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Benzodiazepine use among older adults with schizophrenia spectrum disorder: prevalence and associated factors in a multicenter study.

Abstract：

OBJECTIVES:Data on psychotropic medications of older patients with schizophrenia spectrum disorder are scarce. Specifically, information about the use of benzodiazepines among older patients with schizophrenia spectrum disorder is very limited. Because benzodiazepine use in older patients has been associated with many disabling side effects, its use in actual practice must be described and questioned. This study aimed at exploring the prevalence of benzodiazepine use and the clinical factors associated with such use among older patients with schizophrenia spectrum disorder. METHODS/DESIGN:Data from the Cohort of individuals with Schizophrenia Aged 55 years or more (CSA) were used to examine the prevalence of benzodiazepine use among older patients with schizophrenia spectrum disorder. Demographic and clinical characteristics associated with benzodiazepine prescription were also explored. RESULTS:The prevalence of benzodiazepine use was 29.8% of older patients with schizophrenia spectrum disorder. These patients were significantly more likely to have medical comorbidities, cognitive and social functioning impairments, to report a lifetime history of suicide attempt, to be institutionalized, and to have been hospitalized in a psychiatric service in the past year compared to those without a benzodiazepine prescription (all p<0.05). There were no between-group differences in schizophrenia severity and psychiatric comorbidity. CONCLUSIONS:Although it can be hypothesized that benzodiazepine prescription is part of a short-term therapeutic strategy toward patients with more severe trouble or comorbid disorders, our results suggest a strong link between benzodiazepine prescription and a particularly vulnerable subpopulation of older patients with schizophrenia spectrum disorder.

journal_name

Int Psychogeriatr

journal_title

International psychogeriatrics

authors

Schuster JP,Hoertel N,von Gunten A,Seigneurie AS,Limosin F,CSA Study group.

doi

10.1017/S1041610219000358

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

441-451

issue

eissn

1041-6102

issn

1741-203X

pii

S1041610219000358

journal_volume

pub_type

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Benzodiazepine use among older adults with schizophrenia spectrum disorder: prevalence and associated factors in a multicenter study.