Abstract:
BACKGROUND:The aim of this study was to investigate the clustering of symptoms on the Neuropsychiatric Inventory (NPI) and the relative prevalence of symptom clusters in mild and moderate Alzheimer's disease (AD). METHODS:Confirmatory factor analysis (CFA) was performed on the polychoric correlation matrix of 12 NPI items (scored yes or no) using the weighted least squares with mean and variance adjustment (WLSMV) estimator in Mplus (N = 224 community-dwelling Chinese persons with mild/moderate AD). Severity of AD was determined by Clinical Dementia Rating scores. The relative model fit of three competing measurement models (also known as factor structures) was tested using a modified χ2 difference test. Prevalence rates across mild and moderate stages were compared using χ2 tests. Furthermore, the measurement model of choice was cross-validated in an independent sample of 181 community-dwelling persons with dementia. RESULTS:CFA supported a four-factor model, namely behavioral problems (agitation/aggressiveness, disinhibition, irritability, and aberrant motor behavior), psychosis (delusions and hallucinations), mood disturbance (depression, anxiety, sleep, appetite, and apathy), and euphoria (a stand-alone item that is equivalent to the factor). The most prevalent symptom clusters were behavioral (72%) and mood (69%) disturbances, followed by psychosis (45%). Euphoria was rare (6%). All syndromes were more prevalent in moderate than in mild stage, except for euphoria. In addition, the four-factor model was replicated in the cross-validation sample. CONCLUSIONS:The four syndromes provide a parsimonious conceptualization of neuropsychiatric symptoms corresponding to clinical observations and neurochemical changes of the disease. The independent replication in the second sample supports generalization of the four-factor model in Chinese persons with AD.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Cheng ST,Kwok T,Lam LCdoi
10.1017/S1041610212000609subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1465-73issue
9eissn
1041-6102issn
1741-203Xpii
S1041610212000609journal_volume
24pub_type
杂志文章abstract::The focus of this report is the treatment of persons with dementia who are of a non-English-speaking background (NESB). Noisemaking is one behavioral manifestation associated with severe dementia. It can have devastating effects on persons with dementia by limiting their access to activity programs and social interact...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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journal_title:International psychogeriatrics
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journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/S1041610203009190
更新日期:2003-01-01 00:00:00
abstract::ABSTRACTThe aim of the present study is to investigate the impact of benzodiazepine use on cognitive performance in primary care patients with first cognitive complaints. The association between the exposition to benzodiazepines (short and long half-life) and cognitive performance, evaluated through the Mini Mental St...
journal_title:International psychogeriatrics
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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journal_title:International psychogeriatrics
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020800817X
更新日期:2009-04-01 00:00:00
abstract::ABSTRACTBackground:US suicide rates among older women have substantially increased over the past decade. We examined potential differences in sociodemographic and risk/precipitating factors among older female suicide decedents who died by drug overdose versus firearms, hanging/suffocation, and other means, and postmor...
journal_title:International psychogeriatrics
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pub_type: 杂志文章,评审
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更新日期:2004-06-01 00:00:00
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更新日期:2009-04-01 00:00:00
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更新日期:2007-06-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2001-06-01 00:00:00
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更新日期:2013-04-01 00:00:00
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更新日期:2019-01-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2010-05-01 00:00:00
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更新日期:2003-03-01 00:00:00
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更新日期:2008-08-01 00:00:00
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更新日期:2019-04-01 00:00:00
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更新日期:2000-09-01 00:00:00
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