Abstract:
:Alzheimer´s disease (AD) is a severe neurodegenerative brain disorder characterized by beta-amyloid plaques, Tau pathology, inflammation, neurodegeneration, and cerebrovascular dysfunction. Besides that, alterations in monocytes and platelets have been reported in the blood of Alzheimer patients. In the present study, we measured circulating levels of platelet-monocyte aggregates in EDTA blood of cognitively healthy participants and 40 AD patients, and examined their changes induced by stimulation with beta-amyloid peptides. We measured CD14, CD62P, and CD42a using fluorescence-activated cell scanning (FACS) analysis. Our data show that the levels of circulating monocyte-platelet aggregates were not different between healthy controls and AD patients. However, incubation with beta-amyloid-40, -42, and pyroglutamate-beta-amyloid increased the platelet-monocyte aggregation in healthy subjects, but not AD patients. Our data conclude that the interaction between monocytes and platelets is not altered in whole blood of AD patients, but their sensitivity toward beta-amyloid peptides is decreased. There might be a critical link between the interaction of platelets and monocytes in AD, which has to be explored in further studies.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Defrancesco M,Marksteiner J,Humpel Cdoi
10.1017/S1041610217001612subject
Has Abstractpub_date
2018-01-01 00:00:00pages
147-152issue
1eissn
1041-6102issn
1741-203Xpii
S1041610217001612journal_volume
30pub_type
杂志文章abstract:BACKGROUND:A third of family members caring for people with dementia report acting abusively towards them, but there are currently no evidence-based interventions to reduce or prevent such behavior. Family carers who act abusively have not previously been consulted about what may help to reduce abuse. METHOD:We prospe...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020800834X
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:The Charles Bonnet syndrome (CBS) is characterized by distinct visual hallucinations and ocularpathology causing visual impairment in patients with insight and the absence of psychiatric comorbidity. The number of reported cases of CBS is expanding as the population ages and the prevalence of vision disorder...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213000719
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Nearly half of care home residents with advanced dementia have clinically significant agitation. Little is known about costs associated with these symptoms toward the end of life. We calculated monetary costs associated with agitation from UK National Health Service, personal social services, and societal per...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219002059
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Emotional distress associated with Parkinson's disease (PD) increases disease burden and decreases functioning. The literature supports the benefits of psychological interventions for amelioration of emotional distress in persons with PD. The objective of this study is to apply the Contextual Adult Lifespan ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216000569
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The field of geriatric medicine has identified a need for an evaluative tool that can rapidly quantify global cognitive ability and accurately monitor change over time in patients with a wide range of impairments. We hypothesized that the development of an adaptive test approach to cognitive measurement woul...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211000615
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:In a previous paper, we presented results from a 12-week study of a Psychomotor DANCe Therapy INtervention (DANCIN) based on Danzón Latin Ballroom that involves motor, emotional-affective, and cognitive domains, using a multiple-baseline single-case design in three care homes. This paper reports the results ...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S104161021600171X
更新日期:2017-02-01 00:00:00
abstract::ABSTRACTBackground:Delirium is a complex clinical syndrome characterized by disturbed consciousness, cognitive function, or perception and associated with serious adverse outcomes such as death, dementia, and the need for long-term care. However, recognition and management of delirium is poorly prioritized even though...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218001369
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Since its development, the Qualidem has had items that were considered unsuited for people with very severe dementia. This study attempted to investigate the applicability of all Qualidem items in people with all stages of dementia severity. METHODS:Four data sets that contained Qualidem observations on peo...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001405
更新日期:2017-09-04 00:00:00
abstract:BACKGROUND:Older people have a higher risk of drug-related problems (DRPs). However, little is known about the prevalence of DRPs in community-dwelling people who screened positive for dementia. Our study aimed to determine (1) the prevalence and types of DRPs and (2) the socio-demographic and clinical variables associ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001442
更新日期:2017-11-01 00:00:00
abstract::ABSTRACTAssociations between high body mass index (BMI) and subsequent cognitive decline, reported in elderly averaging below age 75, become less consistent at older ages. We compared the associations of BMI with cognition in moderately old (ages 75-84, N = 154) and oldest-old (85+, N = 93) samples. BMI and cognition ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218001412
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:The aim of this study was to examine the impact of residential respite care on disruptive behavior displayed by older people, particularly those with dementia. METHODS:A quasi-experimental, repeated-measures, single-group design was used. The participants were a consecutive series of 100 older people with a...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002553
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Differentiating Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), two of the commonest forms of dementia in older age, remains a diagnostic challenge. To assist with better understanding of the differences between the conditions during life, we assessed limbic and subcortical brain volumes in AD,...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215001805
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Effectiveness of educational interventions targeted at improving delirium care is limited by implementation barriers. Studying factors which shape learning needs can overcome these knowledge transfer barriers. This in-depth qualitative study explores learning needs of hospital staff relating to care needs of...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212002074
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Whereas the State-Trait Anxiety Inventory (STAI-Y) is probably the most widely used self-reported measure of anxiety, the lack of current norms among elderly people appears to be problematic in both a clinical and research context. The objective of the present study was to provide normative data for the STAI...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000300
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Large randomized controlled trials have shown that risperidone reduces the frequency and severity of behavioral and psychological symptoms of dementia (BPSD) in patients with dementia. Since such trials are obliged to use very strict inclusion and exclusion criteria, their information about the efficacy is l...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章
doi:10.1017/s1041610204000122
更新日期:2004-03-01 00:00:00
abstract::Observed cognitive decline in the elderly has been widely reported in the literature. The relation of experimental cognitive ability measures to real-world cognitive competence has been questioned. This research examines the validity of English-language versions of two measures of everyday competency: the Memory in Re...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610295001839
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to investigate the psychometric characteristics of the Perceived Stress Scale (PSS) in a sample of dementia patients and their spousal caregivers. METHODS:We investigated the reliability and validity of the 14-item PSS in a sample of 80 couples, each including one spouse who...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001387
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Health services are encouraged to adopt a strong person-centered approach to the provision of care and services for older people. The aim of this project was to establish a user-friendly, psychometrically valid, and reliable measure of healthcare staff's practice, attitudes, and beliefs regarding person-cent...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213000471
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:We assessed the relationship between cognitive impairment (including mild cognitive impairment with no signs of dementia, and dementia) and risk for depression in old age (60 years and older). METHODS:MEDLINE, EMBASE and the Cochrane Library database were used to identify potential studies. All of the clini...
journal_title:International psychogeriatrics
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S1041610210000049
更新日期:2011-05-01 00:00:00
abstract::Major depression in the elderly is often a relapsing, chronic illness with high risk for chronic invalidism, poor treatment compliance, and suicide. In most cases, maintenance treatment to prevent recurrence and to enhance the quality of life is thought to be indicated. We review recent data from our ongoing studies t...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s104161029500233x
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:There is currently a lack of consensus on the definition of successful aging (SA) and existing implementations have omitted constructs associated with SA. We used empirical methods to develop a dimensional model of SA that incorporates a wider range of associated variables, and we examined the relationship a...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211002055
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:The objectives of this study were to examine the factors modifying the relationship between cortisol level and prevalent/incident cognitive impairment in older adults and to verify whether these relationships were non-linear. METHODS:Data were collected from 1,226 individuals aged 65 and older by two in-hom...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001706
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Verbal fluency (VF) tasks are simple and efficient clinical tools to detect executive dysfunction and lexico-semantic impairment. VF tasks are widely used in patients with suspected dementia, but their accuracy for detection of mild cognitive impairment (MCI) is still under investigation. Schooling in partic...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209990639
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Elderly suicide rates are associated with the elderly population size, the proportion of elderly in the general population and the elderly dependency ratio. METHODS:A cross-national study examining the "a priori" hypothesis that the relationship between elderly suicide rates and average annual population gr...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610208007953
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Subjective memory complaints (SMCs) are a common occurrence for adults, which increase with age, and cause considerable distress. Traditionally SMCs have been assessed by either questionnaires, which ask whether a person has experienced given examples of SMCs, or open-ended questions which elicit spontaneous...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214001161
更新日期:2015-01-01 00:00:00
abstract::ABSTRACTObjectives:Centenarians have survived into very late life, but whether they reach very old age in good health remains unclear. The purpose of this study was to compare the cardiovascular health status and cognitive functioning of centenarians in the United States with centenarians in Japan. DESIGN, SETTING, A...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218001813
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to give an in-depth description of the impact of disclosure of the diagnosis of dementia on a patient and the patient's partner. METHODS:Grounded theory interview study. RESULTS:Analysis of the interviews revealed that disclosure had an impact on three key domains: awareness of dem...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610205001316
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:It is currently not known whether elderly men and women present with different subtypes of depression and mania/bipolar disorder. The aim of this study was to compare the prevalence of subtypes of a single depressive episode and mania/bipolar disorder according to the ICD-10 for elderly men and women in a na...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020600319X
更新日期:2006-12-01 00:00:00
abstract::With now over 50 million people worldwide with dementia (Prince et al., 2013), there are almost certainly well over 100 million people with cognitive concerns and many of these will attend their health professional keen to know what is going on. We need those without intensive training in this field to be more confide...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610217001818
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:To evaluate the impact of external memory devices on the efficacy of a package of internal mnemonic techniques. Participants wrote two types of lists during the study phase: (a) a list of study words and/or (b) a loci list. At recall, participants were not allowed to refer to either of the lists they had wri...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610203008755
更新日期:2003-03-01 00:00:00