inclu...

journal_title：RNA biology

authors： Umu SU,Langseth H,Bucher-Johannessen C,Fromm B,Keller A,Meese E,Lauritzen M,Leithaug M,Lyle R,Rounge TB

更新日期：2018-02-01 00:00:00

abstract：:Eukaryotic gene expression must be coordinated for the proper functioning of biological processes. This coordination can be achieved both at the transcriptional and post-transcriptional levels. In both cases, regulatory sequences placed at either promoter regions or on UTRs function as markers recognized by regulators...

journal_title：RNA biology

authors： Yoon K,Ko D,Doderer M,Livi CB,Penalva LO

更新日期：2008-10-01 00:00:00

abstract：:Alzheimer's disease (AD) has devastating consequences for patients during its slow, progressive course. It is important to understand the pathology of AD onset. Recently, circular RNAs (circRNAs) have been found to participate in many human diseases including cancers and neurodegenerative conditions. In this study, we...

journal_title：RNA biology

authors： Lo I,Hill J,Vilhjálmsson BJ,Kjems J

更新日期：2020-12-01 00:00:00

abstract：:microRNAs (miRNAs) are critical regulators of gene expression. For elucidating functional roles of miRNAs, it is critical to identify their direct targets. There are debates about whether pulldown of biotinylated miRNA mimics can be used to identify miRNA targets or not. Here we show that biotin-labelled miR-34a can b...

journal_title：RNA biology

authors： Awan HM,Shah A,Rashid F,Wei S,Chen L,Shan G

更新日期：2018-01-02 00:00:00

abstract：:Ribosome biogenesis drives cell growth and proliferation, but mechanisms that modulate this process remain poorly understood. For a long time, small rRNA sequences have been widely treated as non-specific degradation products and neglected as garbage sequences. Recently, we identified a new class of antisense ribosoma...

journal_title：RNA biology

authors： Zhou X,Chen X,Wang Y,Feng X,Guang S

更新日期：2017-11-02 00:00:00

abstract：:The development of rigorous molecular taxonomy pioneered by Carl Woese has freed evolution science to explore numerous cellular activities that lead to genome change in evolution. These activities include symbiogenesis, inter- and intracellular horizontal DNA transfer, incorporation of DNA from infectious agents, and ...

journal_title：RNA biology

authors： Shapiro JA

更新日期：2014-01-01 00:00:00

abstract：:Changing the abundance of transcripts by regulated RNA degradation is a critical step in the control of various biological pathways. Recently, genome-wide inhibitor-free technologies for determining RNA stabilities in mammalian cells have been developed. In these methods, endogenous RNAs are pulse labeled by uridine a...

journal_title：RNA biology

authors： Tani H,Akimitsu N

更新日期：2012-10-01 00:00:00

abstract：:The quaking viable (qk(v)) mice have attracted attention because of their characteristic tremor caused by their dysmyelination. In the central nervous system, qk(v) mice fail to develop mature myelinating oligodendrocytes and display uncompacted myelin. The genetic defect in the qk(v) mice prevents the proper expressi...

journal_title：RNA biology

authors： Larocque D,Richard S

更新日期：2005-04-01 00:00:00

abstract：:In mammals, the genic disequilibrium between males (XY) and females (XX) is resolved through the inactivation of one of the X-chromosomes in females. X-chromosome inactivation (XCI) takes place in all mammalian species, but has mainly been studied in the mouse model where it was shown to be controlled by the interplay...

journal_title：RNA biology

authors： Vallot C,Rougeulle C

更新日期：2013-08-01 00:00:00

abstract：:All organisms must keep their DNA intact and free of lesions to obtain faithful transmission of genetic information, and many cellular proteins are involved in genome maintenance. However, also other macromolecules may be subject to repair. Deleterious lesions in proteins can be reversed by several mechanisms, and thi...

journal_title：RNA biology

authors： Falnes PØ

更新日期：2005-01-01 00:00:00

abstract：:Significant structural and mechanistic similarities between the spliceosomal snRNAs and catalytically critical domains of self-splicing group II introns have led to the hypothesis that the spliceosomes and group II introns may be evolutionarily related. We have previously shown that in vitro-transcribed, protein-free ...

journal_title：RNA biology

authors： Jaladat Y,Zhang B,Mohammadi A,Valadkhan S

更新日期：2011-05-01 00:00:00

abstract：:While disruption of alternative splicing underlies many diseases, modulation of splicing using antisense oligonucleotides (AONs) can have therapeutic implications. The most notable example is Duchenne muscular dystrophy (DMD), where antisense-mediated exon skipping can restore the open reading frame and allow the synt...

journal_title：RNA biology

authors： Aartsma-Rus A

更新日期：2010-07-01 00:00:00