Abstract:
:This paper presents updated analyses on the genetic associations of sleep disruption in individuals with Alzheimer's disease (AD). We published previously a study of the association between single nucleotide polymorphisms (SNPs) found in eight genes related to circadian rhythms and objective measures of sleep-wake disturbances in 124 individuals with AD. Here, we present new relevant analyses using polygenic risk scores (PRS) and variable number tandem repeats (VNTRs) enumerations. PRS were calculated using the genetic data from the original participants and relevant genome wide association studies (GWAS). VNTRs for the same circadian rhythm genes studied with SNPs were obtained from a separate cohort of participants using whole genome sequencing (WGS). Objectively (wrist actigraphy) determined wake after sleep onset (WASO) was used as a measure of sleep disruption. None of the PRS were associated with sleep disturbance. Computer analyses using VNTRseek software generated a total of 30 VNTRs for the circadian-related genes but none appear relevant to our objective sleep measure. In addition, of 71 neurotransmitter function-related genes, 29 genes had VNTRs that differed from the reference VNTR, but it was not clear if any of these might affect circadian function in AD patients. Although we have not found in either the current analyses or in our previous published analyses of SNPs any direct linkages between identified genetic factors and WASO, research in this area remains in its infancy.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Yesavage JA,Noda A,Heath A,McNerney MW,Domingue BW,Hernandez Y,Benson G,Hallmayer J,O'Hara R,Williams LM,Goldstein-Piekarski AN,Zeitzer JM,Fairchild JKdoi
10.1017/S1041610219001777subject
Has Abstractpub_date
2020-07-01 00:00:00pages
807-813issue
7eissn
1041-6102issn
1741-203Xpii
S1041610219001777journal_volume
32pub_type
杂志文章abstract:BACKGROUND:It is currently not known whether elderly men and women present with different subtypes of depression and mania/bipolar disorder. The aim of this study was to compare the prevalence of subtypes of a single depressive episode and mania/bipolar disorder according to the ICD-10 for elderly men and women in a na...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020600319X
更新日期:2006-12-01 00:00:00
abstract::There is no doubt that family carers who look after a family member with dementia or with a functional mental illness fulfill an important role, not only for their loved one, but also for the health and aged care systems of the countries they live in. Due to increasing life expectancy, but also improved healthcare the...
journal_title:International psychogeriatrics
pub_type: 社论
doi:10.1017/S1041610217002150
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:This review presents an overview of the published literature on the effectiveness of continuing professional education (CPE), which includes continuing medical education (CME) of different health care professionals in healthcare settings, for improving patient management and patient outcomes. This review sum...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610209008746
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Elder mistreatment, social ageism, and human rights are increasingly powerful discourses in positioning older people in society, yet the relationship between them has rarely been subjected to critical investigation. This perceived relationship will have implications for how mistreatment is understood and res...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212002372
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Overlap between neuropsychiatric symptoms of dementia and delirium complicates diagnosis of delirium superimposed on dementia (DSD). This study sought to examine differences in delirium presentation and outcomes between DSD patients with and without pre-existing behavioral and psychological symptoms of demen...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216001836
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:The growing and welcome interest in the issues leading to distress and impairment in younger doctors has not been mirrored by a focus on the similar issues in older doctors which is surprising given the aging medical workforce. OBJECTIVES:To improve understanding of impairment in older doctors and to facili...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610207005431
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Delirium is a risk factor for long-term cognitive impairment and dementia. Yet, the nature of these cognitive deficits is unknown as is the extent to which the persistence of delirium symptoms and presence of depression at follow-up may account for the association between delirium and cognitive impairment at...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213000574
更新日期:2013-09-01 00:00:00
abstract::This community-based epidemiological survey concerns relationships between social and health factors and depression in a Finnish population aged 60 years or over. A multivariate analysis based on log-linear models is used in this study. The log-linear model showed five interactions for the depressed men and eight for ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s104161029300136x
更新日期:1993-04-01 00:00:00
abstract:OBJECTIVES:Data on psychotropic medications of older patients with schizophrenia spectrum disorder are scarce. Specifically, information about the use of benzodiazepines among older patients with schizophrenia spectrum disorder is very limited. Because benzodiazepine use in older patients has been associated with many ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219000358
更新日期:2020-04-01 00:00:00
abstract::ABSTRACTBackground:The number of elderly individuals living in China is increasing rapidly. The aim of this study was to examine the potential risk factors of geriatric depression in rural areas. METHODS:A repeated cross-sectional study was conducted between January 2015 and October 2016 in rural China. Nine hundred ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000030
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that the verbal fluency test (VFT) is a sensitive measure of cognitive dysfunction in Alzheimer's disease (AD). However, other studies have shown that the performances were significantly influenced by education in the normal elderly population. In order to examine the utility of t...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210000839
更新日期:2010-09-01 00:00:00
abstract::ABSTRACTBackground:Dementia is a neurodegenerative syndrome that interferes with multiple aspects of life, including cognition, daily functioning, and behavior. Despite the large heterogeneity in symptom development, these three domains are seldom studied simultaneously. This study investigates how trajectories of the...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S1041610217000321
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Understanding the prevalence, incidence and cofactors of depression among long-term elderly nursing home (LTNH) residents domiciled for eight months or more may help optimize depression treatment in this vulnerable group. We quantified first year depression in American LTNH residents and the associations bet...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210000578
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the clustering of symptoms on the Neuropsychiatric Inventory (NPI) and the relative prevalence of symptom clusters in mild and moderate Alzheimer's disease (AD). METHODS:Confirmatory factor analysis (CFA) was performed on the polychoric correlation matrix of 12 NPI i...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000609
更新日期:2012-09-01 00:00:00
abstract::ABSTRACTBackground:Walking ability recently emerged as a sub-clinical marker of cognitive decline. Hence, the relationship between baseline gait and future cognitive decline was examined in geriatric patients. Because a "loss of complexity" (LOC) is a key phenomenon of the aging process that exhibits in multiple syste...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217002770
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Inability to walk compromises the well-being of the growing number of nursing home residents with dementia. The purpose of this study was to estimate the incidence and identify predictors of walking disability that may be remediable. METHODS:A cohort was followed fortnightly for a year in 15 nursing homes i...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S1041610210000116
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Concerns about suicide risk in people with dementia have been increasing in recent years along with a discourse about rational suicide and assisted suicide. METHODS:A systematic narrative literature review of suicidal behavior and assisted suicide in persons with dementia. RESULTS:Most studies that have ex...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610215000629
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Irregular circadian rhythm and cognitive impairment are frequently observed in patients with chronic schizophrenia. However, their effects in different living environments or with aging remain unclear. The aim of this study was to clarify the characteristics of circadian rhythm and cognition function in the ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214001604
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The use of benzodiazepines is associated with increased risk of fall-related injuries in the elderly. However, it is unclear if the risks vary across the products and how they depend on the pattern of use and dosage. Specifically, the possibility of cumulative effects of past benzodiazepine use has not been ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211002031
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND AND AIM:Previous research suggested caregiver singing could influence persons with severe dementia to communicate with increased competence, to cease aggression, and to cease disruptive screaming, while at the same time they seemed to understand what was going on when being cared for during morning care sess...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:This study determined the reliability, validity, and factor structure of self-report emotions in persons with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI) relative to controls. METHODS:Participants (mild AD, n = 73; MCI, n = 159; controls, n = 96) rated current emotions with the Visual ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021100041X
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Socioeconomic status (SES) has been identified as a possible risk factor for the development of dementia, with low SES shown to be associated with a higher prevalence of dementia, increased psychiatric comorbidity and worse baseline cognitive functioning. Few studies have actually looked at the impact of SES...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209990846
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To identify, in caregivers of patients with Alzheimer's disease (AD) dementia, factors associated with subjective (personal, physical, emotional, and social) and objective (informal caregiver time and costs) caregiver burden. DESIGN:Prospective longitudinal European observational study: post-hoc analysis. S...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219000425
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Raising understanding of dementia has become a key focus of international health and social care. An up-to-date, psychometrically sound measure of dementia knowledge that embraces a biopsychosocial perspective is lacking. The aim of this study is to develop and evaluate the psychometric properties of the DK-...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213001142
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:The delirium index (DI) is a valid measure of delirium severity. We proposed to describe longitudinal patterns of severity scores in older long-term care (LTC) residents. METHODS:A prospective cohort study of 280 residents in seven LTC facilities in Montreal and Quebec City, Canada, was conducted. DI, Barth...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S104161021600137X
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Older migrants with dementia and limited English language proficiency in residential care may have unmet needs for social interaction. This project compared verbal communication and prescribed psychiatric medication of Greek and Italian residents with dementia in ethno-specific and mainstream residential car...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211002134
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Foreign home care services provided to frail older adults by individuals from the developing world are a global phenomenon. This study evaluated the challenges associated with live-in foreign home care from the perspective of older care recipients and their family members. METHODS:Qualitative interviews wer...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209990421
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:In old age, both apathy and depression have been associated with an increased cardiovascular disease (CVD) risk. This study evaluated the mediating role of cardiovascular risk factors in the relationship of apathy and mood symptoms with incident CVD. METHODS:Prospective cohort study of 1,790 community-dwell...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215001751
更新日期:2016-04-01 00:00:00
abstract::The authors would like to apologise for a typographical error in the discussion of the above mentioned article. In the discussion on page 830 of the article, paragraph 'In the present sample, when we tested the accuracy of the MoCA to discriminate between MCI and healthy participants using ROC curves, the best cut-off...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021600212X
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Most research on family members' experience of dementia has focused on the time after diagnosis. Yet, once people reach clinical attention, families have already been living with the changes for some time. These pre-diagnosis experiences can influence later caregiving. We aimed to synthesize qualitative rese...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610217000862
更新日期:2017-09-01 00:00:00