Abstract:
:Transcriptional regulation of microRNA (miRNA) expression is one of the least understood aspects of miRNA biogenesis. In C. elegans the list of miRNAs whose transcriptional control has been described in some detail is currently limited to four: let-7, lin-4, lsy-6, and mir-61. Each of these genes has been shown experimentally to be transcriptionaly regulated by cis- and/or trans-acting factors that either promote or inhibit expression. Additionally, computational methods based on conservation among miRNA genes have yielded predicted regulatory sequences in C. elegans that may function to regulate miRNA expression on a genome-wide scale.
journal_name
RNA Bioljournal_title
RNA biologyauthors
Turner MJ,Slack FJdoi
10.4161/rna.6.1.7574subject
Has Abstractpub_date
2009-01-01 00:00:00pages
49-53issue
1eissn
1547-6286issn
1555-8584pii
7574journal_volume
6pub_type
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