Abstract:
OBJECTIVE:This study sought to conduct a comprehensive search for genetic risk of cognitive decline in the context of geriatric depression. DESIGN:A genome-wide association study (GWAS) analysis in the Neurocognitive Outcomes of Depression in the Elderly (NCODE) study. SETTING:Longitudinal, naturalistic follow-up study. PARTICIPANTS:Older depressed adults, both outpatients and inpatients, receiving care at an academic medical center. MEASUREMENTS:The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery was administered to the study participants at baseline and a minimum of twice within a subsequent 3-year period in order to measure cognitive decline. A GWAS analysis was conducted to identify genetic variation that is associated with baseline and change in the CERAD Total Score (CERAD-TS) in NCODE. RESULTS:The GWAS of baseline CERAD-TS revealed a significant association with an intergenic single-nucleotide polymorphism (SNP) on chromosome 6, rs17662598, that surpassed adjustment for multiple testing (p = 3.7 × 10-7; false discovery rate q = 0.0371). For each additional G allele, average baseline CERAD-TS decreased by 8.656 points. The most significant SNP that lies within a gene was rs11666579 in SLC27A1 (p = 1.1 × 10-5). Each additional copy of the G allele was associated with an average decrease of baseline CERAD-TS of 4.829 points. SLC27A1 is involved with processing docosahexaenoic acid (DHA), an endogenous neuroprotective compound in the brain. Decreased levels of DHA have been associated with the development of Alzheimer's disease. The most significant SNP associated with CERAD-TS decline over time was rs73240021 in GRXCR1 (p = 1.1 × 10-6), a gene previously linked with deafness. However, none of the associations within genes survived adjustment for multiple testing. CONCLUSIONS:Our GWAS of cognitive function and decline among individuals with late-life depression (LLD) has identified promising candidate genes that, upon replication in other cohorts of LLD, may be potential biomarkers for cognitive decline and suggests DHA supplementation as a possible therapy of interest.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Steffens DC,Garrett ME,Soldano KL,McQuoid DR,Ashley-Koch AE,Potter GGdoi
10.1017/S1041610220001143subject
Has Abstractpub_date
2020-07-09 00:00:00pages
1-9eissn
1041-6102issn
1741-203Xpii
S1041610220001143pub_type
杂志文章abstract::ABSTRACT Background: The consequences of co-occurring persistent loneliness and late life depression are yet unknown. The aim of this study was to get a deeper insight into the mental health consequences of loneliness in older persons with depressive symptoms and their perspectives of emotional distress by using a mix...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214000581
更新日期:2014-04-09 00:00:00
abstract:BACKGROUND:This study determined the reliability, validity, and factor structure of self-report emotions in persons with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI) relative to controls. METHODS:Participants (mild AD, n = 73; MCI, n = 159; controls, n = 96) rated current emotions with the Visual ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021100041X
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Addenbrooke's Cognitive Examination III (ACE-III) is a screening test that was recently validated for diagnosing dementia. Since it assesses attention, language, memory, fluency, and visuospatial function separately, it may also be useful for general neuropsychological assessments. The aim of this study was ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216001496
更新日期:2017-01-01 00:00:00
abstract::Health-related quality of life (HRQL) was investigated in 211 inhabitants of five residential homes in The Netherlands and was assessed again 1 year later. It was examined (a) if HRQL was related to the presence of specific general medical illnesses, (b) if comorbidity resulted in poorer HRQL, independent of the type ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610299006067
更新日期:1999-12-01 00:00:00
abstract::Few would argue that achieving the age of 100 years is extraordinary, but what about the quality of life at this extreme age? Is it worth it to live to 100 and beyond? The study by Araújo, Ribero, Teixeira, and Paúl (2015) in three ways provided an answer to this question substantiating and complementing recent findin...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610215002021
更新日期:2016-02-01 00:00:00
abstract::Current approaches to the diagnosis of delirium are based upon the recognition of symptoms that emerge in the pathological state. As an alternative, we propose an approach to case identification for research purposes based on the recognition of significant changes in the cognitive or cerebral state of the individual p...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s104161029100073x
更新日期:1991-01-01 00:00:00
abstract::The World Alzheimer Report 2016 estimated that 47 million people are living with dementia worldwide (Alzheimer's Disease International, 2016). In the inaugural World Health Organization Ministerial Conference on Global Action against Dementia, six of the top ten research priorities were focused on prevention, identifi...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610218000042
更新日期:2018-02-01 00:00:00
abstract::The objectives of this randomized clinical trial were to investigate the impact of the discontinuation of long-term antipsychotics in residents with dementia in chronic care institutions and to identify clinical predictors of safe discontinuation. Subjects included 34 residents with dementia who were on antipsychotics...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s1041610202008396
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Cognitive impairment places older adults at increased risk of functional decline, injuries, and hospitalization. Assessments to determine whether older persons are still capable of meeting the cognitive challenges of everyday living are crucial to ensure their safe and independent living in the community. Th...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213001889
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:The objectives of this study were to examine the factors modifying the relationship between cortisol level and prevalent/incident cognitive impairment in older adults and to verify whether these relationships were non-linear. METHODS:Data were collected from 1,226 individuals aged 65 and older by two in-hom...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001706
更新日期:2013-02-01 00:00:00
abstract::ABSTRACTBackground:The number of elderly individuals living in China is increasing rapidly. The aim of this study was to examine the potential risk factors of geriatric depression in rural areas. METHODS:A repeated cross-sectional study was conducted between January 2015 and October 2016 in rural China. Nine hundred ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000030
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Patients with dementia often receive poor end-of-life care, with inadequate pain control and without access to the palliative care services that patients with cancer are offered. This has been identified as an area of need in recent UK. Government reports and by the Alzheimer's Society (UK). Our objective wa...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610205001018
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Overlap between neuropsychiatric symptoms of dementia and delirium complicates diagnosis of delirium superimposed on dementia (DSD). This study sought to examine differences in delirium presentation and outcomes between DSD patients with and without pre-existing behavioral and psychological symptoms of demen...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216001836
更新日期:2017-03-01 00:00:00
abstract::Alzheimer´s disease (AD) is a severe neurodegenerative brain disorder characterized by beta-amyloid plaques, Tau pathology, inflammation, neurodegeneration, and cerebrovascular dysfunction. Besides that, alterations in monocytes and platelets have been reported in the blood of Alzheimer patients. In the present study,...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001612
更新日期:2018-01-01 00:00:00
abstract::ABSTRACTBackground:Delirium is a complex clinical syndrome characterized by disturbed consciousness, cognitive function, or perception and associated with serious adverse outcomes such as death, dementia, and the need for long-term care. However, recognition and management of delirium is poorly prioritized even though...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218001369
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Understanding the prevalence, incidence and cofactors of depression among long-term elderly nursing home (LTNH) residents domiciled for eight months or more may help optimize depression treatment in this vulnerable group. We quantified first year depression in American LTNH residents and the associations bet...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210000578
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Inability to walk compromises the well-being of the growing number of nursing home residents with dementia. The purpose of this study was to estimate the incidence and identify predictors of walking disability that may be remediable. METHODS:A cohort was followed fortnightly for a year in 15 nursing homes i...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S1041610210000116
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:The study aimed to evaluate the Cognitive Assessment Battery (CAB) in a specialist clinic setting in order to find out if it if it could be a supplement to the Mini-mental State Examination (MMSE) and distinguish between normal aging, mild cognitive impairment (MCI) and dementia, as well as MCI of different ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210002334
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:This study aimed to assess the prevalence, incidence, and persistence of suicidal ideation (SI), and to investigate the psychosocial factors associated with these. METHODS:A total of 1,204 community dwelling elderly adults aged 65 years or older were evaluated at baseline, 909 (75%) of whom were followed tw...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213001634
更新日期:2014-01-01 00:00:00
abstract::ABSTRACTBackground:The current research sought to characterize current mood state profiles in healthy young versus older adults using 100-point visual analogue mood scales (VAMS), provide within-sample and new sample replication of age-group differences, assess sex differences, and compare with commonly used standardi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000996
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:There is suggestion that self-reported depressive syndromes can independently manifest in the general population as cognitive/affective or somatic/vegetative. The Beck Depression Inventory, 2nd edition (BDI-II), a self-report measure of depressive symptoms, has been shown to support this two-factor structure...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001676
更新日期:2013-03-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610298005444
更新日期:1998-12-01 00:00:00
abstract::ABSTRACTThe aim of the present study is to investigate the impact of benzodiazepine use on cognitive performance in primary care patients with first cognitive complaints. The association between the exposition to benzodiazepines (short and long half-life) and cognitive performance, evaluated through the Mini Mental St...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021700223X
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:Despite delirium being common in older hospitalized people, little is known about its management. The aims of this study are (1) to describe the pharmacological management of delirium in an acute care setting as a baseline measure prior to the implementation of newly developed Australian guidelines; and (2) t...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610208008028
更新日期:2009-02-01 00:00:00
abstract::In order to conceptually define quality of life (QOL) in dementia, the literature on QOL in the elderly population, in chronic disease and in dementia was studied. Dementia is a progressive, age-related, chronic condition and to avoid omissions within the dementia-specific concept of QOL, a broad orientation was the p...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610205002073
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:The elderly are at high risk of developing tuberculosis. The prevalence and incidence of depression and anxiety are higher in those with tuberculosis than in the general population. A positive correlation between national suicide rates and rates of mortality due to tuberculosis has been reported. METHODS:Th...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209990378
更新日期:2009-12-01 00:00:00
abstract::Noisemaking is one of the most disturbing behavior disorders associated with dementia. Standard management practices, including pharmacological interventions, are not very successful in treating the behavior. Very little research has been carried out to evaluate innovative treatments or to determine the etiology of no...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610297004547
更新日期:1997-12-01 00:00:00
abstract::In this editorial, we challenge the current understanding of "Living Well with Dementia." Such discourse introduces the possibility of not living well with the condition or even of "living badly with dementia." Numerous words might be relevant here - grief, pain, anguish, depression - but in this editorial we consciou...
journal_title:International psychogeriatrics
pub_type: 社论
doi:10.1017/S104161021600199X
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:To validate a shorter version of the Geriatric Depression Scale (GDS) for older, visually impaired patients. PARTICIPANTS:Subjects were 70 visually impaired adults over age 65 who were presenting for services at a low vision clinic. METHOD:Subjects were interviewed by a geriatric nurse practitioner. A struc...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610200006554
更新日期:2000-12-01 00:00:00
abstract::Exposure to general anesthesia has been suggested as a possible cause of long-term cognitive impairment in elderly subjects. The present study reviews the literature in this field in order to describe postoperative cognitive impairment in elderly populations, to determine to what extent this may be attributed to anest...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610297004468
更新日期:1997-09-01 00:00:00