Assessing the cumulative effects of exposure to selected benzodiazepines on the risk of fall-related injuries in the elderly.

Abstract:

BACKGROUND:The use of benzodiazepines is associated with increased risk of fall-related injuries in the elderly. However, it is unclear if the risks vary across the products and how they depend on the pattern of use and dosage. Specifically, the possibility of cumulative effects of past benzodiazepine use has not been thoroughly investigated. METHODS:We used the administrative database for a cohort of 23,765 new users of benzodiazepines, aged 65 years and older, in Quebec, Canada, between 1990 and 1994. The associations between the use of seven benzodiazepines and the risk of fall-related injuries were assessed using several statistical models, including a novel weighted cumulative exposure model. That model assigns to each dose taken in the past a weight that represents the importance of that dose in explaining the current risk of fall. RESULTS:For flurazepam, the best-fitting model indicated a cumulative effect of doses taken in the last two weeks. Uninterrupted use of flurazepam in the past months was associated with a highly significant increase in the risk of fall-related injuries (HR = 2.83, 95% CI: 1.45-4.34). The cumulative effect of a 30-day exposure to alprazolam was 1.27 (1.13-1.42). For temazepam, the results suggested a potential withdrawal effect. CONCLUSIONS:Mechanisms affecting the risk of falls differ across benzodiazepines, and may include cumulative effects of use in the previous few weeks. Thus, benzodiazepine-specific analyses that account for individual patterns of use should be preferred over simpler analyses that group different benzodiazepines together and limit exposure to current use or current dose.

journal_name

Int Psychogeriatr

authors

Sylvestre MP,Abrahamowicz M,Čapek R,Tamblyn R

doi

10.1017/S1041610211002031

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

577-86

issue

4

eissn

1041-6102

issn

1741-203X

pii

S1041610211002031

journal_volume

24

pub_type

杂志文章
  • Physician don't heal thyself: a descriptive study of impaired older doctors.

    abstract:BACKGROUND:The growing and welcome interest in the issues leading to distress and impairment in younger doctors has not been mirrored by a focus on the similar issues in older doctors which is surprising given the aging medical workforce. OBJECTIVES:To improve understanding of impairment in older doctors and to facili...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610207005431

    authors: Peisah C,Wilhelm K

    更新日期:2007-10-01 00:00:00

  • World War II-related post-traumatic stress disorder and breast cancer risk among Israeli women: a case-control study.

    abstract:BACKGROUND:Several studies have suggested that post-traumatic stress disorder (PTSD) is related to adverse health outcomes. There are limited data on PTSD and cancer, which has a long latency period. We investigated the association between World War II (WWII)-related PTSD and subsequent breast cancer (BC) risk among Je...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610213002081

    authors: Vin-Raviv N,Dekel R,Barchana M,Linn S,Keinan-Boker L

    更新日期:2014-03-01 00:00:00

  • Food group intake and brain lesions in late-life vascular depression.

    abstract:BACKGROUND:Studies indicate that diet may be related to the occurrence of brain lesions. The cross-sectional association between food intake and brain lesion volumes in late-life depression was examined in a cohort of elderly individuals with current or prior depression. METHODS:Food intake was assessed in 54 elderly ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610206004431

    authors: Payne ME,Haines PS,Chambless LE,Anderson JJ,Steffens DC

    更新日期:2007-04-01 00:00:00

  • Feasibility and effectiveness of activity-scheduling as a guided self-help intervention for the prevention of depression and anxiety in residents in homes for the elderly: a pragmatic randomized controlled trial.

    abstract:BACKGROUND:Elderly people living in residential homes are at high risk for developing major depressive and anxiety disorders, and therefore deserve attention in terms of preventive interventions. We evaluated the feasibility and effectiveness of a guided self-help intervention for the prevention of depression and anxie...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S1041610211000202

    authors: Dozeman E,van Schaik DJ,van Marwijk HW,Stek ML,Beekman AT,van der Horst HE

    更新日期:2011-08-01 00:00:00

  • Translation and validation of Chinese version of the problems in everyday living (PEDL) test in patients with mild cognitive impairment.

    abstract:BACKGROUND:Cognitive impairment places older adults at increased risk of functional decline, injuries, and hospitalization. Assessments to determine whether older persons are still capable of meeting the cognitive challenges of everyday living are crucial to ensure their safe and independent living in the community. Th...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610213001889

    authors: Law LL,Barnett F,Gray MA,Yau MK,Siu AM

    更新日期:2014-02-01 00:00:00

  • Aerobic fitness and multidomain cognitive function in advanced age.

    abstract:BACKGROUND:Studies generally describe the relationship between physical fitness and cognitive function by measuring only one or two specific cognitive tasks. In addition, in spite of the significant increase in life expectancy, the age of participants in these studies does not extend beyond a mean age of 70 years. This...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610210000797

    authors: Netz Y,Dwolatzky T,Zinker Y,Argov E,Agmon R

    更新日期:2011-02-01 00:00:00

  • Frontotemporal dementia and dementia with Lewy bodies in a case-control study of Alzheimer's disease.

    abstract:BACKGROUND:The clinical presentations in dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD) overlap considerably with that of Alzheimer's disease (AD) despite different pathological processes. Autopsy studies have also shown that multiple brain pathology occurs frequently, even in cases with a single cli...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610209009454

    authors: Piguet O,Halliday GM,Creasey H,Broe GA,Kril JJ

    更新日期:2009-08-01 00:00:00

  • Mental capacity assessments among general hospital inpatients referred to a specialist liaison psychiatry service for older people.

    abstract:BACKGROUND:Mental capacity has been little studied among older general hospital inpatients. METHODS:A retrospective analysis was undertaken of routinely collected data (age, gender, ethnicity, admission diagnosis, psychiatric diagnosis, Mini-mental State Examination score, whether capacity was assessed, the outcome of...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S104161020900917X

    authors: Mujic F,Von Heising M,Stewart RJ,Prince MJ

    更新日期:2009-08-01 00:00:00

  • The association between cognitive decline and incident depressive symptoms in a sample of older Puerto Rican adults with diabetes.

    abstract:BACKGROUND:Older Puerto Rican adults have particularly high risk of diabetes compared to the general US population. Diabetes is associated with both higher depressive symptoms and cognitive decline, but less is known about the longitudinal relationship between cognitive decline and incident depressive symptoms in those...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610217000746

    authors: Bell T,Dávila AL,Clay O,Markides KS,Andel R,Crowe M

    更新日期:2017-08-01 00:00:00

  • Associations between modifiable lifestyle factors and multidimensional cognitive health among community-dwelling old adults: stratified by educational level.

    abstract::ABSTRACTBackground:Cognition is multidimensional, and each domain plays a unique and crucial part in successful daily life engagement. However, less attention has been paid to multi-domain cognitive health for the elderly, and the role of lifestyle factors in each domain remains unclear. METHODS:We conducted a cross-...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610217003076

    authors: Yuan M,Chen J,Han Y,Wei X,Ye Z,Zhang L,Hong YA,Fang Y

    更新日期:2018-10-01 00:00:00

  • Geriatric Depression Scale as a community screening instrument for elderly Chinese immigrants.

    abstract::Depression is the most prevalent mental health problem among the elderly, including Chinese-American elderly. A Chinese-language version of the popular Geriatric Depression Scale Long Form (GDS-LF) and Short Form (GDS-SF) was developed. Based on the responses of 50 elderly Chinese immigrants to the U.S. (25 women and ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610296002803

    authors: Mui AC

    更新日期:1996-10-01 00:00:00

  • Frailty and adverse outcomes: impact of multiple bed moves for older inpatients.

    abstract:BACKGROUND:A consequence of pressure on hospitals to accommodate care needs of older patients is "boarding" or out-lying from their home ward. This may have greater adverse effects on older inpatients who are frail. METHODS:A retrospective matched cohort study was conducted in an outer metropolitan general hospital. R...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610216001605

    authors: Ranasinghe C,Fleury A,Peel NM,Hubbard RE

    更新日期:2017-02-01 00:00:00

  • Midlife improvements in financial situation are associated with a reduced dementia risk later in life: the CAIDE 30-year study.

    abstract:OBJECTIVES:Perceived financial strain is associated with various health conditions, but it is unknown whether it is associated with an increased risk for dementia. The goal is to examine the associations between midlife perceptions of financial situation and dementia risk later in life. METHODS:Participants were deriv...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S104161021900173X

    authors: Sindi S,Darin-Mattsson A,Kåreholt I,Kulmala J,Ngandu T,Laatikainen T,Soininen H,Kivipelto M

    更新日期:2020-11-01 00:00:00

  • Individualized guidelines for the management of aggression in dementia - Part 2: appraisal of current guidelines.

    abstract:BACKGROUND:Individualized guidelines have the potential to offer clinicians assistance in decision-making at the point of consultation to improve health outcomes for patients. This project aims to develop individualized guidelines for the management of aggression in dementia. At an earlier stage, we developed a map of ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S104161021200004X

    authors: Vickland V,Chilko N,Draper B,Low LF,O'Connor D,Brodaty H

    更新日期:2012-07-01 00:00:00

  • Relationships between social and health factors and depression in old age in a multivariate analysis.

    abstract::This community-based epidemiological survey concerns relationships between social and health factors and depression in a Finnish population aged 60 years or over. A multivariate analysis based on log-linear models is used in this study. The log-linear model showed five interactions for the depressed men and eight for ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s104161029300136x

    authors: Pahkala K,Kivelä SL,Laippala P

    更新日期:1993-04-01 00:00:00

  • The association between late-life cognitive test scores and retrospective informant interview data.

    abstract:BACKGROUND:Cognitive assessment of older persons, particularly those with impairment, is hampered by measurement error and the ethical issues of testing people with dementia. A potential source of valuable information about end-of-life cognitive status can be gained from those who knew the respondent well - mostly rela...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610210001201

    authors: Marioni RE,Matthews FE,Brayne C,MRC Cognitive Function and Ageing Study.

    更新日期:2011-03-01 00:00:00

  • Can leisure activities slow dementia progression in nursing home residents? A cluster-randomized controlled trial.

    abstract:BACKGROUND:To examine the effects of complex cognitive (mahjong) and physical (Tai Chi) activities on dementia severity in nursing home residents with dementia. METHODS:Cluster-randomized open-label controlled design. 110 residents were randomized by nursing home into three conditions: mahjong, Tai Chi, and simple han...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S1041610213002524

    authors: Cheng ST,Chow PK,Song YQ,Yu EC,Lam JH

    更新日期:2014-04-01 00:00:00

  • Efficacy of donepezil on behavioral symptoms in patients with moderate to severe Alzheimer's disease.

    abstract:OBJECTIVE:This subanalysis of a large, double-blind, placebo-controlled trial examined the prevalence of behavioral symptoms in moderate to severe Alzheimer's disease (AD), and the effect of treatment with donepezil. METHODS:Two hundred ninety patients with moderate to severe AD (standardized Mini-Mental State Examina...

    journal_title:International psychogeriatrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1017/s104161020200858x

    authors: Gauthier S,Feldman H,Hecker J,Vellas B,Ames D,Subbiah P,Whalen E,Emir B,Donepezil MSAD Study Investigators Group.

    更新日期:2002-12-01 00:00:00

  • Clinico-tomographical aspects in the pathogenesis of vascular dementia.

    abstract::This article discusses the role of some pathogenetical factors in the main morphological variants of vascular dementia and their correlation with certain clinical parameters. On the basis of computer-tomographical (CT) studies of 62 patients with dementia, it was possible to distinguish three groups of patients, accor...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610292001054

    authors: Kontsevoy VA,Medvedev AV,Vavilov SB,Shchirina MG

    更新日期:1992-10-01 00:00:00

  • The development and evaluation of the DK-20: a knowledge of dementia measure.

    abstract:BACKGROUND:Raising understanding of dementia has become a key focus of international health and social care. An up-to-date, psychometrically sound measure of dementia knowledge that embraces a biopsychosocial perspective is lacking. The aim of this study is to develop and evaluate the psychometric properties of the DK-...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610213001142

    authors: Shanahan N,Orrell M,Schepers AK,Spector A

    更新日期:2013-11-01 00:00:00

  • Elder mistreatment, ageism, and human rights.

    abstract:BACKGROUND:Elder mistreatment, social ageism, and human rights are increasingly powerful discourses in positioning older people in society, yet the relationship between them has rarely been subjected to critical investigation. This perceived relationship will have implications for how mistreatment is understood and res...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610212002372

    authors: Biggs S,Haapala I

    更新日期:2013-08-01 00:00:00

  • Elderly suicide attempters by self-poisoning in Korea.

    abstract:BACKGROUND:Suicide is a major public health concern. The elderly have the highest rate of suicide and they make more lethal suicide attempts and have fewer psychiatric interventions than young people. Furthermore, they have old-age specific psychosocial difficulties. The present study investigated psychosocial risk fac...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610211000263

    authors: Kim YR,Choi KH,Oh Y,Lee HK,Kweon YS,Lee CT,Lee KU

    更新日期:2011-08-01 00:00:00

  • Behavioral correlates of anxiety in well-functioning older adults.

    abstract:BACKGROUND:Research on the behavioral correlates of anxiety in older adults is sparse. The aim of this study was to explore the association of anxiety with behavioral patterns defined by health, activity, emotional and social variables. METHODS:A convenience sample of 395 older adults completed measures of health, act...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610214001148

    authors: Losada A,Márquez-González M,Pachana NA,Wetherell JL,Fernández-Fernández V,Nogales-González C,Ruiz-Díaz M

    更新日期:2015-07-01 00:00:00

  • Family group conferencing in dementia care: an exploration of opportunities and challenges.

    abstract:BACKGROUND:The Family Group Conference (FGC) is an approach to partnership working which brings together service users, their support network and care professionals in a family-led decision making forum. Evidence, though limited, indicates that that FGC can enhance outcomes for service providers and their users. This s...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610215001507

    authors: Górska S,Forsyth K,Prior S,Irvine L,Haughey P

    更新日期:2016-02-01 00:00:00

  • Efficacy of psychosocial treatments for noisemaking in severe dementia.

    abstract::Noisemaking is one of the most disturbing behavior disorders associated with dementia. Standard management practices, including pharmacological interventions, are not very successful in treating the behavior. Very little research has been carried out to evaluate innovative treatments or to determine the etiology of no...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610297004547

    authors: Doyle C,Zapparoni T,O'Connor D,Runci S

    更新日期:1997-12-01 00:00:00

  • One-year outcomes of minor and subsyndromal depression in older primary care patients.

    abstract:BACKGROUND:Despite the high prevalence and morbidity of minor and subsyndromal depression in primary care elderly people, there are few data to identify those at highest risk of poor outcomes. The goal of this observational cohort study was to characterize the one-year outcomes of minor and subsyndromal depression, exa...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610208007746

    authors: Lyness JM,Chapman BP,McGriff J,Drayer R,Duberstein PR

    更新日期:2009-02-01 00:00:00

  • A novel approach to assessing memory at the population level: vulnerability to semantic interference.

    abstract:BACKGROUND:There is increasing interest in identifying novel cognitive paradigms to help detect preclinical dementia. Promising results have been found in clinical settings using the Semantic Interference Test (SIT), a modification of an existing episodic memory test (Fuld Object Memory Evaluation) that exploits vulner...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610209991657

    authors: Snitz BE,Loewenstein DA,Chang CC,Lee CW,Vander Bilt J,Saxton J,Ganguli M

    更新日期:2010-08-01 00:00:00

  • Public perceptions about risk and protective factors for cognitive health and impairment: a review of the literature.

    abstract:BACKGROUND:Preventing and/or delaying cognitive impairment is a public health priority. To increase awareness of and participation in behaviors that may help maintain cognitive function or reduce risk of impairment, we need to understand public perceptions about risk and protective factors. METHODS:We conducted a scop...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审

    doi:10.1017/S1041610214002877

    authors: Friedman DB,Becofsky K,Anderson LA,Bryant LL,Hunter RH,Ivey SL,Belza B,Logsdon RG,Brannon S,Vandenberg AE,Lin SY

    更新日期:2015-08-01 00:00:00

  • Non-pharmacological interventions for aggressive behavior in older adults living in long-term care facilities.

    abstract:BACKGROUND:Aggressive behavior (AB) is common in institutional settings. It is an important issue because of its consequences on both the person manifesting such behaviors and their caregivers. Although there are numerous studies assessing non-pharmacologic strategies to manage AB in older adults, no extensive review o...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610205002929

    authors: Landreville P,Bédard A,Verreault R,Desrosiers J,Champoux N,Monette J,Voyer P

    更新日期:2006-03-01 00:00:00

  • Attachment anxiety, depression, and perceived social support: a moderated mediation model of suicide ideation among the elderly.

    abstract:OBJECTIVES:Issues concerning the association among attachment anxiety, depression and suicidal ideation among the elderly have rarely been explored. The present study investigated the relationship among attachment anxiety, depression and perceived support concerning suicidal ideation among older people. DESIGN:Cross-s...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S104161022000054X

    authors: Oonarom A,Wongpakaran T,Kuntawong P,Wongpakaran N

    更新日期:2020-05-07 00:00:00