Abstract:
:This article reviews longitudinal data collected from patients with Alzheimer's disease (AD) that are relevant to the design and interpretation of clinical treatment trials. Longitudinal data from patients tested with the Alzheimer's Disease Assessment Scale demonstrate that cognitive symptoms, including memory loss, dysphasia, and dyspraxia, worsen relentlessly over time with the rate of change depending upon baseline dementia severity. Noncognitive symptoms, such as agitation, depressed mood, and psychosis, are episodic, do not necessarily worsen over time, and tend not to be highly correlated with one another. The reliability of cognitive change measures increases with follow-up duration so that the likelihood of detecting drug effects on the rate of cognitive deterioration is greater with longer treatment trials. Functional measures of activities of daily living are difficult to standardize for AD patients but are important for determining the overall clinical and economic impact of AD treatments.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Mohs RCdoi
10.1017/s1041610296002578subject
Has Abstractpub_date
1996-07-01 00:00:00pages
195-203issue
2eissn
1041-6102issn
1741-203Xjournal_volume
8pub_type
杂志文章,评审abstract::Few would argue that achieving the age of 100 years is extraordinary, but what about the quality of life at this extreme age? Is it worth it to live to 100 and beyond? The study by Araújo, Ribero, Teixeira, and Paúl (2015) in three ways provided an answer to this question substantiating and complementing recent findin...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610215002021
更新日期:2016-02-01 00:00:00
abstract::There was a five-year delay between the two waves of the Canadian Study of Health and Aging during which 2,982 participants died. Their cognitive status before death should be taken into account in estimating the incidence of dementia in the cohort. Information concerning antemortem cognitive status was available from...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/s1041610202008037
更新日期:2001-01-01 00:00:00
abstract::Dementia can interfere with the maintenance of social interactions. The ability to participate in social interactions is one of the elements that enables good social health (Hubert et al., 2011), and having dementia does not automatically eliminates the person's opportunity to have good social health (Vernooij-Dassen ...
journal_title:International psychogeriatrics
pub_type: 信件
doi:10.1017/S1041610217002046
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:An association between metabolic syndrome (MetS) and disturbances in neurocognitive function has been identified in Caucasians but the nature and extent of impaired cognition in Asian MetS patients, who may be at greater risk of degenerative cognitive decline, remains unspecified. METHODS:A cross-sectional ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021400057X
更新日期:2014-08-01 00:00:00
abstract::Health-related quality of life (HRQL) was investigated in 211 inhabitants of five residential homes in The Netherlands and was assessed again 1 year later. It was examined (a) if HRQL was related to the presence of specific general medical illnesses, (b) if comorbidity resulted in poorer HRQL, independent of the type ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610299006067
更新日期:1999-12-01 00:00:00
abstract::ABSTRACT Background: The association between disability and depression is complex, with disability well established as a correlate and consequence of late life depression. Studies in community samples report that greater volumes of cerebral white matter hyperintensities (WMHs) seen on brain imaging are linked with fun...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214000829
更新日期:2014-05-09 00:00:00
abstract:OBJECTIVES:Disability in older adults is associated with a need for support in work, education, and community activities, reduced independence, and poorer quality of life. This study examines potential determinants of disability in a clinical sample of older adults across the continuum of cognitive decline, including s...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218002144
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Alterations in iron metabolism have been suggested as potential pathological markers in patients with manifest depression. No data on the association between iron and depression exist from population-based studies, in which milder forms of depressive symptoms are much more common. The aim of this study was t...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002759
更新日期:2006-09-01 00:00:00
abstract::Seventy-eight nondemented elderly depressed patients underwent an extensive battery of cognitive tests both before and after seven weeks of treatment with nortriptyline, phenelzine, or placebo. Clinical and cognitive evaluations of the patients were under double-blind conditions. Response to treatment did not appear t...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s1041610289000141
更新日期:1989-10-01 00:00:00
abstract::This paper provides a review of research issues and findings on the epidemiology of delirium. Despite the fact that research on this important geriatric syndrome has been conducted for many decades, several methodological issues make it difficult to compare findings across studies. In this paper we first discuss broad...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610291000625
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate survival time and life-expectancy in people with young-onset dementia (YOD) and to examine the relationship with age, sex, dementia subtype and comorbidity. DESIGN, SETTING AND PARTICIPANTS:Survival was examined in 198 participants in the Needs in Young-onset Dementi...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S1041610219000152
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to test the association between anxiety at the time of hospitalization and falls occurring within one month of discharge, and to offer potential mechanisms for this association. METHODS:One-month, prospective cohort study of 556 older adults in two medical centers in Israel. Anxiet...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215002306
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Qualitative research has suggested that spousal carers of someone with dementia differ in terms of whether they perceive their relationship with that person as continuous with the premorbid relationship or as radically different, and that a perception of continuity may be associated with more person-centered...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001743
更新日期:2013-02-01 00:00:00
abstract::ABSTRACT Background: Cognitive impairment is underrecognized and misdiagnosed among community-dwelling older adults. At present, there is no consensus about which cognitive screening tool represents the "gold standard." However, one tool that shows promise is the Brief Cognitive Assessment Tool (BCAT), which was origi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214001458
更新日期:2014-08-13 00:00:00
abstract::This issue of International Psychogeriatrics contains three papers from three continents that explore the use of sedatives-hypnotics and opioids in the treatment of older adults (Hamina et al., 2018; Machado-Duque et al., 2018; Tseng et al., 2018), and a fourth paper reporting on a qualitative study that addresses the...
journal_title:International psychogeriatrics
pub_type: 社论
doi:10.1017/S104161021800087X
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Dementia caregiving has been linked to negative consequences for mental health in caregivers. Although depression seems to be an enduring psychological consequence associated with caregiving, little is known about the longitudinal effects that modulating variables related to coping strategies have on caregiv...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211002237
更新日期:2012-08-01 00:00:00
abstract::ABSTRACTBackground:Evidence suggests that semantic interference may be a sensitive indicator of early dementia. We examined the utility of the Semantic Interference Test (SIT), a cognitive stress memory paradigm which taps proactive and retroactive semantic interference, for predicting progression from mild cognitive ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217002666
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Quality of Life-Alzheimer's Disease (QOL-AD) is a widely used scale for the study of quality of life in patients with dementia. The aim of this study is the transcultural adaptation and validation of the QOL-AD scale in Portugal. METHODS:Translation and transcultural adaptation was performed according to st...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213000379
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The IPA Taskforce on Mental Health Issues in Long-Term Care Homes seeks to improve mental health care in long-term care (LTC) homes. The aim of this paper is to provide recommendations on comprehensive assessment of depression and behavioral problems in order to further stimulate countries and professionals ...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610210000736
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Suicide is a major public health concern. The elderly have the highest rate of suicide and they make more lethal suicide attempts and have fewer psychiatric interventions than young people. Furthermore, they have old-age specific psychosocial difficulties. The present study investigated psychosocial risk fac...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211000263
更新日期:2011-08-01 00:00:00
abstract::Depression is the most prevalent mental health problem among the elderly, including Chinese-American elderly. A Chinese-language version of the popular Geriatric Depression Scale Long Form (GDS-LF) and Short Form (GDS-SF) was developed. Based on the responses of 50 elderly Chinese immigrants to the U.S. (25 women and ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610296002803
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Children of patients with young onset dementia (YOD) who are confronted with a parent who has a progressive disease, often assist in caregiving tasks, which may have a great impact on their lives. The objective of the present study is to explore the experiences of children living with a young parent with dem...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213001890
更新日期:2014-12-01 00:00:00
abstract::Noisemaking is one of the most disturbing behavior disorders associated with dementia. Standard management practices, including pharmacological interventions, are not very successful in treating the behavior. Very little research has been carried out to evaluate innovative treatments or to determine the etiology of no...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610297004547
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVES:Older people commonly present with memory loss although on assessment are not found to have a full dementia complex. Previous studies have suggested however that people with subjective and objective cognitive loss are at higher risk of dementia. We aimed to determine from the literature the rate of conversio...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610204000092
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:The aim of this survey is to investigate professional attitudes to the presence and value of spiritual care from Old Age Psychiatrists. METHOD:All registered members of the Faculty of the Psychiatry of Old Age in the United Kingdom were asked to complete a 21-question semi-structured questionnaire. The firs...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610206004339
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Recognizing and diagnosing early onset dementia (EOD) can be complex and often takes longer than for late onset dementia. The objectives of this study are to investigate the barriers to diagnosis and to develop a typology of the diagnosis pathway for EOD caregivers. METHODS:Semi-structured interviews with 9...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211001013
更新日期:2011-11-01 00:00:00
abstract::ABSTRACTObjectives:Centenarians have survived into very late life, but whether they reach very old age in good health remains unclear. The purpose of this study was to compare the cardiovascular health status and cognitive functioning of centenarians in the United States with centenarians in Japan. DESIGN, SETTING, A...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218001813
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:A single-item depression measure may not be adequate in capturing the complex entity of mental health, despite wide use of this indicator in community studies. This study evaluated the accuracy of a single-question depression measure in comparison to two composite indices-the Center for Epidemiologic Studies...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001673
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Australia has a growing aging migrant population and rates of dementia in residential care are high. The communication of persons with dementia and limited English language proficiency in residential care is an area that has received little attention in the research literature. METHOD:Thirty-nine Italian-ba...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002309
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:The negative image of Alzheimer's disease (AD) in our society has a substantial impact on treating, caring for and integrating those suffering from the disease and their relatives. Little research has been conducted on social perception of AD in the community. METHODS:The aim of this study was to investigat...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211001529
更新日期:2012-01-01 00:00:00