当前位置： SCI文献检索 > INTERNATIONAL PSYCHOGERIATRICS期刊下所有文献 > Interrelationship of age, depression, and central serotonergic function: evidence from fenfluramine challenge studies.

Interrelationship of age, depression, and central serotonergic function: evidence from fenfluramine challenge studies.

Abstract：

:The purpose of this study was to examine the relationship between age-associated changes in central serotonergic function and abnormalities associated with major depression. Under randomized double-blind conditions, prolactin and cortisol responses to the serotonin-releasing agent d,l-fenfluramine hydrochloride (60 mg orally) and placebo were examined in 30 normal subjects (15 men, 15 women; age range 21-84 years) and 39 patients with major depressive disorder, endogenous subtype (14 men, 25 women; age range 29-72 years). In the normal subjects, a significant Age x Challenge x Time interaction was observed in the prolactin response (p = .03). This was primarily due to the elevated prolactin responses of the younger healthy women. Peak minus baseline (delta) prolactin responses were negatively correlated with age (women, p = .004; men, p = .06). In the depressed patients there was no age-related decline in prolactin response to fenfluramine. When depressed and healthy younger subjects were compared, delta prolactin responses to fenfluramine were significantly blunted in young patients with depression (p = .003) irrespective of the significant effect of gender (p = .01), but not in older depressed patients. Cortisol responses to fenfluramine did not reveal consistent effects of age, gender, or diagnosis. Age-related decline in central serotonergic function may make older individuals more vulnerable to depression and possibly render depressive episodes more frequent, more severe, and less amenable to treatment.

journal_name

Int Psychogeriatr

journal_title

International psychogeriatrics

authors

Lerer B,Gillon D,Lichtenberg P,Gorfine M,Gelfin Y,Shapira B

doi

10.1017/s1041610296002499

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

83-102

issue

1

eissn

1041-6102

issn

1741-203X

journal_volume

8

pub_type

临床试验,杂志文章,随机对照试验

相关文献

INTERNATIONAL PSYCHOGERIATRICS文献大全
  • Epidemiology of delirium: an overview of research issues and findings.

    abstract：:This paper provides a review of research issues and findings on the epidemiology of delirium. Despite the fact that research on this important geriatric syndrome has been conducted for many decades, several methodological issues make it difficult to compare findings across studies. In this paper we first discuss broad...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章,评审

    doi：10.1017/s1041610291000625

    authors： Levkoff S,Cleary P,Liptzin B,Evans DA

    更新日期：1991-01-01 00:00:00

  • The clinical course and interrelations of dementia related symptoms.

    abstract：:ABSTRACTBackground:Dementia is a neurodegenerative syndrome that interferes with multiple aspects of life, including cognition, daily functioning, and behavior. Despite the large heterogeneity in symptom development, these three domains are seldom studied simultaneously. This study investigates how trajectories of the...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章,多中心研究

    doi：10.1017/S1041610217000321

    authors： Haaksma ML,Leoutsakos JS,Bremer JAE,Aalten P,Ramakers IHGB,Verhey FRJ,Olde Rikkert MGM,Melis RJF

    更新日期：2018-06-01 00:00:00

  • Contribution of self-reported health ratings to predicting frailty, institutionalization, and death over a 5-year period.

    abstract：:Cross-sectional data from Phase 1 of the Canadian Study of Health and Aging was used to examine the relationship between two self-report health measures: "How would you say your health is these days?"(HEALTH) and "How much do your health troubles stand in the way of your doing the things you want to do?"(TROUBLE). The...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章,多中心研究

    doi：10.1017/s1041610202008165

    authors： Gutman GM,Stark A,Donald A,Beattie BL

    更新日期：2001-01-01 00:00:00

  • Mental capacity assessments among general hospital inpatients referred to a specialist liaison psychiatry service for older people.

    abstract：BACKGROUND:Mental capacity has been little studied among older general hospital inpatients. METHODS:A retrospective analysis was undertaken of routinely collected data (age, gender, ethnicity, admission diagnosis, psychiatric diagnosis, Mini-mental State Examination score, whether capacity was assessed, the outcome of...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S104161020900917X

    authors： Mujic F,Von Heising M,Stewart RJ,Prince MJ

    更新日期：2009-08-01 00:00:00

  • A dynamic long-term care system for the demented elderly.

    abstract：:The dynamic processes and the way they interact in shaping a care system for demented patients are analyzed and discussed. The development of disability/dependency, interpreted in a simulation model based on Katz's index of ADL and Berger's scale "Rating the severity of senility," gave insight into the interplay of fo...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/s1041610296002888

    authors： Annerstedt L,Sanada J,Gustafson L

    更新日期：1996-01-01 00:00:00

  • Gender differences in subtypes of late-onset depression and mania.

    abstract：BACKGROUND:It is currently not known whether elderly men and women present with different subtypes of depression and mania/bipolar disorder. The aim of this study was to compare the prevalence of subtypes of a single depressive episode and mania/bipolar disorder according to the ICD-10 for elderly men and women in a na...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S104161020600319X

    authors： Kessing LV

    更新日期：2006-12-01 00:00:00

  • Elder mistreatment, ageism, and human rights.

    abstract：BACKGROUND:Elder mistreatment, social ageism, and human rights are increasingly powerful discourses in positioning older people in society, yet the relationship between them has rarely been subjected to critical investigation. This perceived relationship will have implications for how mistreatment is understood and res...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S1041610212002372

    authors： Biggs S,Haapala I

    更新日期：2013-08-01 00:00:00

  • Modern technology to support carers of care recipients with dementia or functional mental illness: promising progress, but a long road ahead.

    abstract：:There is no doubt that family carers who look after a family member with dementia or with a functional mental illness fulfill an important role, not only for their loved one, but also for the health and aged care systems of the countries they live in. Due to increasing life expectancy, but also improved healthcare the...

    journal_title：International psychogeriatrics

    pub_type： 社论

    doi：10.1017/S1041610217002150

    authors： Lautenschlager NT,Diehl-Schmid J,Loi SM,Mayer J,Tensil M,Kurz AF

    更新日期：2017-12-01 00:00:00

  • Engagement in social activities and progression from mild to severe cognitive impairment: the MYHAT study.

    abstract：BACKGROUND:It is of considerable public health importance to prevent or delay the progression of mild cognitive impairment (MCI) to more severely impaired cognitive states. This study examines the risk of progression from mild to severe cognitive impairment in relation to engagement in social activities while mildly im...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S1041610212002086

    authors： Hughes TF,Flatt JD,Fu B,Chang CC,Ganguli M

    更新日期：2013-04-01 00:00:00

  • Caregivers' perspectives on the pre-diagnostic period in early onset dementia: a long and winding road.

    abstract：BACKGROUND:Recognizing and diagnosing early onset dementia (EOD) can be complex and often takes longer than for late onset dementia. The objectives of this study are to investigate the barriers to diagnosis and to develop a typology of the diagnosis pathway for EOD caregivers. METHODS:Semi-structured interviews with 9...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S1041610211001013

    authors： van Vliet D,de Vugt ME,Bakker C,Koopmans RT,Pijnenburg YA,Vernooij-Dassen MJ,Verhey FR

    更新日期：2011-11-01 00:00:00

  • Individualized guidelines for the management of aggression in dementia - Part 2: appraisal of current guidelines.

    abstract：BACKGROUND:Individualized guidelines have the potential to offer clinicians assistance in decision-making at the point of consultation to improve health outcomes for patients. This project aims to develop individualized guidelines for the management of aggression in dementia. At an earlier stage, we developed a map of ...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S104161021200004X

    authors： Vickland V,Chilko N,Draper B,Low LF,O'Connor D,Brodaty H

    更新日期：2012-07-01 00:00:00

  • An empirical test of language-relevant interventions for dementia.

    abstract：:The focus of this report is the treatment of persons with dementia who are of a non-English-speaking background (NESB). Noisemaking is one behavioral manifestation associated with severe dementia. It can have devastating effects on persons with dementia by limiting their access to activity programs and social interact...

    journal_title：International psychogeriatrics

    pub_type： 临床试验,杂志文章

    doi：10.1017/s1041610299005864

    authors： Runci S,Doyle C,Redman J

    更新日期：1999-09-01 00:00:00

  • Clinico-tomographical aspects in the pathogenesis of vascular dementia.

    abstract：:This article discusses the role of some pathogenetical factors in the main morphological variants of vascular dementia and their correlation with certain clinical parameters. On the basis of computer-tomographical (CT) studies of 62 patients with dementia, it was possible to distinguish three groups of patients, accor...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/s1041610292001054

    authors： Kontsevoy VA,Medvedev AV,Vavilov SB,Shchirina MG

    更新日期：1992-10-01 00:00:00

  • Attachment anxiety, depression, and perceived social support: a moderated mediation model of suicide ideation among the elderly.

    abstract：OBJECTIVES:Issues concerning the association among attachment anxiety, depression and suicidal ideation among the elderly have rarely been explored. The present study investigated the relationship among attachment anxiety, depression and perceived support concerning suicidal ideation among older people. DESIGN:Cross-s...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S104161022000054X

    authors： Oonarom A,Wongpakaran T,Kuntawong P,Wongpakaran N

    更新日期：2020-05-07 00:00:00

  • Can older "at risk" adults benefit from psychoeducation targeting healthy brain aging?

    abstract：BACKGROUND:Multifactorial strategies that prevent or delay the onset or progress of cognitive decline and dementia are needed, and should include education regarding recognized risk factors. The current study sought to investigate whether older adults "at risk" of cognitive decline benefit from psychoeducation targetin...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S1041610210001109

    authors： Norrie LM,Diamond K,Hickie IB,Rogers NL,Fearns S,Naismith SL

    更新日期：2011-04-01 00:00:00

  • Success at 100 is easier said than done--comments on Araújo et al: successful aging at 100 years.

    abstract：:Few would argue that achieving the age of 100 years is extraordinary, but what about the quality of life at this extreme age? Is it worth it to live to 100 and beyond? The study by Araújo, Ribero, Teixeira, and Paúl (2015) in three ways provided an answer to this question substantiating and complementing recent findin...

    journal_title：International psychogeriatrics

    pub_type： 评论,杂志文章

    doi：10.1017/S1041610215002021

    authors： Martin P,Poon LW

    更新日期：2016-02-01 00:00:00

  • Incidence and predictors of excess disability in walking among nursing home residents with middle-stage dementia: a prospective cohort study.

    abstract：BACKGROUND:Inability to walk compromises the well-being of the growing number of nursing home residents with dementia. The purpose of this study was to estimate the incidence and identify predictors of walking disability that may be remediable. METHODS:A cohort was followed fortnightly for a year in 15 nursing homes i...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章,多中心研究

    doi：10.1017/S1041610210000116

    authors： Slaughter SE,Eliasziw M,Morgan D,Drummond N

    更新日期：2011-02-01 00:00:00

  • Use of antipsychotic medications for the management of delirium: an audit of current practice in the acute care setting.

    abstract：OBJECTIVE:Despite delirium being common in older hospitalized people, little is known about its management. The aims of this study are (1) to describe the pharmacological management of delirium in an acute care setting as a baseline measure prior to the implementation of newly developed Australian guidelines; and (2) t...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S1041610208008028

    authors： Tropea J,Slee J,Holmes AC,Gorelik A,Brand CA

    更新日期：2009-02-01 00:00:00

  • Elderly suicide attempters by self-poisoning in Korea.

    abstract：BACKGROUND:Suicide is a major public health concern. The elderly have the highest rate of suicide and they make more lethal suicide attempts and have fewer psychiatric interventions than young people. Furthermore, they have old-age specific psychosocial difficulties. The present study investigated psychosocial risk fac...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S1041610211000263

    authors： Kim YR,Choi KH,Oh Y,Lee HK,Kweon YS,Lee CT,Lee KU

    更新日期：2011-08-01 00:00:00

  • A preliminary cross-national study of a possible relationship between elderly suicide rates and tuberculosis.

    abstract：BACKGROUND:The elderly are at high risk of developing tuberculosis. The prevalence and incidence of depression and anxiety are higher in those with tuberculosis than in the general population. A positive correlation between national suicide rates and rates of mortality due to tuberculosis has been reported. METHODS:Th...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S1041610209990378

    authors： Shah A

    更新日期：2009-12-01 00:00:00

  • Anxiety, depression, and comorbid anxiety and depression: risk factors and outcome over two years.

    abstract：BACKGROUND:This study aimed to determine: (1) the prevalence of depression, anxiety, and depression associated with anxiety (DA); (2) the risk factor profile of depression, anxiety, and DA; (3) the course of depression, anxiety, and DA over 24 months. METHODS:Two-year longitudinal study of 20,036 adults aged 60+ years...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S104161021200107X

    authors： Almeida OP,Draper B,Pirkis J,Snowdon J,Lautenschlager NT,Byrne G,Sim M,Stocks N,Kerse N,Flicker L,Pfaff JJ

    更新日期：2012-10-01 00:00:00

  • Levels and rates of depression among Chinese people living in Chinese ethno-specific and mainstream residential care in Sydney.

    abstract：BACKGROUND:This study aimed to examine the levels and rates of depression in Chinese residents living in ethno-specific nursing homes (NHs), and Chinese residents living in mainstream NHs in Sydney. Australia has a growing aging migrant population and rates of depression in NHs are high, but the prevalence of depressio...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S104161020999069X

    authors： Goh I,Low LF,Brodaty H

    更新日期：2010-03-01 00:00:00

  • Qualitative analysis of the clinician interview-based impression of change (Plus): methodological issues and implications for clinical research.

    abstract：:The Clinician Interview-Based Impression of Change, plus carer interview (CIBIC-Plus), is widely used in antidementia drug trials. It comprises Likert scales for disease severity and changes, and written accounts summarizing semistructured interviews evaluating behavior, cognition, and function. Studies using the CIBI...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/s1041610200006505

    authors： Joffres C,Graham J,Rockwood K

    更新日期：2000-09-01 00:00:00

  • Depression in later-life Puerto Rican primary care patients: the role of illness, stress, social integration, and religiosity.

    abstract：BACKGROUND:Older Puerto Ricans belong to two rapidly growing demographic groups known to have high rates of depression: the aging and Hispanic populations. Studies of depression in Puerto Ricans have primarily focused on the impact of demographic factors and health. This study expands previous research, examining the r...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/s1041610203009505

    authors： Robison J,Curry L,Gruman C,Covington T,Gaztambide S,Blank K

    更新日期：2003-09-01 00:00:00

  • Vascular lesions and functional limitations among older adults: does depression make a difference?

    abstract：:ABSTRACT Background: The association between disability and depression is complex, with disability well established as a correlate and consequence of late life depression. Studies in community samples report that greater volumes of cerebral white matter hyperintensities (WMHs) seen on brain imaging are linked with fun...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S1041610214000829

    authors： Hybels CF,Pieper CF,Landerman LR,Payne ME,Steffens DC

    更新日期：2014-05-09 00:00:00

  • Neuropsychiatric symptom clusters of Alzheimer's disease in Hong Kong Chinese: prevalence and confirmatory factor analysis of the Neuropsychiatric Inventory.

    abstract：BACKGROUND:The aim of this study was to investigate the clustering of symptoms on the Neuropsychiatric Inventory (NPI) and the relative prevalence of symptom clusters in mild and moderate Alzheimer's disease (AD). METHODS:Confirmatory factor analysis (CFA) was performed on the polychoric correlation matrix of 12 NPI i...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S1041610212000609

    authors： Cheng ST,Kwok T,Lam LC

    更新日期：2012-09-01 00:00:00

  • The STAI-Y trait scale: psychometric properties and normative data from a large population-based study of elderly people.

    abstract：BACKGROUND:Whereas the State-Trait Anxiety Inventory (STAI-Y) is probably the most widely used self-reported measure of anxiety, the lack of current norms among elderly people appears to be problematic in both a clinical and research context. The objective of the present study was to provide normative data for the STAI...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S1041610212000300

    authors： Bergua V,Meillon C,Potvin O,Bouisson J,Le Goff M,Rouaud O,Ritchie K,Dartigues JF,Amieva H

    更新日期：2012-07-01 00:00:00

  • Using sedatives-hypnotics or opioids in older adults: a narrow path.

    abstract：:This issue of International Psychogeriatrics contains three papers from three continents that explore the use of sedatives-hypnotics and opioids in the treatment of older adults (Hamina et al., 2018; Machado-Duque et al., 2018; Tseng et al., 2018), and a fourth paper reporting on a qualitative study that addresses the...

    journal_title：International psychogeriatrics

    pub_type： 社论

    doi：10.1017/S104161021800087X

    authors： Davies SJC,Mulsant BH

    更新日期：2018-07-01 00:00:00

  • A process evaluation of a Psychomotor Dance Therapy Intervention (DANCIN) for behavior change in dementia: attitudes and beliefs of participating residents and staff.

    abstract：BACKGROUND:In a previous paper, we presented results from a 12-week study of a Psychomotor DANCe Therapy INtervention (DANCIN) based on Danzón Latin Ballroom that involves motor, emotional-affective, and cognitive domains, using a multiple-baseline single-case design in three care homes. This paper reports the results ...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章,多中心研究

    doi：10.1017/S104161021600171X

    authors： Guzmán A,Robinson L,Rochester L,James IA,Hughes JC

    更新日期：2017-02-01 00:00:00

  • Anxiety symptoms during hospitalization of elderly are associated with increased risk of post-discharge falls.

    abstract：BACKGROUND:The aim of this study was to test the association between anxiety at the time of hospitalization and falls occurring within one month of discharge, and to offer potential mechanisms for this association. METHODS:One-month, prospective cohort study of 556 older adults in two medical centers in Israel. Anxiet...

    journal_title：International psychogeriatrics

    pub_type： 杂志文章

    doi：10.1017/S1041610215002306

    authors： Agmon M,Zisberg A,Tonkikh O,Sinoff G,Shadmi E

    更新日期：2016-06-01 00:00:00