Abstract:
:ABSTRACTThe aim of the present study is to investigate the impact of benzodiazepine use on cognitive performance in primary care patients with first cognitive complaints. The association between the exposition to benzodiazepines (short and long half-life) and cognitive performance, evaluated through the Mini Mental State Examination (MMSE), was tested through analysis of the covariance and logistic regression models. Within the 4,249 participants (mean age 77.0 ± 8.2, 66.4% women), 732 (17%) were on benzodiazepines. When compared with non-users, short- and long-acting benzodiazepine users presented overlapping adjusted MMSE mean scores (respectively, mean MMSE score: 25.3, 95%CI 25.2-25.5; 25.4, 95%CI 25.1-25.7, and 25.9, 95%CI 25.3-26.4; p = 0.156). When tested according to the logistical regression model, after adjusting for potential confounders, no association was found between short and long acting benzodiazepine use and a MMSE < 24 (respectively, OR 0.9, 95%CI 0.7-1.2; OR 0.8, 95%CI 0.7-1.3) as compared with non-users. In conclusion, according to the results of our study, benzodiazepine use seems not to impact on cognitive performance- as assessed with the MMSE- of primary care patients referring to GPs for first cognitive complaints.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Grande G,Tramacere I,Vetrano DL,Pomati S,Mariani C,Filippini Gdoi
10.1017/S104161021700223Xsubject
Has Abstractpub_date
2018-04-01 00:00:00pages
597-601issue
4eissn
1041-6102issn
1741-203Xpii
S104161021700223Xjournal_volume
30pub_type
杂志文章abstract:BACKGROUND:Young-onset dementia (YOD) is defined as dementia that develops before the age of 65 years. The prevalence and type of neuropsychiatric symptoms (NPS) in YOD differ from patients with late onset dementia. NPS in dementia patients are often treated with psychotropic drugs. The aim of this study was to investi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213002330
更新日期:2014-12-01 00:00:00
abstract::The pervasive scarcity of resources relative to the demands upon them makes it necessary for decision makers to think carefully about choices. Evidence from economics can help to inform such choices, particularly as it relates to costs, outcomes, the efficiency with which resources are used, the distribution of benefi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610207005157
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:The purpose of the study was to examine the attention deficit hyperactivity disorder (ADHD) symptomatology across the lifespan by comparing older individuals' self-reports about current ADHD symptoms and symptoms in childhood. METHODS:The 25-item Wender Utah Rating Scale (WURS) was initially administered in...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212002050
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:To investigate the effect of a social robot intervention on depression, loneliness, and quality of life of older adults in long-term care (LTC) and to explore participants' experiences and perceptions after the intervention. DESIGN:A mixed-methods approach consisting of a single group, before and after quas...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220000459
更新日期:2020-08-01 00:00:00
abstract::Dementia can interfere with the maintenance of social interactions. The ability to participate in social interactions is one of the elements that enables good social health (Hubert et al., 2011), and having dementia does not automatically eliminates the person's opportunity to have good social health (Vernooij-Dassen ...
journal_title:International psychogeriatrics
pub_type: 信件
doi:10.1017/S1041610217002046
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Due to previously reported mixed findings, there is a need for further empirical research on the factorial structure of the commonly used Geriatric Anxiety Inventory (GAI). Therefore, the psychometric properties of the GAI and its short form version (GAI-SF) were evaluated in a psychogeriatric mixed in-and-o...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001004
更新日期:2017-10-01 00:00:00
abstract::ABSTRACTBackground:Evidence suggests that semantic interference may be a sensitive indicator of early dementia. We examined the utility of the Semantic Interference Test (SIT), a cognitive stress memory paradigm which taps proactive and retroactive semantic interference, for predicting progression from mild cognitive ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217002666
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:In old age, both apathy and depression have been associated with an increased cardiovascular disease (CVD) risk. This study evaluated the mediating role of cardiovascular risk factors in the relationship of apathy and mood symptoms with incident CVD. METHODS:Prospective cohort study of 1,790 community-dwell...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215001751
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Recognizing and diagnosing early onset dementia (EOD) can be complex and often takes longer than for late onset dementia. The objectives of this study are to investigate the barriers to diagnosis and to develop a typology of the diagnosis pathway for EOD caregivers. METHODS:Semi-structured interviews with 9...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211001013
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:While the relationship of apolipoprotein E (APOE) to behavioral symptoms of dementia (BSD) has been studied in community-dwelling persons with AD, it has received limited attention within the nursing home (NH) population. The aim of this study was to examine the association between APOE genotype and BSD in N...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209009235
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Earlier research showed that multi-component dyadic interventions - including a combination of intervention strategies and addressing both the person with dementia and caregiver - have a beneficial impact on the mental and physical health of people with dementia and their family caregivers. A randomized cont...
journal_title:International psychogeriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1017/S104161021500071X
更新日期:2015-12-01 00:00:00
abstract::This issue of International Psychogeriatrics contains three papers from three continents that explore the use of sedatives-hypnotics and opioids in the treatment of older adults (Hamina et al., 2018; Machado-Duque et al., 2018; Tseng et al., 2018), and a fourth paper reporting on a qualitative study that addresses the...
journal_title:International psychogeriatrics
pub_type: 社论
doi:10.1017/S104161021800087X
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:The negative image of Alzheimer's disease (AD) in our society has a substantial impact on treating, caring for and integrating those suffering from the disease and their relatives. Little research has been conducted on social perception of AD in the community. METHODS:The aim of this study was to investigat...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211001529
更新日期:2012-01-01 00:00:00
abstract::ABSTRACT Background: The consequences of co-occurring persistent loneliness and late life depression are yet unknown. The aim of this study was to get a deeper insight into the mental health consequences of loneliness in older persons with depressive symptoms and their perspectives of emotional distress by using a mix...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214000581
更新日期:2014-04-09 00:00:00
abstract:BACKGROUND:There is suggestion that self-reported depressive syndromes can independently manifest in the general population as cognitive/affective or somatic/vegetative. The Beck Depression Inventory, 2nd edition (BDI-II), a self-report measure of depressive symptoms, has been shown to support this two-factor structure...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001676
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:Data on psychotropic medications of older patients with schizophrenia spectrum disorder are scarce. Specifically, information about the use of benzodiazepines among older patients with schizophrenia spectrum disorder is very limited. Because benzodiazepine use in older patients has been associated with many ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219000358
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Cognitive assessment of older persons, particularly those with impairment, is hampered by measurement error and the ethical issues of testing people with dementia. A potential source of valuable information about end-of-life cognitive status can be gained from those who knew the respondent well - mostly rela...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210001201
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:The Addenbrooke's Cognitive Examination (ACE) and its Revised version (ACE-R) are relatively new screening tools for cognitive impairment that may improve upon the well-known Mini-Mental State Examination (MMSE) and other brief batteries. We systematically reviewed diagnostic accuracy studies of ACE and ACE-...
journal_title:International psychogeriatrics
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S1041610213002329
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Workforce shortages to meet the mental health needs of the world's aging population are well documented. Within the field of professional geropsychology in the U.S.A., a national conference was convened in 2006 to delineate competencies for psychological practice with older adults and a training model for th...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209991736
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Young-onset dementia (YOD) has a profound impact on spouses. However, little is known on how the quality of the relationship changes over time in YOD. This study aims to determine how the quality of the relationship changes over time and identify predictors of this change. METHODS:This study used data from ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220000332
更新日期:2020-03-10 00:00:00
abstract::This article reviews longitudinal data collected from patients with Alzheimer's disease (AD) that are relevant to the design and interpretation of clinical treatment trials. Longitudinal data from patients tested with the Alzheimer's Disease Assessment Scale demonstrate that cognitive symptoms, including memory loss, ...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610296002578
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:This study sought to conduct a comprehensive search for genetic risk of cognitive decline in the context of geriatric depression. DESIGN:A genome-wide association study (GWAS) analysis in the Neurocognitive Outcomes of Depression in the Elderly (NCODE) study. SETTING:Longitudinal, naturalistic follow-up stu...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220001143
更新日期:2020-07-09 00:00:00
abstract:BACKGROUND:The impact of spousal bereavement on mental health varies among the widowed. More information is needed on factors influencing bereavement outcome. METHOD:We conducted a cross-sectional study on a sample of 216 widowed individuals. Initial non-response was high, with only 8% of all approached persons partic...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610206004248
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Concerns about suicide risk in people with dementia have been increasing in recent years along with a discourse about rational suicide and assisted suicide. METHODS:A systematic narrative literature review of suicidal behavior and assisted suicide in persons with dementia. RESULTS:Most studies that have ex...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610215000629
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Neuropsychiatric symptoms (NPS) are prevalent in nursing-home (NH) patients with dementia, but little is known about the long-term course of these symptoms. METHODS:In this study, 931 NH patients with dementia took part in a prospective cohort study with four assessments over a 53-month follow-up period. NP...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213001609
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Seeking medical advice for dementia involves an understanding of norms, values and attitudes towards care-giving and inter-dependency, which are culturally bounded. We hypothesize that local culture and socioeconomic structure affect our Chinese patients who present with forgetfulness to our memory clinic. ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020800817X
更新日期:2009-04-01 00:00:00
abstract::In order to conceptually define quality of life (QOL) in dementia, the literature on QOL in the elderly population, in chronic disease and in dementia was studied. Dementia is a progressive, age-related, chronic condition and to avoid omissions within the dementia-specific concept of QOL, a broad orientation was the p...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610205002073
更新日期:2005-09-01 00:00:00
abstract::The reliability and validity of the Subjective Burden Scale (SBS) were investigated in 255 Japanese family caregivers of elderly relatives with dementia. Values of the Cronbach's alpha reliability, split-half reliability (r), and test-retest reliability (r) were .87, .80, and .72, respectively. The SBS score was signi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610299005712
更新日期:1999-06-01 00:00:00
abstract::This paper presents updated analyses on the genetic associations of sleep disruption in individuals with Alzheimer's disease (AD). We published previously a study of the association between single nucleotide polymorphisms (SNPs) found in eight genes related to circadian rhythms and objective measures of sleep-wake dis...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219001777
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:The anxiety disorders are a prevalent mental health problem in older age with a considerable impact on quality of life. Until recently there have been few longitudinal studies on anxiety in this age group, consequently most of the evidence to date has been cross-sectional in nature. METHODS:We undertook a l...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610214001847
更新日期:2015-07-01 00:00:00