Preserved brain metabolic activity at the age of 96 years.


:Loss of brain tissue becomes notable to cerebral magnetic resonance imaging (MRI) at age 30 years, and progresses more rapidly from mid 60s. The incidence of dementia increases exponentially with age, and is all too frequent in the oldest old (≥ 90 years of age), the fastest growing age group in many countries. However, brain pathology and cognitive decline are not inevitable, even at extremely old age (den Dunnen et al., 2008).


Int Psychogeriatr


Apostolova I,Lange C,Spies L,Ritter K,Mäurer A,Seybold J,Fiebach JB,Steinhagen-Thiessen E,Buchert R




Has Abstract


2016-09-01 00:00:00














  • Leisure activities, education, and cognitive impairment in Chinese older adults: a population-based longitudinal study.

    abstract:BACKGROUND:We examine the association between leisure-time activities and the risk of developing cognitive impairment among Chinese older people, and further investigate whether the association varies by educational level. METHODS:This follow-up study included 6,586 participants (aged 79.5 ± 9.8 years, range 65-105 ye...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Zhu X,Qiu C,Zeng Y,Li J

    更新日期:2017-05-01 00:00:00

  • Perspectives of the community-based dementia care workforce: "occupational communion" a key finding from the Work 4 Dementia Project.

    abstract:BACKGROUND:Community care workers' experience of delivering support to people with dementia is less researched than that of residential workers. The purpose of the study is to explore community-based dementia care workers' perspectives about their roles and the contextual variables that impact upon their work experienc...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Elliott KE,Stirling CM,Martin AJ,Robinson AL,Scott JL

    更新日期:2013-05-01 00:00:00

  • Feasibility and effectiveness of activity-scheduling as a guided self-help intervention for the prevention of depression and anxiety in residents in homes for the elderly: a pragmatic randomized controlled trial.

    abstract:BACKGROUND:Elderly people living in residential homes are at high risk for developing major depressive and anxiety disorders, and therefore deserve attention in terms of preventive interventions. We evaluated the feasibility and effectiveness of a guided self-help intervention for the prevention of depression and anxie...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,随机对照试验


    authors: Dozeman E,van Schaik DJ,van Marwijk HW,Stek ML,Beekman AT,van der Horst HE

    更新日期:2011-08-01 00:00:00

  • Cognition, coping, and outcome in Parkinson's disease.

    abstract:BACKGROUND:Cognitive impairment and depression are common and disabling non-motor symptoms of Parkinson's disease (PD). Previous studies have shown associations between them but the nature of the relationship remains unclear. In chronic illness, problem- or task-oriented coping strategies are associated with better out...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Hurt CS,Landau S,Burn DJ,Hindle JV,Samuel M,Wilson K,Brown RG,PROMS-PD Study Group.

    更新日期:2012-10-01 00:00:00

  • Wandering in dementia: a longitudinal study.

    abstract:OBJECTIVE:This article analyzes the natural history of wandering behavior throughout the course of dementia. DESIGN:Prospective, 10-year, longitudinal study of wandering behavior in dementia, with autopsy follow-up. SETTING:Participants with dementia, living at home with a carer. All lived in Oxfordshire, UK. PARTIC...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Hope T,Keene J,McShane RH,Fairburn CG,Gedling K,Jacoby R

    更新日期:2001-06-01 00:00:00

  • Does vascular MCI progress at a different rate than does amnestic MCI?

    abstract::This article reviews the evidence available from natural history studies and randomized clinical trials (RCT) concerning what is now coined as amnestic MCI and vascular MCI and will answer the question about the similarity and difference of their progression toward dementia. The issues to be resolved prior to the use ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Gauthier S,Rockwood K

    更新日期:2003-01-01 00:00:00

  • The impact of diagnostic disclosure in dementia: a qualitative case analysis.

    abstract:OBJECTIVE:The aim of this study was to give an in-depth description of the impact of disclosure of the diagnosis of dementia on a patient and the patient's partner. METHODS:Grounded theory interview study. RESULTS:Analysis of the interviews revealed that disclosure had an impact on three key domains: awareness of dem...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Derksen E,Vernooij-Dassen M,Gillissen F,Olde-Rikkert M,Scheltens P

    更新日期:2005-06-01 00:00:00

  • Diagnosis and disclosure of a memory problem is associated with quality of life in community based older Australians with dementia.

    abstract:BACKGROUND:Identification of factors associated with quality of life (QoL) in people having dementia will help develop strategies for maintenance and improvement of patient QoL. This study examined the predictors of QoL in a community-dwelling population aged 75 years and over, with or without dementia. METHODS:This w...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Mate KE,Pond CD,Magin PJ,Goode SM,McElduff P,Stocks NP

    更新日期:2012-12-01 00:00:00

  • Statistical analysis, trial design and duration in Alzheimer's disease clinical trials: a review.

    abstract:BACKGROUND:The social and economic burden of Alzheimer's disease (AD) and its increasing prevalence has led to much work on new treatment strategies and clinical trials. The search for surrogate markers of disease progression continues but traditional parallel group trial designs that use well-established, but often in...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审


    authors: Thompson PA,Wright DE,Counsell CE,Zajicek J

    更新日期:2012-05-01 00:00:00

  • Early symptoms and signs of cognitive deficits might not always be detectable in persons who develop Alzheimer's disease.

    abstract:OBJECTIVE:Clinical syndromes such as amnestic mild cognitive impairment (MCI) are highly predictive of future development of Alzheimer's disease (AD), but it is not known how many of the individuals that develop the disease can be identified with these syndromes. This study aims to determine how many individuals with A...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Palmer K,Bäckman L,Winblad B,Fratiglioni L

    更新日期:2008-04-01 00:00:00

  • Positive psychiatry comes of age.

    abstract::Positive psychiatry is the science and practice of psychiatry that focuses on psycho-bio-social study and promotion of well-being and health through enhancement of positive psychosocial factors (such as resilience, optimism, wisdom, and social support) in people with illnesses or disabilities as well as the in communi...

    journal_title:International psychogeriatrics

    pub_type: 社论


    authors: Jeste DV

    更新日期:2018-12-01 00:00:00

  • Qualitative analysis of the clinician interview-based impression of change (Plus): methodological issues and implications for clinical research.

    abstract::The Clinician Interview-Based Impression of Change, plus carer interview (CIBIC-Plus), is widely used in antidementia drug trials. It comprises Likert scales for disease severity and changes, and written accounts summarizing semistructured interviews evaluating behavior, cognition, and function. Studies using the CIBI...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Joffres C,Graham J,Rockwood K

    更新日期:2000-09-01 00:00:00

  • Clinical and economic characteristics associated with direct costs of Alzheimer's, frontotemporal and vascular dementia in Argentina.

    abstract:BACKGROUND:The economic cost of dementia is high and can be predicted by cognitive and neuropsychiatric profiles. The differential costs of the various subtypes of dementia are unknown in Argentina, and this study therefore aimed to compare these costs. METHODS:Patients with a diagnosis of dementia of Alzheimer-type (...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Rojas G,Bartoloni L,Dillon C,Serrano CM,Iturry M,Allegri RF

    更新日期:2011-05-01 00:00:00

  • Efficacy of risperidone for treating patients with behavioral and psychological symptoms of dementia.

    abstract:BACKGROUND:Large randomized controlled trials have shown that risperidone reduces the frequency and severity of behavioral and psychological symptoms of dementia (BPSD) in patients with dementia. Since such trials are obliged to use very strict inclusion and exclusion criteria, their information about the efficacy is l...

    journal_title:International psychogeriatrics

    pub_type: 临床试验,杂志文章


    authors: Wancata J

    更新日期:2004-03-01 00:00:00

  • Geriatric Depression Scale as a community screening instrument for elderly Chinese immigrants.

    abstract::Depression is the most prevalent mental health problem among the elderly, including Chinese-American elderly. A Chinese-language version of the popular Geriatric Depression Scale Long Form (GDS-LF) and Short Form (GDS-SF) was developed. Based on the responses of 50 elderly Chinese immigrants to the U.S. (25 women and ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Mui AC

    更新日期:1996-10-01 00:00:00

  • Relationship between cortisol level and prevalent/incident cognitive impairment and its moderating factors in older adults.

    abstract:BACKGROUND:The objectives of this study were to examine the factors modifying the relationship between cortisol level and prevalent/incident cognitive impairment in older adults and to verify whether these relationships were non-linear. METHODS:Data were collected from 1,226 individuals aged 65 and older by two in-hom...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Potvin O,Forget H,Préville M,Berbiche D,Chagnon YC,Hudon C

    更新日期:2013-02-01 00:00:00

  • The brief cognitive assessment tool (BCAT): cross-validation in a community dwelling older adult sample.

    abstract::ABSTRACT Background: Cognitive impairment is underrecognized and misdiagnosed among community-dwelling older adults. At present, there is no consensus about which cognitive screening tool represents the "gold standard." However, one tool that shows promise is the Brief Cognitive Assessment Tool (BCAT), which was origi...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: MacDougall EE,Mansbach WE,Clark K,Mace RA

    更新日期:2014-08-13 00:00:00

  • Reconceptualizing models of delirium education: findings of a Grounded Theory study.

    abstract:BACKGROUND:Effectiveness of educational interventions targeted at improving delirium care is limited by implementation barriers. Studying factors which shape learning needs can overcome these knowledge transfer barriers. This in-depth qualitative study explores learning needs of hospital staff relating to care needs of...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Teodorczuk A,Mukaetova-Ladinska E,Corbett S,Welfare M

    更新日期:2013-04-01 00:00:00

  • Validation of the Rowland Universal Dementia Assessment Scale (RUDAS) in a multicultural sample across five Western European countries: diagnostic accuracy and normative data.

    abstract::ABSTRACTBackground:With increasing cultural diversity and growing elderly immigrant populations in Western European countries, the availability of brief cognitive screening instruments adequate for assessment of dementia in people from diverse backgrounds becomes increasingly important. The aim of the present study wa...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,多中心研究


    authors: Nielsen TR,Segers K,Vanderaspoilden V,Bekkhus-Wetterberg P,Bjørkløf GH,Beinhoff U,Minthon L,Pissiota A,Tsolaki M,Gkioka M,Waldemar G

    更新日期:2019-02-01 00:00:00

  • Prevalence and correlates of psychotropic drug use in community-dwelling people with young-onset dementia: the NeedYD-study.

    abstract:BACKGROUND:Young-onset dementia (YOD) is defined as dementia that develops before the age of 65 years. The prevalence and type of neuropsychiatric symptoms (NPS) in YOD differ from patients with late onset dementia. NPS in dementia patients are often treated with psychotropic drugs. The aim of this study was to investi...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Koopmans RT,Reinders R,van Vliet D,Verhey FR,de Vugt ME,Bor H,Bakker C

    更新日期:2014-12-01 00:00:00

  • Bedside clinical and electrophysiological assessment: assessment of change in vulnerable patients.

    abstract::Current approaches to the diagnosis of delirium are based upon the recognition of symptoms that emerge in the pathological state. As an alternative, we propose an approach to case identification for research purposes based on the recognition of significant changes in the cognitive or cerebral state of the individual p...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Katz IR,Mossey J,Sussman N,Muenz L,Harner R,Curlik Sm,Sands LP

    更新日期:1991-01-01 00:00:00

  • Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer's disease.

    abstract::Cholinergic deficits are a hallmark of Alzheimer's disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in ne...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Schumacher J,Thomas AJ,Peraza LR,Firbank M,O'Brien JT,Taylor JP

    更新日期:2021-01-08 00:00:00

  • The use of CT in dementia.

    abstract::Neuroimaging has become part of the required investigations when assessing a patient with dementia. In this brief paper, we summarize the role of computed tomography (CT) in the routine work-up in dementia and provide some information about the role of the CT scan in the field of dementia research. Although CT is far ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审


    authors: Pasi M,Poggesi A,Pantoni L

    更新日期:2011-09-01 00:00:00

  • A randomized, placebo-controlled trial of the discontinuation of long-term antipsychotics in dementia.

    abstract::The objectives of this randomized clinical trial were to investigate the impact of the discontinuation of long-term antipsychotics in residents with dementia in chronic care institutions and to identify clinical predictors of safe discontinuation. Subjects included 34 residents with dementia who were on antipsychotics...

    journal_title:International psychogeriatrics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: van Reekum R,Clarke D,Conn D,Herrmann N,Eryavec G,Cohen T,Ostrander L

    更新日期:2002-06-01 00:00:00

  • Five-year trajectories of social networks and social support in older adults with major depression.

    abstract:BACKGROUND:Research with nondepressed adults suggests that social networks and social support are stable over the life course until very late age. This may not hold true for older adults with depression. We examined baseline status and trajectories of social networks and social support at the group and individual level...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Voils CI,Allaire JC,Olsen MK,Steffens DC,Hoyle RH,Bosworth HB

    更新日期:2007-12-01 00:00:00

  • The neuropsychological sequelae of delirium in elderly patients with hip fracture three months after hospital discharge.

    abstract:BACKGROUND:Delirium is a risk factor for long-term cognitive impairment and dementia. Yet, the nature of these cognitive deficits is unknown as is the extent to which the persistence of delirium symptoms and presence of depression at follow-up may account for the association between delirium and cognitive impairment at...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Witlox J,Slor CJ,Jansen RW,Kalisvaart KJ,van Stijn MF,Houdijk AP,Eikelenboom P,van Gool WA,de Jonghe JF

    更新日期:2013-09-01 00:00:00

  • Older women who died by suicide: suicide means, sociodemographic and psychiatric risk factors, and other precipitating circumstances.

    abstract::ABSTRACTBackground:US suicide rates among older women have substantially increased over the past decade. We examined potential differences in sociodemographic and risk/precipitating factors among older female suicide decedents who died by drug overdose versus firearms, hanging/suffocation, and other means, and postmor...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Choi NG,DiNitto DM,Sagna AO,Marti CN

    更新日期:2018-10-01 00:00:00

  • The relationship between gait dynamics and future cognitive decline: a prospective pilot study in geriatric patients.

    abstract::ABSTRACTBackground:Walking ability recently emerged as a sub-clinical marker of cognitive decline. Hence, the relationship between baseline gait and future cognitive decline was examined in geriatric patients. Because a "loss of complexity" (LOC) is a key phenomenon of the aging process that exhibits in multiple syste...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Kikkert LHJ,Vuillerme N,van Campen JP,Appels BA,Hortobágyi T,Lamoth CJC

    更新日期:2018-09-01 00:00:00

  • Midlife improvements in financial situation are associated with a reduced dementia risk later in life: the CAIDE 30-year study.

    abstract:OBJECTIVES:Perceived financial strain is associated with various health conditions, but it is unknown whether it is associated with an increased risk for dementia. The goal is to examine the associations between midlife perceptions of financial situation and dementia risk later in life. METHODS:Participants were deriv...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Sindi S,Darin-Mattsson A,Kåreholt I,Kulmala J,Ngandu T,Laatikainen T,Soininen H,Kivipelto M

    更新日期:2020-11-01 00:00:00

  • Clinicians' attitudes to spirituality in old age psychiatry.

    abstract:BACKGROUND:The aim of this survey is to investigate professional attitudes to the presence and value of spiritual care from Old Age Psychiatrists. METHOD:All registered members of the Faculty of the Psychiatry of Old Age in the United Kingdom were asked to complete a 21-question semi-structured questionnaire. The firs...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Lawrence RM,Head J,Christodoulou G,Andonovska B,Karamat S,Duggal A,Hillam J,Eagger S

    更新日期:2007-10-01 00:00:00