Abstract:
:Relative to intravenous drug self-administration, locomotor activity is easier to measure with high throughput, particularly in mice. Therefore its potential to predict differences in self-administration between genotypes (e.g., targeted mutations, recombinant inbred strains) is appealing, but such predictive value is unverified. The main goal of this study was to evaluate the utility of the locomotor assay for accurately predicting differences in cocaine self-administration. A second goal was to evaluate any correlation between activity in a novel environment, and cocaine-induced hyperactivity, between strains. We evaluated locomotor activity in male and female Sprague-Dawley rats and 15 mouse strains (129S1/SvImJ, 129S6/SvEvTac, 129X1/SvJ, A/J, BALB/cByJ, BALB/cJ, C3H/HeJ, C57BL/6J, CAST/EiJ, DBA/2J, FVB/NJ, SJL/J, SPRET/EiJ, and outbred Swiss Webster and CD-1/ICR), as well as cocaine self-administration in BALB substrains. All but BALB/cJ mice showed locomotor habituation and significant cocaine-induced hyperactivity. BALB/cJ mice also failed to self-administer cocaine. BALB/cByJ mice showed modest locomotor habituation, cocaine-induced locomotion, and cocaine self-administration. As previously reported, female rats showed greater cocaine-induced locomotion than males, but this was only observed in one of 15 mouse strains (FVB/NJ), and the reverse was observed in two strains (129X1/SvJ, BALB/cByJ). The intriguing phenotype of the BALB/cJ strain may indicate some correlation between all-or-none locomotion in a novel environment, and stimulant and reinforcing effects of cocaine. However, neither novelty- nor cocaine-induced activity offered a clear prediction of relative reinforcing effects among strains. Additionally, these results should aid in selecting mouse strains for future studies in which relative locomotor responsiveness to psychostimulants is a necessary consideration.
journal_name
Exp Clin Psychopharmacoljournal_title
Experimental and clinical psychopharmacologyauthors
Thomsen M,Caine SBdoi
10.1037/a0024798subject
Has Abstractpub_date
2011-10-01 00:00:00pages
321-41issue
5eissn
1064-1297issn
1936-2293pii
2011-17698-001journal_volume
19pub_type
杂志文章abstract::In a combined sample of more than 2600 smokers, immediate postcessation craving is shown to be prospectively associated with smokers' ability to maintain abstinence. Relapse is strikingly rapid among those reporting high levels of craving following cessation. More than 32% of those with high craving scores relapsed wi...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.5.2.137
更新日期:1997-05-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000300
更新日期:2020-04-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.6.3.264
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0025482
更新日期:2012-02-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2013-12-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-11-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
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更新日期:2001-05-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000063
更新日期:2016-04-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0036607
更新日期:2014-06-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037//1064-1297.10.4.425
更新日期:2002-11-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000071
更新日期:2016-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1037/1064-1297.13.3.259
更新日期:2005-08-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000344
更新日期:2020-12-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0038467
更新日期:2015-02-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0014505
更新日期:2009-02-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000022
更新日期:2015-10-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,评审
doi:10.1037/1064-1297.14.2.265
更新日期:2006-05-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1037/a0032768
更新日期:2013-06-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2004-02-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章
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journal_title:Experimental and clinical psychopharmacology
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更新日期:2019-02-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000297
更新日期:2020-04-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1037//1064-1297.7.4.354
更新日期:1999-11-01 00:00:00
abstract::Antipsychotic polypharmacy refers to the clinical practice of treating a patient with two or more antipsychotic drugs concurrently. There is abundant evidence in the clinical literature that treatment with antipsychotic polypharmacy is associated with an increased prevalence of drug side effects compared with monother...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0031228
更新日期:2013-04-01 00:00:00
abstract::Drug abuse and impulsive choice are related in humans. In female rats, impulsive choice predicted the rate of acquisition of IV cocaine self-administration. The objectives of the present experiments were to: (a) compare impulsive choice in males and females, (b) extend previous research on impulsive choice and acquisi...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/1064-1297.16.2.165
更新日期:2008-04-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0026379
更新日期:2012-04-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,meta分析,评审
doi:10.1037/pha0000148
更新日期:2017-10-01 00:00:00
abstract::The review article "Regulation of Drug Taking by Sensitization and Habituation" by F. K. McSweeney, E. S. Murphy, and B. P. Kowal introduces 2 basic principles of behavior, sensitization and habituation, into a comprehensive model for studying drug intake and drug addiction. A key assumption of the model is that the r...
journal_title:Experimental and clinical psychopharmacology
pub_type: 评论,杂志文章
doi:10.1037/1064-1297.13.3.187
更新日期:2005-08-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) are ubiquitous environmental toxicants known to adversely impact human health. Ortho-substituted PCBs affect the nervous system, including the brain dopaminergic system. The reinforcing effects of psychostimulants are typically modulated via the dopaminergic system, so this study used ...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000113
更新日期:2017-04-01 00:00:00