Abstract:
OBJECTIVE:Cognitive impairment and negative signs are common in patients with schizophrenia. Up to 35% of elderly patients with schizophrenia fulfill the diagnostic criteria of dementia. Donepezil inhibits cholinesterase, thus enhancing cholinergic neurotransmission. We tested the efficacy of donepezil in elderly patients with chronic schizophrenia and severe cognitive impairment. METHOD:Following baseline assessment, patients were randomly assigned to receive either donepezil or placebo. The dose was 5 mg daily for the first week and 10 mg for an additional 11 weeks. The procedure was repeated using the crossover compound. The Positive and Negative Symptom Scale (PANSS), Clinical Global Impression Scale (CGI) and Alzheimer Disease Assessment Scale - Cognitive subscale (ADAS-Cog) were used to assess the severity of symptoms, cognitive status and intervention effects. RESULTS:Twenty subjects were enrolled (15 females, five males), mean age 70.2 years (SD 6.5) and mean duration of disease 38.5 years (SD 9.3). A modest treatment effect was found for both placebo and donepezil treatment periods. No crossover effect was found. No statistical differences were demonstrated between the two treatment groups (CGI p = 0.37, PANSS p = 0.71, ADAS-Cog p = 0.86). Two patients died during the study period due to unrelated causes and one patient discontinued participation due to increased agitation. CONCLUSION:Donepezil does not seem to improve negative signs and cognitive impairment in elderly patients with chronic schizophrenia.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Mazeh D,Zemishlani H,Barak Y,Mirecki I,Paleacu Ddoi
10.1017/S1041610205003017keywords:
subject
Has Abstractpub_date
2006-09-01 00:00:00pages
429-36issue
3eissn
1041-6102issn
1741-203Xpii
S1041610205003017journal_volume
18pub_type
杂志文章,随机对照试验abstract::ABSTRACTBackground:The current research sought to characterize current mood state profiles in healthy young versus older adults using 100-point visual analogue mood scales (VAMS), provide within-sample and new sample replication of age-group differences, assess sex differences, and compare with commonly used standardi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000996
更新日期:2019-03-01 00:00:00
abstract::Dementia is a neurodegenerative disorder with global impact, with the largest proportion of cases occurring in low- and middle-income countries. It is estimated that there are 46.8 million cases globally with approximately 10 million new cases each year or a new case occurring every 3 sec (Prince et al., 2015). For co...
journal_title:International psychogeriatrics
pub_type: 社论
doi:10.1017/S1041610217001685
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journal_title:International psychogeriatrics
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doi:10.1017/S1041610203009098
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abstract::Major depression in the elderly is often a relapsing, chronic illness with high risk for chronic invalidism, poor treatment compliance, and suicide. In most cases, maintenance treatment to prevent recurrence and to enhance the quality of life is thought to be indicated. We review recent data from our ongoing studies t...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s104161029500233x
更新日期:1995-01-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610215000629
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journal_title:International psychogeriatrics
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journal_title:International psychogeriatrics
pub_type: 杂志文章,meta分析,评审
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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journal_title:International psychogeriatrics
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journal_title:International psychogeriatrics
pub_type: 社论
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更新日期:2018-07-01 00:00:00
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journal_title:International psychogeriatrics
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journal_title:International psychogeriatrics
pub_type: 社论
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更新日期:2016-11-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002759
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610207004966
更新日期:2007-06-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020800817X
更新日期:2009-04-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-04-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610209008746
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Mild cognitive impairment (MCI) is proposed to describe the transitional stage between normal cognitive aging and dementia. It has had significant impact in the field of dementia research, but it remains controversial whether or not it should be used as a diagnostic category in clinical practice. METHODS:Se...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610208007126
更新日期:2008-08-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001442
更新日期:2017-11-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610297004213
更新日期:1997-03-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610205001924
更新日期:2005-01-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
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更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Patients with dementia often receive poor end-of-life care, with inadequate pain control and without access to the palliative care services that patients with cancer are offered. This has been identified as an area of need in recent UK. Government reports and by the Alzheimer's Society (UK). Our objective wa...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
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更新日期:2005-03-01 00:00:00