Riboswitch control of induction of aminoglycoside resistance acetyl and adenyl-transferases.

abstract：:Chemical modification of nucleobases plays an important role for the control of gene expression on different levels. That includes the modulation of translation by modified tRNA-bases or silencing and reactivation of genes by methylation and demethylation of cytosine in promoter regions. Especially dynamic methylation...

journal_title：RNA biology

authors： Traube FR,Carell T

更新日期：2017-09-02 00:00:00

abstract：:MicroRNAs (miRNAs) are key regulators of gene expression and play critical roles in modulating metabolism, development and physiology in animals and plants. miRNA levels are transcriptionally and post-transcriptionally controlled for their proper function. Recent studies have shown that RNA-binding proteins play impor...

journal_title：RNA biology

authors： Ren G,Yu B

更新日期：2012-12-01 00:00:00

abstract：:Conserved RNA secondary structures were predicted in the nucleoprotein (NP) segment of the influenza A virus genome using comparative sequence and structure analysis. A number of structural elements exhibiting nucleotide covariations were identified over the whole segment length, including protein-coding regions. Calc...

journal_title：RNA biology

authors： Gultyaev AP,Tsyganov-Bodounov A,Spronken MI,van der Kooij S,Fouchier RA,Olsthoorn RC

更新日期：2014-01-01 00:00:00

abstract：:We investigated the gene-expression variation among humans by analysing previously published mRNA-seq and ribosome footprint profiling of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features ...

journal_title：RNA biology

authors： Domitrovic T,Moreira MH,Carneiro RL,Ribeiro-Alves M,Palhano FL

更新日期：2020-12-11 00:00:00

abstract：:Previous mRNA transcriptome studies of Euglena gracilis have shown that this organism possesses a large and diverse complement of protein coding genes; however, the study of non-coding RNA classes has been limited. The natural extensive fragmentation of the E. gracilis large subunit ribosomal RNA presents additional b...

journal_title：RNA biology

authors： Moore AN,McWatters DC,Hudson AJ,Russell AG

更新日期：2018-01-01 00:00:00

abstract：:Skeletal muscle is the dominant executant in locomotion and regulator in energy metabolism. Embryonic myogenesis and postnatal muscle growth are controlled by a cascade of transcription factors and epigenetic regulatory mechanisms. MicroRNAs (miRNAs), a family of non-coding RNA of 22 nucleotides in length, post-transc...

journal_title：RNA biology

authors： Ma M,Wang X,Chen X,Cai R,Chen F,Dong W,Yang G,Pang W

更新日期：2017-03-04 00:00:00

abstract：:RNA-binding proteins (RBPs) are key regulators of posttranscriptional processes such as RNA maturation, localization, turnover and translation. Despite their dysregulation in various diseases including cancer, the landscape of RBP expression in human cancer has not been well elucidated. Here, we built a comprehensive ...

journal_title：RNA biology

authors： Zhang B,Babu KR,Lim CY,Kwok ZH,Li J,Zhou S,Yang H,Tay Y

更新日期：2020-02-01 00:00:00

abstract：:One of the many important consequences that temperature down-shift has on cells is stabilization of secondary structures of RNAs. This stabilization has wide-spread effects, such as inhibition of expression of several genes due to termination of their transcription and inefficient RNA degradation that adversely affect...

journal_title：RNA biology

authors： Phadtare S,Severinov K

更新日期：2010-11-01 00:00:00

abstract：:The genus Xanthomonas comprises a large group of plant-pathogenic bacteria. The infection and bacterial multiplication in the plant tissue depends on the type III secretion system and other virulence determinants. Recent studies revealed that bacterial virulence is also controlled at the post-transcriptional level by ...

journal_title：RNA biology

authors： Abendroth U,Schmidtke C,Bonas U

更新日期：2014-01-01 00:00:00

abstract：:The Hedgehog (HH) signaling pathway has important roles in tumorigenesis and in embryonal patterning. The Glioma-associated oncogene 1 (GLI1) is a key molecule in HH signaling, acting as a transcriptional effector and, moreover, is considered to be a potential therapeutic target for several types of cancer. To extend ...

journal_title：RNA biology

authors： Shimokawa T,Rahman MF,Tostar U,Sonkoly E,Ståhle M,Pivarcsi A,Palaniswamy R,Zaphiropoulos PG

更新日期：2013-02-01 00:00:00

abstract：:All organisms must keep their DNA intact and free of lesions to obtain faithful transmission of genetic information, and many cellular proteins are involved in genome maintenance. However, also other macromolecules may be subject to repair. Deleterious lesions in proteins can be reversed by several mechanisms, and thi...

journal_title：RNA biology

authors： Falnes PØ

更新日期：2005-01-01 00:00:00

abstract：:YchF is one of two universally conserved GTPases with unknown cellular function. As a first step toward elucidating YchF's cellular role, we performed a detailed biochemical characterization of the protein from Escherichia coli. Our data from fluorescence titrations not only confirmed the surprising finding that YchFE...

journal_title：RNA biology

authors： Becker M,Gzyl KE,Altamirano AM,Vuong A,Urban K,Wieden HJ

更新日期：2012-10-01 00:00:00

abstract：:Sin Nombre hantavirus (SNV) is a New World hantavirus and causes hantavirus cardiopulmonary syndrome. The viral nucleocapsid protein (N) is an RNA chaperone and has multiple functions important in virus replication. The three negative sense RNA segments of hantaviruses form panhandle structures through imperfect hydro...

journal_title：RNA biology

authors： Brown BA,Panganiban AT

更新日期：2010-11-01 00:00:00

abstract：:Differential mRNA stability is an important mechanism for regulation of virulence factors in Streptococcus pyogenes (group A streptococcus, GAS), a serious and prevalent human pathogen. We have described 2 Classes of mRNA in GAS that are distinguishable by 1) stability in the stationary phase of growth, 2) kinetics of...

journal_title：RNA biology

authors： Bugrysheva JV,Scott JR

更新日期：2010-09-01 00:00:00

abstract：:The quaking viable (qk(v)) mice have attracted attention because of their characteristic tremor caused by their dysmyelination. In the central nervous system, qk(v) mice fail to develop mature myelinating oligodendrocytes and display uncompacted myelin. The genetic defect in the qk(v) mice prevents the proper expressi...

journal_title：RNA biology

authors： Larocque D,Richard S

更新日期：2005-04-01 00:00:00

abstract：:Traditionally the principles of protein folding in vivo have been obtained largely from molecular chaperone studies. Through extensive studies on molecular chaperones, it becomes clear that most proteins can fold without their assistance in vivo, suggesting the existence of other chaperone types and mechanisms. Since ...

journal_title：RNA biology

authors： Choi SI,Ryu K,Seong BL

更新日期：2009-01-01 00:00:00

abstract：:Ribosome biogenesis drives cell growth and proliferation, but mechanisms that modulate this process remain poorly understood. For a long time, small rRNA sequences have been widely treated as non-specific degradation products and neglected as garbage sequences. Recently, we identified a new class of antisense ribosoma...

journal_title：RNA biology

authors： Zhou X,Chen X,Wang Y,Feng X,Guang S

更新日期：2017-11-02 00:00:00

abstract：:Circular RNAs (circRNAs) constitute a large class of RNA species formed by the back-splicing of co-linear exons, often within protein-coding transcripts. Despite much progress in the field, it remains elusive whether the majority of circRNAs are merely aberrant splicing by-products with unknown functions, or their pro...

journal_title：RNA biology

authors： Ng WL,Marinov GK,Liau ES,Lam YL,Lim YY,Ea CK

更新日期：2016-09-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are pervasively transcribed and critical regulators of the epigenome[1, 2]. These long, polyadenylated RNAs do not code for proteins, but function directly as RNAs, recruiting chromatin modifiers to mediate transcriptional changes in processes ranging from X-inactivation (XIST) to imprint...

journal_title：RNA biology

authors： Hung T,Chang HY

更新日期：2010-09-01 00:00:00

abstract：:Prokaryotes immunize themselves against transmissible genetic elements by the integration (acquisition) in clustered regularly interspaced short palindromic repeats (CRISPR) loci of spacers homologous to invader nucleic acids, defined as protospacers. Following acquisition, mono-spacer CRISPR RNAs (termed crRNAs) guid...

journal_title：RNA biology

authors： Díez-Villaseñor C,Guzmán NM,Almendros C,García-Martínez J,Mojica FJ

更新日期：2013-05-01 00:00:00

abstract：:The instructions to make proteins and structural RNAs are laid down in gene sequences. Yet, in certain instances, these primary instructions need to be modified considerably during gene expression, most often at the transcript level. Here we review a case of massive post-transcriptional revisions via trans-splicing an...

journal_title：RNA biology

authors： Valach M,Moreira S,Faktorová D,Lukeš J,Burger G

更新日期：2016-12-01 00:00:00

abstract：:RNA editing in flowering plant mitochondria targets several hundred C nucleotides mostly in mRNAs to be altered to U. Several nuclear encoded genes have been recently identified predominantly in Arabidopsis thaliana which code for proteins involved in specific RNA editing events in plastids or mitochondria. These nucl...

journal_title：RNA biology

authors： Zehrmann A,Verbitskiy D,Härtel B,Brennicke A,Takenaka M

更新日期：2011-01-01 00:00:00

abstract：:MicroRNAs are small, non-coding RNAs that are increasingly appreciated to play critical roles in the modulation of gene expression. In mammalian cells, our knowledge regarding the full impact of microRNAs on cellular behavior remains fragmentary. This has been due, in significant part, to the limited availability of e...

journal_title：RNA biology

authors： Valastyan S,Weinberg RA

更新日期：2009-11-01 00:00:00

abstract：:microRNAs (miRNAs) play significant regulatory roles in gene expression at the post-transcriptional level. This includes modulating processes such as development, immunity, cancer, and host-pathogen interactions. It was recently shown that the phylogenetically deeply conserved miRNA, miR-8, plays a role in maintaining...

journal_title：RNA biology

authors： Etebari K,Asgari S

更新日期：2013-08-01 00:00:00

abstract：:Two different isolates of the myxomycete Didymium iridis harbour homing endonuclease genes that are expressed from group I introns inserted into identical sites within the small subunit ribosomal DNA. The homing endonuclease proteins are related in sequence, and their gene structures share similar features such as the...

journal_title：RNA biology

authors： Johansen SD,Vader A,Sjøttem E,Nielsen H

更新日期：2006-10-01 00:00:00

abstract：:The innate immune system is the first line of defense against microbial pathogens, but tight regulation of gene expression is necessary to prevent the detrimental effects of unrestrained activation. Although the functions of most long noncoding RNAs (lncRNAs; >200 nucleotides) are unknown, many have been shown to regu...

journal_title：RNA biology

authors： Li Z,Rana TM

更新日期：2014-01-01 00:00:00

abstract：:Population bottlenecks often cause strong reductions in genetic diversity and alter population structure. In the context of host-parasite interactions, bottlenecks could in theory benefit either the host or the pathogen. We predicted that bottlenecking of bacterial populations that evolve CRISPR immunity against bacte...

journal_title：RNA biology

authors： Common J,Westra ER

更新日期：2019-04-01 00:00:00

abstract：:The human genome contains some thousands of long non coding RNAs (lncRNAs). Many of these transcripts are presently considered crucial regulators of gene expression and functionally implicated in developmental processes in Eukaryotes. Notably, despite a huge number of lncRNAs are expressed in the Central Nervous Syste...

journal_title：RNA biology

authors： Bevilacqua V,Gioia U,Di Carlo V,Tortorelli AF,Colombo T,Bozzoni I,Laneve P,Caffarelli E

更新日期：2015-01-01 00:00:00

abstract：:Nuclear export of mRNA is a critical event in mRNA biogenesis. Passage of mature messenger ribonucleoproteins (mRNPs) through nuclear pore complexes (NPCs) is facilitated by the Mex67/Mtr2 heterodimer. At the NPC cytoplasmic face, the DEAD-box RNA helicase Dbp5 remodels mRNPs by removing Mex67/Mtr2. This remodeling pr...

journal_title：RNA biology

authors： Ling SH,Song H

更新日期：2010-01-01 00:00:00

abstract：:At low temperatures the Escherichia coli rpoS mRNA, encoding the stationary phase sigma factor RpoS, forms an intramolecular secondary structure (iss) that impedes translation initiation. Under these conditions the small RNA DsrA, which is stabilzed by Hfq, forms a duplex with rpoS mRNA sequences opposite of the ribos...

journal_title：RNA biology

authors： Hämmerle H,Večerek B,Resch A,Bläsi U

更新日期：2013-12-01 00:00:00