Abstract:
:Cigarette smoking is highly prevalent among patients who are being treated for opioid-dependence, yet there have been limited scientific efforts to promote smoking cessation in this population. Contingency management (CM) is a behavioral treatment that provides monetary incentives contingent upon biochemical evidence of drug abstinence. This paper discusses the results of two studies that utilized CM to promote brief smoking cessation among opioid-maintained patients. Participants in a pilot study were randomly assigned for a 2-week period to a Contingent group that earned monetary vouchers for providing biochemical samples that met criteria for smoking abstinence, or a Noncontingent group that earned monetary vouchers independent of smoking status (Dunn et al., 2008). Results showed Contingent participants provided significantly more smoking-negative samples than Noncontingent participants (55% vs. 5%, respectively). A second randomized trial that utilized the same 2-week intervention and provided access to the smoking cessation pharmacotherapy bupropion replicated the results of the pilot study (55% and 17% abstinence in Contingent and Noncontingent groups, respectively; Dunn et al, 2010). Relapse to illicit drug use was also evaluated prospectively and no association between smoking abstinence and relapse to illicit drug use was observed (Dunn et al., 2009). It will be important for future studies to evaluate participant characteristics that might predict better treatment outcome, to assess the contribution that pharmacotherapies might have alone or in combination with a CM intervention on smoking cessation and to evaluate methods for maintaining the abstinence that is achieved during this brief intervention for longer periods of time.
journal_name
Exp Clin Psychopharmacoljournal_title
Experimental and clinical psychopharmacologyauthors
Dunn KE,Saulsgiver KA,Sigmon SCdoi
10.1037/a0022039subject
Has Abstractpub_date
2011-02-01 00:00:00pages
20-30issue
1eissn
1064-1297issn
1936-2293pii
2011-03057-003journal_volume
19pub_type
杂志文章abstract::This study shows that a moderate dose of alcohol (0.62 g/kg) can impair cognitive processes controlling behavioral inhibition and flexibility (i.e., inhibiting one response and making a different one). Two groups of male social drinkers (n = 8) received alcohol or a placebo and performed two change tasks that required...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1037//1064-1297.8.3.387
更新日期:2000-08-01 00:00:00
abstract::Delay discounting, reflected in the tendency to prefer immediate rewards over delayed rewards, is associated with most forms of problematic substance use. When assessed multiple times to examine within-individual changes, for example, following acute drug administration or an intervention, shifts in delay discounting ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000211
更新日期:2018-10-01 00:00:00
abstract::Drug cue reactivity is theoretically and clinically important. The modified Stroop task has been widely used to assess attention capture by drug cues (attentional bias). Attentional bias to drug cues is assumed to reflect the incentive value of those cues, but this has not been directly tested. The authors examined wh...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0016658
更新日期:2009-08-01 00:00:00
abstract::Sprague-Dawley (Rattus norvegicus) rats were trained in a drug discrimination task using the state-dependent interoceptive stimulus attributes of cocaine's delayed or rebound effects (CDE) versus "normal" basal homeostasis. Rats were injected with either 32 mg/kg cocaine or equivalent volumes of saline (SAL), subcutan...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.6.3.264
更新日期:1998-08-01 00:00:00
abstract::Drug abuse and impulsive choice are related in humans. In female rats, impulsive choice predicted the rate of acquisition of IV cocaine self-administration. The objectives of the present experiments were to: (a) compare impulsive choice in males and females, (b) extend previous research on impulsive choice and acquisi...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/1064-1297.16.2.165
更新日期:2008-04-01 00:00:00
abstract::Drug abuse and obesity are serious public health problems. Dopamine plays a central role in mediating the reinforcing effects of drugs and food. Prolonged use of drugs is known to alter the function and/or sensitivity of many neurotransmitter systems, including dopamine; however, the impact of consuming foods high in ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000019
更新日期:2015-08-01 00:00:00
abstract::Methylphenidate (MPH) is one of the most widely prescribed drugs for treating attention-deficit hyperactivity disorder. Previous research suggested that MPH is a reinforcer for rats, but not all of the manipulations to show that lever pressing is controlled by the contingency to obtain MPH have been examined. In Exper...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0019814
更新日期:2010-06-01 00:00:00
abstract::The effects of using several nicotine replacement treatments on self-reported withdrawal symptoms and side effects during 2-day periods of smoking cessation, with 5 days of ad lib smoking between cessation days, were evaluated. Participants (N = 18) experienced the following conditions: nicotine gum, 24-hr patch, 16-h...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1037//1064-1297.5.1.54
更新日期:1997-02-01 00:00:00
abstract::The ability of nicotine to decrease sensitivity to pain in humans has been a subject of dispute. Decreased sensitivity has been demonstrated in studies involving men, whereas the effect has been less obvious or absent in studies involving predominantly, or entirely, women. To determine whether there are gender differe...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1037//1064-1297.6.1.96
更新日期:1998-02-01 00:00:00
abstract::In this experiment, the observing-response procedure was adapted for use with drug self-administration. Rats' responding for oral ethanol was sometimes reinforced on a random-ratio schedule, whereas at other times it had no effect (i.e., extinction). Behavior producing stimuli associated with the otherwise unsignaled ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.10.1.3
更新日期:2002-02-01 00:00:00
abstract::P. R. Giancola's (2000) macroconstruct framework of executive functions (EF) characterizes how cognitive processes work together to inhibit aggressive responding in provocative situations, and how alcohol intoxication increases the likelihood of aggression by disrupting these processes. His framework can be considered...
journal_title:Experimental and clinical psychopharmacology
pub_type: 评论,杂志文章
doi:10.1037//1064-1297.8.4.598
更新日期:2000-11-01 00:00:00
abstract::This report describes a novel procedure for computer-controlled drug-dose determination for IV drug self-administration studies. By modifying the duration of each infusion of a single concentration of a drug solution, five or more unit doses (mg/kg/inj) can be dispensed from the same syringe. The advantages of this pr...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0023037
更新日期:2011-04-01 00:00:00
abstract::Binge drinking is frequently reported by young adults, despite being associated with a number of negative consequences. This type of heavy drinking is associated with deficits in many executive functions, including working memory. Poor working memory may contribute to increased alcohol use by limiting one's ability to...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000205
更新日期:2018-08-01 00:00:00
abstract::There are important individual differences in acute subjective responses to alcohol, which have often been assessed using self-report measures. There is also evidence of meaningful between-persons variation in alcohol's disinhibiting effects on behavior, such that some individuals become more impaired on tasks of inhi...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000065
更新日期:2016-04-01 00:00:00
abstract::In this study, crack/cocaine-dependent (CD) and non-drug-using matched control (MC) participants were presented with hypothetical immediate and delayed rewards, with 16 delay conditions ranging from 5 min to 25 years. All participants were presented with hypothetical monetary rewards; however, the CD group was also pr...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1037//1064-1297.11.1.18
更新日期:2003-02-01 00:00:00
abstract::Several studies examining both control and substance-dependent populations have found delay discounting to remain stable over time. In this report, we examine whether delay discounting changes in opioid-dependent individuals who complete a 12-week treatment. The 159 subjects who completed discounting assessments at ba...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0027391
更新日期:2012-08-01 00:00:00
abstract::The social environment plays a critical role in determining the likelihood that an individual will use drugs or will develop a drug use disorder. Recent evidence obtained from preclinical studies reveals that proximal social factors (i.e., those factors that are immediately present at the time of drug exposure) exert ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,评审
doi:10.1037/a0034669
更新日期:2014-02-01 00:00:00
abstract::Two studies were conducted to determine the anger-attenuating effects of nicotine as a function of trait hostility. The 1st study examined the effects of nicotine on diary ratings of anger during a 24-hr period in a natural setting in 30 smokers and 30 nonsmokers. Participants took part in 2 monitoring sessions involv...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1037//1064-1297.7.4.454
更新日期:1999-11-01 00:00:00
abstract::Antipsychotic polypharmacy refers to the clinical practice of treating a patient with two or more antipsychotic drugs concurrently. There is abundant evidence in the clinical literature that treatment with antipsychotic polypharmacy is associated with an increased prevalence of drug side effects compared with monother...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0031228
更新日期:2013-04-01 00:00:00
abstract::When 2 stimuli that occasion cocaine self-administration are presented in compound, their ability to increase cocaine-reinforced operant responding is substantially enhanced. The goal of the present experiment was to determine whether stimulus compounding could produce analogous enhancements of a classically condition...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.8.1.6
更新日期:2000-02-01 00:00:00
abstract::The present study explores the relation among 4 personality traits associated with impulsive behavior and alcohol abuse. Personality traits were measured using the 4 subscales of the UPPS Impulsive Behavior Scale (UPPS; S. P. Whiteside & D. R. Lynam, 2001). The UPPS and measures of psychopathology were administered to...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1037/1064-1297.11.3.210
更新日期:2003-08-01 00:00:00
abstract::Although marijuana is the most commonly used illicit drug in the United States, it is not established whether withdrawal from chronic use results in a clinically significant abstinence syndrome. The present study was conducted to characterize symptoms associated with marijuana withdrawal following chronic use during a...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.8.4.483
更新日期:2000-11-01 00:00:00
abstract::Varenicline reduces drinking in people with alcohol use disorder, but little is known about the mechanisms underlying this effect. Varenicline targets α4β2 and α7 nicotinic acetylcholine receptors, which are associated with several cognitive functions such as working memory. Varenicline may improve drinking outcomes b...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1037/pha0000161
更新日期:2018-02-01 00:00:00
abstract::Relative to intravenous drug self-administration, locomotor activity is easier to measure with high throughput, particularly in mice. Therefore its potential to predict differences in self-administration between genotypes (e.g., targeted mutations, recombinant inbred strains) is appealing, but such predictive value is...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0024798
更新日期:2011-10-01 00:00:00
abstract::Maternal smoking is a leading preventable cause of poor pregnancy outcomes and infant morbidity and mortality. Whereas pregnancy has been thought of as a "window of opportunity" when women are more motivated to change health behaviors such as smoking, only 20% of pregnant women quit smoking upon learning they are preg...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/1064-1297.14.2.165
更新日期:2006-05-01 00:00:00
abstract::The affectively valenced scripts used by S. Tiffany (1990) suggest that different scripts produce relatively equivalent levels of cue reactivity, although it is unclear if these laboratory findings generalize to clinical samples. In this study, cessation-motivated smokers were tested 7 days before they tried to quit s...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.6.2.179
更新日期:1998-05-01 00:00:00
abstract::Substantial evidence links greater impulsivity and stress exposure to poorer smoking cessation outcomes. Results from adolescents also indicate that stress-related change in risk taking can impede cessation attempts. We investigated the effects of stress-related change in impulsivity, risk taking, attention and nicoti...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000066
更新日期:2016-04-01 00:00:00
abstract::Discounting is a behavioral phenomenon in which the value of an outcome diminishes as a function of its increased delay or decreased probability and is related to substance abuse research because of its theoretical ties with behavioral models of impulsive choice. Research to date suggests that hypothetical outcomes us...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0024141
更新日期:2011-08-01 00:00:00
abstract::Delay discounting, the devaluation of delayed reinforcers, is one defining behavioral economic characteristic of cigarette smokers. Attempts at abstinence by smokers that result in relapse are conceptualized in this framework as preference reversals. Despite preference reversals being predicted by delay discounting mo...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000224
更新日期:2019-02-01 00:00:00
abstract::In the United States, the Food and Drug Administration (FDA) has initiated a public dialogue about reducing the nicotine content of cigarettes. A reduced-nicotine standard could increase withdrawal symptoms among current smokers. We examined the impact of switching smokers to cigarettes that varied in nicotine content...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1037/pha0000179
更新日期:2018-06-01 00:00:00