Abstract:
BACKGROUND:We assessed the relationship between cognitive impairment (including mild cognitive impairment with no signs of dementia, and dementia) and risk for depression in old age (60 years and older). METHODS:MEDLINE, EMBASE and the Cochrane Library database were used to identify potential studies. All of the clinical studies that produced data on the association between cognitive function and risk of depression among individuals aged 55 years or older were identified and included in this review. The studies were classified into cross-sectional and longitudinal subsets. The quantitative meta-analysis of cross-sectional and longitudinal studies were performed. For prevalence and incidence rates of depression, odds risk (OR) and relative risk (RR) were calculated, respectively. RESULTS:Since all but two studies found in the search were for individuals aged 60 years or over, we assessed and reported on results for this larger group only. In this review we included 13 cross-sectional and four prospective longitudinal studies. The quantitative meta-analysis showed that, in old age, individuals with non-dementia cognitive impairment had neither significant higher prevalence nor incidence rates of depression than those without (odds risk (OR): 1.48, 95% confidence intervals (95% CI): 0.87-2.52; relative risk (RR): 1.12, 95% CI: 0.62-2.01). In old age, individuals with dementia had both significant higher prevalence and incidence rates of depression than those without (OR: 1.82, 95% CI: 1.15-2.89; RR: 3.92, 95% CI: 1.93-7.99). CONCLUSIONS:Despite the methodological limitations of this meta-analysis, we found that in old age, there was no association between depression and cognitive impairment with no dementia; however, there was a definite association between depression and dementia and thus dementia might be a risk for depression.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Huang CQ,Wang ZR,Li YH,Xie YZ,Liu QXdoi
10.1017/S1041610210000049subject
Has Abstractpub_date
2011-05-01 00:00:00pages
516-25issue
4eissn
1041-6102issn
1741-203Xpii
S1041610210000049journal_volume
23pub_type
杂志文章,meta分析,评审abstract:BACKGROUND:The IPA Taskforce on Mental Health Issues in Long-Term Care Homes seeks to improve mental health care in long-term care (LTC) homes. The aim of this paper is to provide recommendations on comprehensive assessment of depression and behavioral problems in order to further stimulate countries and professionals ...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610210000736
更新日期:2010-11-01 00:00:00
abstract::ABSTRACT Background: The association between disability and depression is complex, with disability well established as a correlate and consequence of late life depression. Studies in community samples report that greater volumes of cerebral white matter hyperintensities (WMHs) seen on brain imaging are linked with fun...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214000829
更新日期:2014-05-09 00:00:00
abstract::Noisemaking is one of the most disturbing behavior disorders associated with dementia. Standard management practices, including pharmacological interventions, are not very successful in treating the behavior. Very little research has been carried out to evaluate innovative treatments or to determine the etiology of no...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610297004547
更新日期:1997-12-01 00:00:00
abstract::ABSTRACTBackground and Purpose:The impact of dementia-related stressors and strains have been examined for their potential to threaten the well-being of either the person with dementia or the family care partner, but rarely have studies considered the dyadic nature of well-being in dementia. The purpose of this study ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021800203X
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Cognitive assessment of older persons, particularly those with impairment, is hampered by measurement error and the ethical issues of testing people with dementia. A potential source of valuable information about end-of-life cognitive status can be gained from those who knew the respondent well - mostly rela...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210001201
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Older Puerto Rican adults have particularly high risk of diabetes compared to the general US population. Diabetes is associated with both higher depressive symptoms and cognitive decline, but less is known about the longitudinal relationship between cognitive decline and incident depressive symptoms in those...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217000746
更新日期:2017-08-01 00:00:00
abstract::ABSTRACTBackground:With increasing cultural diversity and growing elderly immigrant populations in Western European countries, the availability of brief cognitive screening instruments adequate for assessment of dementia in people from diverse backgrounds becomes increasingly important. The aim of the present study wa...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S1041610218000832
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Apathy, characterized by diminished motivation, is a highly prevalent neuropsychiatric symptom in dementia. However, there is a substantial knowledge gap with regard to prevalence rates, neurobiological underpinnings, and effective treatments for apathy in pre-dementia states, including mild cognitive impair...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610217000527
更新日期:2018-02-01 00:00:00
abstract::Major advances in understanding the physiology and genetics of circadian rhythm in the past decade challenge the researcher of sleep/wake disorders in Alzheimer's disease (AD) to distinguish patient characteristics stable across the course of illness ("traits") from characteristics that vary with stage of illness ("st...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610202008293
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Intracranial volume (ICV) has been proposed as a measure of maximum lifetime brain size. Accurate ICV measures require neuroimaging which is not always feasible for epidemiologic investigations. We examined head circumference as a useful surrogate for ICV in older adults. METHODS:99 older adults underwent M...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021500037X
更新日期:2016-01-01 00:00:00
abstract::Seventy-eight nondemented elderly depressed patients underwent an extensive battery of cognitive tests both before and after seven weeks of treatment with nortriptyline, phenelzine, or placebo. Clinical and cognitive evaluations of the patients were under double-blind conditions. Response to treatment did not appear t...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s1041610289000141
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:People with Young Onset Dementia (YOD) have specific needs for care. These people eventually require institutional care, usually delivered by institutions designed for the elderly. The Dutch network of care organizations delivering specialized YOD care offers a unique opportunity to obtain more knowledge of ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214001859
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Cognitive impairment and depression are common and disabling non-motor symptoms of Parkinson's disease (PD). Previous studies have shown associations between them but the nature of the relationship remains unclear. In chronic illness, problem- or task-oriented coping strategies are associated with better out...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000749
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Cognitive impairment places older adults at increased risk of functional decline, injuries, and hospitalization. Assessments to determine whether older persons are still capable of meeting the cognitive challenges of everyday living are crucial to ensure their safe and independent living in the community. Th...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213001889
更新日期:2014-02-01 00:00:00
abstract::This paper presents updated analyses on the genetic associations of sleep disruption in individuals with Alzheimer's disease (AD). We published previously a study of the association between single nucleotide polymorphisms (SNPs) found in eight genes related to circadian rhythms and objective measures of sleep-wake dis...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219001777
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:This study was conducted to estimate prevalence rates and risk factors for late-life depression in a large nationwide representative sample from Taiwan. METHODS:A total of 5,664, randomly sampled individuals aged ≥55 years were enrolled. Clinically, relevant depressive symptoms were classified using the Cen...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217000199
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:It remains unclear so far whether the role of cognitive reserve may differ between physically frail compared to less frail individuals. Therefore, the present study set out to investigate the relation of key markers of cognitive reserve to cognitive status in old age and its interplay with physical frailty i...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217000795
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine levels, rates and progression of apathy in healthy older persons and to investigate factors associated with its progression. METHODS:Seventy-six healthy elderly subjects, aged 58-85 years (mean 69.9), who were recruited by general advertisement and through local commun...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209991335
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:There is increasing interest in identifying novel cognitive paradigms to help detect preclinical dementia. Promising results have been found in clinical settings using the Semantic Interference Test (SIT), a modification of an existing episodic memory test (Fuld Object Memory Evaluation) that exploits vulner...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209991657
更新日期:2010-08-01 00:00:00
abstract::ABSTRACTBackground:Getting lost is a recognized complication in patients with dementia. Preventive measures are lacking. This study aims to investigate the effectiveness of a home-based missing incident prevention program (HMIPP) in reducing missing incidents, time of searching, and caregivers' stress. METHODS:The de...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000546
更新日期:2019-01-01 00:00:00
abstract::Few would argue that achieving the age of 100 years is extraordinary, but what about the quality of life at this extreme age? Is it worth it to live to 100 and beyond? The study by Araújo, Ribero, Teixeira, and Paúl (2015) in three ways provided an answer to this question substantiating and complementing recent findin...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610215002021
更新日期:2016-02-01 00:00:00
abstract::The purpose of this study was to examine the relationship between age-associated changes in central serotonergic function and abnormalities associated with major depression. Under randomized double-blind conditions, prolactin and cortisol responses to the serotonin-releasing agent d,l-fenfluramine hydrochloride (60 mg...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s1041610296002499
更新日期:1996-04-01 00:00:00
abstract::ABSTRACTBackground:US suicide rates among older women have substantially increased over the past decade. We examined potential differences in sociodemographic and risk/precipitating factors among older female suicide decedents who died by drug overdose versus firearms, hanging/suffocation, and other means, and postmor...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000212
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Mild cognitive impairment (MCI) is proposed to describe the transitional stage between normal cognitive aging and dementia. It has had significant impact in the field of dementia research, but it remains controversial whether or not it should be used as a diagnostic category in clinical practice. METHODS:Se...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610208007126
更新日期:2008-08-01 00:00:00
abstract::Loss of brain tissue becomes notable to cerebral magnetic resonance imaging (MRI) at age 30 years, and progresses more rapidly from mid 60s. The incidence of dementia increases exponentially with age, and is all too frequent in the oldest old (≥ 90 years of age), the fastest growing age group in many countries. Howeve...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216000673
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:In dementia, cognitive and psychological disorders might interfere with maintaining social interactions. We have little information about the nature of these interactions of people with dementia in nursing homes. The aim of this study is to investigate social interactions between people with dementia and to ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215002483
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Understanding the prevalence, incidence and cofactors of depression among long-term elderly nursing home (LTNH) residents domiciled for eight months or more may help optimize depression treatment in this vulnerable group. We quantified first year depression in American LTNH residents and the associations bet...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210000578
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the clustering of symptoms on the Neuropsychiatric Inventory (NPI) and the relative prevalence of symptom clusters in mild and moderate Alzheimer's disease (AD). METHODS:Confirmatory factor analysis (CFA) was performed on the polychoric correlation matrix of 12 NPI i...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000609
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Depression in late life is a risk factor for cognitive decline. Depression is also associated with increased disability and social support deficits; these may precede conversion to dementia and inform risk. In this study, we examined if baseline or one-year change in disability and social support predicted l...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214002543
更新日期:2015-05-01 00:00:00
abstract::Cholinergic deficits are a hallmark of Alzheimer's disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in ne...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220003944
更新日期:2021-01-08 00:00:00