Abstract:
BACKGROUND:Previous studies have shown that the verbal fluency test (VFT) is a sensitive measure of cognitive dysfunction in Alzheimer's disease (AD). However, other studies have shown that the performances were significantly influenced by education in the normal elderly population. In order to examine the utility of the VFT as a tool for screening for AD, it is necessary to study the effect of education not only in the cognitively intact population but also in the population of early AD patients. METHODS:Patients with AD (n = 345) and individuals with amnestic type of mild cognitive impairment (MCI) (n = 123) were asked to generate as many words as possible belonging to a category "animal" and beginning with " [ka]" in syllabic Japanese "kana" script. In order to determine the education effect after adjusting for age and cognitive state on the VFT performance in early stage of AD, we performed multiple regression analysis with 396 individuals including both amnestic MCI and AD. RESULTS:After adjusting for patients' age, sex, and cognitive state, the years of education were significantly related to category fluency test scores, but not significantly related to letter fluency test scores. CONCLUSION:Our results demonstrated that a category fluency performance reflected not only AD-specific changes but also educational background. These results suggest the limitation of using the category fluency task for screening subjects at risk for developing AD without taking subjects' educational background into consideration.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Kawano N,Umegaki H,Suzuki Y,Yamamoto S,Mogi N,Iguchi Adoi
10.1017/S1041610210000839subject
Has Abstractpub_date
2010-09-01 00:00:00pages
995-1002issue
6eissn
1041-6102issn
1741-203Xpii
S1041610210000839journal_volume
22pub_type
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journal_title:International psychogeriatrics
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journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
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pub_type: 杂志文章,随机对照试验
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