The DExD box ATPase DDX55 is recruited to domain IV of the 28S ribosomal RNA by its C-terminal region.

abstract：:Myocyte enhancer factor 2c (MEF2C) is the MADS-box type transcription factor involved in the differentiation of cardiac and skeletal muscle and synaptic formation. Alternatively spliced transcripts of the MEF2C gene were proven to encode isoforms which exert distinct functions in transcriptional regulation. During the...

journal_title：RNA biology

authors： Lin JC

更新日期：2015-01-01 00:00:00

abstract：:Glioma is the most malignant primary brain cancer which frequently occurred in adults. In recent years, long-non coding RNAs (lncRNAs) have been demonstrated to play pivotal roles in human cancers. However, the role of most lncRNAs in gliomagenesis has not been probed. Presently, through TCGA, a novel lncRNA LINC01198...

journal_title：RNA biology

authors： Xie Y,Cheng Y

更新日期：2020-07-01 00:00:00

abstract：:Circular RNAs (circRNAs) are closely associated with the development of non-small cell lung cancer (NSCLC); however, it is still unclear whether circular RNA circ-LDLRAD3 participated in the regulation of NSCLC progression. In this study, we found that circ-LDLRAD3 was high-expressed and miR-137 was low-expressed in N...

journal_title：RNA biology

authors： Xue M,Hong W,Jiang J,Zhao F,Gao X

更新日期：2020-12-01 00:00:00

abstract：:The signal recognition particle (SRP) is a ribonucleoprotein complex which participates in the targeting of protein to cellular membranes. The RNA component of the SRP has been found in all domains of life, but the size of the molecule and the number of RNA secondary structure elements vary considerably between the di...

journal_title：RNA biology

authors： Rosenblad MA,Larsen N,Samuelsson T,Zwieb C

更新日期：2009-11-01 00:00:00

abstract：:Riboswitches are cis-encoded, cis-acting RNA elements that directly sense a physiological signal. Signal response results in a change in RNA structure that impacts gene expression. Elements of this type play an important role in bacteria, where they regulate a variety of fundamental cellular pathways. Riboswitch-media...

journal_title：RNA biology

authors： Smith AM,Fuchs RT,Grundy FJ,Henkin TM

更新日期：2010-01-01 00:00:00

abstract：:RNA-binding proteins (RBPs) are key regulators of posttranscriptional processes such as RNA maturation, localization, turnover and translation. Despite their dysregulation in various diseases including cancer, the landscape of RBP expression in human cancer has not been well elucidated. Here, we built a comprehensive ...

journal_title：RNA biology

authors： Zhang B,Babu KR,Lim CY,Kwok ZH,Li J,Zhou S,Yang H,Tay Y

更新日期：2020-02-01 00:00:00

abstract：:Selenoproteins are a unique class of proteins that contain the 21st amino acid, selenocysteine (Sec). Addition of Sec into a protein is achieved by recoding of the UGA stop codon. All 25 mammalian selenoprotein mRNAs possess a 3' UTR stem-loop structure, the Selenocysteine Insertion Sequence (SECIS), which is required...

journal_title：RNA biology

authors： Cockman EM,Narayan V,Willard B,Shetty SP,Copeland PR,Driscoll DM

更新日期：2019-12-01 00:00:00

abstract：:Single-stranded oligonucleotides (ssOligos) are efficiently taken up by living cells without the use of transfection reagents. This phenomenon called 'gymnosis' enables the sequence-specific silencing of target genes in various types of cells. Several antisense ssOligos are used for the treatment of human diseases. Ho...

journal_title：RNA biology

authors： Takahashi M,Contu VR,Kabuta C,Hase K,Fujiwara Y,Wada K,Kabuta T

更新日期：2017-11-02 00:00:00

abstract：:We previously showed that miR-122 was frequently downregulated in hepatocellular carcinoma (HCC) and C/EBPα transactivated miR-122 expression. In this study, we found that Sp1 bound to the miR-122 promoter at two different sites. Interestingly, either inhibition or overexpression of Sp1 could decrease the miR-122 prom...

journal_title：RNA biology

authors： Zeng C,Sang Y,Wang FY,Zhuang SM

更新日期：2020-02-01 00:00:00

abstract：:Processing bodies (P-bodies) are cytoplasmatic mRNP granules containing non-translating mRNAs and proteins from the mRNA decay and silencing machineries. The mechanism of P-body assembly has been typically addressed by depleting P-body components. Here we apply a complementary approach and establish an automated cell-...

journal_title：RNA biology

authors： Martínez JP,Pérez-Vilaró G,Muthukumar Y,Scheller N,Hirsch T,Diestel R,Steinmetz H,Jansen R,Frank R,Sasse F,Meyerhans A,Díez J

更新日期：2013-11-01 00:00:00

abstract：:AU-rich elements (AREs) are cis-acting instability and translation inhibition elements that are present in the 3'UTR of most inducible inflammatory mRNAs such as TNF and Cxcl2. mRNAs that contain AREs are, by default, repressed and only transiently expressed in response to stimuli. They are targeted by the inducible R...

journal_title：RNA biology

authors： Mahmoud L,Moghrabi W,Khabar KSA,Hitti EG

更新日期：2019-03-01 00:00:00

abstract：:The chromatoid body is a large perinuclear ribonucleoprotein particle of germ cells. The chromatoid body is also present in stem cells from planarians. This particle shares markers specific to protein aggresomes and P-bodies, and concentrate several RNA pathways. The assembly mechanism of chromatoid bodies is unknown,...

journal_title：RNA biology

authors： Roucou X

更新日期：2009-04-01 00:00:00

abstract：:The RNase II family of enzymes is ubiquitous and has crucial roles in the processing, degradation and quality control of all types of RNA. These exoribonucleases processively degrade RNA from the 3'-end releasing 5'-nucleotide monophosphates. In prokaryotes, RNase II and RNase R have two N-terminal CSD and one C-termi...

journal_title：RNA biology

authors： Arraiano CM,Matos RG,Barbas A

更新日期：2010-05-01 00:00:00

abstract：:The development of rigorous molecular taxonomy pioneered by Carl Woese has freed evolution science to explore numerous cellular activities that lead to genome change in evolution. These activities include symbiogenesis, inter- and intracellular horizontal DNA transfer, incorporation of DNA from infectious agents, and ...

journal_title：RNA biology

authors： Shapiro JA

更新日期：2014-01-01 00:00:00

abstract：:Human Enterovirus 71 (EV71) is an emerging pathogen of infectious disease and a serious threat to public health. Currently, there are no antivirals or vaccines to slow down or prevent EV71 infections, thus underscoring the urgency to better understand mechanisms of host-enterovirus interactions. EV71 uses a type I int...

journal_title：RNA biology

authors： Levengood JD,Tolbert M,Li ML,Tolbert BS

更新日期：2013-07-01 00:00:00

abstract：:The innate immune system is the frontline host protection against pathogens. Effective antiviral immunity is elicited upon recognition of viral RNAs by the host pattern recognition receptors. One of the major viral RNA sensors is retinoic acid inducible gene-1, which triggers the production of interferons (IFNs). In t...

journal_title：RNA biology

authors： Kuo YP,Ma CP,Chen HW,Chen YT,Lai YH,Liu H,Kuo RL,Chin-Ming Tan B

更新日期：2019-09-01 00:00:00

abstract：:The Hedgehog (HH) signaling pathway has important roles in tumorigenesis and in embryonal patterning. The Glioma-associated oncogene 1 (GLI1) is a key molecule in HH signaling, acting as a transcriptional effector and, moreover, is considered to be a potential therapeutic target for several types of cancer. To extend ...

journal_title：RNA biology

authors： Shimokawa T,Rahman MF,Tostar U,Sonkoly E,Ståhle M,Pivarcsi A,Palaniswamy R,Zaphiropoulos PG

更新日期：2013-02-01 00:00:00

abstract：:The tight gene expression regulation controls the development and pathogenesis of human malaria parasite Plasmodium falciparum throughout the complex life cycle. Recent studies have revealed the pervasive nascent transcripts in the genome of P. falciparum, suggesting the existence of a hidden transcriptome involved in...

journal_title：RNA biology

authors： Yin S,Fan Y,He X,Wei G,Wen Y,Zhao Y,Shi M,Wei J,Chen H,Han J,Jiang L,Zhang Q

更新日期：2020-06-01 00:00:00

abstract：:One of the many important consequences that temperature down-shift has on cells is stabilization of secondary structures of RNAs. This stabilization has wide-spread effects, such as inhibition of expression of several genes due to termination of their transcription and inefficient RNA degradation that adversely affect...

journal_title：RNA biology

authors： Phadtare S,Severinov K

更新日期：2010-11-01 00:00:00

abstract：:Changing the abundance of transcripts by regulated RNA degradation is a critical step in the control of various biological pathways. Recently, genome-wide inhibitor-free technologies for determining RNA stabilities in mammalian cells have been developed. In these methods, endogenous RNAs are pulse labeled by uridine a...

journal_title：RNA biology

authors： Tani H,Akimitsu N

更新日期：2012-10-01 00:00:00

abstract：:Viroids are the smallest autonomous infectious nucleic acids known today. They are non-coding, unencapsidated, circular RNAs with sizes ranging from 250 to 400 nucleotides and infect certain plants. These RNAs are transcribed by rolling-circle mechanisms in the plant host's nuclei (Pospiviroidae) or chloroplasts (Avsu...

journal_title：RNA biology

authors： Hammann C,Steger G

更新日期：2012-06-01 00:00:00

abstract：:In metazoan organisms, alternative splicing is a central mechanism for the regulation of gene expression. However, many questions remain about the underlying molecular mechanisms. Our recent work suggests that U1 snRNP-independent premRNA splicing occurs in humans, which contributes to the regulation of alternative sp...

journal_title：RNA biology

authors： Fukumura K,Inoue K

更新日期：2009-09-01 00:00:00

abstract：:Epstein-Barr virus (EBV) was the first human cancer-causing virus to be discovered over fifty years ago. Given its relatively large genome size for a virus and hence the capacity to store more than mere protein-coding information, EBV also harbours genetic material for producing an array of distinct noncoding (nc)RNAs...

journal_title：RNA biology

authors： Lee N

更新日期：2021-01-30 00:00:00

abstract：:Editing by ADAR enzymes is essential for mammalian life. Still, knowledge of the spatio-temporal editing patterns in mammals is limited. By use of 454 amplicon sequencing we examined the editing status of 12 regionally extracted mRNAs from porcine developing brain encompassing a total of 64 putative ADAR editing sites...

journal_title：RNA biology

authors： Venø MT,Bramsen JB,Bendixen C,Panitz F,Holm IE,Öhman M,Kjems J

更新日期：2012-08-01 00:00:00

abstract：:Seryl-tRNA synthetase (SerRS) catalyzes the ligation of serine to the 3'-end of serine tRNA (tRNA(Ser)), which is typical of the type-2 tRNAs characterized by a long extra arm. The SerRSs are divided into two types, the archaeal/eukaryal and bacterial types. In this study, we solved the crystal structures of the SerRS...

journal_title：RNA biology

authors： Itoh Y,Sekine S,Kuroishi C,Terada T,Shirouzu M,Kuramitsu S,Yokoyama S

更新日期：2008-07-01 00:00:00

abstract：:The NOVA (neuro-oncological ventral antigen) protein family, composed of two paralogs, NOVA1 and NOVA2, consists of RNA-binding proteins involving in processes such as alternative splicing and transport of some target mRNAs. The function of NOVA has been well studied, and increasing evidence has shown that NOVA protei...

journal_title：RNA biology

authors： Tang S,Zhao Y,He X,Zhu J,Chen S,Wen J,Deng Y

更新日期：2020-06-01 00:00:00

abstract：:Enzymes of the cytosine-5 RNA methyltransferase Trm4/NSun2 family methylate tRNAs at C48 and C49 in multiple tRNAs, as well as C34 and C40 in selected tRNAs. In contrast to most other organisms, fission yeast Schizosaccharomyces pombe carries two Trm4/NSun2 homologs, Trm4a (SPAC17D4.04) and Trm4b (SPAC23C4.17). Here, ...

journal_title：RNA biology

authors： Müller M,Samel-Pommerencke A,Legrand C,Tuorto F,Lyko F,Ehrenhofer-Murray AE

更新日期：2019-03-01 00:00:00

abstract：:In eukaryotes and viruses that infect them, the 5' end of mRNA molecules, and also many other functionally important RNAs, are modified to form a so-called cap structure that is important for interactions of these RNAs with many nuclear and cytoplasmic proteins. The RNA cap has multiple roles in gene expression, inclu...

journal_title：RNA biology

authors： Byszewska M,Śmietański M,Purta E,Bujnicki JM

更新日期：2014-01-01 00:00:00

abstract：:The immaculate annotation of all microRNAs (miRNAs) is a prerequisite to study their biological function on a genome-wide scale. However, the original criteria for proper miRNA annotation seem unsuited for the automated analysis of the immense number of small RNA reads available in next generation sequencing (NGS) dat...

journal_title：RNA biology

authors： Hansen TB,Kjems J,Bramsen JB

更新日期：2011-05-01 00:00:00

abstract：:The endoribonuclease RNase-L requires 2',5'-linked oligoadenylates for activation, and mediates antiviral and antiproliferative activities. We previously determined that RNase-L activation induces senescence; to determine potential mechanisms underlying this activity, we used microarrays to identify RNase-L-regulated ...

journal_title：RNA biology

authors： Andersen JB,Mazan-Mamczarz K,Zhan M,Gorospe M,Hassel BA

更新日期：2009-07-01 00:00:00