Maintenance therapies for late-life recurrent major depression: research and review circa 1995.


:Major depression in the elderly is often a relapsing, chronic illness with high risk for chronic invalidism, poor treatment compliance, and suicide. In most cases, maintenance treatment to prevent recurrence and to enhance the quality of life is thought to be indicated. We review recent data from our ongoing studies that support both the efficacy and the safety of pharmacotherapeutic and psychotherapeutic maintenance treatments. However, the challenges of conducting maintenance therapy research (particularly with a placebo control) with the elderly are many, involving such areas as recruitment, retention, compliance, choice of outcome measures, and informed consent. We discuss each of these challenges and our responses to them. Finally, we suggest that maintenance therapy trials should be extended in several directions: (a) long-term treatment of bipolar and delusional subtypes in the elderly, as well as depression associated with progressive neurodegenerative disorders such as Alzheimer's dementia; (b) assessment of the benefits and risks of long-term therapy with other than tricyclic and monoamine oxidase inhibitor antidepressant agents, such as selective serotonin reuptake inhibitors; and (c) development of models of long-term course, including the interaction of treatments with medical and psychosocial variables that can have a profound impact on illness onset and offset. These issues are illustrated with a discussion of a new protocol designed to test the acute and maintenance efficacy of antidepressant therapy for depressed patients with Alzheimer's disease.


Int Psychogeriatr


Reynolds CF 3rd,Frank E,Perel JM,Mazumdar S,Kupfer DJ




Has Abstract


1995-01-01 00:00:00








7 Suppl


  • The process of family-centered counseling for caregivers of persons with dementia: barriers, facilitators and benefits.

    abstract:BACKGROUND:Despite the high consistency of evidence in favor of person-centered care, little information is available on how person-centered and family-centered interventions are actually provided. The aim of this study is to gain insight into the provision of the effective New York University Caregiver Intervention (N...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Vernooij-Dassen M,Joling K,van Hout H,Mittelman MS

    更新日期:2010-08-01 00:00:00

  • Escitalopram for antipsychotic nonresponsive visual hallucinosis: eight patients suffering from Charles Bonnet syndrome.

    abstract:BACKGROUND:The Charles Bonnet syndrome (CBS) is characterized by distinct visual hallucinations and ocularpathology causing visual impairment in patients with insight and the absence of psychiatric comorbidity. The number of reported cases of CBS is expanding as the population ages and the prevalence of vision disorder...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Bergman Y,Barak Y

    更新日期:2013-09-01 00:00:00

  • Effects of active psychosocial stimulation on social interactions of people with dementia living in a nursing home: a comparative study.

    abstract::Dementia can interfere with the maintenance of social interactions. The ability to participate in social interactions is one of the elements that enables good social health (Hubert et al., 2011), and having dementia does not automatically eliminates the person's opportunity to have good social health (Vernooij-Dassen ...

    journal_title:International psychogeriatrics

    pub_type: 信件


    authors: Mabire JB,Gay MC,Vrignaud P,Garitte C,Jeon YH,Vernooij-Dassen M

    更新日期:2018-06-01 00:00:00

  • What would help me stop abusing? The family carer's perspective.

    abstract:BACKGROUND:A third of family members caring for people with dementia report acting abusively towards them, but there are currently no evidence-based interventions to reduce or prevent such behavior. Family carers who act abusively have not previously been consulted about what may help to reduce abuse. METHOD:We prospe...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Selwood A,Cooper C,Owens C,Blanchard M,Livingston G

    更新日期:2009-04-01 00:00:00

  • Development of a tool to evaluate geropsychology knowledge and skill competencies.

    abstract:BACKGROUND:Workforce shortages to meet the mental health needs of the world's aging population are well documented. Within the field of professional geropsychology in the U.S.A., a national conference was convened in 2006 to delineate competencies for psychological practice with older adults and a training model for th...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Karel MJ,Emery EE,Molinari V,CoPGTP Task Force on the Assessment of Geropsychology Competencies.

    更新日期:2010-09-01 00:00:00

  • Risk factors of geriatric depression in rural China based on a generalized estimating equation.

    abstract::ABSTRACTBackground:The number of elderly individuals living in China is increasing rapidly. The aim of this study was to examine the potential risk factors of geriatric depression in rural areas. METHODS:A repeated cross-sectional study was conducted between January 2015 and October 2016 in rural China. Nine hundred ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Zhao D,Hu C,Chen J,Dong B,Ren Q,Yu D,Zhao Y,Li J,Huang Y,Sun Y

    更新日期:2018-10-01 00:00:00

  • Does bipolar disorder have a benign course?

    abstract::Written records have been describing extreme states of emotions since ancient Greece (Angst and Marneros, 2001), but Aretaeus of Cappadocia (which is geographically located in modern Turkey) was probably the first to outline the close relationship between depression and mania nearly 2000 years ago: "I think that melan...

    journal_title:International psychogeriatrics

    pub_type: 社论


    authors: Almeida OP

    更新日期:2016-11-01 00:00:00

  • Comparison of behavioral and psychological symptoms of Alzheimer's disease among institution residents and memory clinic outpatients.

    abstract:BACKGROUND:Behavioral and psychological symptoms of dementia (BPSD) cause caregiver distress and earlier institutionalization. We compared the prevalence and characteristics of BPSD between institution residents and memory clinic outpatients with Alzheimer's disease (AD) to test the hypothesis that there is more BPSD a...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Cheng TW,Chen TF,Yip PK,Hua MS,Yang CC,Chiu MJ

    更新日期:2009-12-01 00:00:00

  • Quality of life in patients with cognitive impairment: validation of the Quality of Life-Alzheimer's Disease scale in Portugal.

    abstract:BACKGROUND:Quality of Life-Alzheimer's Disease (QOL-AD) is a widely used scale for the study of quality of life in patients with dementia. The aim of this study is the transcultural adaptation and validation of the QOL-AD scale in Portugal. METHODS:Translation and transcultural adaptation was performed according to st...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Bárrios H,Verdelho A,Narciso S,Gonçalves-Pereira M,Logsdon R,de Mendonça A

    更新日期:2013-07-01 00:00:00

  • Effect of SSRI and calcium channel blockers on depression symptoms and cognitive function in elderly persons treated for hypertension: three city cohort study.

    abstract::ABSTRACTBackground:Emerging genetic, ex-vivo, and clinical trial evidence indicates that calcium channel blockers (CCB) can improve mood and cognitive function. The objective of this study was to examine the effect of selective serotonin reuptake inhibitor (SSRI) therapy augmented with CCB on depression and cognitive ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,多中心研究


    authors: Tully PJ,Peters R,Pérès K,Anstey KJ,Tzourio C

    更新日期:2018-09-01 00:00:00

  • Prevalence, neurobiology, and treatments for apathy in prodromal dementia.

    abstract:BACKGROUND:Apathy, characterized by diminished motivation, is a highly prevalent neuropsychiatric symptom in dementia. However, there is a substantial knowledge gap with regard to prevalence rates, neurobiological underpinnings, and effective treatments for apathy in pre-dementia states, including mild cognitive impair...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审


    authors: Sherman C,Liu CS,Herrmann N,Lanctôt KL

    更新日期:2018-02-01 00:00:00

  • The concept of quality of life in dementia in the different stages of the disease.

    abstract::In order to conceptually define quality of life (QOL) in dementia, the literature on QOL in the elderly population, in chronic disease and in dementia was studied. Dementia is a progressive, age-related, chronic condition and to avoid omissions within the dementia-specific concept of QOL, a broad orientation was the p...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审


    authors: Ettema TP,Dröes RM,de Lange J,Ooms ME,Mellenbergh GJ,Ribbe MW

    更新日期:2005-09-01 00:00:00

  • Five-year trajectories of social networks and social support in older adults with major depression.

    abstract:BACKGROUND:Research with nondepressed adults suggests that social networks and social support are stable over the life course until very late age. This may not hold true for older adults with depression. We examined baseline status and trajectories of social networks and social support at the group and individual level...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Voils CI,Allaire JC,Olsen MK,Steffens DC,Hoyle RH,Bosworth HB

    更新日期:2007-12-01 00:00:00

  • Clinico-tomographical aspects in the pathogenesis of vascular dementia.

    abstract::This article discusses the role of some pathogenetical factors in the main morphological variants of vascular dementia and their correlation with certain clinical parameters. On the basis of computer-tomographical (CT) studies of 62 patients with dementia, it was possible to distinguish three groups of patients, accor...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Kontsevoy VA,Medvedev AV,Vavilov SB,Shchirina MG

    更新日期:1992-10-01 00:00:00

  • Structural validity and internal consistency of the Qualidem in people with severe dementia.

    abstract:BACKGROUND:Since its development, the Qualidem has had items that were considered unsuited for people with very severe dementia. This study attempted to investigate the applicability of all Qualidem items in people with all stages of dementia severity. METHODS:Four data sets that contained Qualidem observations on peo...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Arons AMM,Wetzels RB,Zwijsen S,Verbeek H,van de Ven G,Ettema TP,Koopmans RTCM,Gerritsen DL

    更新日期:2017-09-04 00:00:00

  • Self-reported memory impairment and brain PET of amyloid and tau in middle-aged and older adults without dementia.

    abstract:BACKGROUND:Whether perceived changes in memory parallel changes in brain pathology is uncertain. Positron emission tomography (PET) scans using 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP) can measure levels of amyloid plaques and tau neurofibrillary tangles in vivo. Here we ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Merrill DA,Siddarth P,Saito NY,Ercoli LM,Burggren AC,Kepe V,Lavretsky H,Miller KJ,Kim J,Huang SC,Bookheimer SY,Barrio JR,Small GW

    更新日期:2012-07-01 00:00:00

  • The multiple dimensions of frailty: physical capacity, cognition, and quality of life.

    abstract:BACKGROUND:Frailty is a complex health state of increased vulnerability associated with adverse outcomes such as disability, falls, hospitalization, and death. Along with physical impairments, cognition and quality of life may be affected in frail older adults. Yet, evidence is still lacking. The aim of this study was ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Langlois F,Vu TT,Kergoat MJ,Chassé K,Dupuis G,Bherer L

    更新日期:2012-09-01 00:00:00

  • The Cognitive Assessment Battery (CAB): a rapid test of cognitive domains.

    abstract:BACKGROUND:The study aimed to evaluate the Cognitive Assessment Battery (CAB) in a specialist clinic setting in order to find out if it if it could be a supplement to the Mini-mental State Examination (MMSE) and distinguish between normal aging, mild cognitive impairment (MCI) and dementia, as well as MCI of different ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Nordlund A,Påhlsson L,Holmberg C,Lind K,Wallin A

    更新日期:2011-09-01 00:00:00

  • Variables modulating depression in dementia caregivers: a longitudinal study.

    abstract:BACKGROUND:Dementia caregiving has been linked to negative consequences for mental health in caregivers. Although depression seems to be an enduring psychological consequence associated with caregiving, little is known about the longitudinal effects that modulating variables related to coping strategies have on caregiv...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Romero-Moreno R,Márquez-González M,Mausbach BT,Losada A

    更新日期:2012-08-01 00:00:00

  • Use of an external mnemonic to augment the efficacy of an internal mnemonic in older adults.

    abstract:OBJECTIVES:To evaluate the impact of external memory devices on the efficacy of a package of internal mnemonic techniques. Participants wrote two types of lists during the study phase: (a) a list of study words and/or (b) a loci list. At recall, participants were not allowed to refer to either of the lists they had wri...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Brooks JO 3rd,Friedman L,Yesavage JA

    更新日期:2003-03-01 00:00:00

  • Do interventions with staff in long-term residential facilities improve quality of care or quality for life people with dementia? A systematic review of the evidence.

    abstract:BACKGROUND:Common sense suggests and research indicates relationships between staff factors in residential dementia care and quality of life (QOL) for residents, with poor care increasing suffering. However, we do not have a coherent picture of which staff interventions have an impact on quality of care (QOC) or reside...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Bird M,Anderson K,MacPherson S,Blair A

    更新日期:2016-12-01 00:00:00

  • Physician don't heal thyself: a descriptive study of impaired older doctors.

    abstract:BACKGROUND:The growing and welcome interest in the issues leading to distress and impairment in younger doctors has not been mirrored by a focus on the similar issues in older doctors which is surprising given the aging medical workforce. OBJECTIVES:To improve understanding of impairment in older doctors and to facili...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Peisah C,Wilhelm K

    更新日期:2007-10-01 00:00:00

  • Vocally disruptive behavior in the elderly: a systematic review.

    abstract:BACKGROUND:Vocally disruptive behavior (VDB) in the elderly is a common condition, especially in people with dementia, but difficult to treat. It may occur in as many as 40% of nursing home residents. This study is a review of the existing literature on this condition. METHOD:The literature review was conducted using ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审


    authors: von Gunten A,Alnawaqil AM,Abderhalden C,Needham I,Schupbach B

    更新日期:2008-08-01 00:00:00

  • Diagnosis and disclosure of a memory problem is associated with quality of life in community based older Australians with dementia.

    abstract:BACKGROUND:Identification of factors associated with quality of life (QoL) in people having dementia will help develop strategies for maintenance and improvement of patient QoL. This study examined the predictors of QoL in a community-dwelling population aged 75 years and over, with or without dementia. METHODS:This w...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Mate KE,Pond CD,Magin PJ,Goode SM,McElduff P,Stocks NP

    更新日期:2012-12-01 00:00:00

  • Association of neuropsychiatric syndromes with global clinical deterioration in Alzheimer's disease patients.

    abstract:BACKGROUND:Data on the relationship between behavioral disturbances in Alzheimer's disease (AD) and global clinical deterioration is still controversial. The purpose of this study was to explore potential correlations of neuropsychiatric syndromes with global clinical deterioration in patients with AD, with particular ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,多中心研究


    authors: Stella F,Laks J,Govone JS,de Medeiros K,Forlenza OV

    更新日期:2016-05-01 00:00:00

  • Association between childhood socioeconomic status and subjective memory complaints among older adults: results from the Japan Gerontological Evaluation Study 2010.

    abstract:BACKGROUND:Subjective memory complaints (SMC) have been suggested as an early marker of mild cognitive impairment and dementia. However, there is a paucity of evidence on the effects of early life conditions on the development of SMC in old age. This study is aimed at investigating the association between childhood soc...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Nishizawa T,Morita A,Fujiwara T,Kondo K

    更新日期:2019-12-01 00:00:00

  • Development of a shorter version of the geriatric depression scale for visually impaired older patients.

    abstract:OBJECTIVE:To validate a shorter version of the Geriatric Depression Scale (GDS) for older, visually impaired patients. PARTICIPANTS:Subjects were 70 visually impaired adults over age 65 who were presenting for services at a low vision clinic. METHOD:Subjects were interviewed by a geriatric nurse practitioner. A struc...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Galaria II,Casten RJ,Rovner BW

    更新日期:2000-12-01 00:00:00

  • Successful aging in Spanish older adults: the role of psychosocial resources.

    abstract::ABSTRACTBackground:Psychological and social resources such as extraversion, optimism, social support, or social networks contribute to adaptation and to successful aging. Building on assumptions derived from successful aging and from the developmental adaptation models, this study aims to analyze the joint impact of d...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Dumitrache CG,Rubio L,Cordón-Pozo E

    更新日期:2019-02-01 00:00:00

  • Depressive symptoms and depressive episodes in recently widowed older men.

    abstract::Older widowers have high rates of completed suicide but have rarely been the subject of systematic inquiry. We investigated the prevalence of depressive symptoms and major depressive episodes (MDEs) in recently widowed older men over the first 13 months after bereavement. We employed a matched-pair longitudinal design...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Byrne GJ,Raphael B

    更新日期:1999-03-01 00:00:00

  • Suicide and aging in Japan: an examination of treated elderly suicide attempters.

    abstract::Although individuals aged 65 and over accounted for 12% of the total population of Japan in 1990, suicides in this age group consisted of 29% of all suicides. The elderly population of Japan is expected to grow rapidly to 24% of the total population by the year 2020, and suicide prevention for the elderly is an urgent...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章


    authors: Takahashi Y,Hirasawa H,Koyama K,Asakawa O,Kido M,Onose H,Udagawa M,Ishikawa Y,Uno M

    更新日期:1995-07-01 00:00:00